Francisella tularensis 2-C-Methyl-D-Erythritol 4-phosphate Cytidylyltransferase: Kinetic characterization and phosphoregulation

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Tsang, Arthur ^a   Seidle, Heather ^a   Jawaid, Safdar ^a   Zhou, Weidong ^a   Smith, Clint ^b   Couch, Robin D ^a  

^a GEORGE MASON UNIVERSITY   (United States)

^b US ARMY ENGINEER RESEARCH AND DEVELOPMENT CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 C METHYL DEXTRO ERYTHRITOL 4 PHOSPHATE CYTIDYLYLTRANSFERASE; CYTIDINE TRIPHOSPHATE; MAGNESIUM ION; NUCLEOTIDYLTRANSFERASE; UNCLASSIFIED DRUG; 2 C METHYL ERYTHRITOL 4 PHOSPHATE CYTIDYLYLTRANSFERASE; 2-C-METHYL ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE; ANTIINFECTIVE AGENT; NUCLEOTIDE;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ASSAY; ENZYME KINETICS; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SPECIFICITY; FRANCISELLA TULARENSIS; GEL PERMEATION CHROMATOGRAPHY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHOREGULATION; TANDEM MASS SPECTROMETRY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECT; ENZYMOLOGY; GENETICS; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; PHOSPHORYLATION; PROTEIN QUATERNARY STRUCTURE; REPRODUCIBILITY;

FRANCISELLA TULARENSIS; MAMMALIA;

ANTI-BACTERIAL AGENTS; BINDING SITES; CLONING, MOLECULAR; DRUG DISCOVERY; FRANCISELLA TULARENSIS; KINETICS; MODELS, MOLECULAR; NUCLEOTIDES; NUCLEOTIDYLTRANSFERASES; PHOSPHORYLATION; PROTEIN STRUCTURE, QUATERNARY; REPRODUCIBILITY OF RESULTS; SUBSTRATE SPECIFICITY;

EID: 79958275846     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020884     Document Type: Article

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