Metabolism of N-methyl-amide by cytochrome P450s Formation and characterization of highly stable carbinol-amide intermediate

FEBS Journal

Volumn 278, Issue 12, 2011, Pages 2167-2178

  Perrin, Lionel ^a,b,c,d,e   Loiseau, Nicolas ^e   André, François ^c,d   Delaforge, Marcel ^b,c,d,f  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b Institut National des Sciences Appliquées   (France)

^c SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^d CNRS   (France)

^e CEMAGREF   (France)

^f CEA   (France)

Author keywords

carbinol amide; carbinol amine; cytochrome P450; metabolism; tentoxin

Indexed keywords

AMIDE; CARBINOLAMIDE; CYCLOPEPTIDE; CYTOCHROME P450; TENTOXIN; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; MALE; METABOLITE; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN STABILITY; PROTON TRANSPORT; RAT;

AMIDES; ANIMALS; CARBON RADIOISOTOPES; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MALE; METHANOL; METHYLATION; MICROSOMES, LIVER; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES, CYCLIC; PROTEIN STABILITY; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; THERMODYNAMICS;

EID: 79958099774     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08133.x     Document Type: Article

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