A simplified method to determine five cytochrome P450 probe drugs by HPLC in a single run

Biological and Pharmaceutical Bulletin

Volumn 32, Issue 4, 2009, Pages 717-720

  Liu, Ying ^a,b   Jiao, Jianjie ^b   Zhang, Caili ^a   Lou, Jianshi ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b Tianjin Center for ADR Monitoring   (China)

Author keywords

Cocktail approach; Cytochrome P450; HPLC; Probe drug

Indexed keywords

CAFFEINE; CHLORZOXAZONE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; DIAZEPAM; METHANOL; METOPROLOL; MIDAZOLAM; PHOSPHATE BUFFERED SALINE; TOLBUTAMIDE;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; NONHUMAN; PH; RAT; STANDARD;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; INJECTIONS, INTRAVENOUS; ISOENZYMES; PHARMACEUTICAL PREPARATIONS; QUALITY CONTROL; RATS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SOLUTIONS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 65249119393     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.32.717     Document Type: Article

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