Gemcitabine in the chemoradiotherapy for locally advanced pancreatic cancer: A meta-analysis

Radiotherapy and Oncology

Volumn 99, Issue 2, 2011, Pages 108-113

  Zhu, Chang Peng ^a   Shi, Jian ^a   Chen, Yue Xiang ^a   Xie, Wei Fen ^a   Lin, Yong ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Chemoradiotherapy; Gemcitabine; Locally advanced pancreatic cancer; Meta analysis

Indexed keywords

CAPECITABINE; CISPLATIN; ERLOTINIB; FLUOROURACIL; GEMCITABINE; IRINOTECAN; PACLITAXEL;

ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CHEMORADIOTHERAPY; COCHRANE LIBRARY; EMBASE; HUMAN; LOCALLY ADVANCED PANCREATIC CANCER; MEDLINE; META ANALYSIS; PANCREAS CANCER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SURVIVAL RATE;

ANTIMETABOLITES, ANTINEOPLASTIC; DEOXYCYTIDINE; FLUOROURACIL; HUMANS; PANCREATIC NEOPLASMS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SURVIVAL ANALYSIS;

EID: 79958172857     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.04.001     Document Type: Article

References (57)

1. A. Jemal, R. Siegel, and E. Ward Cancer statistics CA Cancer J Clin 58 2008 71 96
2. S. Rosewicz, and B. Wiedenmann Pancreatic carcinoma Lancet 349 1997 485 489 (Pubitemid 27077838)
3. M. Hidalgo Pancreatic cancer N Engl J Med 362 2010 1605 1617
4. R. Kim, and M.W. Saif Is there an optimal neoadjuvant therapy for locally advanced pancreatic cancer? JOP 8 2007 279 288 (Pubitemid 46876786)
5. J. Richter, and M.W. Saif Locally advanced pancreatic adenocarcinoma: where are we and where are we going? Highlights from the "2010 ASCO gastrointestinal cancers symposium", Orlando, FL, USA, January 22-24, 2010 JOP 11 2010 139 143
6. F. Huguet, N. Girard, and C.S. Guerche Chemoradiotherapy in the management of locally advanced pancreatic carcinoma: a qualitative systematic review J Clin Oncol 27 2009 2269 2277
7. D. Yip, C. Karapetis, and A. Strickland Chemotherapy, radiotherapy for inoperable advanced pancreatic cancer Cochrane Database Syst Rev 3 2006 CD002093
8. A. Sultana, S.C. Tudur, and D. Cunningham Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy Br J Cancer 96 2007 1183 1190 (Pubitemid 46625082)
9. W. Plunkett, P. Huang, and C.E. Searcy Gemcitabine: preclinical pharmacology and mechanisms of action Semin Oncol 23 1996 3 15 (Pubitemid 26362189)
10. H.A. Burris, M.J. Moore, and J. Andersen Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial J Clin Oncol 15 1997 2403 2413 (Pubitemid 27251144)
11. M.Y. Merl, J. Li, and M.W. Saif The first-line treatment for advanced pancreatic cancer. Highlights from the "2010 ASCO gastrointestinal cancers symposium", Orlando, FL, USA, January 22-24, 2010 JOP 11 2010 148 150
12. H. Ishii, J. Furuse, and N. Boku Phase II study of gemcitabine chemotherapy alone for locally advanced pancreatic carcinoma: JCOG0506 Jpn J Clin Oncol 40 2010 573 579
13. T.S. Lawrence, E.Y. Chang, and T.M. Hahn Radiosensitization of pancreatic cancer cells by 2′,2′-difluoro-2′-deoxycytidine Int J Radiat Oncol Biol Phys 34 1996 867 872
14. T.S. Lawrence, A. Eisbruch, and D.S. Shewach Gemcitabine-mediated radiosensitization Semin Oncol 24 1997 S7 S28
15. L. Milas, T. Fujii, and N. Hunter Enhancement of tumor radioresponse in vivo by gemcitabine Cancer Res 59 1999 107 114 (Pubitemid 29062965)
16. P.I. Huang, Y. Chao, and C.P. Li Efficacy and factors affecting outcome of gemcitabine concurrent chemoradiotherapy in patients with locally advanced pancreatic cancer Int J Radiat Oncol Biol Phys 73 2009 159 165
17. M. Michael, T. Price, and S.Y. Ngan A phase I trial of capecitabine + gemcitabine with radical radiation for locally advanced pancreatic cancer Br J Cancer 100 2009 37 43
18. A. Duffy, J. Kortmansky, and G.K. Schwartz A phase I study of erlotinib in combination with gemcitabine and radiation in locally advanced, non-operable pancreatic adenocarcinoma Ann Oncol 19 2008 86 91
19. T. Budiharto, K. Haustermans, and E. Van Cutsem A phase I radiation dose-escalation study to determine the maximal dose of radiotherapy in combination with weekly gemcitabine in patients with locally advanced pancreatic adenocarcinoma Radiat Oncol 22 2008 30 36
20. M. Cengiz, F. Zorlu, and S. Yalcin Concurrent gemcitabine and radiotherapy for locally advanced pancreatic cancer Med Oncol 24 2007 239 243 (Pubitemid 350135977)
21. J. Furuse, H. Ishii, and M. Kawashima A phase I study of hypofractionated radiotherapy followed by systemic chemotherapy with full-dose gemcitabine in patients with unresectable locally advanced pancreatic cancer Hepatogastroenterology 54 2007 1575 1578 (Pubitemid 47203475)
22. D. Goldstein, G. Van Hazel, and E. Walpole Gemcitabine with a specific conformal 3D 5FU radiochemotherapy technique is safe and effective in the definitive management of locally advanced pancreatic cancer Br J Cancer 97 2007 464 471 (Pubitemid 47258454)
23. M.G. Haddock, R. Swaminathan, and N.R. Foster Gemcitabine, cisplatin, and radiotherapy for patients with locally advanced pancreatic adenocarcinoma: results of the North Central Cancer Treatment Group Phase II Study N9942 J Clin Oncol 25 2007 2567 2572 (Pubitemid 47041230)
24. E. Kurt, M. Kurt, and O. Kanat Phase II study of induction chemotherapy with gemcitabine plus 5-fluorouracil followed by gemcitabine-based concurrent chemoradiotherapy for unresectable locally advanced pancreatic cancer Tumori 92 2006 481 486 (Pubitemid 46170315)
25. D. Iannitti, T. Dipetrillo, and P. Akerman Erlotinib and chemoradiation followed by maintenance erlotinib for locally advanced pancreatic cancer: a phase I study Am J Clin Oncol 28 2005 570 575 (Pubitemid 41790008)
26. A. Magnino, M. Gatti, and P. Massucco Phase II trial of primary radiation therapy and concurrent chemotherapy for patients with locally advanced pancreatic cancer Oncology 68 2005 493 499 (Pubitemid 41160982)
27. G. Mishra, J. Butler, and C. Ho Phase II trial of induction gemcitabine/CPT-11 followed by a twice-weekly infusion of gemcitabine and concurrent external beam radiation for the treatment of locally advanced pancreatic cancer Am J Clin Oncol 28 2005 345 350 (Pubitemid 41099538)
28. A.M. Moore, H. Cardenes, and C.S. Johnson A phase II study of gemcitabine in combination with radiation therapy in patients with localized, unresectable, pancreatic cancer: a Hoosier Oncology Group Trial J Clin Oncol 22 2004 4105a
29. McGinn CJ, Talamonti MS, Small W, et al. A phase II trial of full-dose gemcitabine with concurrent radiation therapy in patients with resectable or unresectable non-metastatic pancreatic cancer. Presented at the 2004 gastrointestinal cancers symposium, San-Francisco, CA, January 22-24, 2004.
30. T. Okusaka, Y. Ito, and H. Ueno Phase II study of radiotherapy combined with gemcitabine for locally advanced pancreatic cancer Br J Cancer 91 2004 673 677 (Pubitemid 39141622)
31. A.W. Blackstock, J.E. Tepper, and D. Niedwiecki Cancer and leukemia group B (CALGB) 89805: phase II chemoradiation trial using gemcitabine in patients with locoregional adenocarcinoma of the pancreas Int J Gastrointest Cancer 34 2003 107 116 (Pubitemid 39279726)
32. T.B. Brunner, G.G. Grabenbauer, and P. Klein Phase I trial of strictly time-scheduled gemcitabine and cisplatin with concurrent radiotherapy in patients with locally advanced pancreatic cancer Int J Radiat Oncol Biol Phys 5 2003 144 153 (Pubitemid 36020354)
33. J.A. Martenson, A.P. Vigliotti, and H.C. Pitot A phase I study of radiation therapy and twice-weekly gemcitabine and cisplatin in patients with locally advanced pancreatic cancer Int J Radiat Oncol Biol Phys 55 2003 1305 1310 (Pubitemid 36338298)
34. R. Epelbaum, E. Rosenblatt, and S. Nasrallah Phase II study of gemcitabine combined with radiation therapy in patients with localized, unresectable pancreatic cancer J Surg Oncol 81 2002 138 143 (Pubitemid 35253625)
35. S.M. de Lange, C.J. van Groeningen, and O.W. Meijer Gemcitabine- radiotherapy in patients with locally advanced pancreatic cancer Eur J Cancer 38 2002 1212 1217 (Pubitemid 34603482)
36. A.W. Blackstock, S.A. Melin, and J.M. Butler Irinotecan/gemcitabine followed by twice-weekly gemcitabine/radiation in locally advanced pancreatic cancer Oncology (Williston Park) 16 2002 25 28
37. M. Ikeda, S. Okada, and K. Tokuuye A phase I trial of weekly gemcitabine and concurrent radiotherapy in patients with locally advanced pancreatic cancer Br J Cancer 86 2002 1551 1554 (Pubitemid 34628107)
38. H. Safran, T. Dipetrillo, and D. Iannitti Gemcitabine, paclitaxel, and radiation for locally advanced pancreatic cancer: a Phase I trial Int J Radiat Oncol Biol Phys 54 2002 137 141
39. R.A. Wolff, D.B. Evans, and D.M. Gravel Phase I trial of gemcitabine combined with radiation for the treatment of locally advanced pancreatic adenocarcinoma Clin Cancer Res 7 2001 2246 2253 (Pubitemid 32751621)
40. G.V. Kornek, R. Pötter, and E. Selzer Combined radiochemotherapy of locally advanced unresectable pancreatic adenocarcinoma with mitomycin C plus 24-hour continuous infusional gemcitabine Int J Radiat Oncol Biol Phys 49 2001 665 671 (Pubitemid 32112194)
41. M.S. Talamonti, P.J. Catalano, and D.J. Vaughn Eastern Cooperative Oncology Group Phase I trial of protracted venous infusion fluorouracil plus weekly gemcitabine with concurrent radiation therapy in patients with locally advanced pancreas cancer: a regimen with unexpected early toxicity J Clin Oncol 18 2000 3384 3389
42. A.W. Blackstock, S.A. Bernard, and F. Richards Phase I trial of twice-weekly gemcitabine and concurrent radiation in patients with advanced pancreatic cancer J Clin Oncol 17 1999 2208 2212 (Pubitemid 29318854)
43. C.H. Crane, J.L. Abbruzzese, and D.B. Evans Is the therapeutic index better with gemcitabine-based chemoradiation than with 5-fluorouracil-based chemoradiation in locally advanced pancreatic cancer? Int J Radiat Oncol Biol Phys 52 2002 1293 1302 (Pubitemid 34302881)
44. C.P. Li, Y. Chao, and K.H. Chi Concurrent chemoradiotherapy treatment of locally advanced pancreatic cancer: gemcitabine versus 5-fluorouracil, a randomized controlled study Int J Radiat Oncol Biol Phys 57 2003 98 104 (Pubitemid 36959744)
45. B. Brasiuniene, and E. Juozaityte The effect of combined treatment methods on survival and toxicity in patients with pancreatic cancer Medicina (Kaunas) 43 2007 716 725
46. A.R. Jadad, R.A. Moore, and D. Carroll Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17 1996 1 12 (Pubitemid 26120810)
47. L.L. Kjaergard, J. Villumsen, and C. Gluud Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses Ann Intern Med 135 2001 982 989 (Pubitemid 33131619)
48. D. Moher, B. Pham, and A. Jones Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? Lancet 352 1998 609 613 (Pubitemid 28380142)
49. T. Aurelio Assessing the influence of a single study in the meta-analysis estimate Stata Tech Bull 8 1999 15 17
50. M. Egger, S.G. Davey, and M. Schneider Bias in meta-analysis detected by a simple, graphical test BMJ 315 1997 629 634 (Pubitemid 27387172)
51. R. Wilkowski, S. Boeck, and S. Ostermaier Chemoradiotherapy with concurrent gemcitabine and cisplatin with or without sequential chemotherapy with gemcitabine/cisplatin vs chemoradiotherapy with concurrent 5-fluorouracil in patients with locally advanced pancreatic cancer - a multi-centre randomised phase II study Br J Cancer 101 2009 1853 1859
52. National Comprehensive Cancer Network. Pancreatic Adenocarcinoma V.2.2010. NCCN clinical practice guidelines in oncology.
53. C.G. Moertel, S. Frytak, and R.G. Hahn Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil: The Gastrointestinal Tumor Study Group Cancer 48 1981 1705 1710 (Pubitemid 11022870)
54. S.J. Cohen, R. Dobelbower Jr., and S. Lipsitz A randomized phase III study of radiotherapy alone or with 5-fluorouracil and mitomycin-C in patients with locally advanced adenocarcinoma of the pancreas: Eastern Cooperative Oncology Group study E8282 Int J Radiat Oncol Biol Phys 62 2005 1345 1350 (Pubitemid 40982053)
55. H. Igarashi, T. Ito, K. Kawabe, and T. Hisano Chemoradiotherapy with twice-weekly administration of low-dose gemcitabine for locally advanced pancreatic cancer World J Gastroenterol 14 2008 5311 5315
56. V. Heinemann, S. Boeck, and A. Hinke Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer BMC Cancer 8 2008 82 92
57. F.A. Calvo, and V. Valentini Radiotherapy for pancreatic cancer: systematic nihilism or intraoperative realism Radiother Oncol 87 2008 314 317