메뉴 건너뛰기




Volumn 16, Issue 1, 2011, Pages 91-101

Pharmacologic use of Niacin

Author keywords

Depression; Dyslipidemia; Lipid metabolism; Migraine; Niacin; Niacinamide; Pellagra

Indexed keywords


EID: 79957941119     PISSN: 21565872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (16)

References (108)
  • 2
    • 0345394062 scopus 로고
    • The relation of diet to pellagra
    • Goldberger J. The relation of diet to pellagra. JAMA. 1922;78: 1676-1680.
    • (1922) JAMA , vol.78 , pp. 1676-1680
    • Goldberger, J.1
  • 3
    • 0002679866 scopus 로고
    • Relation of nicotinic acid and nicotinic acid amide to canine black tongue
    • Elvehjem CA, Madden RJ, Strong FM, Woolley DM. Relation of nicotinic acid and nicotinic acid amide to canine black tongue. J Am Chem Soc. 1937;59:1767-1768.
    • (1937) J Am Chem Soc , vol.59 , pp. 1767-1768
    • Elvehjem, C.A.1    Madden, R.J.2    Strong, F.M.3    Woolley, D.M.4
  • 4
    • 34547991087 scopus 로고    scopus 로고
    • Niacin
    • In: Rucker R, Zempleni J, Suttie JW, McCormick DB, eds., 4th ed. New York, NY: Taylor & Francis
    • Kirkland JB. Niacin. In: Rucker R, Zempleni J, Suttie JW, McCormick DB, eds. Handbook of Vitamins. 4th ed. New York, NY: Taylor & Francis; 2007:191-232.
    • (2007) Handbook of Vitamins , pp. 191-232
    • Kirkland, J.B.1
  • 5
    • 62149150332 scopus 로고    scopus 로고
    • Niacin status, NAD distribution and ADP-ribose metabolism
    • Kirkland JB. Niacin status, NAD distribution and ADP-ribose metabolism. Curr Pharm Des. 2009;15:3-11.
    • (2009) Curr Pharm Des , vol.15 , pp. 3-11
    • Kirkland, J.B.1
  • 6
    • 77952564025 scopus 로고    scopus 로고
    • Poly ADP-ribose polymerase-1 and health
    • Kirkland JB. Poly ADP-ribose polymerase-1 and health. Exp Biol Med (Maywood). 2010;235:561-568.
    • (2010) Exp Biol Med (Maywood) , vol.235 , pp. 561-568
    • Kirkland, J.B.1
  • 7
    • 77953256775 scopus 로고    scopus 로고
    • Chronic niacin overload may be involved in the increased prevalence of obesity in US children
    • Li D, Sun WP, Zhou YM, et al. Chronic niacin overload may be involved in the increased prevalence of obesity in US children. World J Gastroenterol. 2010;16:2378-2387.
    • (2010) World J Gastroenterol , vol.16 , pp. 2378-2387
    • Li, D.1    Sun, W.P.2    Zhou, Y.M.3
  • 8
    • 0027321708 scopus 로고
    • Niacin deficiency and cancer in women
    • Jacobson EL. Niacin deficiency and cancer in women. J Am Coll Nutr. 1993;12:412-416.
    • (1993) J Am Coll Nutr , vol.12 , pp. 412-416
    • Jacobson, E.L.1
  • 9
    • 0036199911 scopus 로고    scopus 로고
    • High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): Relevance to genetic disease and polymorphisms
    • Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. Am J Clin Nutr. 2002;75:616-658.
    • (2002) Am J Clin Nutr , vol.75 , pp. 616-658
    • Ames, B.N.1    Elson-Schwab, I.2    Silver, E.A.3
  • 10
    • 0005840015 scopus 로고
    • Effect of sunlight on the clinical manifestations of pellagra
    • Ruffin JM, Smith DT. Effect of sunlight on the clinical manifestations of pellagra. Arch Intern Med. 1937;59:631-645.
    • (1937) Arch Intern Med , vol.59 , pp. 631-645
    • Ruffin, J.M.1    Smith, D.T.2
  • 11
    • 0023780252 scopus 로고
    • The clinical spectrum of alcoholic pellagra encephalopathy. A retrospective analysis of 22 cases studied pathologically
    • Serdaru M, Hausser-Hauw C, Laplane D, et al. The clinical spectrum of alcoholic pellagra encephalopathy. A retrospective analysis of 22 cases studied pathologically. Brain. 1988;111(pt 4):829-842.
    • (1988) Brain , vol.111 , Issue.pt 4 , pp. 829-842
    • Serdaru, M.1    Hausser-Hauw, C.2    Laplane, D.3
  • 13
    • 0017689263 scopus 로고
    • Pellagra: An analysis of 18 patients and a review of the literature
    • Spivak JL, Jackson DL. Pellagra: an analysis of 18 patients and a review of the literature. Johns Hopkins Med J. 1977;140: 295-309.
    • (1977) Johns Hopkins Med J , vol.140 , pp. 295-309
    • Spivak, J.L.1    Jackson, D.L.2
  • 14
    • 0038011831 scopus 로고    scopus 로고
    • Pellagra may be a rare secondary complication of anorexia nervosa: A systematic review of the literature
    • Prousky JE. Pellagra may be a rare secondary complication of anorexia nervosa: a systematic review of the literature. Altern Med Rev. 2003;8:180-185.
    • (2003) Altern Med Rev , vol.8 , pp. 180-185
    • Prousky, J.E.1
  • 15
    • 4344669458 scopus 로고    scopus 로고
    • Niacin metabolite excretion in alcoholic pellagra and AIDS patients with and without diarrhea
    • Monteiro JP, da Cunha DF, Filho DC, et al. Niacin metabolite excretion in alcoholic pellagra and AIDS patients with and without diarrhea. Nutrition. 2004;20:778-782.
    • (2004) Nutrition , vol.20 , pp. 778-782
    • Monteiro, J.P.1    da Cunha, D.F.2    Filho, D.C.3
  • 18
  • 20
    • 0020677595 scopus 로고
    • Biochemistry of tryptophan in health and disease
    • Bender DA. Biochemistry of tryptophan in health and disease. Mol Aspects Med. 1983;6:101-197.
    • (1983) Mol Aspects Med , vol.6 , pp. 101-197
    • Bender, D.A.1
  • 22
    • 33646350271 scopus 로고    scopus 로고
    • Diuretic medication therapy use and low thiamin intake in homebound older adults
    • McCabe-Sellers BJ, Sharkey JR, Browne BA. Diuretic medication therapy use and low thiamin intake in homebound older adults. J Nutr Elder. 2005;24:57-71.
    • (2005) J Nutr Elder , vol.24 , pp. 57-71
    • McCabe-Sellers, B.J.1    Sharkey, J.R.2    Browne, B.A.3
  • 23
    • 30944451366 scopus 로고    scopus 로고
    • Vitamin status and cognitive function in a long-term care population
    • Paulionis L, Kane SL, Meckling KA. Vitamin status and cognitive function in a long-term care population. BMC Geriatr. 2005;5:16.
    • (2005) BMC Geriatr , vol.5 , pp. 16
    • Paulionis, L.1    Kane, S.L.2    Meckling, K.A.3
  • 24
    • 0024852957 scopus 로고
    • Biochemical markers for assessment of niacin status in young men: Levels of ery-throcyte niacin coenzymes and plasma tryptophan
    • Fu CS, Swendseid ME, Jacob RA, McKee RW. Biochemical markers for assessment of niacin status in young men: levels of ery-throcyte niacin coenzymes and plasma tryptophan. J Nutr. 1989;119:1949-1955.
    • (1989) J Nutr , vol.119 , pp. 1949-1955
    • Fu, C.S.1    Swendseid, M.E.2    Jacob, R.A.3    McKee, R.W.4
  • 25
    • 0022980977 scopus 로고
    • Skin and mucosal manifestations in vitamin deficiency
    • Barthelemy H, Chouvet B, Cambazard F. Skin and mucosal manifestations in vitamin deficiency. J Am Acad Dermatol. 1986;15: 1263-1274.
    • (1986) J Am Acad Dermatol , vol.15 , pp. 1263-1274
    • Barthelemy, H.1    Chouvet, B.2    Cambazard, F.3
  • 27
    • 0023681744 scopus 로고
    • Chroma-tolysis in alcoholic encephalopathies. Pellagra-like changes in 22 cases
    • Hauw JJ, De Baecque C, Hausser-Hauw C, Serdaru M. Chroma-tolysis in alcoholic encephalopathies. Pellagra-like changes in 22 cases. Brain. 1988;111(pt 4):843-857.
    • (1988) Brain , vol.111 , Issue.pt 4 , pp. 843-857
    • Hauw, J.J.1    de Baecque, C.2    Hausser-Hauw, C.3    Serdaru, M.4
  • 28
    • 84964139959 scopus 로고
    • The neurological complications of malnutrition: I-psychic manifestations of nicotinic acid deficiency
    • Sydenstricker VP. The neurological complications of malnutrition: I-psychic manifestations of nicotinic acid deficiency. Proc R Soc Med. 1943;36:169-171.
    • (1943) Proc R Soc Med , vol.36 , pp. 169-171
    • Sydenstricker, V.P.1
  • 29
    • 0000808276 scopus 로고
    • Influence of nicotinic acid on serum cholesterol
    • Altschul R, Hoffer A, Stephen JD. Influence of nicotinic acid on serum cholesterol. Arch Biochem. 1955;54:558-559.
    • (1955) Arch Biochem , vol.54 , pp. 558-559
    • Altschul, R.1    Hoffer, A.2    Stephen, J.D.3
  • 31
    • 0038050331 scopus 로고    scopus 로고
    • Niacin as a component of combination therapy for dys-lipidemia
    • Miller M. Niacin as a component of combination therapy for dys-lipidemia. Mayo Clin Proc. 2003;78:735-742.
    • (2003) Mayo Clin Proc , vol.78 , pp. 735-742
    • Miller, M.1
  • 32
    • 37449029988 scopus 로고    scopus 로고
    • Shedding light on high-density lipoprotein cholesterol: The post-ILLUMINATE era
    • Lavie CJ, Milani RV. Shedding light on high-density lipoprotein cholesterol: the post-ILLUMINATE era. J Am Coll Cardiol. 2008;51:56-58.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 56-58
    • Lavie, C.J.1    Milani, R.V.2
  • 33
    • 34548433987 scopus 로고    scopus 로고
    • Clinical practice. Hypertriglyceridemia
    • Brunzell JD. Clinical practice. Hypertriglyceridemia. N Engl J Med. 2007;357:1009-1017.
    • (2007) N Engl J Med , vol.357 , pp. 1009-1017
    • Brunzell, J.D.1
  • 34
    • 0028057319 scopus 로고
    • A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients
    • McKenney JM, Proctor JD, Harris S, Chinchili VM. A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients. JAMA. 1994; 271:672-677.
    • (1994) JAMA , vol.271 , pp. 672-677
    • McKenney, J.M.1    Proctor, J.D.2    Harris, S.3    Chinchili, V.M.4
  • 35
    • 77953121328 scopus 로고    scopus 로고
    • The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): Final results and the impact of medication adherence, dose, and treatment duration
    • Villines TC, Stanek EJ, Devine PJ, et al. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration. J Am Coll Cardiol. 2010;55:2721-2726.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2721-2726
    • Villines, T.C.1    Stanek, E.J.2    Devine, P.J.3
  • 36
    • 75349106253 scopus 로고    scopus 로고
    • Long-term safety and efficacy of triple combination ezetimibe/simvastatin plus extended-release niacin in patients with hyperlipidemia
    • Fazio S, Guyton JR, Polis AB, et al. Long-term safety and efficacy of triple combination ezetimibe/simvastatin plus extended-release niacin in patients with hyperlipidemia. Am J Cardiol.
    • Am J Cardiol
    • Fazio, S.1    Guyton, J.R.2    Polis, A.B.3
  • 37
    • 0023144019 scopus 로고
    • Adverse effects of hypolipidaemic drugs
    • Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol. 1987;2:10-32.
    • (1987) Med Toxicol , vol.2 , pp. 10-32
    • Knodel, L.C.1    Talbert, R.L.2
  • 39
    • 77952397461 scopus 로고    scopus 로고
    • Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis
    • Bruckert E, Labreuche J, Amarenco P. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis. 2010;210:353-361.
    • (2010) Atherosclerosis , vol.210 , pp. 353-361
    • Bruckert, E.1    Labreuche, J.2    Amarenco, P.3
  • 40
    • 0023001772 scopus 로고
    • Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin
    • Canner PL, Berge KG, Wenger NK, et al. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol. 1986;8:1245-1255.
    • (1986) J Am Coll Cardiol , vol.8 , pp. 1245-1255
    • Canner, P.L.1    Berge, K.G.2    Wenger, N.K.3
  • 41
    • 31044448925 scopus 로고    scopus 로고
    • GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
    • Benyo Z, Gille A, Kero J, et al. GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J Clin Invest. 2005; 115:3634-3640.
    • (2005) J Clin Invest , vol.115 , pp. 3634-3640
    • Benyo, Z.1    Gille, A.2    Kero, J.3
  • 42
    • 0034644442 scopus 로고    scopus 로고
    • Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: The ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial
    • Elam MB, Hunninghake DB, Davis KB, et al. Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: a randomized trial. Arterial Disease Multiple Intervention Trial. JAMA. 2000;284:1263-1270.
    • (2000) JAMA , vol.284 , pp. 1263-1270
    • Elam, M.B.1    Hunninghake, D.B.2    Davis, K.B.3
  • 43
  • 44
    • 55449091198 scopus 로고    scopus 로고
    • Of mice and men: Blowing away the cobwebs from the mechanism of action of niacin on HDL metabolism
    • Watts GF, Chan DC. Of mice and men: blowing away the cobwebs from the mechanism of action of niacin on HDL metabolism. Arterioscler Thromb Vasc Biol. 2008;28:1892-1895.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1892-1895
    • Watts, G.F.1    Chan, D.C.2
  • 46
    • 0024505123 scopus 로고
    • Enhanced myocardial preservation by nicotinic acid, an antilipolytic compound: Mechanism of action
    • Datta S, Das DK, Engelman RM, et al. Enhanced myocardial preservation by nicotinic acid, an antilipolytic compound: mechanism of action. Basic Res Cardiol. 1989;84:63-76.
    • (1989) Basic Res Cardiol , vol.84 , pp. 63-76
    • Datta, S.1    Das, D.K.2    Engelman, R.M.3
  • 47
    • 66449134807 scopus 로고    scopus 로고
    • Niacin status and treatment-related leukemogenesis
    • Kirkland JB. Niacin status and treatment-related leukemogenesis. Mol Cancer Ther. 2009;8:725-732.
    • (2009) Mol Cancer Ther , vol.8 , pp. 725-732
    • Kirkland, J.B.1
  • 48
    • 0034053990 scopus 로고    scopus 로고
    • Niacin deficiency in rats increases the severity of ethylnitrosourea-induced anemia and leukopenia
    • Boyonoski AC, Gallacher LM, ApSimon MM, et al. Niacin deficiency in rats increases the severity of ethylnitrosourea-induced anemia and leukopenia. J Nutr. 2000;130:1102-1107.
    • (2000) J Nutr , vol.130 , pp. 1102-1107
    • Boyonoski, A.C.1    Gallacher, L.M.2    Apsimon, M.M.3
  • 49
    • 34249907589 scopus 로고    scopus 로고
    • Niacin deficiency alters p53 expression and impairs etoposide-induced cell cycle arrest and apoptosis in rat bone marrow cells
    • Spronck JC, Nickerson JL, Kirkland JB. Niacin deficiency alters p53 expression and impairs etoposide-induced cell cycle arrest and apoptosis in rat bone marrow cells. Nutr Cancer. 2007;57: 88-99.
    • (2007) Nutr Cancer , vol.57 , pp. 88-99
    • Spronck, J.C.1    Nickerson, J.L.2    Kirkland, J.B.3
  • 50
    • 35548963303 scopus 로고    scopus 로고
    • Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow
    • Kostecki LM, Thomas M, Linford G, et al. Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow. Mutat Res. 2007;625:50-61.
    • (2007) Mutat Res , vol.625 , pp. 50-61
    • Kostecki, L.M.1    Thomas, M.2    Linford, G.3
  • 51
    • 41449091343 scopus 로고    scopus 로고
    • Niacin supplementation decreases the incidence of alkylation-induced nonlymphocytic leukemia in Long-Evans rats
    • Bartleman AP, Jacobs R, Kirkland JB. Niacin supplementation decreases the incidence of alkylation-induced nonlymphocytic leukemia in Long-Evans rats. Nutr Cancer. 2008;60:251-258.
    • (2008) Nutr Cancer , vol.60 , pp. 251-258
    • Bartleman, A.P.1    Jacobs, R.2    Kirkland, J.B.3
  • 52
    • 33846934456 scopus 로고    scopus 로고
    • Mortality experiences among 15{thorn} year survivors of childhood and adolescent cancers
    • Lawless SC, Verma P, Green DM, Mahoney MC. Mortality experiences among 15{thorn} year survivors of childhood and adolescent cancers. Pediatr Blood Cancer. 2007;48:333-338.
    • (2007) Pediatr Blood Cancer , vol.48 , pp. 333-338
    • Lawless, S.C.1    Verma, P.2    Green, D.M.3    Mahoney, M.C.4
  • 53
    • 58949092542 scopus 로고    scopus 로고
    • Acute leukemia as a secondary malignancy in children and adolescents: Current findings and issues
    • Hijiya N, Ness KK, Ribeiro RC, Hudson MM. Acute leukemia as a secondary malignancy in children and adolescents: current findings and issues. Cancer. 2009;115:23-35.
    • (2009) Cancer , vol.115 , pp. 23-35
    • Hijiya, N.1    Ness, K.K.2    Ribeiro, R.C.3    Hudson, M.M.4
  • 54
    • 62649092475 scopus 로고    scopus 로고
    • Accelerated Radiotherapy, car-bogen, and nicotinamide (ARCON) in the treatment of advanced bladder cancer: Mature results of a phase ii nonrandomized study
    • Hoskin P, Rojas A, Saunders M. Accelerated Radiotherapy, car-bogen, and nicotinamide (ARCON) in the treatment of advanced bladder cancer: mature results of a phase ii nonrandomized study. Int J Radiat Oncol Biol Phys. 2009;73:1425-1431.
    • (2009) Int J Radiat Oncol Biol Phys , vol.73 , pp. 1425-1431
    • Hoskin, P.1    Rojas, A.2    Saunders, M.3
  • 55
    • 33846990517 scopus 로고    scopus 로고
    • Effect of coenzyme Q10, riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy
    • Premkumar VG, Yuvaraj S, Vijayasarathy K, Gangadaran SG, Sachdanandam P. Effect of coenzyme Q10, riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy. Biol Pharm Bull. 2007;30:367-370.
    • (2007) Biol Pharm Bull , vol.30 , pp. 367-370
    • Premkumar, V.G.1    Yuvaraj, S.2    Vijayasarathy, K.3    Gangadaran, S.G.4    Sachdanandam, P.5
  • 57
    • 0037955885 scopus 로고    scopus 로고
    • The trigemino-cervical reflex in tension-type headache
    • Nardone R, Tezzon F. The trigemino-cervical reflex in tension-type headache. Eur J Neurol. 2003;10:307-312.
    • (2003) Eur J Neurol , vol.10 , pp. 307-312
    • Nardone, R.1    Tezzon, F.2
  • 58
    • 1242276345 scopus 로고    scopus 로고
    • Relationship between chronic tension-type headache, cranial hemodynamics, and cerebrospinal pressure: Study involving provocation with sumatriptan
    • Hannerz J, Jogestrand T. Relationship between chronic tension-type headache, cranial hemodynamics, and cerebrospinal pressure: study involving provocation with sumatriptan. Headache. 2004;44:154-159.
    • (2004) Headache , vol.44 , pp. 154-159
    • Hannerz, J.1    Jogestrand, T.2
  • 59
  • 60
    • 14644437112 scopus 로고    scopus 로고
    • The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): Systematic review of the literature
    • Prousky J, Seely D. The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature. Nutr J. 2005;4:3.
    • (2005) Nutr J , vol.4 , pp. 3
    • Prousky, J.1    Seely, D.2
  • 61
    • 14644387938 scopus 로고
    • Migraine headache: Some clinical observations on the vascular mechanism and its control
    • Atkinson M. Migraine headache: some clinical observations on the vascular mechanism and its control. Ann Intern Med. 1944; 21:990-997.
    • (1944) Ann Intern Med , vol.21 , pp. 990-997
    • Atkinson, M.1
  • 62
    • 14644420666 scopus 로고
    • Treatment of headache with intravenous sodium nicotinate
    • Goldzieher JW, Popkin GL. Treatment of headache with intravenous sodium nicotinate. J Am Med Assoc. 1946;131:103-105.
    • (1946) J Am Med Assoc , vol.131 , pp. 103-105
    • Goldzieher, J.W.1    Popkin, G.L.2
  • 63
    • 14644430759 scopus 로고
    • Treatment of migraine with nicotinic acid
    • Grenfell RF. Treatment of migraine with nicotinic acid. Am Pract Dig Treat. 1949;3:542-544.
    • (1949) Am Pract Dig Treat , vol.3 , pp. 542-544
    • Grenfell, R.F.1
  • 64
    • 14644387286 scopus 로고
    • Treatment of tension headache
    • Grenfell RF. Treatment of tension headache. Am Pract Dig Treat. 1951;2:933-936.
    • (1951) Am Pract Dig Treat , vol.2 , pp. 933-936
    • Grenfell, R.F.1
  • 65
    • 14644412196 scopus 로고
    • Nicotinic acid therapy in vasoconstriction type of headache
    • Morgan ZR. Nicotinic acid therapy in vasoconstriction type of headache. Md State Med J. 1953;2:377-382.
    • (1953) Md State Med J , vol.2 , pp. 377-382
    • Morgan, Z.R.1
  • 66
    • 14644391320 scopus 로고
    • A newer method of nicotinic acid therapy in headache of the vasoconstrictive type
    • Morgan ZR. A newer method of nicotinic acid therapy in headache of the vasoconstrictive type. J Am Geriatr Soc. 1955;3:545-551.
    • (1955) J Am Geriatr Soc , vol.3 , pp. 545-551
    • Morgan, Z.R.1
  • 67
    • 0042288007 scopus 로고
    • Enhancing niacin's effects for migraine
    • Hall JA. Enhancing niacin's effects for migraine. Cortlandt Forum. 1991;46:47.
    • (1991) Cortlandt Forum , vol.46 , pp. 47
    • Hall, J.A.1
  • 68
    • 0043170840 scopus 로고    scopus 로고
    • Two case reports on the treatment of acute migraine with niacin. Its hypothetical mechanism of action upon calcitonin-gene related peptide and platelets
    • Prousky J, Sykes E. Two case reports on the treatment of acute migraine with niacin. Its hypothetical mechanism of action upon calcitonin-gene related peptide and platelets. J Orthomol Med. 2003;18:108-110.
    • (2003) J Orthomol Med , vol.18 , pp. 108-110
    • Prousky, J.1    Sykes, E.2
  • 69
    • 0038050302 scopus 로고    scopus 로고
    • Sustained-release niacin for prevention of migraine headache
    • Velling DA, Dodick DW, Muir JJ. Sustained-release niacin for prevention of migraine headache. Mayo Clin Proc. 2003;78: 770-771.
    • (2003) Mayo Clin Proc , vol.78 , pp. 770-771
    • Velling, D.A.1    Dodick, D.W.2    Muir, J.J.3
  • 70
    • 0024335924 scopus 로고
    • Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid
    • Morrow JD, Parsons WG III, Roberts LJ. Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. Prostaglandins. 1989;38:263-274.
    • (1989) Prostaglandins , vol.38 , pp. 263-274
    • Morrow, J.D.1    Parsons, W.G.2    Roberts, L.J.3
  • 71
    • 0026508010 scopus 로고
    • Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans
    • Morrow JD, Awad JA, Oates JA, Roberts LJ. Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J Invest Dermatol. 1992;98: 812-815.
    • (1992) J Invest Dermatol , vol.98 , pp. 812-815
    • Morrow, J.D.1    Awad, J.A.2    Oates, J.A.3    Roberts, L.J.4
  • 72
    • 0142014705 scopus 로고
    • 3rd ed. Milwaukee, WI: Life Foundation for Nutritional Research
    • Bicknell F, Prescott F. The Vitamins in Medicine. 3rd ed. Milwaukee, WI: Life Foundation for Nutritional Research; 1953.
    • (1953) The Vitamins In Medicine
    • Bicknell, F.1    Prescott, F.2
  • 73
    • 0029767854 scopus 로고    scopus 로고
    • Cerebral blood flow effects of piracetam, pentifylline, and nicotinic acid in the baboon model compared with the known effect of acetazolamide
    • Jordaan B, Oliver DW, Dormehl IC, Hugo N. Cerebral blood flow effects of piracetam, pentifylline, and nicotinic acid in the baboon model compared with the known effect of acetazolamide. Arznei-mittelforschung. 1996;46:844-847.
    • (1996) Arznei-mittelforschung , vol.46 , pp. 844-847
    • Jordaan, B.1    Oliver, D.W.2    Dormehl, I.C.3    Hugo, N.4
  • 74
    • 3042631898 scopus 로고    scopus 로고
    • Antidepressants and brain monoaminergic systems: A dimensional approach to understanding their behavioural effects in depression and anxiety disorder
    • s
    • Morilak DA, Frazer A. Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders. Int J Neuropsychopharmacol. 2004;7:193-218.
    • (2004) Int J Neuropsychopharmacol , vol.7 , pp. 193-218
    • Morilak, D.A.1    Frazer, A.2
  • 75
  • 76
    • 77649340796 scopus 로고    scopus 로고
    • Cerebrovascular reactivity over time-course-from major depressive episode to remission
    • Lemke H, de Castro AG, Schlattmann P, Heuser I, Neu P. Cerebrovascular reactivity over time-course-from major depressive episode to remission. J Psychiatr Res. 2010;44:132-136.
    • (2010) J Psychiatr Res , vol.44 , pp. 132-136
    • Lemke, H.1    de Castro, A.G.2    Schlattmann, P.3    Heuser, I.4    Neu, P.5
  • 77
    • 76549255194 scopus 로고
    • Nicotinic acid in the treatment of certain depressed states; a preliminary report
    • Washburne AC. Nicotinic acid in the treatment of certain depressed states; a preliminary report. Ann Intern Med. 1950;32:261-269.
    • (1950) Ann Intern Med , vol.32 , pp. 261-269
    • Washburne, A.C.1
  • 78
    • 34247206728 scopus 로고
    • Nicotinic acid in the treatment of depression
    • Tonge WL. Nicotinic acid in the treatment of depression. Ann Intern Med. 1953;38:551-553.
    • (1953) Ann Intern Med , vol.38 , pp. 551-553
    • Tonge, W.L.1
  • 79
    • 34247243411 scopus 로고
    • Depressive and anxiety reactions treated with nicotinic acid and phenobarbital
    • Thompson LJ, Proctor RC. Depressive and anxiety reactions treated with nicotinic acid and phenobarbital. N C Med J. 1953; 14:420-426.
    • (1953) N C Med J , vol.14 , pp. 420-426
    • Thompson, L.J.1    Proctor, R.C.2
  • 80
    • 0016834952 scopus 로고
    • Letter: Treatment of unipolar depression
    • MacSweeney DA. Letter: Treatment of unipolar depression. Lancet. 1975;2:510-511.
    • (1975) Lancet , vol.2 , pp. 510-511
    • Macsweeney, D.A.1
  • 82
    • 0018418609 scopus 로고
    • Tryptophan-nicotinamide, imipramine and their combination in depression. A controlled study
    • Chouinard G, Young SN, Annable L, Sourkes TL. Tryptophan-nicotinamide, imipramine and their combination in depression. A controlled study. Acta Psychiatr Scand. 1979;59:395-414.
    • (1979) Acta Psychiatr Scand , vol.59 , pp. 395-414
    • Chouinard, G.1    Young, S.N.2    Annable, L.3    Sourkes, T.L.4
  • 83
    • 0016573391 scopus 로고
    • Letter: Tryptophan plus a pyrrolase inhibitor for depression
    • Badawy AA, Evans M. Letter: Tryptophan plus a pyrrolase inhibitor for depression. Lancet. 1975;2:869.
    • (1975) Lancet , vol.2 , pp. 869
    • Badawy, A.A.1    Evans, M.2
  • 84
    • 0035031546 scopus 로고    scopus 로고
    • Nicotinamide: A nutritional supplement that provides protection against neuronal and vascular injury
    • Lin SH, Chong ZZ, Maiese K. Nicotinamide: a nutritional supplement that provides protection against neuronal and vascular injury. J Med Food. 2001;4:27-38.
    • (2001) J Med Food , vol.4 , pp. 27-38
    • Lin, S.H.1    Chong, Z.Z.2    Maiese, K.3
  • 85
    • 77954023854 scopus 로고    scopus 로고
    • Metabolic syndrome, age-associated neuroendo-crine disorders, and dysregulation of tryptophan-kynurenine metabolism
    • Oxenkrug GF. Metabolic syndrome, age-associated neuroendo-crine disorders, and dysregulation of tryptophan-kynurenine metabolism. Ann N Y Acad Sci. 2010;1199:1-14.
    • (2010) Ann N Y Acad Sci , vol.1199 , pp. 1-14
    • Oxenkrug, G.F.1
  • 86
    • 78049503294 scopus 로고    scopus 로고
    • Beyond the dopamine receptor: Novel therapeutic targets for treating schizophrenia
    • Coyle JT, Balu D, Benneyworth M, Basu A, Roseman A. Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia. Dialogues Clin Neurosci. 2010;12: 359-382.
    • (2010) Dialogues Clin Neurosci , vol.12 , pp. 359-382
    • Coyle, J.T.1    Balu, D.2    Benneyworth, M.3    Basu, A.4    Roseman, A.5
  • 87
    • 75549107318 scopus 로고
    • The adrenochrome theory of schizophrenia: A review
    • Hoffer A. The adrenochrome theory of schizophrenia: a review. Dis Nerv Syst. 1964;25:173-178.
    • (1964) Dis Nerv Syst , vol.25 , pp. 173-178
    • Hoffer, A.1
  • 88
    • 0030459314 scopus 로고    scopus 로고
    • Endogenous neurotoxins relevant to schizophrenia
    • Smythies J. Endogenous neurotoxins relevant to schizophrenia. J R Soc Med. 1996;89:679-680.
    • (1996) J R Soc Med , vol.89 , pp. 679-680
    • Smythies, J.1
  • 89
    • 0030933056 scopus 로고    scopus 로고
    • Oxidative reactions and schizophrenia: A review-discussion
    • Smythies JR. Oxidative reactions and schizophrenia: a review-discussion. Schizophr Res. 1997;24:357-364.
    • (1997) Schizophr Res , vol.24 , pp. 357-364
    • Smythies, J.R.1
  • 90
    • 0036203805 scopus 로고    scopus 로고
    • The adrenochrome hypothesis of schizophrenia revisited
    • Smythies J. The adrenochrome hypothesis of schizophrenia revisited. Neurotox Res. 2002;4:147-150.
    • (2002) Neurotox Res , vol.4 , pp. 147-150
    • Smythies, J.1
  • 92
    • 0015181325 scopus 로고
    • Megavitamin B-3 therapy for schizophrenia
    • Hoffer A. Megavitamin B-3 therapy for schizophrenia. Can Psychiatr Assoc J. 1971;16:499-504.
    • (1971) Can Psychiatr Assoc J , vol.16 , pp. 499-504
    • Hoffer, A.1
  • 93
    • 0021847607 scopus 로고
    • Vitamins in psychiatry. Do they have a role?
    • Petrie WM, Ban TA. Vitamins in psychiatry. Do they have a role? Drugs. 1985;30:58-65.
    • (1985) Drugs , vol.30 , pp. 58-65
    • Petrie, W.M.1    Ban, T.A.2
  • 94
    • 33644963618 scopus 로고    scopus 로고
    • Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder
    • Miller CL, Llenos IC, Dulay JR, Weis S. Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Res. 2006;1073-1074:25-37.
    • (2006) Brain Res , pp. 1073-1074
    • Miller, C.L.1    Llenos, I.C.2    Dulay, J.R.3    Weis, S.4
  • 95
    • 51749124907 scopus 로고    scopus 로고
    • The high-affinity niacin receptor HM74A is decreased in the anterior cingulate cortex of individuals with schizophrenia
    • Miller CL, Dulay JR. The high-affinity niacin receptor HM74A is decreased in the anterior cingulate cortex of individuals with schizophrenia. Brain Res Bull. 2008;77:33-41.
    • (2008) Brain Res Bull , vol.77 , pp. 33-41
    • Miller, C.L.1    Dulay, J.R.2
  • 96
    • 24244433099 scopus 로고    scopus 로고
    • Niacin deficient SKH-1 mice are more susceptible to ultraviolet B radiation-induced skin carcinogenesis
    • Shah GM, Le Rhun Y, Sutarjono I, Kirkland JB. Niacin deficient SKH-1 mice are more susceptible to ultraviolet B radiation-induced skin carcinogenesis. J Nutr. 2001;131(11 suppl):3150S.
    • (2001) J Nutr , vol.131 , Issue.11 SUPPL
    • Shah, G.M.1    le Rhun, Y.2    Sutarjono, I.3    Kirkland, J.B.4
  • 97
    • 0032854152 scopus 로고    scopus 로고
    • Oral niacin prevents photocarcinogenesis and photoimmunosuppression in mice
    • Gensler HL, Williams T, Huang AC, Jacobson EL. Oral niacin prevents photocarcinogenesis and photoimmunosuppression in mice. Nutr Cancer. 1999;34:36-41.
    • (1999) Nutr Cancer , vol.34 , pp. 36-41
    • Gensler, H.L.1    Williams, T.2    Huang, A.C.3    Jacobson, E.L.4
  • 98
    • 79955408736 scopus 로고    scopus 로고
    • Role of nicotinamide in DNA damage, mutagenesis, and DNA repair
    • Surjana D, Halliday GM, Damian DL. Role of nicotinamide in DNA damage, mutagenesis, and DNA repair. J Nucleic Acids. 2010;2010:157591.
    • (2010) J Nucleic Acids , vol.2010 , pp. 157591
    • Surjana, D.1    Halliday, G.M.2    Damian, D.L.3
  • 100
    • 0029025028 scopus 로고
    • Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris
    • Shalita AR, Smith JG, Parish LC, Sofman MS, Chalker DK. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol. 1995;34:434-437.
    • (1995) Int J Dermatol , vol.34 , pp. 434-437
    • Shalita, A.R.1    Smith, J.G.2    Parish, L.C.3    Sofman, M.S.4    Chalker, D.K.5
  • 101
    • 31944451377 scopus 로고    scopus 로고
    • Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: A review
    • Niren NM. Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review. Cutis. 2006; 77(1 suppl):11-16.
    • (2006) Cutis , vol.77 , Issue.1 SUPPL , pp. 11-16
    • Niren, N.M.1
  • 102
    • 79957931020 scopus 로고
    • Peripheral vasodilators in the treatment of macular degenerative changes in the eye
    • Laws HW. Peripheral vasodilators in the treatment of macular degenerative changes in the eye. Can Med Assoc J. 1964;91: 325-330.
    • (1964) Can Med Assoc J , vol.91 , pp. 325-330
    • Laws, H.W.1
  • 103
    • 0035409538 scopus 로고    scopus 로고
    • Use of nicotinic acid in the management of recurrent hypoglycemic episodes in diabetes
    • Hannan F, Davoren P. Use of nicotinic acid in the management of recurrent hypoglycemic episodes in diabetes. Diabetes Care. 2001;24:1301.
    • (2001) Diabetes Care , vol.24 , pp. 1301
    • Hannan, F.1    Davoren, P.2
  • 104
    • 0025897009 scopus 로고
    • Lactic acidosis associated with high-dose niacin therapy
    • Earthman TP, Odom L, Mullins CA. Lactic acidosis associated with high-dose niacin therapy. South Med J. 1991;84:496-497.
    • (1991) South Med J , vol.84 , pp. 496-497
    • Earthman, T.P.1    Odom, L.2    Mullins, C.A.3
  • 108
    • 33746806864 scopus 로고    scopus 로고
    • Effect of niacin on retinal vascular diameter in patients with age-related macular degeneration
    • Barakat MR, Metelitsina TI, DuPont JC, Grunwald JE. Effect of niacin on retinal vascular diameter in patients with age-related macular degeneration. Curr Eye Res. 2006;31:629-634.
    • (2006) Curr Eye Res , vol.31 , pp. 629-634
    • Barakat, M.R.1    Metelitsina, T.I.2    Dupont, J.C.3    Grunwald, J.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.