Toll-like receptor 3 activation during pregnancy elicits preeclampsia-like symptoms in rats

American Journal of Hypertension

Volumn 22, Issue 12, 2009, Pages 1314-1319

  Tinsley, John H ^a   Chiasson, Valorie L ^a   Mahajan, Ashutosh ^a   Young, Kristina J ^a   Mitchell, Brett M ^a  

^a Scott White Memorial Hospital and Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; PHENYLEPHRINE; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; FEMALE; FETUS GROWTH; GESTATION PERIOD; INTRAUTERINE GROWTH RETARDATION; MALE; NONHUMAN; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; PROTEINURIA; RAT; SYSTOLIC BLOOD PRESSURE; VASODILATATION;

ANIMALS; FEMALE; POLY I-C; PRE-ECLAMPSIA; PREGNANCY; RATS; TOLL-LIKE RECEPTOR 3;

EID: 70450224468     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1038/ajh.2009.185     Document Type: Article

References (41)

1. Campbell S, Rowe J, Jackson CJ, Gallery ED. Interaction of cocultured decidual endothelial cells and cytotrophoblasts in preeclampsia. Biol Reprod 2004; 71:244-252.
2. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D'Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme V P, Letarte M, Karumanchi SA. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 2006; 12:642-649. (Pubitemid 43865232)
3. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs B P, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA; CPEP Study Group. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 2006; 355:992-1005.
4. Pottecher J, Huet O, Degos V, Bonnet M P, Gaussem P, Duranteau J, Ozier Y, Mignon A, Tsatsaris V. In vitro plasma-induced endothelial oxidative stress and circulating markers of endothelial dysfunction in preeclampsia: an observational study. Hypertens Pregnancy 2009; 28:212-223.
5. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989; 161: 1200-1204.
6. Redman CW, Sargent IL. Preeclampsia and the systemic inflammatory response. Semin Nephrol 2004; 24:565-570.
7. Redman CW, Sacks G P, Sargent IL. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999; 180:499-506.
8. Meekins JW, McLaughlin PJ, West DC, McFadyen IR, Johnson PM. Endothelial cell activation by tumour necrosis factor-α (TNF-α) and the development of pre-eclampsia. Clin Exp Immunol 1994; 98:110-114.
9. Sunder-Plassmann G, Derfler K, Wagner L, Stockenhuber F, Endler M, Nowotny C, Balcke P. Increased serum activity of interleukin-2 in patients with pre-eclampsia. J Autoimmun 1989; 2:203-205.
10. Vince GS, Starkey PM, Austgulen R, Kwiatkowski D, Redman CW. Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia. Br J Obstet Gynaecol 1995; 102:20-25.
11. Rusterholz C, Hahn S, Holzgreve W. Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia. Semin Immunopathol 2007; 29:151-162.
12. Banerjee S, Smallwood A, Moorhead J, Chambers AE, Papageorghiou A, Campbell S, Nicolaides K. Placental expression of interferon-γ (IFN-γ) and its receptor IFN-γ R2 fail to switch from early hypoxic to late normotensive development in preeclampsia. J Clin Endocrinol Metab 2005; 90:944-952.
13. Mazouni C, Capo C, Ledu R, Honstettre A, Agostini A, Capelle M, Mege JL, Bretelle F. Preeclampsia: impaired inflammatory response mediated by Toll-like receptors. J Reprod Immunol 2008; 78:80-83.
14. Gilbert JS, Ryan MJ, LaMarca BB, Sedeek M, Murphy SR, Granger J P. Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction. Am J Physiol Heart Circ Physiol 2008; 294:H541-H550.
15. Sitras V, Paulssen RH, Grønaas H, Leirvik J, Hanssen TA, Vårtun A, Acharya G. Differential placental gene expression in severe preeclampsia. Placenta 2009; 30:424-433.
16. Germain SJ, Sacks G P, Sooranna SR, Soorana SR, Sargent IL, Redman CW. Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles. J Immunol 2007; 178:5949-5956.
17. Bonney EA. Preeclampsia: a view through the danger model. J Reprod Immunol 2007; 76:68-74.
18. Abrahams VM, Visintin I, Aldo PB, Guller S, Romero R, Mor G. A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells. J Immunol 2005; 176:8096-8104.
19. Gonzalez JM, Xu H, Ofori E, Elovitz MA. Toll-like receptors in the uterus, cervix, and placenta: is pregnancy an immunosuppressed state? Am J Obstet Gynecol 2007; 197:296.e1-296.e6.
20. Kawai T, Akira S. TLR signaling. Semin Immunol 2007; 19:24-32.
21. Koga K, Cardenas I, Aldo P, Abrahams VM, Peng B, Fill S, Romero R, Mor G. Activation of TLR3 in the trophoblast is associated with preterm delivery. A m J Reprod Immunol 2009; 61:196-212.
22. Zenclussen AC, Fest S, Joachim R, Klapp BF, Arck PC. Introducing a mouse model for pre-eclampsia: adoptive transfer of activated Th1 cells leads to pre-eclampsia-like symptoms exclusively in pregnant mice. Eur J Immunol 2004; 34:377-387.
23. Faas MM, Schuiling GA, Baller JF, Visscher CA, Bakker WW. A new animal model for human preeclampsia: ultra-low-dose endotoxin infusion in pregnant rats. Am J Obstet Gynecol 1994; 171:158-164.
24. Whitesall SE, Hoff JB, Vollmer A P, D'Alecy LG. Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods. Am J Physiol Heart Circ Physiol 2004; 286:H2408-H2415.
25. Robillard PY, Hulsey TC, Dekker GA, Chaouat G. Preeclampsia and human reproduction. An essay of a long term reflection. J Reprod Immunol 2003; 59:93-100.
26. Robillard PY, Hulsey TC, Alexander GR, Keenan A, de Caunes F, Papiernik E. Paternity patterns and risk of preeclampsia in the last pregnancy in multiparae. J Reprod Immunol 1993; 24:1-12.
27. Trupin LS, Simon L P, Eskenazi B. Change in paternity: a risk factor for preeclampsia in multiparas. Epidemiology 1996; 7:240-244.
28. Mattar R, Amed AM, Lindsey PC, Sass N, Daher S. Preeclampsia and HIV infection. Eur J Obstet Gynecol Reprod Biol 2004; 117:240-241.
29. Anand A, Gray ES, Brown T, Clewley J P, Cohen BJ. Human parvovirus infection in pregnancy and hydrops fetalis. N Engl J Med 1987; 316:183-186.
30. Fowler KB, Stagno S, Pass RF, Britt WJ, Boll TJ, Alford CA. The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N Engl J Med 1992; 326:663-667.
31. Brown ZA, Selke S, Zeh J, Kopelman J, Maslow A, Ashley RL, Watts DH, Berry S, Herd M, Corey L. The acquisition of herpes simplex virus during pregnancy. N Engl J Med 1997; 337:509-515.
32. Tolfvenstam T, Papadogiannakis N, Norbeck O, Petersson K, Broliden K. Frequency of human parvovirus B19 infection in intrauterine fetal death. Lancet 2001; 357:1494-1497.
33. Arechavaleta-Velasco F, Ma Y, Zhang J, McGrath CM, Parry S. Adeno-associated virus-2 (AAV-2) causes trophoblast dysfunction, and placental AAV-2 infection is associated with preeclampsia. Am J Pathol 2006; 168:1951-1959.
34. Lucchi NW, Moore JM. LPS induces secretion of chemokines by human syncytiotrophoblast cells in a MAPK-dependent manner. J Reprod Immunol 2007; 73:20-27.
35. Rustveld LO, Kelsey SF, Sharma R. Association between maternal infections and preeclampsia: a systematic review of epidemiologic studies. Matern Child Health J 2008; 12:223-242.
36. Chiu BC, Stolberg VR, Chensue SW. Mononuclear phagocyte-derived IL-10 suppresses the innate IL-12/IFN-γ axis in lung-challenged aged mice. J Immunol 2008; 181:3156-3166.
37. Matthiesen L, Berg G, Ernerudh J, Ekerfelt C, Jonsson Y, Sharma S. Immunology of preeclampsia. Chem Immunol Allergy 2005; 89:49-61.
38. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21:335-376.
39. Faas MM, Broekema M, Moes H, van der Schaaf G, Heineman MJ, de Vos P. Altered monocyte function in experimental preeclampsia in the rat. Am J Obstet Gynecol 2004; 191:1192-1198.
40. Kim YM, Romero R, Oh SY, Kim CJ, Kilburn BA, Armant DR, Nien JK, Gomez R, Mazor M, Saito S, Abrahams VM, Mor G. Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia? Am J Obstet Gynecol 2005; 193:921.e1-921.e8.
41. Ilievski V, Lu SJ, Hirsch E. Activation of toll-like receptors 2 or 3 and preterm delivery in the mouse. Reprod Sci 2007; 14:315-320.