Measurement of 20-Hydroxyeicosatetraenoic Acid in Human Urine by Gas Chromatography-Mass Spectrometry

Clinical Chemistry

Volumn 50, Issue 1, 2004, Pages 224-226

  Rivera, Jennifer ^a   Ward, Natalie ^a   Hodgson, Jonathan ^a   Puddey, Ian B ^a   Falck, John R ^b   Croft, Kevin D ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID;

ADULT; ANION EXCHANGE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DILUTION; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYDROLYSIS; MALE; MASS SPECTROMETRY; MEASUREMENT; NORMAL HUMAN; PH; RELIABILITY; ROOM TEMPERATURE; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; TIME; URINALYSIS; URINE LEVEL;

DISACCHARIDES; FEMALE; GLUCURONATES; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; MALE; MIDDLE AGED;

EID: 1642451703     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2003.025775     Document Type: Article

References (9)

1. Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 2002;82:131-85.
2. McGiff JC, Quilley J. 20-Hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids and blood pressure. Curr Opin Nephrol Hypertens 2001;10:231-7.
3. Croft KD, McGiff JC, Sanchez-Mendoza A, Carroll MA. Angiotensin II releases 20-HETE from rat renal microvessels. Am J Physiol Renal Physiol 2000;279: F544-51.
4. Harder DR, Campbell WB, Roman RJ. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid In the control of vascular tone. J Vasc Res 1995;32:79-92.
5. Laffer CL, Laniado-Schwartzman M, Wang MH, Nasjletti A, Elijovich F. Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic acid in human salt-sensitive versus salt-resistant hypertension. Circulation 2003;107:574-8.
6. Prakash C, Zhang JY, Falck JR, Chauhan K, Blair IA. 20- Hydroxyelcosatetraenoic acid is excreted as a glucuronide conjugate in human urine. Biochem Biophys Res Commun 1992;185:728-33.
7. Sacerdoti D, Balazy M, Angeli P, Gatta A, McGiff JC. Eicosanoid excretion in hepatic cirrhosis. Predominance of 20-HETE. J Clin Invest 1997;100:1264-70.
8. Maier KG, Henderson L, Narayanan J, Alonso-Galicia M, Falck JR, Roman RJ. Fluorescent HPLC assay for 20-HETE and other P-450 metabolites of arachidonic acid. Am J Physiol Heart Circ Physiol 2000;279:H863-71.
9. Lin F, Rios A, Falck JR, Belosludtsev Y, Schwartzman ML. 20-Hydroxyeicosatetraenoic acid is formed in response to EGF and is a mitogen in rat proximal tubule. Am J Physiol 1995;269:F806-16.