Intrinsic local disorder and a network of charge-charge interactions are key to actinoporin membrane disruption and cytotoxicity

FEBS Journal

Volumn 278, Issue 12, 2011, Pages 2080-2089

  Pardo Cea, Miguel A ^a   Castrillo, Inés ^a   Alegre Cebollada, Jorge ^b,c   Martínez Del Pozo, Álvaro ^b   Gavilanes, José G ^b   Bruix, Marta ^a  

^a INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

actinoporin; dynamics; electrostatic interactions; NMR structure; sticholysin

Indexed keywords

CYTOLYSIN; STICHOLYSIN II; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CYTOTOXICITY; LYSIS; MEMBRANE BINDING; MEMBRANE DAMAGE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN VARIANT; STATIC ELECTRICITY;

AMINO ACID SUBSTITUTION; ANIMALS; CNIDARIAN VENOMS; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PORE FORMING CYTOTOXIC PROTEINS; PROTEIN CONFORMATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; SEA ANEMONES; STATIC ELECTRICITY; TERPENES;

ACTINIARIA;

EID: 79958156446     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08123.x     Document Type: Article

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