Expression of AniA, the major anaerobically induced outer membrane protein of Neisseria gonorrhoeae, provides protection against killing by normal human sera

Infection and Immunity

Volumn 68, Issue 7, 2000, Pages 4368-4369

  Cardinale, J A ^a,c   Clark, V L ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE PHOSPHATE; N ACETYLNEURAMINIC ACID; OUTER MEMBRANE PROTEIN;

ANAEROBIC METABOLISM; ARTICLE; CELL KILLING; GENE CONTROL; HOST RESISTANCE; HUMAN; NEISSERIA GONORRHOEAE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; SERUM; SIALYLATION;

ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BLOOD BACTERICIDAL ACTIVITY; FEMALE; GENE EXPRESSION; GENES, BACTERIAL; HUMANS; NEISSERIA GONORRHOEAE;

EID: 0033944864     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.7.4368-4369.2000     Document Type: Article

References (14)

1. + Neisseria gonorrhoeae from the bactericidal action of normal human serum. Infect. Immun. 63:1790-1785.
2. Clark, V. L., J. S. Knapp, S. Thompson, and K. W. Klimpel. 1988. Presence of antibodies to the major anaerobically induced gonococcal outer membrane protein in sera from patients with gonococcal infections. Microb. Pathog. 5:381-390.
3. Clark, V. L., L. A. Campbell, D. A. Palermo, T. M. Evans, and K. W. Klimpel. 1987. Induction and repression of outer membrane proteins by anaerobic growth of Neisseria gonorrhoeae. Infect. Immun. 55:1359-1364.
4. Densen, P. 1989. Interaction of complement with Neisseria meningitidis and Neisseria gonorrhoeae. Clin. Microbiol. Rev. 2(Suppl.):S11-S17.
5. Frangipane, J. V., and R. F. Rest. 1993. Anaerobic growth and cytidine 5′-monophospho-N-acetylneuramic acid act synergistically to induce high level serum resistance in N. gonorrhoeae. Infect. Immun. 61:1657-1666.
6. Householder, T. C., W. A. Belli, S. Lissenden, J. A. Cole, and V. L. Clark. 1999. cis- and trans-acting elements involved in regulation of aniA, the gene encoding the major anaerobically induced outer membrane protein in Neisseria gonorrhoeae. J. Bacteriol. 181:541-551.
7. Källström, H., M. K. Liszewski, J. P. Atkinson, and A.-B. Jonsson. 1997. Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. Mol. Microbiol. 25:639-647.
8. McNeeley, S. G., Jr. 1989. Gonococcal infections in women. Sex. Transm. Dis. 16:467-478.
9. Pangburn, M. K., M. A. Atkinson, and S. Meri. 1991. Localization of the heparin-binding site on complement factor H. J. Biol. Chem. 266:16847-16852.
10. Parsons, N. J., J. R. C. Andrade, P. V. Patel, J. A. Cole, and H. Smith. 1989. Sialylation of lipopolysaccharide and loss of absorption of bactericidal antibodies during conversion of gonococci to serum resistance by cytidine 5′-monophospho-N-acetyl-neuraminic acid. Microb. Pathog. 7:63-72.
11. Ram, S., D. P. McQuillen, S. Gulati, C. Elkins, M. K. Pangburn, and P. A. Rice. 1998. Binding of complement factor H to loop 5 of porin protein 1A: a molecular mechanism of serum resistance of nonsialylated Neisseria gonorrhoeae. J. Exp. Med. 188:671-680.
12. Rest, R. F., J. Liu, R. Talukdar, J. V. Frangipane, and D. Simon. 1994. Interaction of pathogenic Neisseria with host defenses: what happens in vivo? Ann. N. Y. Acad. Sci. 730:182-196.
13. Schneider, H., J. M. Grifiiss, G. D. Williams, and G. B. Pier. 1982. Immunological basis of serum resistance of Neisseria gonorrhoeae. J. Gen. Microbiol. 128:13-22.
14. Vogel, U., and M. Frosch. 1999. Mechanisms of neisserial serum resistance. Mol. Microbiol. 32:1133-1139.