Regulation of Pax6 by CTCF during induction of mouse ES cell differentiation

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Gao, Jie ^a   Wang, Jie ^a   Wang, Yumei ^a   Dai, Wei ^b   Lu, Luo ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; RETINOIC ACID; TRANSCRIPTION FACTOR CTCF; TRANSCRIPTION FACTOR PAX6; CCCTC-BINDING FACTOR; EYE PROTEIN; HOMEODOMAIN PROTEIN; NUCLEOTIDE; PAIRED BOX TRANSCRIPTION FACTOR; REPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CPG ISLAND; DEVELOPMENTAL GENE; DNA BINDING MOTIF; DNA METHYLATION; EMBRYO; EMBRYONIC STEM CELL; EPIGENETICS; GENE CONTROL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INTERACTION; GENE REPRESSION; GLIA CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; PROMOTER REGION; REGULATOR GENE; TRANSCRIPTION FACTOR CTCF GENE; TRANSCRIPTION FACTOR PAX6 GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; ANIMAL; BINDING SITE; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECT; GENETIC EPIGENESIS; GENETICS; GLIA; METABOLISM;

ANIMALS; BINDING SITES; CELL DIFFERENTIATION; DNA METHYLATION; EMBRYONIC STEM CELLS; EPIGENESIS, GENETIC; EYE PROTEINS; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; MICE; NEUROGLIA; NUCLEOTIDES; PAIRED BOX TRANSCRIPTION FACTORS; REPRESSOR PROTEINS; TRETINOIN;

EID: 79958702274     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020954     Document Type: Article

References (43)

1. Fukuda H, Takahashi J, (2005) Embryonic stem cells as a cell source for treating Parkinson's disease. Expert Opin Biol Ther 5: 1273-1280.
2. Mitjavila-Garcia MT, Simonin C, Peschanski M, (2005) Embryonic stem cells: meeting the needs for cell therapy. Adv Drug Deliv Rev 57: 1935-1943.
3. Sugaya K, Alvarez A, Marutle A, Kwak YD, Choumkina E, (2006) Stem cell strategies for Alzheimer's disease therapy. Panminerva Med 48: 87-96.
4. Bibel M, Richter J, Lacroix E, Barde YA, (2007) Generation of a defined and uniform population of CNS progenitors and neurons from mouse embryonic stem cells. Nat Protoc 2: 1034-1043.
5. Bibel M, Richter J, Schrenk K, Tucker KL, Staiger V, et al. (2004) Differentiation of mouse embryonic stem cells into a defined neuronal lineage. Nat Neurosci 7: 1003-1009.
6. Ying QL, Stavridis M, Griffiths D, Li M, Smith A, (2003) Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol 21: 183-186.
7. Gotz M, Barde YA, (2005) Radial glial cells defined and major intermediates between embryonic stem cells and CNS neurons. Neuron 46: 369-372.
8. Malatesta P, Appolloni I, Calzolari F, (2008) Radial glia and neural stem cells. Cell Tissue Res 331: 165-178.
9. Gehring WJ, Ikeo K, (1999) Pax 6: mastering eye morphogenesis and eye evolution. Trends Genet 15: 371-377.
10. Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, et al. (2009) The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet 5: e1000511.
11. Plaza S, Dozier C, Saule S, (1993) Quail Pax-6 (Pax-QNR) encodes a transcription factor able to bind and trans-activate its own promoter. Cell Growth Differ 4: 1041-1050.
12. Plaza S, Dozier C, Turque N, Saule S, (1995) Quail Pax-6 (Pax-QNR) mRNAs are expressed from two promoters used differentially during retina development and neuronal differentiation. Mol Cell Biol 15: 3344-3353.
13. Xu PX, Zhang X, Heaney S, Yoon A, Michelson AM, et al. (1999) Regulation of Pax6 expression is conserved between mice and flies. Development 126: 383-395.
14. Canto-Soler MV, Huang H, Romero MS, Adler R, (2008) Transcription factors CTCF and Pax6 are segregated to different cell types during retinal cell differentiation. Dev Dyn 237: 758-767.
15. Li T, Lu Z, Lu L, (2006) Pax6 regulation in retinal cells by CCCTC binding factor. Invest Ophthalmol Vis Sci 47: 5218-5226.
16. Li T, Lu Z, Lu L, (2004) Regulation of eye development by transcription control of CCCTC binding factor (CTCF). J Biol Chem 279: 27575-27583.
17. Wu D, Li T, Lu Z, Dai W, Xu M, et al. (2006) Effect of CTCF-binding motif on regulation of PAX6 transcription. Invest Ophthalmol Vis Sci 47: 2422-2429.
18. Phillips JE, Corces VG, (2009) CTCF: master weaver of the genome. Cell 137: 1194-1211.
19. Ohlsson R, Lobanenkov V, Klenova E, Does CTCF mediate between nuclear organization and gene expression? Bioessays 32: 37-50.
20. Ohlsson R, Renkawitz R, Lobanenkov V, (2001) CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. Trends Genet 17: 520-527.
21. Renaud S, Loukinov D, Abdullaev Z, Guilleret I, Bosman FT, et al. (2007) Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene. Nucleic Acids Res 35: 1245-1256.
22. Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, et al. (1996) An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol 16: 2802-2813.
23. Witcher M, Emerson BM, (2009) Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell 34: 271-284.
24. Bell AC, West AG, Felsenfeld G, (1999) The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell 98: 387-396.
25. Bell AC, Felsenfeld G, (2000) Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature 405: 482-485.
26. Kanduri C, Pant V, Loukinov D, Pugacheva E, Qi CF, et al. (2000) Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr Biol 10: 853-856.
27. Li T, Lu L, (2005) Epidermal growth factor-induced proliferation requires down-regulation of Pax6 in corneal epithelial cells. J Biol Chem 280: 12988-12995.
28. Li T, Lu L, (2007) Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis. Exp Cell Res 313: 3057-3065.
29. Lu L, Wang L, Li T, Wang J, NF-kappaB subtypes regulate CCCTC binding factor affecting corneal epithelial cell fate. J Biol Chem 285: 9373-9382.
30. Osumi N, Shinohara H, Numayama-Tsuruta K, Maekawa M, (2008) Concise review: Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator. Stem Cells 26: 1663-1672.
31. Zhang X, Huang CT, Chen J, Pankratz MT, Xi J, et al. Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell 7: 90-100.
32. Heins N, Malatesta P, Cecconi F, Nakafuku M, Tucker KL, et al. (2002) Glial cells generate neurons: the role of the transcription factor Pax6. Nat Neurosci 5: 308-315.
33. Gotz M, Stoykova A, Gruss P, (1998) Pax6 controls radial glia differentiation in the cerebral cortex. Neuron 21: 1031-1044.
34. Shibata M, Nakao H, Kiyonari H, Abe T, Aizawa S, (2011) MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. J Neurosci 31: 3407-3422.
35. Mohn F, Weber M, Rebhan M, Roloff TC, Richter J, et al. (2008) Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell 30: 755-766.
36. Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, et al. (2008) Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454: 766-770.
37. Shahhoseini M, Taei A, Mehrjardi NZ, Salekdeh GH, Baharvand H, (2010) Epigenetic analysis of human embryonic carcinoma cells during retinoic acid-induced neural differentiation. Biochem Cell Biol 88: 527-538.
38. Shen Y, Chow J, Wang Z, Fan G, (2006) Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells. Hum Mol Genet 15: 2623-2635.
39. Yeo S, Jeong S, Kim J, Han JS, Han YM, et al. (2007) Characterization of DNA methylation change in stem cell marker genes during differentiation of human embryonic stem cells. Biochem Biophys Res Commun 359: 536-542.
40. Alexanian AR, (2007) Epigenetic modifiers promote efficient generation of neural-like cells from bone marrow-derived mesenchymal cells grown in neural environment. J Cell Biochem 100: 362-371.
41. Warnecke PM, Mann JR, Frommer M, Clark SJ, (1998) Bisulfite sequencing in preimplantation embryos: DNA methylation profile of the upstream region of the mouse imprinted H19 gene. Genomics 51: 182-190.
42. Warnecke PM, Stirzaker C, Melki JR, Millar DS, Paul CL, et al. (1997) Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA. Nucleic Acids Res 25: 4422-4426.
43. Gonzalgo ML, Jones PA, (2002) Quantitative methylation analysis using methylation-sensitive single- nucleotide primer extension (Ms-SNuPE). Methods 27: 128-133.