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Volumn 300, Issue 6, 2011, Pages

Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice

Author keywords

Cardiac efficiency; Cardiac function; Cardiac metabolism; Diabetic cardiomyopathy; Ischemia reperfusion

Indexed keywords

ANTILIPEMIC AGENT; ANTIOXIDANT; FATTY ACID; PEROXISOME PROLIFERATOR; TETRADECYLTHIOACETIC ACID; UNCLASSIFIED DRUG;

EID: 79958070133     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00357.2010     Document Type: Article
Times cited : (12)

References (41)
  • 2
    • 18844376847 scopus 로고    scopus 로고
    • Effect of BM 17.0744, a PPARalpha ligand, on the metabolism of perfused hearts from control and diabetic mice
    • Aasum E, Cooper M, Severson DL, Larsen TS. Effect of BM 17.0744, a PPARalpha ligand, on the metabolism of perfused hearts from control and diabetic mice. Can J Physiol Pharmacol 83: 183-190, 2005.
    • (2005) Can J Physiol Pharmacol , vol.83 , pp. 183-190
    • Aasum, E.1    Cooper, M.2    Severson, D.L.3    Larsen, T.S.4
  • 3
    • 0037315085 scopus 로고    scopus 로고
    • Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice
    • Aasum E, Hafstad AD, Severson DL, Larsen TS. Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. Diabetes 52: 434-441, 2003.
    • (2003) Diabetes , vol.52 , pp. 434-441
    • Aasum, E.1    Hafstad, A.D.2    Severson, D.L.3    Larsen, T.S.4
  • 4
    • 37549067407 scopus 로고    scopus 로고
    • Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice
    • Aasum E, Khalid AM, Gudbrandsen OA, How OJ, Berge RK, Larsen TS. Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice. J Mol Cell Cardiol 44: 201-209, 2008.
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 201-209
    • Aasum, E.1    Khalid, A.M.2    Gudbrandsen, O.A.3    How, O.J.4    Berge, R.K.5    Larsen, T.S.6
  • 5
    • 33749321945 scopus 로고    scopus 로고
    • Role of changes in cardiac metabolism in development of diabetic cardiomyopathy
    • An D, Rodrigues B. Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol 291: H1489-H1506, 2006.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • An, D.1    Rodrigues, B.2
  • 8
    • 66149154177 scopus 로고    scopus 로고
    • Increased O2 cost of basal metabolism and excitation-contraction coupling in hearts from type 2 diabetic mice
    • Boardman NT, Hafstad AD, Larsen T, Severson D, Aasum E. Increased O2 cost of basal metabolism and excitation-contraction coupling in hearts from type 2 diabetic mice. Am J Physiol Heart Circ Physiol 296: H1373-H1379, 2009.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296
    • Boardman, N.T.1    Hafstad, A.D.2    Larsen, T.3    Severson, D.4    Aasum, E.5
  • 9
    • 70349617679 scopus 로고    scopus 로고
    • Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats
    • Bonen A, Holloway GP, Tandon NN, Han XX, McFarlan J, Glatz JF, Luiken JJ. Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol 297: R1202-R1212, 2009.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297
    • Bonen, A.1    Holloway, G.P.2    Tandon, N.N.3    Han, X.X.4    McFarlan, J.5    Glatz, J.F.6    Luiken, J.J.7
  • 10
    • 34548848059 scopus 로고    scopus 로고
    • Mitochondrial energetics in the heart in obesity-related diabetes: Direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    • Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED. Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes 56: 2457-2466, 2007.
    • (2007) Diabetes , vol.56 , pp. 2457-2466
    • Boudina, S.1    Sena, S.2    Theobald, H.3    Sheng, X.4    Wright, J.J.5    Hu, X.X.6    Aziz, S.7    Johnson, J.I.8    Bugger, H.9    Zaha, V.G.10    Abel, E.D.11
  • 11
    • 64049095859 scopus 로고    scopus 로고
    • PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: Involvement of the PI3-Kinase/ Akt and NO pathway
    • Bulhak AA, Jung C, Ostenson CG, Lundberg JO, Sjoquist PO, Pernow J. PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/ Akt and NO pathway. Am J Physiol Heart Circ Physiol 296: H719-H727, 2009.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296
    • Bulhak, A.A.1    Jung, C.2    Ostenson, C.G.3    Lundberg, J.O.4    Sjoquist, P.O.5    Pernow, J.6
  • 12
    • 19444384446 scopus 로고    scopus 로고
    • Fatty acid metabolism is enhanced in type 2 diabetic hearts
    • Carley AN, Severson DL. Fatty acid metabolism is enhanced in type 2 diabetic hearts. Biochim Biophys Acta 1734: 112-126, 2005.
    • (2005) Biochim Biophys Acta , vol.1734 , pp. 112-126
    • Carley, A.N.1    Severson, D.L.2
  • 14
    • 33845577985 scopus 로고    scopus 로고
    • The PPAR regulatory system in cardiac physiology and disease
    • Finck BN. The PPAR regulatory system in cardiac physiology and disease. Cardiovasc Res 73: 269-277, 2007.
    • (2007) Cardiovasc Res , vol.73 , pp. 269-277
    • Finck, B.N.1
  • 15
    • 0035155343 scopus 로고    scopus 로고
    • Bioenergetics at low oxygen: Dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply
    • Gnaiger E. Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply. Respir Physiol 128: 277-297, 2001.
    • (2001) Respir Physiol , vol.128 , pp. 277-297
    • Gnaiger, E.1
  • 17
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
    • Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339: 229-234, 1998.
    • (1998) N Engl J Med , vol.339 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Ronnemaa, T.3    Pyorala, K.4    Laakso, M.5
  • 19
    • 34247576754 scopus 로고    scopus 로고
    • Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice
    • Hafstad AD, Khalid AM, How OJ, Larsen TS, Aasum E. Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice. Am J Physiol Endocrinol Metab 292: E1288-E1294, 2007.
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Hafstad, A.D.1    Khalid, A.M.2    How, O.J.3    Larsen, T.S.4    Aasum, E.5
  • 20
    • 78650318083 scopus 로고    scopus 로고
    • In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidation
    • Holloway GP, Snook LA, Harris RJ, Glatz JF, Luiken JJ, Bonen A. In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidation. J Physiol 589: 169-180, 2011.
    • (2011) J Physiol , vol.589 , pp. 169-180
    • Holloway, G.P.1    Snook, L.A.2    Harris, R.J.3    Glatz, J.F.4    Luiken, J.J.5    Bonen, A.6
  • 22
    • 33644784921 scopus 로고    scopus 로고
    • Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice
    • How OJ, Aasum E, Severson DL, Chan WY, Essop MF, Larsen TS. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes 55: 466-473, 2006.
    • (2006) Diabetes , vol.55 , pp. 466-473
    • How, O.J.1    Aasum, E.2    Severson, D.L.3    Chan, W.Y.4    Essop, M.F.5    Larsen, T.S.6
  • 25
    • 61549119476 scopus 로고    scopus 로고
    • Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation
    • Lovas K, Rost TH, Skorve J, Ulvik RJ, Gudbrandsen OA, Bohov P, Wensaas AJ, Rustan AC, Berge RK, Husebye ES. Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation. Diabetes Obes Metab 11: 304-314, 2009.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 304-314
    • Lovas, K.1    Rost, T.H.2    Skorve, J.3    Ulvik, R.J.4    Gudbrandsen, O.A.5    Bohov, P.6    Wensaas, A.J.7    Rustan, A.C.8    Berge, R.K.9    Husebye, E.S.10
  • 28
    • 0034106606 scopus 로고    scopus 로고
    • Tetradecylthioacetic acid and tetradecylselenoacetic acid inhibit lipid peroxidation and interact with superoxide radical
    • Muna ZA, Bolann BJ, Chen X, Songstad J, Berge RK. Tetradecylthioacetic acid and tetradecylselenoacetic acid inhibit lipid peroxidation and interact with superoxide radical. Free Radic Biol Med 28: 1068-1078, 2000.
    • (2000) Free Radic Biol Med , vol.28 , pp. 1068-1078
    • Muna, Z.A.1    Bolann, B.J.2    Chen, X.3    Songstad, J.4    Berge, R.K.5
  • 30
    • 0026761747 scopus 로고
    • Triacylglycerol metabolism in hypoxic, glucose-deprived rat cardiomyocytes
    • Myrmel T, Forsdahl K, Larsen TS. Triacylglycerol metabolism in hypoxic, glucose-deprived rat cardiomyocytes. J Mol Cell Cardiol 24: 855-868, 1992.
    • (1992) J Mol Cell Cardiol , vol.24 , pp. 855-868
    • Myrmel, T.1    Forsdahl, K.2    Larsen, T.S.3
  • 32
    • 0032452225 scopus 로고    scopus 로고
    • Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years
    • Randle PJ. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14: 263-283, 1998.
    • (1998) Diabetes Metab Rev , vol.14 , pp. 263-283
    • Randle, P.J.1
  • 33
    • 54449089267 scopus 로고    scopus 로고
    • Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export
    • Seifert EL, Bezaire V, Estey C, Harper ME. Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export. J Biol Chem 283: 25124-25131, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 25124-25131
    • Seifert, E.L.1    Bezaire, V.2    Estey, C.3    Harper, M.E.4
  • 34
    • 77957010982 scopus 로고
    • Citrate synthase
    • Srere P. Citrate synthase. Methodes Enzymol 13: 3-5, 1969.
    • (1969) Methodes Enzymol , vol.13 , pp. 3-5
    • Srere, P.1
  • 35
    • 2642581745 scopus 로고    scopus 로고
    • Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation
    • Tabernero A, Schoonjans K, Jesel L, Carpusca I, Auwerx J, Andriantsitohaina R. Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation. BMC Pharmacol 2: 10, 2002.
    • (2002) BMC Pharmacol , vol.2 , pp. 10
    • Tabernero, A.1    Schoonjans, K.2    Jesel, L.3    Carpusca, I.4    Auwerx, J.5    Andriantsitohaina, R.6
  • 37
    • 33645396685 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha agonist, clofibrate, has profound influence on myocardial fatty acid composition
    • Tian Q, Grzemski FA, Panagiotopoulos S, Ahokas JT. Peroxisome proliferator-activated receptor alpha agonist, clofibrate, has profound influence on myocardial fatty acid composition. Chem Biol Interact 160: 241-251, 2006.
    • (2006) Chem Biol Interact , vol.160 , pp. 241-251
    • Tian, Q.1    Grzemski, F.A.2    Panagiotopoulos, S.3    Ahokas, J.T.4
  • 38
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • RESEARCH0034
    • Vandesompele J, De PK, Pattyn F, Poppe B, Van RN, De PA, Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3: RESEARCH0034, 2002.
    • (2002) Genome Biol , vol.3
    • Vandesompele, J.1    de, P.K.2    Pattyn, F.3    Poppe, B.4    van, R.N.5    de, P.A.6    Speleman, F.7
  • 39
    • 47249145191 scopus 로고    scopus 로고
    • Long term treatment with tetradecylthioacetic acid improves the antioxidant status in obese zucker (fa/fa) rats
    • Wergedahl H, Berge K, Bohov P, Tronstad KJ, Madsen L, Berge RK. Long term treatment with tetradecylthioacetic acid improves the antioxidant status in obese zucker (fa/fa) rats. Drug Metab Lett 2: 138-145, 2008.
    • (2008) Drug Metab Lett , vol.2 , pp. 138-145
    • Wergedahl, H.1    Berge, K.2    Bohov, P.3    Tronstad, K.J.4    Madsen, L.5    Berge, R.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.