Aldol derivatives of Thioxoimidazolidinones as potential anti-prostate cancer agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3291-3301

  Khatik, Gopal L ^a   Kaur, Jasmine ^a   Kumar, Varun ^a   Tikoo, Kulbhushan ^a   Venugopalan, P ^b   Nair, Vipin A ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

Aldol; Androgen; Prostate; Thioxoimidazolidinone

Indexed keywords

2 CHLORO 4 [4 [(4 BROMOPHENYL)HYDROXY METHYL] 4 METHYL 5 OXO 2 THIOXOIMIDAZOLIDIN 1 YL]BENZONITRILE; 2 CHLORO 4 [4 [(4 CHLOROPHENYL)HYDROXY METHYL] 4 METHYL 5 OXO 2 THIOXOIMIDAZOLIDIN 1 YL]BENZONITRILE; 2 CHLORO 4 [4 [(4 FLUOROPHENYL)HYDROXY METHYL] 4 METHYL 5 OXO 2 THIOXOIMIDAZOLIDIN 1 YL]BENZONITRILE; 3 (3 CHLORO 4 FLUOROPHENYL) 5 [(4 BROMOPHENYL)HYDROXY METHYL] 5 METHYL 4 OXO 2 THIOXOIMIDAZOLIDINE; 3 (3 CHLORO 4 FLUOROPHENYL) 5 [(4 CHLOROPHENYL)HYDROXY METHYL] 5 METHYL 4 OXO 2 THIOXOIMIDAZOLIDINE; 3 (3 CHLORO 4 FLUOROPHENYL) 5 [(4 FLUOROPHENYL)HYDROXY METHYL] 5 METHYL 4 OXO 2 THIOXOIMIDAZOLIDINE; 3 (4 CHLORO 3 TRIFLUOROMETHYLPHENYL) 5 [(4 BROMOPHENYL)HYDROXY METHYL] 5 METHYL 4 OXO 2 THIOXOIMIDAZOLIDINE; 3 (4 CHLORO 3 TRIFLUOROMETHYLPHENYL) 5 [(4 CHLOROPHENYL)HYDROXY METHYL] 5 METHYL 4 OXO 2 THIOXOIMIDAZOLIDINE; 3 (4 CHLORO 3 TRIFLUOROMETHYLPHENYL) 5 [(4 FLUOROPHENYL)HYDROXY METHYL] 5 METHYL 4 OXO 2 THIOXOIMIDAZOLIDINE; 3 (4 CHLOROPHENYL) 5 [(4 BROMOPHENYL)HYDROXY METHYL] 5 METHYL 4 OXO 2 THIOXOIMIDAZOLIDINE; 3 (4 CHLOROPHENYL) 5 [(4 CHLOROPHENYL)HYDROXY METHYL] 5 METHYL 4 OXO 2 THIOXOIMIDAZOLIDINE; 3 (4 CHLOROPHENYL) 5 [(4 FLUOROPHENYL)HYDROXY METHYL] 5 METHYL 4 OXO 2 THIOXOIMIDAZOLIDINE; 3 [4 CHLOROPHENYL] 5 [(4 CHLOROPHENYL) HYDROXY METHYL] 5 METHYL 4 OXO 2 THIOXOIMIDAZOLIDINE; 4 [4 [(4 BROMOPHENYL)HYDROXY METHYL] 4 METHYL 5 OXO 2 THIOXOIMIDAZOLIDIN 1 YL]2 TRIFLUOROMETHYLBENZONITRILE; 4 [4 [(4 CHLOROPHENYL)HYDROXY METHYL] 4 METHYL 5 OXO 2 THIOXOIMIDAZOLIDIN 1 YL]2 TRIFLUOROMETHYLBENZONITRILE; 4 [4 [(4 FLUOROPHENYL)HYDROXY METHYL] 4 METHYL 5 OXO 2 THIOXOIMIDAZOLIDIN 1 YL]2 TRIFLUOROMETHYLBENZONITRILE; 4 OXO 2 THIOXOIMIDAZOLIDINE; 5 [(4 BROMOPHENYL)HYDROXY METHYL] 5 METHYL 3 (4 NITRO 3 TRIFLUOROMETHYLPHENYL) 4 OXO 2 THIOXOIMIDAZOLIDINE; 5 [(4 CHLOROPHENYL)HYDROXY METHYL] 5 METHYL 3 (4 NITRO 3 TRIFLUOROMETHYLPHENYL) 4 OXO 2 THIOXOIMIDAZOLIDINE; 5 [(4 FLUOROPHENYL)HYDROXY METHYL] 5 METHYL 3 (4 NITRO 3 TRIFLUOROMETHYLPHENYL) 4 OXO 2 THIOXOIMIDAZOLIDINE; ANTINEOPLASTIC AGENT; DOXORUBICIN; FLUTAMIDE; IMIDAZOLIDINE DERIVATIVE; THIOXOIMIDAZOLIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CHIRALITY; CONCENTRATION RESPONSE; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DIASTEREOISOMER; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; SUBSTITUTION REACTION; X RAY DIFFRACTION;

ALDEHYDES; ANDROGEN RECEPTOR ANTAGONISTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMIDAZOLIDINES; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROSTATE; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 79958278786     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.050     Document Type: Article

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