Adult grade II diffuse astrocytomas are genetically distinct from and more aggressive than their paediatric counterparts

Acta Neuropathologica

Volumn 121, Issue 6, 2011, Pages 753-761

  Jones, David T W ^a,c   Mulholland, Shani A ^a   Pearson, Danita M ^a   Malley, Deborah S ^a   Openshaw, Samuel W S ^a   Lambert, Sally R ^a   Liu, Lu ^a   Bäcklund, L Magnus ^b   Ichimura, Koichi ^a   Collins, V Peter ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Astrocytoma; Differentiation; IDH; MGMT; Paediatric; TP53

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CELL PROTEIN; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE ISOENZYME; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN BAMBI; PROTEIN DLL3; PROTEIN P53; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR HES 5; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; ASTROCYTOMA; CANCER GRADING; CELL CYCLE PROGRESSION; CELL RENEWAL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; DNA REPLICATION; FEMALE; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENOME ANALYSIS; HUMAN; HUMAN TISSUE; MALE; MUTATION RATE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; PHENOTYPIC VARIATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; PROTEIN METHYLATION; SCHOOL CHILD; TRANSCRIPTOMICS;

ADOLESCENT; ADULT; AGE FACTORS; ASTROCYTOMA; BRAIN NEOPLASMS; CHILD; DNA COPY NUMBER VARIATIONS; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA MUTATIONAL ANALYSIS; DNA REPAIR ENZYMES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOCITRATE DEHYDROGENASE; MALE; MIDDLE AGED; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; YOUNG ADULT;

EID: 79958136272     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-011-0810-6     Document Type: Article

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