Metabolism of flavonoids

Forum of Nutrition

Volumn 61, Issue , 2009, Pages 64-74

  Wang, Yu ^a   Ho, Chi Tang ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; FLAVONOID;

ANIMAL; ARTICLE; CHEMISTRY; HUMAN; METABOLISM; MOUSE; RAT;

ANIMALS; ANTIOXIDANTS; FLAVONOIDS; HUMANS; MICE; RATS;

EID: 67650228022     PISSN: 16600347     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000212739     Document Type: Article

References (30)

1. Hollman PCH, Arts ICW: Flavonols, flavones and flavanols - nature, occurrence and dietary burden. J Food Sci Agric 2000;80:1081-1093.
2. Li S, Pan MH, Lo CY, Tan D, Wang Y, Shahidi F, Ho CT: Chemistry and health effects of polymethoxy-flavones and hydroxylated polymethoxyflavones. J Funct Foods 2009;1:2-12.
3. Coward L, Barnes NC, Setchell KDR, Barnes S: Genistein, daidzein, and their beta-glycoside conjugates: antitumor isoflavones in soybean foods from American and Asian diets. J Agric Food Chem 1993; 41:1961-1967.
4. Rousseff RL, Martin SF, Youtsey CO: Quantitative survey of narirutin, naringin, heperidin, and neo-hesperidin in Citrus. J Agric Food Chem 1987;35: 1027-1030.
5. Arts ICW, van de Putte B, Hollman PCH: Catechin contents of foods commonly consumed in The Netherlands. 1. Fruits, vegetables, staple foods, and processed foods. J Agric Food Chem 2000;48:1746- 1751.
6. Arts IC, van de Putte B, Hollman PC: Catechin contents of foods commonly consumed in The Netherlands. 2. Tea, wine, fruit juices, and chocolate milk. J Agric Food Chem 2000;48:1752-1757.
7. Mazza G, Maniati E: Anthocyanins in Fruits, Vegetables, and Grains. Boca Raton, CRC Press, 1993.
8. Pan MH, Ho CT: Chemopreventive effects of natural dietary compounds on cancer development. Chem Soc Rev 2008;37:2558-2574.
9. Yan Z, Caldwell GW: Metabolism profiling, and cytochrome P450 inhibition and induction in drug discovery. Curr Top Med Chem 2001;1:403-425.
10. Lambert JD, Sang S, Yang CS: Biotransformation of green tea polyphenols and the biological activities of those metabolites. Mol Pharm 2007;4:819-825.
11. Spencer JPE, Chowrimootoo G, Choudhury R, Debnam ES, Srai SK, Rice-Evans C: The small intestine can both absorb and glucuronidate luminal fla-vonoids. FEBS Lett 1999;458:224-230.
12. Cao G, Prior RL: Anthocyanins are detected in human plasma after oral administration of an elderberry extract. Clin Chem 1999;45:574-576.
13. Kulling SE, Honig DM, Metzler M: Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo. J Agric Food Chem 2001;49:3024-3033.
14. Otake Y, Walle T: Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2 and CYP2C9. Drug Metab Dispos 2001;30:103-105.
15. Spencer JPE, Rice-Evans C, Williams RJ: Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J Biol Chem 2003;278:34783-34793.
16. de Boer VC, Dihal AA, van der Woude H, Arts IC, Wolffram S, Alink GM, et al: Tissue distribution of quercetin in rats and pigs. J Nutr 2005;135:1718- 1725.
17. Ichiyanagi T, Rahman MM, Kashiwada Y, Ikeshiro Y, Shida Y, Hatano Y, Matsumoto H, Hirayama M, Tsuda T, Konishi T: Absorption and metabolism of delphinidin 3-O-β-d-glucopyranoside in rats. Free Radic Biol Med 2004;36:930-937.
18. Prior RL, Wu X, Gu L: Perspective flavonoid metabolism and challenges to understanding mechanics of health effects. J Sci Food Agric 2006;86:2487- 2491.
19. Day AJ, Bao Y, Morgan MRA, Williamson G: Conjugation position of quercetin glucuronides and effect on biological activity. Free Radic Biol Med 2000;29:1234-1243.
20. O'Leary KA, Day AJ, Needs PW, Mellon FA, O'Brien NM, Williamson G: Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human β-glucuronidase, sulfo-transferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism. Biochem Pharmacol 2003;65:479-491.
21. Tsang C, Auger C, Mullen W, Bornet A, Rouanet JM, Crozier A, Teissedre PL: The absorption, metabolism and excretion of flavan-3-ols and pro-cyanidins following the ingestion of a grape seed extract by rats. Br J Nutr 2006;95:847.
22. Bayer T, Colnot T, Dekant W: Disposition and biotransformation of the estrogenic isoflavone daid-zein in rats. Toxicol Sci 2001;62:205-211.
23. Zhang Y, Hendrich S, Murphy PA: Glucuronides are the main isoflavone metabolites in woman. J Nutr 2003;133:399-404.
24. Kay CD, Mazza GJ, Holub BJ: Anthocyanins exist in the circulation primarily as metabolites in adult men. J Nutr 2005;135:2582-2588.
25. Awad HM, Boersma MG, Boeren S, van Bladeren PJ, Vervoort J, Rietjens IM: Quenching of quercetin quinone/quinone methides by different thiolate scavengers: stability and reversibility of conjugate formation. Chem Res Toxicol 2003;16:822-831.
26. Spencer JPE, Mohsen MMAE, Rice-Evans C: Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity. Arch Biochem Biophys 2004;423:148-161.
27. Hollman PCH: Absorption, bioavailability, and metabolism of flavonoids. Pharm Biol 2004;42:74-83.
28. Rechner AR, Smith MA, Kuhnle G, Gibson GR, Debnam ES, Srai SKS, Moore K P, Rice Evans CA: Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products. Free Radic Biol Med 2004;36:212-225.
29. Peppercorn MA, Goldman P: Caffeic acid metabolism by bacteria of the human gastrointestinal tract. J Bacteriol 1971;108:996-1000.
30. Galvano F, Vitaglione P, Volti GL, Giacomo CD, Gazzolo D, Vanella L, Fauci LL, Fogliano V: Proto-catechuic acid: the missing human cyanidins' metabolite. Mol Nutr Food Res 2008;52:386-387.