An acidic loop and cognate phosphorylation sites define a molecular switch that modulates ubiquitin charging activity in cdc34-like enzymes

PLoS Computational Biology

Volumn 7, Issue 5, 2011, Pages

  Papaleo, Elena ^a   Ranzani, Valeria ^a   Tripodi, Farida ^a   Vitriolo, Alessandro ^a   Cirulli, Claudia ^a   Fantucci, Piercarlo ^a   Alberghina, Lilia ^a   Vanoni, Marco ^a   de Gioia, Luca ^a   Coccetti, Paola ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYMES; MOLECULAR DYNAMICS;

CASEIN KINASE 2; CELLULAR REGULATION; MOLECULAR LEVELS; MOLECULAR SWITCHES; PHOSPHORYLATION SITES; PROTEIN CONFORMATION; TARGET-SUBSTRATE; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITINATION;

PHOSPHORYLATION;

CASEIN KINASE II; CDC34 LIKE ENZYME; SERINE; UBIQUITIN CONJUGATING ENZYME E2; UNCLASSIFIED DRUG; ANAPHASE PROMOTING COMPLEX; ANAPHASE-PROMOTING COMPLEX; QRI8 PROTEIN, S CEREVISIAE; RECOMBINANT PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; UBE2G2 PROTEIN, HUMAN; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; GENE INSERTION; GENE SWITCHING; GENETIC CONSERVATION; MOLECULAR DYNAMICS; MOLECULAR MODEL; PROTEIN ANALYSIS; RESIDUE ANALYSIS; STATIC ELECTRICITY; STRUCTURE ANALYSIS; YEAST; AMINO ACID SEQUENCE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PRINCIPAL COMPONENT ANALYSIS; PROTEIN TERTIARY STRUCTURE; THERMODYNAMICS;

AMINO ACID SEQUENCE; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE ANNOTATION; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PRINCIPAL COMPONENT ANALYSIS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; THERMODYNAMICS; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

EID: 79958155322     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002056     Document Type: Article

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