A comprehensive evaluation of the toxicology of cigarette ingredients: Carbohydrates and natural products

Inhalation Toxicology

Volumn 23, Issue SUPPL. 1, 2011, Pages 13-40

  Coggins, Christopher R E ^a   Wagner, Karl A ^b   Werley, Michael S ^b   Oldham, Michael J ^b  

^a Carson Watts Consulting   (United States)

^b Research   (United States)

Author keywords

aromatic and aliphatic alcohol compounds; Cigarette ingredients; in vitro and in vivo toxicology; smoke chemistry

Indexed keywords

BETA CYCLODEXTRIN; CARBOHYDRATE; CARBOXYHEMOGLOBIN; CIGARETTE SMOKE; COTININE; FRUCTOSE; INVERT SUGAR; MALTODEXTRIN; MOLASSES; NATURAL PRODUCT; NICOTINE; RAISIN JUICE CONCENTRATE; SORBITOL; SUCROSE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BACTERIAL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; EXPOSURE; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; IN VITRO STUDY; MALE; MORTALITY; MUTAGENICITY; NONHUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; RAT; SALMONELLA; WEIGHT CHANGE;

ADMINISTRATION, INHALATION; ANIMALS; BIOLOGICAL PRODUCTS; CARBOHYDRATES; CELL SURVIVAL; CELLS, CULTURED; EXCIPIENTS; FEMALE; FLAVORING AGENTS; FORMALDEHYDE; MALE; RATS; RATS, SPRAGUE-DAWLEY; SALMONELLA TYPHIMURIUM; SMOKE; SMOKING; TOBACCO; TOXICITY TESTS; XENOBIOTICS;

BACTERIA (MICROORGANISMS); PRUNUS DOMESTICA; RATTUS; SALMONELLA; ZEA MAYS;

EID: 79958694839     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2011.545085     Document Type: Article

References (16)

1. Baker RR, Massey ED, Smith G. 2004a. An overview of the effects of tobacco ingredients on smoke chemistry and toxicity. Food Chem Toxicol, 42S, S53-83 (Pubitemid 38456980)
2. Baker RR, da Silva JRP, Smith G. 2004b. The effect of tobacco ingredients on smoke chemistry Part I: Flavorings and additives. Food Chem Toxicol, 42S, S3-37
3. Baker RR, da Silva JRP, Smith G. 2004c. The effect of tobacco ingredients on smoke chemistry Part II: Casing ingredients. Food Chem Toxicol, 42S, S39-52 (Pubitemid 38456979)
4. Carmines EL. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 1: Cigarette design, testing approach, and review of results. Food Chem Toxicol, 40, 77-91 (Pubitemid 33132143)
5. Gaworski CL, Dozier MM, Heck JD, Gerhart JM, Rajendran N, David RM, Brennecke LH, Morrissey R. 1998. Toxicologic evaluation of flavor ingredients added to cigarette tobacco: 13-week inhalation exposures in rats. Inhal Toxicol, 10, 357-81 (Pubitemid 28300757)
6. Gaworski CL, Heck JD, Bennett MB, Wenk ML. 1999. Toxicologic evaluation of flavor ingredients added to cigarette tobacco: skin painting bioassay of cigarette smoke condensate in SENCAR mice. Toxicology, 139, 1-17 (Pubitemid 29535367)
7. Gaworski CL, Oldham MJ, Coggins CRE. 2010. Toxicological considerations on the use of propylene glycol as a humectant in cigarettes. Toxicology, 269, 54-66
8. Gaworski CL, Oldham MJ, Wagner K, Coggins CRE, Patskan GJ. 2011. A comprehensive evaluation of the toxicology of 95 ingredients added individually to experimental cigarettes: approach and methods. Inhal Toxicol, 23(S1), 1-12
9. Ménache MG, Miller FJ, Raabe OG. 1995. Particle inhalability curves for humans and small laboratory animals. Ann Occup Hyg, 39, 317- 28
10. Patskan GJ, Podraza KF, Meurrens K, Coggins CRE, Friedrichs B, Gerstenberg B, Gomm W, Schnell P, Stabbert R, Veltel D, Weber S, Terpstra PM. 2008. Toxicological comparisons of three styles of a commercial U.S. cigarette (Marlboro) with the 1R4F reference cigarette. Inhal Toxicol, 20, 695-721 (Pubitemid 351882934)
11. Raabe OG, Al-Bayati MA, Teague SV, Rasolt A. 1988. Regional deposition of inhaled monodisperse coarse and fine aerosol particles in small laboratory animals. Ann Occup Hyg, 32 (Suppl. 1), 53-63
12. Renne RA, Yoshimura H, Yoshino K, Lulham G, Minamisawa S, Tribukait A, Dietz DD, Lee KM, Westerberg RB. 2006. Effects of flavoring and casing ingredients on the toxicity of mainstream cigarette smoke in rats. Inhal Toxicol, 18, 685-706 (Pubitemid 44178424)
13. Rodgman A, Perfetti TA. 2009. The chemical components of tobacco and tobacco smoke. Boca Raton, FL: CRC Press
14. Rustemeier K, Stabbert R, Haussmann H-J, Roemer E, Carmines EL. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 2: chemical composition of mainstream smoke. Food Chem Toxicol, 40, 93-104 (Pubitemid 33132144)
15. Stavanja MS, Ayres PH, Meckley DR, Bombick BR, Pence DH, Borgerding MF, Morton M, Mosberg AT, Swauger JE. 2003. Toxicological evaluation of honey as an ingredient added to tobacco. J Toxicol Environ Health, 66, 1453-73 (Pubitemid 36976209)
16. Stavanja MS, Ayres PH, Meckley DR, Bombick ER, Borgerding MF, Morton MJ, Garner CD, Pence DH, Swauger JE. 2006. Safety assessment of high fructose corn syrup (HFCS) as an ingredient added to cigarette tobacco. Exp Toxicol Pathol, 57, 267-81 (Pubitemid 43234011)