Controlled release from crosslinked degradable networks

Critical Reviews in Therapeutic Drug Carrier Systems

Volumn 19, Issue 4-5, 2002, Pages 385-423

  Davis, Kelly A ^a   Anseth, Kristi S ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Drug delivery; Hydrophobic networks; PEG hydrogels

Indexed keywords

2 HYDROXYACID; 2 HYDROXYETHYL METHACRYLATE; ACETIC ACID DERIVATIVE; AMINOETHYLMETHACRYLATE; CINNAMYLIDENE ACETATE; COLLAGEN; DEXTRAN DERIVATIVE; DIETHYLENE GLYCOL; FIBRIN; FUMARIC ACID; HYALURONIC ACID; ITACONIC ACID; MACROGOL DERIVATIVE; MALEIC ANHYDRIDE; MALONIC ACID; N METHACRYLOYLGLYCYLGLYCYLGLYCYLPOLYETHYLENE GLYCOL; POLY(ORTHO ESTER); POLY(TEREPHTHALIC ACID ANHYDRIDE); POLY[BIS(4 CARBOXYPHENOXY)PROPANE SEBACIC ACID] COPOLYMER; POLYACRYLAMIDE; POLYANHYDRIDE; POLYETHYLENE GLYCOL PROLYLGLYCYLLEUCINE DIACRYLATE; POLYETHYLENE GLYCOL SUCCINIMIDYLCARBONATE ESTER; POLYGLUTAMIC ACID; POLYGLYCEROL POLYGLYCIDYL ETHER; POLYPROPYLENE; POLYVINYL ALCOHOL; ROTAXANE; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CONTROLLED DRUG RELEASE; CROSS LINKING; DRUG DELIVERY SYSTEM; HYDROGEL; HYDROPHOBICITY; NONHUMAN; REVIEW;

BIODEGRADATION, ENVIRONMENTAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DESIGN; POLYMERS; TECHNOLOGY, PHARMACEUTICAL;

EID: 0036939643     PISSN: 07434863     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevTherDrugCarrierSyst.v19.i45.30     Document Type: Review

References (133)

1. Heller J. Controlled release of biologically active compounds from bioerodible polymers. Biomaterials 1980; 1:51-57.
2. Langer RS, Peppas NA. Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials 1981; 2:201-214.
3. Langer R. New methods of drug delivery. Science 1990; 249:1527-1533.
4. Langer R. Drug delivery systems. MRS Bull 1991; 16:47-49.
5. Peppas NA. Controlling protein diffusion in hydrogels. Drug Target Deliv 1995; 4:23-37.
6. Baker RW, Tuttle ME, Heller J, Helwing R, Smith KJ. Novel erodible polymers for delivery of macromolecules. Proc Pharm Tech Conf'83; 1983; 243-250.
7. Sawhney AS, Pathak CP, Hubbell JA. Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromers. Macromolecules 1993; 26:581-587.
8. West JL, Hubbell JA. Polymeric biomaterials with degradation sites for proteases involved in cell migration. Macromolecules 1999; 32:241-244.
9. Heller J, Penhale DWH, Fritzinger BK, Rose JE, Helwing RF. Controlled release of contraceptive steroids from biodegradable poly(orthoesters). Contracept Deliv Syst 1983; 4:43-453.
10. Brem H, Walter KA, Langer R. Polymers as controlled drug-delivery devices for the treatment of malignant brain tumors. Eur J Pharm Biopharm 1993; 39:2-7.
11. Tamargo RJ, Langer R, Brem H. Interstitial drug delivery to the central nervous system using controlled release polymers: Chemotherapy for brain tumors. Methods Neurosci 1994; 21:135-149.
12. Guilford Pharmaceuticals Inc. Glidel Wafer, U.S. Food and Drug Administration; NDA 020637, Sept. 23, 1996.
13. Anseth KS, Shastri VR, Langer R. Photopolymerizable degradable polyanhydrides with osteocompatibility. Nat Biotechnol 1999; 17:156-159.
14. Muggli DS, Burkoth AK, Anseth KS. Crosslinked polyanhydrides for use in orthopedic applications: degradation behavior and mechanics. J Biomed Mater Res 1999; 46:271-278.
15. Burdick JA, Mason MN, Anseth KS. In situ forming lactic acid based orthopaedic biomaterials: Influence of oligomer chemistry on osteoblast attachment and function. J Biomater Sci Polym Ed 2001; 12:1253-1265.
16. Burdick JA, Philpott LM, Anseth KS. Synthesis and characterization of tetrafunctional lactic acid oligomers: a potential in situ forming degradable orthopaedic biomaterial. J Polym Sci Part A: Polym Chem 2001; 39:683-692.
17. Kurisawa M, Terano M, Yui N. Double-stimuli-responsive degradable hydrogels for drug delivery: interpenetrating polymer networks composed of oligopeptide-terminated polyethylene glycol and dextran. Macromol Rapid Commun 1995; 16:663-666.
18. Hennink WE, Talsma H, Borchert JCH, De Smedt SC, Demeester J. Controlled release of proteins from dextran hydrogels. J Control Release 1996; 39:47-55.
19. Martens P, Anseth KS. Characterization of hydrogels formed from acrylate modified poly(vinyl alcohol) macromers. Polymer 2000; 41:7715-7722.
20. Martens PJ, Holland TV, Bowman CN, Anseth KS. Synthesis and characterization of degradable poly (vinyl alcohol) hydrogels. 222nd American Chemical Society National Meeting; 2001 Aug. 26-30; Chicago, IL.
21. Anseth KS, Metters AT, Bryant SJ, Martens PJ, Elisseeff JH, Bowman CN. In situ forming degradable networks and their application in tissue engineering and drug delivery. J Control Release 2002; 78:199-209.
22. Yaszemski MJ, Payne RG, Hayes WC, Langer R, Mikos AG. The in vitro mechanical strength and in vivo bone ingrowth of a degrading polymeric composite biomaterial. Mater Res Soc Symp Proc 1995; 394:21-24.
23. Suggs LJ, Payne RG, Yaszemski MJ, Alemany LB, Mikos AG. Synthesis and characterization of a block copolymer consisting of poly(propylene fumarate) and poly(ethylene glycol). Macromolecules 1997; 30:4318-4323.
24. Peter SJ, Miller ST, Zhu G, Yasko AW, Mikos AG. In vivo degradation of a poly(propylene fumarate)/.beta.-tricalcium phosphate injectable composite scaffold. J Biomed Mater Res 1998; 41:1-7.
25. Fan K, Gonzales D, Sevoian M. Hydrolytic and enzymatic degradation of poly(g-glutamic acid) hydrogels and their application in slow-release for proteins. J Environ Polym Degrad 1996; 4:253-260.
26. Gonzales D, Fan K, Sevoian M. Synthesis and swelling characterizations of a poly(gamma-glutamic acid) hydrogel. J Polym Sci Part A Polym Chem 1996; 34:2019-2027.
27. Kim S-H, Won C-Y, Chu C-C. Synthesis and characterization of dextran-maleic acid based hydrogels. J Biomed Mater Res 1999; 46:160-170.
28. Andreopoulos FM, Deible CR, Stauffer MT, Weber SG, Wagner WA, Beckman EJ, Russell AJ. Photoscissable hydrogel synthesis via rapid photopolymerization of novel PEG-based polymers in the absence of photoinitiators. J Am Chem Soc 1996; 118:6235-6340.
29. Heller J, Helwing RF, Baker RW, Tuttle ME. Controlled release of water-soluble macromolecules from bioerodible hydrogels. Biomaterials 1983; 4:262-266.
30. Singh M, Rathi R, Singh A, Heller J, Talwar GP, Kopecek J. Controlled release of LHRH-DT from bioerodible hydrogel microspheres. Int J Pharm 1991; 76:R5-R8.
31. Nathan A, Bolikal D, Vyavahare N, Zalipsky S, Kohn J. Hydrogels based on water-soluble poly(ether urethanes) derived from L-lysine and poly(ethylene glycol). Macromolecules 1992; 25:4476-4484.
32. Nathan A, Zalipsky S, Ertel SI, Agathos SN, Yarmush ML, Kohn J. Copolymers of lysine and polyethylene glycol: a new family of functionalized drug carriers. Bioconjugate Chem 1993; 4:54-62.
33. Vyavahare N, Kohn J. Photocrosslinked hydrogels based on copolymers of polyethylene glycol and lysine. J Polym Sci Part A Polym Chem 1994; 32:1271-81.
34. Younes H, Cohn D. Morphological study of biodegradable PEO/PLA block copolymers. J Biomed Mater Res 1987; 21:1301-1316.
35. Zhu KJ, Lin X, Yang S. Preparation, characterization and properties of polylactide (PLA)-poly(ethylene glycol) (PEG) copolymers: a potential drug carrier. J Appl Polym Sci 1990; 39:1-9.
36. Deng XM, Xiong CD, Cheng LM, Xu RP. Synthesis and characterization of block copolymers from D, L-lactide and poly(ethylene glycol) with stannous chloride. J Polym Sci Part C Polym Lett 1990; 28:411-416.
37. Li Y, Kissel T. Synthesis and properties of biodegradable ABA triblock copolymers consisting of poly(L-lactic acid) or poly(L-lactic-co-glycolic acid) A-blocks attached to central poly(oxyethylene) B-blocks. J Control Release 1993; 27:247-257.
38. Kricheldorf HR, Boettcher C. Polylactones 27. Anionic polymerization of L-lactide. Variation of endgroups and synthesis of block copolymers with poly(ethylene oxide). Makromol Chem, Macromol Symp 1993; 73:47-64.
39. West JL, Hubbell JA. Localized intravascular protein delivery from photopolymerized hydrogels. Proc Int Symp Control Release Bioac Mater 1995; 22:17-18.
40. West JL, Hubbell JA. Photopolymerized hydrogel materials for drug delivery applications. React Polym 1995; 25:139-147.
41. Hubbell JA. Hydrogel systems for barriers and local drug delivery in the control of wound healing. J Control Release 1996; 39:305-313.
42. Hill-West JL, Dunn RC, Hubbell JA. Local release of fibrinolytic agents for adhesion prevention. J Surg Res 1995; 59:759-763.
43. Hubbell JA, West JL, Chowdhury SM. Control of healing with photopolymerizable biodegradable hydrogels. Adv Biomater Biomed Eng Drug Delivery Syst 1996; Iketani 5:179-182.
44. Lu S, Anseth KS. Release behavior of high molecular weight solutes from poly(ethylene glycol)-based degradable networks. Macromolecules 2000; 33:2509-2515.
45. Metters AT, Bowman CN, Anseth KS. A statistical model for the bulk degradation of PLA-b-PEG-b-PLA hydrogel networks. J Phys Chem B 2000; 104:7043-7049.
46. Metters AT, Anseth KS, Bowman CN. A statistical kinetic model for the bulk degradation of PLA-b-PEG-b-PLA hydrogel networks: Incorporating network non-idealities. J Phys Chem B 2001; 105:8069-8076.
47. Metters AT, Bowman CN, Anseth KS. Verification of scaling laws for degrading PLA-b-PEG-b-PLA hydrogels. AICHE J 2001; 47:1432-1437.
48. Mason MN, Metters AT, Bowman CN, Anseth KS. Predicting controlled-release behavior of degradable PLA-b-PEG-b-PLA hydrogels. Macromolecules 2001; 34:4630-4635.
49. Lu S, Ramirez WF, Anseth KS. Modeling and optimization of drug release from laminated polymer matrix devices. AICHE J 1998; 44:1689-1696.
50. Metters AT, Anseth KS, Bowman CN. Fundamental studies of a novel, biodegradable PEG-b-PLA hydrogel. Polymer 2000; 41:3993-4004.
51. Elbert DL, Pratt AB, Lutolf MP, Halstenberg S, Hubbell JA. Protein delivery from materials formed by self-selective conjugate addition reactions. J Control Release 2001; 76:11-25.
52. Elbert DL, Hubbell JA. Conjugate addition reactions combined with free-radical crosslinking for the design of materials for tissue engineering. Biomacromolecules 2001; 2:430-441.
53. Cramer NB, Bowman CN. Kinetics of thiol-ene and thiol-acrylate photopolymerizations with real-time Fourier transform infrared. J Polym Chem Part A Polym Chem 2001; 29:3311-3319.
54. Zhao X, Harris JM. Novel degradable poly(ethylene glycol) hydrogels for controlled release of protein. J Pharm Sci 1998; 87:1450-1458.
55. West JL, Hubbell JA. Proteolytically degradable hydrogels. Proc Int Symp Control Release Bioact Mat 1996; 23:224-225.
56. Ulbrich K, Zacharieva EI, Obereigner B, Kopecek J. Polymers containing enzymatically degradable bonds V. Hydrophilic polymers degradable by papain. Biomaterials 1980; 1:199-204.
57. Ulbrich K, Strohalm J, Kopecek J. Polymers containing enzymatically degradable bonds. VI. Hydrophilic gels cleavable by chymotrypsin. Biomaterials 1982; 3:150-154.
58. Subr V, Duncan R, Kopecek J. Release of macromolecules and daunomycin from hydrophilic gels containing enzymically degradable bonds. J Biomater Sci Polym Ed 1990; 1:261-278.
59. Heller J. Development of poly(ortho esters): a historical overview. Biomaterials 1990; 11:659-365.
60. Heller J, Fritzinger BK, Ng SY, Penhale DWH. In vitro and in vivo release of levonorgestrel from poly(orthoesters) I. Linear polymers. J Control Release 1985; 1:225-232.
61. Heller J, Fritzinger BK, Ng SY, Penhale DWH. In vitro and in vivo release of levonorgestrel from poly(ortho esters). II. Crosslinked polymers. J Control Release 1985; 1:233-238.
62. Heller J, Himmelstein KJ. Biodegradable poly(ortho esters) as drug delivery forms. Direct Drug Deliv 1985:171-188.
63. Heller J. Controlled drug release from monolithic bioerodible polymer devices. Pharm Int 1986; 7:316-318.
64. Rosen HB, Chang J, Wnek GE, Linhardt RJ, Langer R. Bioerodible polyanhydrides for controlled drug delivery. Biomaterials 1983; 4:131-133.
65. Leong KW, Brott BC, Langer R. Bioerodible polyanhydrides as drug-carrier matrixes. I: Characterization, degradation, and release characteristics. J Biomed Mater Res 1985; 19:941-955.
66. Domb AJ, Mathiowitz E, Ron E, Giannos S, Langer R. Polyanhydrides. IV. Unsaturated and crosslinked polyanhydrides. J Polym Sci Part A Polym Chem 1991; 29:571-579.
67. Heller J, Ng SY, Penhale DW, Fritzinger BK, Sanders LM, Bruns RA, Gaynon MG, Bhosale SS. Use of poly(ortho esters) for the controlled release of 5-fluorouracil and a LH-RH analog. J Control Release 1987; 6:217-224.
68. Heller J, Penhale DW, Fritzinger BK, Ng SY. The effect of copolymerized 9,10-dihydroxystearic acid on erosion rates of poly(ortho esters) and its use in the delivery of levonorgestrel. J Control Release 1987; 5:173-177.
69. Merkli A, Heller J, Tabatabay C, Gurny R. Semi-solid hydrophobic bioerodible poly(ortho ester) for potential application in glaucoma filtering surgery. J Control Release 1994; 29:105-112.
70. Seymour LW, Duncan R, Duffy J, Ng SY, Heller J. Poly(ortho ester) matrixes for controlled release of the antitumor agent 5-fluorouracil. J Control Release 1994; 31:201-206.
71. Merkli A, Heller J, Tabatabay C, Gurny R. The use of acidic and basic excipients in the release of 5-fluorouracil and mitomycin C from a semi-solid bioerodible poly(ortho ester). J Control Release 1995; 33:415-421.
72. Sintzel MB, Merkli A, Heller J, Tabatabay C, Gurny R. Synthesis and analysis of viscous poly(ortho-ester) analogs for controlled drug release. Int J Pharm 1997; 155:263-269.
73. Sintzel MB, Heller J, Ng SY, Tabatabay C, Schwach-Abdellaoui K, Gurny R. In vitro drug release from self-catalyzed poly(ortho ester): Case study of 5-fluorouracil. J Control Release 1998; 55:213-218.
74. Einmahl S, Zignani M, Varesio E, Heller J, Veuthey JL, Tabatabay C, Gurny R. Concomitant and controlled release of dexamethasone and 5-fluorouracil from poly(ortho ester). Int J Pharm 1999; 185:189-198.
75. Brem H, Kader A, Epstein JI, Tamargo RJ, Domb A, Langer R, Leong KW. Biocompatibility of a biodegradable, controlled-release polymer in the rabbit brain. Selective Cancer Therapeutics 1989; 5:55-65.
76. Leong KW, Kost J, Mathiowitz E, Langer R. Polyanhydrides for controlled release of bioactive agents. Biomaterials 1986; 7:364-371.
77. Wu MP, Tamada JA, Brem H, Langer R. In vivo versus in vitro degradation of controlled release polymers for intracranial surgical therapy. J Biomed Mater Res 1994; 28:387-395.
78. Laurencin CT, Gerhart T, Witschger P, Satcher R, Domb A, Rosenberg AE, Hanff P, Edsberg L, Hayes W, Langer R. Bioerodible polyanhydrides for antibiotic drug delivery: in vivo osteomyelitis treatment in a rat model system. J Ortho Res 1993; 11:256-262.
79. Anseth KS, Svaldi DC, Laurencin CT, Langer R. Photopolymerization of novel degradable networks for orthopedic applications. In: Scranton AB, Bowman CN, Peiffer RW, editors. Photopolymerization. Washington DC: American Chemical Society, 1997.
80. Muggli DS, Burkoth AK, Keyser SA, Lee HR, Anseth KS. Reaction behavior of biodegradable, photo-crosslinkable polyanhydrides. Macromolecules 1998; 31:4120-4125.
81. Tamada J, Langer R. The development of polyanhydrides for drug delivery applications. J Biomater Sci Polym Ed 1992; 3:315-353.
82. Burkoth AK, Burdick J, Anseth KS. Surface and bulk modifications to photocrosslinked polyanhydrides to control degradation behavior. J Biomed Mater Res 2000; 51:352-359.
83. Anseth KS, Quick DJ. Polymerizations of multifunctional anhydride monomers to form highly crosslinked degradable networks. Macromol Rapid Commun 2001; 22:564-572.
84. Young JS, Gonzales KD, Anseth KS. Photopolymers in orthopedics: Characterization of novel crosslinked polyanhydrides. Biomaterials 2000; 21:1181-1188.
85. Lu S. Controlled drug delivery from photopolymerized, multilaminated matrix devices. Thesis, Chemical Engineering, University of Colorado; 1999.
86. Burdick JA, Padera RF, Huang JV, Anseth KS. An investigation of the cytotoxicity and histocompatibility of in situ forming lactic acid based orthopaedic biomaterials. J Biomed Mater Res Appl Biomater 2002; 63:484-491.
87. Burdick JA, Anseth KS. Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering applications. Biomaterials 2002; 23:4315-4323.
88. Yamamoto N, Kurisawa M, Yui N. Double-stimuli-responsive degradable hydrogels: interpenetrating polymer networks consisting of gelatin and dextran with different phase separation. Macromol Rapid Commun 1996; 17:313-318.
89. Brannon-Peppas L. Enzymically degradable polymers based upon polysaccharides for controlled drug delivery. Proc Int Symp Control Release Bioact Mater 1996; 23:21-22.
90. Hennink WE, Franssen O, van Dijk-Wolthuis WNE, Talsma H. Dextran hydrogels for the controlled release of proteins. J Control Release 1997; 48:107-114.
91. Franssen O, van Ooijen RD, de Boer D, Maes RAA, Herron JN, Hennink WE. Enzymatic degradation of methacrylated dextrans. Macromolecules 1997; 30:7408-7413.
92. Sakiyama-Elbert SE, Hubbell JA. Development of fibrin derivatives for controlled release of heparin-binding growth factors. J Control Release 2000; 65:389-402.
93. van Dijk-Wolthius WNE, Frassen O, Talsma H, van Steenbergen MJ, Kettenes-van den Bosch JJ, Hennink WE. Synthesis, characterization, and polymerization of glycidyl methacrylate derivatized dextran. Macromolecules 1995; 28:6317-6322.
94. van Dijk-Wolthuis WNE, Kettenes-van den Bosch JJ, van der Kerk-van Hoof A, Hennink WE. Reaction of dextran with glycidyl methacrylate: an unexpected transesterification. Macromolecules 1997; 30:3411-3413.
95. Franssen O, Vos OP, Hennink WE. Delayed release of a model protein from enzymically-degrading dextran hydrogels. J Control Release 1997; 44:237-245.
96. Cadee JA, van Luyn MJA, Brouwer LA, van Wachem PB, de Groot CJ, den Otter W, Hennink WE. In vivo biocompatibility and interleukin-2 release behavior of dextran-based hydrogels. Proc Int Symp Control Release Bioact Mater 2000; 27:1056-1057.
97. Franssen O, van Ooijen RD, de Boer D, Maes RAA, Hennink WE. Enzymatic degradation of crosslinked dextrans. Macromolecules 1999; 32:2896-2902.
98. van Dijk-Wolthuis WNE, Hoogeboom JAM, van Steenbergen MJ, Tsang SKY, Hennink WE. Degradation and release behavior of dextran-based hydrogels. Macromolecules 1997; 30:4639-4645.
99. Cadee JA, De Kerf M, De Groot CJ, Den Otter W, Hennink WE. Synthesis, characterization of 2-(methacryloyloxy)ethyl-(di-))L-lactate and their application in dextran-based hydrogels. Polymer 1999; 40:6877-6881.
100. Franssen O, Vandervennet L, Roders P, Hennink WE. Degradable dextran hydrogels: controlled release of a model protein from cylinders and microspheres. J Control Release 1999; 60:211-221.
101. Franssen O, Stenekes RJH, Hennink WE. Controlled release of a model protein from enzymatically degrading dextran microspheres. J Control Release 1999; 59:219-228.
102. van Es RJ, Franssen O, Dullens HF, Bernsen MR, Bosman F, Hennink WE, Slootweg PJ. The VX2 carcinoma in the rabbit auricle as an experimental model for intra-arterial embolization of head and neck squamous cell carcinoma with dextran microspheres. Lab Animals 1999; 33:175-184.
103. Cadee JA, Van Luyn MJA, Brouwer LA, Plantinga JA, Van Wachem PB, De Groot CJ, Den Otter W, Hennink WE. In vivo biocompatibility of dextran-based hydrogels. J Biomed Mater Res 2000; 50:397-404.
104. De Groot CJ, Van Luyn MJA, Van Dijk-Wolthuis WNE, Cadee JA, Plantinga JA, Otter WD, Hennink WE. In vitro biocompatibility of biodegradable dextran-based hydrogels tested with human fibroblasts. Biomaterials 2001; 22:1197-1203.
105. Stenekes RJH, Loebis AE, Fernandes CM, Crommelin DJA, Hennink WE. Controlled release of liposomes from biodegradable dextran microspheres: a novel delivery concept. Pharm Res 2000; 17:690-695.
106. Stenekes RJH, Loebis AE, Fernandes CM, Crommelin DJA, Hennink WE. Degradable dextran microspheres for the controlled release of liposomes. Int J Pharm 2001; 214:17-20.
107. Cadee JA, de Groot CJ, Jiskoot W, den Otter W, Hennink WE. Release of recombinant human interleukin-2 from dextran-based hydrogels. J Control Release 2002; 78:1-13.
108. Kurisawa M, Yui N. Double stimuli-responsive degradable hydrogels: interpenetrating polymer networks of oligopeptide-terminated poly(ethylene glycol) and dextran. Proc Int Symp Control Release Bioact Mater 1996; 23:765-766.
109. Kurisawa M, Terano M, Yui N. Double-stimuli-responsive degradation of hydrogels consisting of oligopeptide-terminated poly(ethylene glycol) and dextran with an interpenetrating polymer network. J Biomater Sci Polym Ed 1997; 8:691-708.
110. Kurisawa M, Yui N. Gelatin/dextran intelligent hydrogels for drug delivery. Dual-stimuli-responsive degradation in relation to miscibility in interpenetrating polymer networks. Macromol Chem Phys 1998; 199:1547-1554.
111. Kurisawa M, Yui N. Dual-stimuli-responsive drug release from interpenetrating polymer network-structured hydrogels of gelatin and dextran. J Control Release 1998; 54:191-200.
112. Moriyama K, Yui N. Regulated insulin release from biodegradable dextran hydrogels containing poly(ethylene glycol). [Erratum to document cited in CA125:284585]. J Control Release 1997; 45:209.
113. Moriyama K, Yui N. Regulated insulin release from biodegradable dextran hydrogels containing poly(ethylene glycol). J Control Release 1996; 42:237-248.
114. Moriyama K, Ooya T, Yui N. Pulsatile peptide release from multi-layered hydrogel formulations consisting of poly(ethylene glycol)-grafted and ungrafted dextrans. J Biomater Sci Polym Ed 1999; 10:1251-1264.
115. Huh KM, Hashi J, Ooya T, Yui N. Synthesis and characterization of dextran grafted with poly(N-isopropylacrylamide-co-N,N-dimethyl-acrylamide). Macromol Chem Phys 2000;201:613-619.
116. Huh KM, Hashi J, Ooya T, Yui N. New synthetic route for dextran graft copolymers containing thermo-responsive polymers. Polym J 2001; 33:108-11.
117. Kumashiro Y, Huh KM, Ooya T, Yui N. Modulatory factors on temperature-synchronized degradation of dextran grafted with thermoresponsive polymers and their hydrogels. Biomacromolecules 2001; 2:874-879.
118. Yui N, Nihira J, Okano T, Sakurai Y. Regulated release of drug microspheres from inflammation-responsive degradable matrixes of crosslinked hyaluronic acid. J Control Release 1993; 25:133-143.
119. Yui N, Okano T, Sakurai Y. Photoresponsive degradation of heterogeneous hydrogels comprising crosslinked hyaluronic acid and lipid microspheres for temporal drug delivery. J Control Release 1993; 26:141-145.
120. Yui N, Okano T, Sakurai Y. Inflammation responsive degradation of crosslinked hyaluronic acid gel. J Control Release 1992; 22:105-116.
121. Sakiyama-Elbert SE, Hubbell JA. Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix. J Control Release 2000; 69:149-158.
122. Schense JC, Hubbell JA. Crosslinking exogenous bifunctional peptides into fibrin gels with factor XIIIa. Bioconjugate Chem 1999; 10:75-81.
123. Sakiyama-Elbert SE, Panitch A, Hubbell JA. Development of novel growth factor fusion proteins with exogenous immobilization domains for cellularly controlled drug delivery. Proc Int Symp Controlled Release Bioact Mater 2000; 27:970-971.
124. Sakiyama-Elbert SE, Panitch A, Hubbell JA. Development of growth factor fusion proteins for cell-triggered drug delivery. FASEB J 2001; 15:1300-1302.
125. Tabata Y, Miyao M, Ozeki M, Ikada Y. Controlled release of vascular endothelial growth factor by use of collagen hydrogels. J Biomater Sci, Polym Ed 2000; 11:915-930.
126. Suggs LJ, Krishnan RS, Garcia CA, Peter SJ, Anderson JM, Mikos AG. In vitro and in vivo degradation of poly(propylene fumarate-co-ethylene glycol) hydrogels. J Biomed Mater Res 1998; 42:312-320.
127. Peter SJ, Kim P, Yasko AW, Yaszemski MJ, Mikos AG. Crosslinking characteristics of an injectable poly(propylene fumarate)/b-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement. J Biomed Mater Res 1999; 44:314-321.
128. He S, Yaszemski MJ, Yasko AJ, Engel PS, Mikos AG. Injectable biodegradable polymer composites based on poly(propylene fumarate) crosslinked with poly(ethylene glycol)-dimethacrylate. Biomaterials 2000; 21:2389-2394.
129. He S, Timmer MD, Yaszemski MJ, Yasko AW, Engel PS, Mikos AG. Synthesis of biodegradable poly(propylene fumarate) networks with poly(propylene fumarate)-diacrylate macromers as crosslinking agents and characterization of their degradation products. Polymer 2001; 42:1251-1260.
130. Kim SH, Won CY, Chu CC. Synthesis and characterization of dextran-based hydrogel prepared by photocrosslinking. Carbohydr Polym 1999; 40:183-190.
131. Martens P, Metters AT, Anseth KS, Bowman CN. A generalized bulk-degradation model for hydrogel networks formed from multivinyl crosslinking molecules. J Phys Chem B 2001; 105:5131-5138.
132. Watanabe J, Ooya T, Park KD, Kim YH, Yui N. Preparation and characterization of poly(ethylene glycol) hydrogels crosslinked by hydrolyzable polyrotaxane. J Biomater Sci Polym Ed 2000; 11:1333-1345.
133. Ichi T, Watanabe J, Ooya T, Yui N. Controllable erosion time and profile in poly(ethylene glycol) hydrogels by supramolecular structure of hydrolyzable polyrotaxane. Biomacromolecules 2001; 2:204-210.