RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Fernández Velasco, María ^a,b   Ruiz Hurtado, Gema ^a   Rueda, Angélica ^a,c   Neco, Patricia ^a   Mercado Morales, Martha ^c   Delgado, Carmen ^d   Napolitano, Carlo ^e,f   Priori, Silvia G ^e,f,g   Richard, Sylvain ^a   MaríaGómez, Ana ^a   Benitah, Jean Pierre ^a  

^a INSERM   (France)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^c DEPARTAMENTO DE FÍSICA   (Mexico)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^e IRCCS   (Italy)

^f NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; CALMODULIN; RYANODINE RECEPTOR; CALCIUM; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CURRENT; CALCIUM DEPLETION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; HYPERPOLARIZATION; MOUSE; NONHUMAN; PROTEIN FUNCTION; SARCOPLASMIC RETICULUM; ANIMAL; C57BL MOUSE; CHANNEL GATING; DRUG ANTAGONISM; DRUG EFFECT; ELECTRIC CONDUCTIVITY; EXCITATION CONTRACTION COUPLING; FEMALE; GENE TARGETING; HEART MUSCLE; HEART VENTRICLE TACHYCARDIA; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

MUS;

ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CALMODULIN; ELECTRIC CONDUCTIVITY; EXCITATION CONTRACTION COUPLING; FEMALE; GENE KNOCK-IN TECHNIQUES; ION CHANNEL GATING; MALE; MICE; MICE, INBRED C57BL; MYOCARDIUM; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SULFONAMIDES; TACHYCARDIA, VENTRICULAR;

EID: 79958161209     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020863     Document Type: Article

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