The immunoconjugate "icon" targets aberrantly expressed endothelial tissue factor causing regression of endometriosis

American Journal of Pathology

Volumn 176, Issue 2, 2010, Pages 1050-1056

  Krikun, Graciela ^a   Hu, Zhiwei ^a   Osteen, Kevin ^b   Bruner Tran, Kaylon L ^b   Schatz, Frederick ^a   Taylor, Hugh S ^a   Toti, Paolo ^c   Arcuri, Felice ^c   Konigsberg, William ^a   Garen, Alan ^a   Booth, Carmen J ^a   Lockwood, Charles J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; ICON PROTEIN; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ADULT; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CONTROLLED STUDY; DRUG BINDING; ENDOMETRIOSIS; ENDOTHELIUM CELL; FEMALE; FERTILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMPLANT; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; REMISSION; TERATOGENESIS;

EID: 76149089873     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2010.090757     Document Type: Article

References (54)

1. Giudice LC, and Kao LC. Endometriosis. Lancet 2004, 364:1789-1799
2. Sharpe-Timms KL, and Young SL: Understanding endometriosis is the key to successful therapeutic management. Fertil Steril 2004, 81:1201-1203
3. Taylor RN, Lebovic DI, and Mueller MD: Angiogenic factors in endometriosis. Ann NY Acad Sci 2002, 955:89-100; discussion 118:396-406
4. Nezhat C, Crowgey SR, and Garrison CP: Surgical treatment of endometriosis via laser laparoscopy and videolaseroscopy. Contrib Gynecol Obstet 1987, 16:303-312
5. Surrey ES, and Schoolcraft WB: Management of endometriosis-associated infertility. Obstet Gynecol Clin North Am 2003, 30:193-208
6. Gazvani R, and Templeton A: New considerations for the pathogenesis of endometriosis. Int J Gynaecol Obstet 2002, 76:117-126
7. Haney AF: Etiology and histogenesis of endometriosis. Prog Clin Biol Res 1990, 323:1-14
8. Ishimura T, and Masuzaki H: Peritoneal endometriosis: endometrial tissue implantation as its primary etiologic mechanism. Am J Obstet Gynecol 1991, 165:210-214
9. Oral E, and Arici A: Pathogenesis of endometriosis. Obstet Gynecol Clin North Am 1997, 24:219-233
10. Fujimoto J, Sakaguchi H, Hirose R, Wen H, and Tamaya T: Angiogenesis in endometriosis and angiogenic factors. Gynecol Obstet Invest 1999, 48:14-20
11. Li XF, Charnock-Jones DS, Zhang E, Hiby S, Malik S, Day K, Licence D, Bowen JM, Gardner L, King A, Loke YW, and Smith SK: Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells. J Clin Endocrinol Metab 2001, 86:1823-1834
12. Mahnke JL, Dawood MY, and Huang JC: Vascular endothelial growth factor and interleukin-6 in peritoneal fluid of women with endometriosis. Fertil Steril 2000, 73:166-170
13. McLaren J, Prentice A, Charnock-Jones DS, Millican SA, Muller KH, Sharkey AM, and Smith SK: Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. J Clin Invest 1996, 98:482-489
14. Carmeliet P, Mackman N, Moons L, Luther T, Gressens P, Van Vlaenderen I, Demunck H, Kasper M, Breier G, Evrard P, Muller M, Risau W, Edgington T, and Collen D: Role of tissue factor in embryonic blood vessel development. Nature 1996, 383:73-75
15. Versteeg HH, Peppelenbosch MP, and Spek CA: Tissue factor signal transduction in angiogenesis. Carcinogenesis 2003, 24:1009-1013
16. Bugge TH, Xiao Q, Kombrinck KW, Flick MJ, Holmback K, Danton MJ, Colbert MC, Witte DP, Fujikawa K, Davie EW, and Degen JL: Fatal embryonic bleeding events in mice lacking tissue factor, the cellassociated initiator of blood coagulation. Proc Natl Acad Sci USA 1996, 93:6258-6263
17. Toomey JR, Kratzer KE, Lasky NM, Stanton JJ, and Broze GJ Jr. Targeted disruption of the murine tissue factor gene results in embryonic lethality. Blood 1996, 88:1583-1587
18. Chand HS, Ness SA, and Kisiel W: Identification of a novel human tissue factor splice variant that is upregulated in tumor cells. Int J Cancer 2006, 118:1713-1720
19. Mackman N: Gene targeting in hemostasis. tissue factor. Front Biosci 2001, 6:D208-D215
20. Belting M, Dorrell MI, Sandgren S, Aguilar E, Ahamed J, Dorfleutner A, Carmeliet P, Mueller BM, Friedlander M, and Ruf W: Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nat Med 2004, 10:502-509
21. Joussen AM: Vascular plasticity-the role of the angiopoietins in modulating ocular angiogenesis. Graefes Arch Clin Exp Ophthalmol 2001, 239:972-975
22. Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, and Ingber DE: Tumor-derived endothelial cells exhibit aberrant Rhomediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci USA 2008, 105:11305-11310
23. Krikun G, Schatz F, Taylor H, and Lockwood CJ: Endometriosis and tissue factor. Ann NY Acad Sci 2008, 1127:101-105
24. Hu Z, and Garen A: Intratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapy. Proc Natl Acad Sci USA 2000, 97:9221-9225
25. Hu Z, and Garen A: Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer. Proc Natl Acad Sci USA 2001, 98:12180-12185
26. Hu Z, Sun Y, and Garen A: Targeting tumor vasculature endothelial cells and tumor cells for immunotherapy of human melanoma in a mouse xenograft model. Proc Natl Acad Sci USA 1999, 96:8161-8166
27. Osteen KG, Bruner-Tran KL, Ong D, and Eisenberg E: Paracrine mediators of endometrial matrix metalloproteinase expression: potential targets for progestin-based treatment of endometriosis. Ann NY Acad Sci 2002, 955:139-146; discussion 157-158, 396-406
28. 1997. Revised American Society for Reproductive Medicine classification of endometriosis. Fertil Steril 1996, 67:817-821
29. Krikun G, Critchley H, Schatz F, Wan L, Caze R, Baergen RN, and Lockwood CJ: Abnormal uterine bleeding during progestin-only contraception may result from free radical-induced alterations in angiopoietin expression. Am J Pathol 2002, 161:979-986
30. Lockwood CJ, Nemerson Y, Guller S, Krikun G, Alvarez M, Hausknecht V, Gurpide E, and Schatz F: Progestational regulation of human endometrial stromal cell tissue factor expression during decidualization. J Clin Endocrinol Metab 1993, 76:231-236
31. Dickinson CD, Kelly CR, and Ruf W: Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa. Proc Natl Acad Sci USA 1996, 93:14379-14384
32. Waxman E, Ross JB, Laue TM, Guha A, Thiruvikraman SV, Lin TC, Konigsberg WH, and Nemerson Y: Tissue factor and its extracellular soluble domain: the relationship between intermolecular association with factor VIIa and enzymatic activity of the complex. Biochemistry 1992, 31:3998-4003
33. Presta L, Sims P, Meng YG, Moran P, Bullens S, Bunting S, Schoenfeld J, Lowe D, Lai J, Rancatore P, Iverson M, Lim A, Chisholm V, Kelley RF, Riederer M, and Kirchhofer D: Generation of a humanized, high affinity anti-tissue factor antibody for use as a novel antithrombotic therapeutic. Thromb Haemost 2001, 85:379-389
34. Kirchhofer D, Moran P, Chiang N, Kim J, Riederer MA, Eigenbrot C, and Kelley RF: Epitope location on tissue factor determines the anticoagulant potency of monoclonal anti-tissue factor antibodies. Thromb Haemost 2000, 84:1072-1081
35. Bromberg ME, Konigsberg WH, Madison JF, Pawashe A, and Garen A: Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation. Proc Natl Acad Sci USA 1995, 92:8205-8209
36. Evans AL, Bryant J, Skepper J, Smith SK, Print CG, and Charnock-Jones DS: Vascular development in embryoid bodies: quantification of transgenic intervention and antiangiogenic treatment. Angiogenesis 2007, 10:217-226
37. Bruner-Tran KL, Zhang Z, Eisenberg E, Winneker RC, and Osteen KG: Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget. J Clin Endocrinol Metab 2006, 91:1554-1560
38. Carlsson G, Gullberg B, and Hafstrom L: Estimation of liver tumor volume using different formulas - an experimental study in rats. J Cancer Res Clin Oncol 1983, 105:20-23
39. Krikun G, Schatz F, Mackman N, Guller S, Demopoulos R, and Lockwood CJ: Regulation of tissue factor gene expression in human endometrium by transcription factors Sp1 and Sp3. Mol Endocrinol 2000, 14:393-400
40. Lockwood CJ, Nemerson Y, Krikun G, Hausknecht V, Markiewicz L, Alvarez M, Guller S, and Schatz F: Steroid-modulated stromal cell tissue factor expression: a model for the regulation of endometrial hemostasis and menstruation. J Clin Endocrinol Metab 1993, 77:1014-1019
41. Lockwood CJ, Murk W, Kayisli UA, Buchwalder LF, Huang ST, Funai EF, Krikun G, and Schatz F: Progestin and thrombin regulate tissue factor expression in human term decidual cells. J Clin Endocrinol Metab 2009, 94:2164-2170
42. Arici A, Seli E, Zeyneloglu HB, Senturk LM, Oral E, and Olive DL: Interleukin-8 induces proliferation of endometrial stromal cells: a potential autocrine growth factor. J Clin Endocrinol Metab 1998, 83:1201-1205
43. Taylor RN, Ryan IP, Moore ES, Hornung D, Shifren JL, and Tseng JF: Angiogenesis and macrophage activation in endometriosis. Ann NY Acad Sci 1997, 828:194-207
44. Parry GC, and Mackman N: Transcriptional regulation of tissue factor expression in human endothelial cells. Arterioscler Thromb Vasc Biol 1995, 15:612-621
45. Reny JL, Laurendeau I, Fontana P, Bieche I, Dupont A, Remones V, Emmerich J, Vidaud M, Aiach M, and Gaussem P: The TF-603A/G gene promoter polymorphism and circulating monocyte tissue factor gene expression in healthy volunteers. Thromb Haemost 2004, 91:248-254
46. Shinohara Y, Iwasaki H, Ota N, Nakajima T, Kodaira M, Kajita M, Shiba T, and Emi M: Novel single nucleotide polymorphisms of the human nuclear factor kappa-B 2 gene identified by sequencing the entire gene. J Hum Genet 2001, 46:50-51
47. Sun XF, and Zhang H: NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases. Histol Histopathol 2007, 22:1387-1398
48. Bora PS, Hu Z, Tezel TH, Sohn JH, Kang SG, Cruz JM, Bora NS, Garen A, and Kaplan HJ: Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration. Proc Natl Acad Sci USA 2003, 100:2679-2684
49. Tezel TH, Bodek E, Sonmez K, Kaliappan S, Kaplan HJ, Hu Z, and Garen A: Targeting tissue factor for immunotherapy of choroidal neovascularization by intravitreal delivery of factor VII-Fc chimeric antibody. Ocul Immunol Inflamm 2007, 15:3-10
50. D'Hooghe TM, Kyama CM, Chai D, Fassbender A, Vodolazkaia A, Bokor A, and Mwenda JM: Nonhuman primate models for translational research in endometriosis. Reprod Sci 2009, 16:152-161
51. Schenken RS: Delayed diagnosis of endometriosis. Fertil Steril 2006, 86:1305-1306; discussion 1317
52. Hadfield R, Mardon H, Barlow D, and Kennedy S: Delay in the diagnosis of endometriosis: a survey of women from the USA and the UK. Human Reprod 1996, 11:878-880
53. Mihalyi A, Simsa P, Mutinda KC, Meuleman C, Mwenda JM, and D'Hooghe TM. Emerging drugs in endometriosis. Expert Opin Emerging Drugs 2006, 11:503-524
54. Tang Y, Borgstrom P, Maynard J, Koziol J, Hu Z, Garen A, and Deisseroth A: Mapping of angiogenic markers for targeting of vectors to tumor vascular endothelial cells. Cancer Gene Therapy 2007, 14:346-353