Prediction of variability in CYP3A4 induction using a combined 1H NMR metabonomics and targeted UPLC-MS approach

Journal of Proteome Research

Volumn 10, Issue 6, 2011, Pages 2807-2816

  Rahmioglu, Nilufer ^a,c   Le Gall, Gwénaëlle ^b   Heaton, James ^a   Kay, Kristine L ^b   Smith, Norman W ^a   Colquhoun, Ian J ^b   Ahmadi, Kourosh R ^a   Kemsley, E Kate ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

1H NMR; Cytochrome P450; drug metabolism; metabonomics; personalized medicine; urine

Indexed keywords

CYTOCHROME P450 3A4; HYPERICUM PERFORATUM EXTRACT; QUININE SULFATE;

ADULT; AGED; ARTICLE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN EXPERIMENT; MASS SPECTROMETRY; METABOLOMICS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TREATMENT RESPONSE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS;

AGED; AGED, 80 AND OVER; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP3A; FEMALE; GLYCINE; HUMANS; HYPERICUM; INOSITOL; LINEAR MODELS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOMICS; MIDDLE AGED; PLANT EXTRACTS; PROLINE; PROTONS; TANDEM MASS SPECTROMETRY; TWINS; UP-REGULATION;

EID: 79958235985     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr200077n     Document Type: Article

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