Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108

Journal of Biological Chemistry

Volumn 285, Issue 53, 2010, Pages 41806-41814

  Dupouy, Christelle ^a   Zhang, Chi ^a,d   Padilla, André ^c,d,e   Pochet, Sylvie ^a,b   Kaminski, Pierre Alexandre ^a,b  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c CENTRE DE BIOCHIMIE STRUCTURALE   (France)

^d INSERM   (France)

^e UNIV MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEOXYRIBOSE 5 PHOSPHATES; ACTIVE SITE; BINDING DETERMINANT; BINDING POCKETS; CATALYTIC TRIAD; GLYCOSIDIC BOND; HETEROCYCLES; HYDROLASES; MOLECULAR BASIS; MONOPHOSPHATES; NUCLEOBASES; PHARMACOLOGICAL PROPERTIES; PHOSPHATE BINDING; PHOSPHATE GROUP; RIBOSE MOIETY; ROADMAP; SITE DIRECTED MUTAGENESIS; SMALL MOLECULES; SOLUTION STRUCTURES; SPECIFIC INHIBITORS; SUBSTRATE BINDING; SUBSTRATE RECOGNITION; SYNTHETIC LIGANDS; THERAPEUTIC TARGETS; WEAK INTERACTIONS;

ALANINE; ARGININE; ASPARTIC ACID; DIDEOXYNUCLEOTIDE; GLUTAMIC ACID; HISTIDINE; HYDROLASE; MYC PROTEIN; NUCLEIC ACID BASE; PROTEIN RCL; SERINE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RAT; SITE DIRECTED MUTAGENESIS;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; GLUTAMIC ACID; KINETICS; MOLECULAR SEQUENCE DATA; N-GLYCOSYL HYDROLASES; NUCLEAR PROTEINS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE;

RATTUS;

EID: 78650675594     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.181594     Document Type: Article

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