Ricin

Toxicon

Volumn 39, Issue 11, 2001, Pages 1723-1728

  Olsnes, Sjur ^a   Kozlov, Jurij V ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Endocytosis; Immunotoxin; Lectin; Ricin; Toxin; Translocation

Indexed keywords

CARBOHYDRATE; DISULFIDE; LECTIN; PLANT TOXIN; POLYPEPTIDE; PROTEIN SEC61P; RICIN; UNCLASSIFIED DRUG;

CELL SURFACE; CYTOSOL; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GOLGI COMPLEX; NONHUMAN; PLANT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVIEW; RIBOSOME;

EID: 0034866880     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(01)00158-1     Document Type: Article

References (61)

1. Introduction of a disulfide bond into ricin A chain decreases the cytotoxicity of the ricin holotoxin
2. Ribosome-inactivating proteins from plants
3. Characterization of a new non-toxic two-chain ribosome-inactivating protein and a structurally-related lectin from rhizomes of dwarf elder (Sambucus ebulus L.)
4. Structure and activity of an active site substitution of ricin A chain
5. Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells
6. The cytotoxins alpha-sarcin and ricin retain their specificity when tested on a synthetic oligoribonucleotide (35-mer) that mimics a region of 28 S ribosomal ribonucleic acid
7. Identity elements for ricin A-chain recognition and catalysis
8. The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins
9. RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes
10. Site of action of a Vero toxin (VT2) from Escherichia coli O157: H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins
11. Free ricin A chain, proricin, and native toxin have different cellular fates when expressed in tobacco protoplasts
12. Refined structure of trichosanthin at 1.73 A resolution
13. Modeccin, the toxin of Adenia digitata. Purification, toxicity and inhibition of protein synthesis in vitro
14. Ribosomal RNA identity elements for ricin A-chain recognition and catalysis. Analysis with tetraloop mutants
15. The ribosomal RNA identity elements for ricin and for alpha-sarcin: Mutations in the putative CG pair that closes a GAGA tetraloop
16. Accumulating evidence suggests that several AB-toxins subvert the endoplasmic reticulum-associated protein degradation pathway to enter target cells
17. X-ray structure of gelonin at 1.8 A resolution
18. Phenotypic reversion of ricin-resistant hamster fibroblasts to a sensitive state after coating with glycolipid receptors
19. MOLMOL: A program for display and analysis of macromolecular structures
20. Toxin entry: Retrograde transport through the secretory pathway
21. Ricin: Structure, mode of action, and some current applications
22. Inhibition by ricin of protein synthesis in vitro. Ribosomes as the target of the toxin
23. The 2.5 A structure of pokeweed antiviral protein
24. Gelonin is an unusual DNA glycosylase that removes adenine from single-stranded DNA, normal base pairs and mismatches
25. A new class of enzyme acting on damaged ribosomes: Ribosomal RNA apurinic site specific lyase found in wheat germ
26. Closing in on ricin action
27. Ribosome inactivation by the toxic lectins abrin and ricin. Kinetics of the enzymic activity of the toxin A-chains
28. Purification and characterization of the highly toxic lectin modeccin
29. Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis
30. Isolation and properties of abrin: A toxic protein inhibiting protein synthesis. Evidence for different biological functions of its two constituent-peptide chains
31. Chimeric toxins
32. On the mechanism of toxin resistance in cell variants resistant to abrin and ricin
33. Mechanism of action of the toxic lectins abrin and ricin
34. Isolation and comparison of galactose-binding lectins from Abrus precatorius and Ricinus communis
35. Immunotoxins - Entry into cells and mechanisms of action
36. Binding uptake, routing and translocation of toxins with intracellular sites of action
37. Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation
38. Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol
39. The cytotoxic activity of Shigella toxin. Evidence for catalytic inactivation of the 60 S ribosomal subunit
40. The N-glycosidase mechanism of ribosome-inactivating proteins implied by crystal structures of alpha-momorcharin
41. Recombinant proricin binds galactose but does not depurinate 28 S ribosomal RNA
42. The use of non-proven therapy among patients treated in Norwegian oncological departments. A cross-sectional national multicentre study
43. DNA-nuclease activity of the single-chain ribosome-inactivating proteins dianthin 30, saporin 6 and gelonin
44. Structure of ricin B-chain at 2.5 A resolution
45. Lectins: Cell-agglutinating and sugar-specific proteins
46. Catalytic and cytotoxic activities of recombinant ricin A chain mutants with charged residues added at the carboxyl terminus
47. Point mutations in the hydrophobic C-terminal region of ricin A chain indicate that Pro250 plays a key role in membrane translocation
48. Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast
49. Mutational analysis of the Ricinus lectin B-chains. Galactose-binding ability of the 2 gamma subdomain of Ricinus communis agglutinin B-chain
50. Properties of volkensin, a toxic lectin from Adenia volkensii
51. Action of viscumin, a toxic lectin from mistletoe, on cells in culture
52. Cytotoxicity of KDEL-terminated ricin toxins correlates with distribution of the KDEL receptor in the Golgi
53. Crystal structure of abrin-a at 2.14 A
54. The ways of endocytosis
55. Routing of internalized ricin and ricin conjugates to the Golgi complex
56. Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells
57. Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol
58. X-ray structure of recombinant ricin A-chain at 1.8 A resolution
59. Structure-based identification of a ricin inhibitor
60. Hybridoma cells containing intracellular anti-ricin antibodies show ricin meets secretory antibody before entering the cytosol
61. Studies on the galactose-binding site of ricin and the hybrid toxin Man6P-ricin