A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet aggregation and angiogenesis

Thrombosis and Haemostasis

Volumn 105, Issue 6, 2011, Pages 1032-1045

  Ma, Dongying ^a   Xu, Xueqing ^b   An, Su ^a,c   Liu, Huan ^a   Yang, Xuening ^a   Andersen, John F ^b   Wang, Yipeng ^a   Tokumasu, Fuyuki ^b   Ribeiro, José M C ^b   Francischetti, Ivo M B ^b   Lai, Ren ^a  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Blood sucking; Disintegrin; Haematophagy; Sialogenins; Thrombosis

Indexed keywords

ABCIXIMAB; ADENOSINE DIPHOSPHATE; ALPHA2B BETA3 INTEGRIN; ARGINYLGLYCYLASPARTIC ACID; COLLAGEN; CONVULXIN; DISINTEGRIN; EDETIC ACID; FIBRINOGEN; FIBROBLAST GROWTH FACTOR; FIBRONECTIN; INTEGRIN; TABLYSIN 15; UNCLASSIFIED DRUG; UROKINASE; VITRONECTIN; VITRONECTIN RECEPTOR;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ISOLATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; ENDOTHELIUM CELL; FLOW CYTOMETRY; FLY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN IMMOBILIZATION; RAT; SALIVARY GLAND; STRUCTURE ACTIVITY RELATION; TABANUS YAO; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION INHIBITION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD PLATELETS; CELL ADHESION; CELL PROLIFERATION; DIPTERA; DISINTEGRINS; ENDOTHELIAL CELLS; INSECT PROTEINS; INTEGRIN ALPHA2; INTEGRIN ALPHA5; INTEGRIN BETA3; OLIGOPEPTIDES; PLATELET AGGREGATION INHIBITORS; PROTEIN BINDING; SALIVARY GLANDS; SALIVARY PROTEINS AND PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; VIPERIDAE;

EID: 79958217683     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH11-01-0029     Document Type: Article

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