Tuning core vs. shell dimensions to adjust the performance of nanoscopic containers for the loading and release of doxorubicin

Journal of Controlled Release

Volumn 152, Issue 1, 2011, Pages 37-48

  Lin, Lily Yun ^a,b   Lee, Nam S ^a,b   Zhu, Jiahua ^c   Nyström, Andreas M ^d   Pochan, Darrin J ^c   Dorshow, Richard B ^e   Wooley, Karen L ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c UNIVERSITY OF DELAWARE   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

^e Clinical Pharmacology and Pharmacokinetics   (United States)

Author keywords

Block copolymers; Core shell nanoparticles; Doxorubicin; Drug delivery; Nanoparticle dimensions; Release kinetics

Indexed keywords

ACRYLIC ACIDS; AMPHIPHILIC DIBLOCK COPOLYMERS; AMPHIPHILICS; AQUEOUS BUFFER; BLOCK LENGTHS; CHEMOTHERAPY AGENTS; CONTROLLED DRUG RELEASE; CORE DIAMETERS; CORE-SHELL NANOPARTICLES; CROSSLINKED; DEGREES OF POLYMERIZATIONS; DOXORUBICIN; FASTER RATES; FUTURE DIRECTIONS; HIGUCHI MODEL; HYDRODYNAMIC DIAMETER; KINETICS OF RELEASE; LARGE CORE; NUMBER-AVERAGE; POLY(ACRYLIC ACID ); POLYMER MICELLES; POLYMER NANOPARTICLES; POLYSTYRENE CORE; QUANTITATIVE DETERMINATIONS; RELEASE KINETICS; SOLUTION PH; VOLUME RATIO;

BLOCK COPOLYMERS; CARBOXYLIC ACIDS; CHEMOTHERAPY; COPOLYMERIZATION; DRUG DELIVERY; HYDROGELS; LOADING; NANOPARTICLES; NEUTRON SCATTERING; PH EFFECTS; POLYMERS; POLYSTYRENES; RATE CONSTANTS; SHELLS (STRUCTURES); STYRENE; TRANSMISSION ELECTRON MICROSCOPY;

CORE SAMPLES;

BUFFER; DOXORUBICIN; NANOPARTICLE; POLYACRYLIC ACID; POLYACRYLIC ACID BLOCK POLYSTYRENE; POLYSTYRENE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CALCULATION; CONCENTRATION RESPONSE; CONTROLLED DRUG RELEASE; CROSS LINKING; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG RELEASE; HUMAN; HYDRODYNAMICS; KINETICS; MICELLE; NEUTRON SCATTERING; PH; POLYMERIZATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; THICKNESS; TRANSMISSION ELECTRON MICROSCOPY;

ANTIBIOTICS, ANTINEOPLASTIC; CROSS-LINKING REAGENTS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; POLYMERS; SOLUBILITY;

EID: 79958101298     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.01.009     Document Type: Article

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