Genistein and tyrphostin AG556 inhibit inwardly-rectifying Kir2.1 channels expressed in HEK 293 cells via protein tyrosine kinase inhibition

Biochimica et Biophysica Acta - Biomembranes

Volumn 1808, Issue 8, 2011, Pages 1993-1999

  Zhang, De Yong ^a   Wu, Wei ^a   Deng, Xiu Ling ^b   Lau, Chu Pak ^a   Li, Gui Rong ^a,c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Epidermal growth factor receptor kinase; Inward rectifier K+ channel; Kir2.1; Protein tyrosine kinase

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; GENISTEIN; N (4 BUTYLPHENYL) ALPHA CYANOCAFFEIC ACID AMIDE; ORTHOVANADIC ACID; PROTEIN TYROSINE KINASE; TYRPHOSTIN; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG ANTAGONISM; DRUG MECHANISM; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INWARDLY RECTIFYING KIR2.1 CHANNEL GENE; MUTAGENESIS; PRECIPITATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECOMBINANT GENE; VOLTAGE CLAMP; WESTERN BLOTTING; WHOLE CELL;

BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; GENISTEIN; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN KINASE INHIBITORS; PROTEIN TYROSINE PHOSPHATASES; PROTEIN-TYROSINE KINASES; PYRIMIDINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SRC-FAMILY KINASES; TIME FACTORS; TRANSFECTION; TYRPHOSTINS; VANADATES;

EID: 79958157096     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2011.04.015     Document Type: Article

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