Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization

Biochemical and Biophysical Research Communications

Volumn 409, Issue 3, 2011, Pages 372-377

  Separovic, Duska ^a   Joseph, Nicholas ^a   Breen, Paul ^a   Bielawski, Jacek ^b   Pierce, Jason S ^b   Buren, Eric Van ^a   Bhatti, Gaurav ^a   Saad, Ziad H ^a   Bai, Aiping ^b   Bielawska, Alicja ^b  

^a WAYNE STATE UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Autophagy; Caspase 3; Clonogenicity; LCL85; PDT; Sphingolipids

Indexed keywords

2 N [16 (1' PYRIDINIUM) HEXADECANOYLAMINO] 1 (4' NITROPHENYL) 1,3 PROPANDIOL BROMIDE; ANTINEOPLASTIC AGENT; CASPASE 3; CERAMIDE; LCL 85; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; ENZYME ACTIVATION; IN VITRO STUDY; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CELL LINE, TUMOR; CERAMIDES; HEAD AND NECK NEOPLASMS; HUMANS; INDOLES; LYSOPHOSPHOLIPIDS; MICE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROPANOLAMINES; PYRIDINIUM COMPOUNDS; SPHINGOLIPIDS; SPHINGOSINE;

EID: 79958230307     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.04.091     Document Type: Article

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