RCL hydrolyzes 2'-deoxyribonucleoside 5'-monophosphate via formation of a reaction intermediate

Biochemistry

Volumn 50, Issue 21, 2011, Pages 4712-4719

  Doddapaneni, Kiran ^a   Zahurancik, Walter ^a   Haushalter, Adam ^a   Yuan, Chunhua ^a   Jackman, Jane ^a   Wu, Zhengrong ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ANALYSIS; BOND CLEAVAGES; CATALYTIC MECHANISMS; CATALYTIC REACTIONS; DISSOCIATION CONSTANT; HOMODIMERS; KINETIC EVIDENCE; METHANOLYSIS; MONOPHOSPHATES; MULTIDIMENSIONAL NMR; NMR STUDIES; PHOSPHATE GROUP; SITE DIRECTED MUTAGENESIS; STRUCTURAL STUDIES; WILD TYPES;

CATALYSIS; CHEMICAL BONDS; DISSOCIATION;

REACTION INTERMEDIATES;

2' DEOXYRIBONUCLEOSIDE 5' MONOPHOSPHATE; DEOXYRIBONUCLEOSIDE; DEOXYRIBOSE; DEOXYRIBOSE 5' PHOSPHATE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; NUCLEOPHILE; NUCLEOSIDE DEOXYRIBOSYLTRANSFERASE; NUCLEOSIDE DERIVATIVE; NUCLEOTIDE DERIVATIVE; PHOSPHATE; PROTEIN RESPONSIVE TO C MYC; SERINE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; DISSOCIATION CONSTANT; HYDROLYSIS; METHANOLYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STEADY STATE; STRUCTURE ANALYSIS;

ANIMALS; BIOCATALYSIS; DEOXYRIBONUCLEOTIDES; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; N-GLYCOSYL HYDROLASES; RATS; SUBSTRATE SPECIFICITY;

EID: 79958123286     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101742z     Document Type: Article

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