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European Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2010, Pages 5397-5405

Phenylmethylene hydantoins as prostate cancer invasion and migration inhibitors. CoMFA approach and QSAR analysis

(2) Khanfar, Mohammad A a El Sayed, Khalid A a

a UNIVERSITY OF LOUISIANA AT MONROE (United States)

Author keywords

Anti invasion; CoMFA; Phenylmethylene Hydantoins; Prostate cancer; QSAR

Indexed keywords

5 ((1H IMIDAZOL 5 YL)METHYLENE)IMIDAZOLIDINE 2,4 DIONE; 5 ((3H PYRROLO[2,3 B]PYRIDIN 3 YL)METHYLENE)IMIDAZOLIDINE 2,4 DIONE; 5 ((4 IODO 1H PYRROL 2 YL)METHYLENE)IMIDAZOLIDINE 2,4 DIONE; 5 ((4 METHYL 1H IMIDAZOL 5 YL)METHYLENE)IMIDAZOLIDINE 2,4 DIONE; 5 ((6 (THIOPHEN 2 YL)PYRIDIN 2 YL)METHYLENE)IMIDAZOLIDINE 2,4 DIONE; 5 ((6 METHOXYPYRIDIN 2 YL)METHYLENE)IMIDAZOLIDINE 2,4 DIONE; 5 (2 METHOXY 4 PROPOXYBENZYLIDENE)IMIDAZOLIDINE 2,4 DIONE; 5 (2,4 DIPROPOXYBENZYLIDENE)IMIDAZOLIDINE 2,4 DIONE; 5 (3 BROMO 5 METHOXY 4 PROPOXYBENZYLIDENE)IMIDAZOLIDINE 2,4 DIONE; 5 (3 CHLORO 2,6 DIMETHOXY 4 PROPOXYBENZYLIDENE)IMIDAZOLIDINE 2,4 DIONE; 5 (3 METHOXY 4 (2 MORPHOLINO 2 OXOETHOXY)BENZYLIDENE)IMIDAZOLIDINE 2,4 DIONE; 5 (3 METHOXY 4 (2 OXO 2 (PYRROLIDIN 1 YL)ETHOXY)BENZYLIDENE)IMIDAZOLIDINE 2,4 DIONE; 5 (3 METHOXY 4 (2 OXO 2 PHENYLETHOXY)BENZYLIDENE)IMIDAZOLIDINE 2,4 DIONE; 5 (4 (ISOPENTYLOXY)BENZYLIDENE)IMIDAZOLIDINE 2,4 DIONE; 5 (4 TERT BUTOXY 3 CHLORO 2 METHOXYBENZYLIDENE)IMIDAZOLIDINE 2,4 DIONE; 5 (4 TERT BUTOXYBENZYLIDENE)IMIDAZOLIDINE 2,4 DIONE; 5 (BENZO[D][1,3]DIOXOL 4 YLMETHYLENE)IMIDAZOLIDINE 2,4 DIONE; 5 (INDOLIN 7 YLMETHYLENE)IMIDAZOLIDINE 2,4 DIONE; ANTIMETASTATIC AGENT; BENZENE; HETEROCYCLIC COMPOUND; HYDANTOIN DERIVATIVE; PHENYLMETHYLENE HYDANTOIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; COMPARATIVE MOLECULAR FIELD ANALYSIS; DOSE RESPONSE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; INFRARED SPECTROSCOPY; MALE; METASTASIS INHIBITION; MOLECULAR MODEL; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; WOUND HEALING;

CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDANTOINS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PRINCIPAL COMPONENT ANALYSIS; PROSTATIC NEOPLASMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 77957845578 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2010.08.066 Document Type: Article

Times cited : (26)

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