Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: A species and gender comparison

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 7, 2011, Pages 967-970

  Yang, Cai Hua ^a   Tang, Lan ^a   Lv, Chang ^a   Ye, Ling ^a   Xia, Bi Jun ^a   Hu, Ming ^a,b   Liu, Zhong Qiu ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

gender; mono hydroxyflavones; regiospecific; species; sulfotransferases

Indexed keywords

4' MONOHYDROXYFLAVONE; 6 MONOHYDROXYFLAVONE; 7 MONOHYDROXYFLAVONE; FLAVONE DERIVATIVE; SULFOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOG; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SULFATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; IN VITRO STUDY; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; RAT; SEX DIFFERENCE; SPECIES COMPARISON; SPECIES DIFFERENCE;

ANIMALS; CYTOSOL; DOGS; FEMALE; FLAVONES; FLAVONOIDS; HUMANS; HYDROXYLATION; ISOMERISM; MALE; MICE; MICROSOMES, LIVER; OSMOLAR CONCENTRATION; RATS; RATS, INBRED F344; SEX CHARACTERISTICS; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY; SULFOTRANSFERASES;

EID: 79958077295     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01298.x     Document Type: Article

References (21)

1. Graf BA, et al,. Flavonols, flavones, flavanones, and human health: epidemiological evidence. J Med Food 2005; 8: 281-290. (Pubitemid 41502409)
2. Manach C, et al,. Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. Eur J Clin Nutr 2003; 57: 235-242. (Pubitemid 36240474)
3. Liu ZQ, et al,. Mechanisms responsible for poor oral bioavailability of paeoniflorin: role of intestinal disposition and interactions with sinomenine. Pharm Res 2006; 23: 2768-2780. (Pubitemid 44885365)
4. Tang L, et al,. Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones. Mol Pharm 2009; 6: 1466-1482.
5. Otake Y, et al,. Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes. Drug Metab Dispos 2002; 30: 576-581. (Pubitemid 34456981)
6. Hu M,. Commentary: bioavailability of flavonoids and polyphenols: call to arms. Mol Pharm 2007; 4: 803-806.
7. Huang C, et al,. Sulfation of dietary flavonoids by human sulfotransferases. Xenobiotica 2009; 39: 312-322.
8. Wang Y, Ho CT,. Metabolism of flavonoids. Forum Nutr 2009; 61: 64-74.
9. Tang L, et al,. Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. Mol Pharm 2010; 7: 664-679.
10. Zhou Q, et al,. Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. Pharm Res 2010; 27: 1568-1583.
11. Jeong EJ, et al,. Disposition mechanisms of raloxifene in the human intestinal Caco-2 model. J Pharmacol Exp Ther 2004; 310: 376-385. (Pubitemid 38812733)
12. Wang Q, et al,. Glucuronidation and sulfation of 7-hydroxycoumarin in liver matrices from human, dog, monkey, rat, and mouse. In Vitro Cell Dev Biol Anim 2005; 41: 97-103. (Pubitemid 41003861)
13. Tanaka E,. Gender-related differences in pharmacokinetics and their clinical significance. J Clin Pharm Ther 1999; 24: 339-346. (Pubitemid 29520783)
14. Punt A, et al,. Tandem mass spectrometry analysis of N2-(trans- Isoestragol-3′-yl)-2′-deoxyguanosine as a strategy to study species differences in sulfotransferase conversion of the proximate carcinogen 1′-hydroxyestragole. Chem Res Toxicol 2007; 20: 991-998. (Pubitemid 47204812)
15. Liu W, et al,. Species and gender differences affect the metabolism of emodin via glucuronidation. AAPS J 2010; 12: 424-436.
16. Alnouti Y, Klaassen CD,. Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults). Xenobiotica 2011; 41: 187-197.
17. Wang Q, et al,. Inter-species comparison of 7-hydroxycoumarin glucuronidation and sulfation in liver S9 fractions. In Vitro Cell Dev Biol Anim 2006; 42: 8-12. (Pubitemid 44264517)
18. Wang L, et al,. Sulfation of o-demethyl apixaban: enzyme identification and species comparison. Drug Metab Dispos 2009; 37: 802-808.
19. Lofgren S, et al,. Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. Xenobiotica 2004; 34: 811-834. (Pubitemid 39546271)
20. Hernandez JP, et al,. Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice. Toxicol Appl Pharmacol 2006; 216: 186-196. (Pubitemid 44479783)
21. Tang J, et al,. Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes. Drug Metab Dispos 2001; 29: 1201-1204. (Pubitemid 32800231)