메뉴 건너뛰기




Volumn 12, Issue 3, 2010, Pages 359-382

Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia;Más allá del receptor de dopamina: Nuevos blancos terapéuticos para tratar la esquizofrenia

Author keywords

aminobutyric acid; Glutamate; Metabotropic glutamate receptor; N methyl D aspartate receptor; Nicotinic acetylcholine receptor

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA3; 4 AMINOBUTYRIC ACID RECEPTOR; BUNGAROTOXIN RECEPTOR; CHLORPROMAZINE; CHOLINERGIC RECEPTOR; CLOZAPINE; DEXTRO AMINO ACID OXIDASE; DEXTRO SERINE; DOPAMINE 2 RECEPTOR; GLUTAMIC ACID; GLYCINE TRANSPORTER 1; HALOPERIDOL; METABOTROPIC RECEPTOR; MUSCARINIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROLEPTIC AGENT; NICOTINIC RECEPTOR; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; DOPAMINE RECEPTOR;

EID: 78049503294     PISSN: 12948322     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (66)

References (247)
  • 1
    • 33645470674 scopus 로고
    • Neuroleptic effects of chlorpromazine in therapeutics of neuropsychiatry
    • Delay J, Denicker P. Neuroleptic effects of chlorpromazine in therapeutics of neuropsychiatry. J Clin Exp Psychopathol. 1955;16:104-112.
    • (1955) J Clin Exp Psychopathol , vol.16 , pp. 104-112
    • Delay, J.1    Denicker, P.2
  • 2
    • 0028293406 scopus 로고
    • Is it possible to predict the clinical effects of neuroleptics from animal data? Part V: From haloperidol and pipamperone to risperidone
    • Janssen PA, Awouters FH. Is it possible to predict the clinical effects of neuroleptics from animal data? Part V: From haloperidol and pipamperone to risperidone. Arzneimittelforschung. 1994;44:269-277.
    • (1994) Arzneimittelforschung , vol.44 , pp. 269-277
    • Janssen, P.A.1    Awouters, F.H.2
  • 3
    • 0017651563 scopus 로고
    • Does dopamine play a role in schizophrenia?
    • Carlsson A. Does dopamine play a role in schizophrenia? Psychol Med. 1977;7:583-597.
    • (1977) Psychol Med , vol.7 , pp. 583-597
    • Carlsson, A.1
  • 4
    • 0017255979 scopus 로고
    • Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
    • Creese I, Burt DR, Snyder SH. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science. 1976;192:481-483.
    • (1976) Science , vol.192 , pp. 481-483
    • Creese, I.1    Burt, D.R.2    Snyder, S.H.3
  • 5
    • 0017068246 scopus 로고
    • Antipsychotic drug doses and neuroleptic/dopamine receptors
    • Seeman P, Lee T, Chau-Wong M, Wong K. Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature. 1976; 261:717-719.
    • (1976) Nature , vol.261 , pp. 717-719
    • Seeman, P.1    Lee, T.2    Chau-Wong, M.3    Wong, K.4
  • 6
    • 33847685647 scopus 로고    scopus 로고
    • Illuminating the molecular basis for some antipsychotic drug-induced metabolic burden
    • Meltzer HY. Illuminating the molecular basis for some antipsychotic drug-induced metabolic burden. Proc Natl Acad Sci U S A. 2007;104:3019-3020.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3019-3020
    • Meltzer, H.Y.1
  • 7
    • 0000439046 scopus 로고
    • Prevalence of alcohol, drug and mental disorders among the homeless: one more time
    • Lehman AF, Cordray DS. Prevalence of alcohol, drug and mental disorders among the homeless: one more time. Contemporary Drug Problems. 1993;20:355-384.
    • (1993) Contemporary Drug Problems , vol.20 , pp. 355-384
    • Lehman, A.F.1    Cordray, D.S.2
  • 8
    • 59249100318 scopus 로고    scopus 로고
    • Penrose's law revisited: the relationship between mental institution beds, prison population and crime rate
    • Hartvig P, Kjelsberg E. Penrose's law revisited: the relationship between mental institution beds, prison population and crime rate. Nord J Psychiatry. 2009;63:51-56.
    • (2009) Nord J Psychiatry , vol.63 , pp. 51-56
    • Hartvig, P.1    Kjelsberg, E.2
  • 9
    • 26644472427 scopus 로고    scopus 로고
    • The economic burden of schizophrenia in the United States in 2002
    • Wu EQ, Birnbaum HG, Shi L, et al. The economic burden of schizophrenia in the United States in 2002. J Clin Psychiatry. 2005;66:1122-1129.
    • (2005) J Clin Psychiatry , vol.66 , pp. 1122-1129
    • Wu, E.Q.1    Birnbaum, H.G.2    Shi, L.3
  • 10
    • 0038653525 scopus 로고    scopus 로고
    • A meta-analysis of the efficacy of secondgeneration antipsychotics
    • Davis JM, Chen N, Glick ID. A meta-analysis of the efficacy of secondgeneration antipsychotics. Arch Gen Psychiatry. 2003;60:553-564.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 553-564
    • Davis, J.M.1    Chen, N.2    Glick, I.D.3
  • 11
    • 25144456112 scopus 로고    scopus 로고
    • Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) investigators: Effectiveness of antipsychotic drugs in patients with chronic schizophrenia
    • Lieberman JA, Stroup TS, McEvoy JP, et al. Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) investigators: Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 2005;353:1209-1223.
    • (2005) N Engl J Med , vol.353 , pp. 1209-1223
    • Lieberman, J.A.1    Stroup, T.S.2    McEvoy, J.P.3
  • 12
    • 33749321169 scopus 로고    scopus 로고
    • Randomized controlled trial of the effect on quality of life of secondvs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1)
    • Jones PB, Barnes TR, Davies L, et al. Randomized controlled trial of the effect on quality of life of secondvs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1). Arch Gen Psychiatry. 2006;63:1079-1087.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 1079-1087
    • Jones, P.B.1    Barnes, T.R.2    Davies, L.3
  • 13
    • 33749333592 scopus 로고    scopus 로고
    • Comparative effectiveness of antipsychotic drugs: a commentary on: Cost Utility Of The Latest Antipsychotic Drugs In Schizophrenia Study (CUtLASS 1) and Clinical Antipsychotic Trials Of Intervention Effectiveness (CATIE)
    • Lieberman JA. Comparative effectiveness of antipsychotic drugs: a commentary on: Cost Utility Of The Latest Antipsychotic Drugs In Schizophrenia Study (CUtLASS 1) and Clinical Antipsychotic Trials Of Intervention Effectiveness (CATIE). Arch Gen Psychiatry. 2006;63:1069-1072.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 1069-1072
    • Lieberman, J.A.1
  • 14
    • 0026746727 scopus 로고
    • Relationship between symptoms rated with the Positive and Negative Syndrome Scale and brain measures in schizophrenia
    • d'Amato T, Rochet T, Dalery J, et al. Relationship between symptoms rated with the Positive and Negative Syndrome Scale and brain measures in schizophrenia. Psychiatry Res. 1992;44:55-62.
    • (1992) Psychiatry Res , vol.44 , pp. 55-62
    • d'Amato, T.1    Rochet, T.2    Dalery, J.3
  • 15
    • 1142285269 scopus 로고    scopus 로고
    • The deficit syndrome in schizophrenia: implications for the treatment of negative symptoms
    • Arango C, Buchanan RW, Kirkpatrick B, Carpenter WT. The deficit syndrome in schizophrenia: implications for the treatment of negative symptoms. Eur Psychiatry. 2004;19:21-26.
    • (2004) Eur Psychiatry , vol.19 , pp. 21-26
    • Arango, C.1    Buchanan, R.W.2    Kirkpatrick, B.3    Carpenter, W.T.4
  • 17
    • 0031903740 scopus 로고    scopus 로고
    • Neurocognitive deficit in schizophrenia: a quantitative review of the evidence
    • Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12:426-445.
    • (1998) Neuropsychology , vol.12 , pp. 426-445
    • Heinrichs, R.W.1    Zakzanis, K.K.2
  • 18
    • 32244437440 scopus 로고    scopus 로고
    • Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultrahigh-risk individuals
    • Velakoulis D, Wood SJ, Wong MT, et al. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultrahigh-risk individuals. Arch Gen Psychiatry. 2006;63:139-149.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 139-149
    • Velakoulis, D.1    Wood, S.J.2    Wong, M.T.3
  • 19
    • 34248145966 scopus 로고    scopus 로고
    • Progressive and interrelated functional and structural evidence of post-onset brain reduction in schizophrenia
    • Salisbury DF, Kuroki N, Kasai K, Shenton ME, McCarley RW. Progressive and interrelated functional and structural evidence of post-onset brain reduction in schizophrenia. Arch Gen Psychiatry. 2007;64:521-529.
    • (2007) Arch Gen Psychiatry , vol.64 , pp. 521-529
    • Salisbury, D.F.1    Kuroki, N.2    Kasai, K.3    Shenton, M.E.4    McCarley, R.W.5
  • 20
    • 77955328701 scopus 로고    scopus 로고
    • Convergent approaches for defining functional imaging endophenotypes in schizophrenia
    • Pearlson GD, Calhoun VD. Convergent approaches for defining functional imaging endophenotypes in schizophrenia. Front Hum Neurosci. 2009;3:37.
    • (2009) Front Hum Neurosci , vol.3 , pp. 37
    • Pearlson, G.D.1    Calhoun, V.D.2
  • 21
    • 62349119965 scopus 로고    scopus 로고
    • Recent diffusion tensor imaging findings in early stages of schizophrenia
    • Kyriakopoulos M, Frangou S. Recent diffusion tensor imaging findings in early stages of schizophrenia. Curr Opin Psychiatry. 2009:22:168-176.
    • Curr Opin Psychiatry , vol.22 , pp. 2009-176
    • Kyriakopoulos, M.1    Frangou, S.2
  • 23
    • 73949124536 scopus 로고    scopus 로고
    • Sensory processing in schizophrenia: neither simple nor intact
    • Javitt DC. Sensory processing in schizophrenia: neither simple nor intact. Schizophr Bull. 2009;35:1059-1064.
    • (2009) Schizophr Bull , vol.35 , pp. 1059-1064
    • Javitt, D.C.1
  • 26
    • 0025952455 scopus 로고
    • Recent advances in the phencyclidine model of schizophrenia
    • Javitt DC, Zukin, SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry. 1991;148:1301-1308.
    • (1991) Am J Psychiatry , vol.148 , pp. 1301-1308
    • Javitt, D.C.1    Zukin, S.R.2
  • 27
    • 0020629581 scopus 로고
    • The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate
    • Anis NA, Berry SC, Burton NR, Lodge D. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br J Pharmacol. 1983;79:565-575.
    • (1983) Br J Pharmacol , vol.79 , pp. 565-575
    • Anis, N.A.1    Berry, S.C.2    Burton, N.R.3    Lodge, D.4
  • 28
    • 0028323167 scopus 로고
    • Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses
    • Krystal JH, Karper LP, Seibyl JP, et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 1994;51:199-214.
    • (1994) Arch Gen Psychiatry , vol.51 , pp. 199-214
    • Krystal, J.H.1    Karper, L.P.2    Seibyl, J.P.3
  • 29
    • 0033080733 scopus 로고    scopus 로고
    • Ketamineinduced NMDA receptor hypofunction as a model of memory impairment and psychosis
    • Newcomer JW, Farber NB, Jevtovic-Todorovic V, et al. Ketamineinduced NMDA receptor hypofunction as a model of memory impairment and psychosis. Neuropsychopharmacology. 1999;20:106-118.
    • (1999) Neuropsychopharmacology , vol.20 , pp. 106-118
    • Newcomer, J.W.1    Farber, N.B.2    Jevtovic-Todorovic, V.3
  • 30
    • 0033663587 scopus 로고    scopus 로고
    • Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia
    • Umbricht D, Schmid L, Koller R, Vollenweider FX, Hell D, Javitt DC. Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia. Arch Gen Psychiatry. 2000;57:1139-1147.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 1139-1147
    • Umbricht, D.1    Schmid, L.2    Koller, R.3    Vollenweider, F.X.4    Hell, D.5    Javitt, D.C.6
  • 31
    • 0032210874 scopus 로고    scopus 로고
    • Does ketamine-mediated N-methyl-D-aspartate receptor antagonism cause schizophrenia-like oculomotor abnormalities?
    • Radant AD, Bowdle TA, Cowley DS, Kharasch ED, Roy-Byrne PP. Does ketamine-mediated N-methyl-D-aspartate receptor antagonism cause schizophrenia-like oculomotor abnormalities? Neuropsychopharmacology 1998;19:434-444.
    • (1998) Neuropsychopharmacology , vol.19 , pp. 434-444
    • Radant, A.D.1    Bowdle, T.A.2    Cowley, D.S.3    Kharasch, E.D.4    Roy-Byrne, P.P.5
  • 32
    • 0034307054 scopus 로고    scopus 로고
    • Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia
    • Kegeles LS, Abi-Dargham A, Zea-Ponce Y, et al. Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia. Biol Psychiatry. 2000;48:627-640.
    • (2000) Biol Psychiatry , vol.48 , pp. 627-640
    • Kegeles, L.S.1    Abi-Dargham, A.2    Zea-Ponce, Y.3
  • 34
    • 0018352931 scopus 로고
    • An analysis of factors influencing measurements of dopamine, noradrenaline, glutamate decarboxylase and choline acetylase in human post-mortem brain tissue
    • Spokes EG. An analysis of factors influencing measurements of dopamine, noradrenaline, glutamate decarboxylase and choline acetylase in human post-mortem brain tissue. Brain. 1979;102:333-346.
    • (1979) Brain , vol.102 , pp. 333-346
    • Spokes, E.G.1
  • 35
  • 36
    • 0032778735 scopus 로고    scopus 로고
    • Evidence for altered trisynaptic circuitry in schizophrenic hippocampus
    • Benes FM. Evidence for altered trisynaptic circuitry in schizophrenic hippocampus. Biol Psychiatry. 1999;46:589-599.
    • (1999) Biol Psychiatry , vol.46 , pp. 589-599
    • Benes, F.M.1
  • 37
    • 43349105701 scopus 로고    scopus 로고
    • Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia
    • Hashimoto T, Bazmi HH, Mirnics K, Wu Q, Sampson AR, Lewis DA. Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. Am J Psychiatry. 2008;165:479489.
    • (2008) Am J Psychiatry , vol.165 , pp. 479489
    • Hashimoto, T.1    Bazmi, H.H.2    Mirnics, K.3    Wu, Q.4    Sampson, A.R.5    Lewis, D.A.6
  • 38
    • 0036784474 scopus 로고    scopus 로고
    • Reciprocal alterations in preand post-synaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia
    • Volk DW, Pierri JN, Fritschy JM, Auh S, Sampson AR, Lewis DA. Reciprocal alterations in preand post-synaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia. Cereb Cortex. 2002;12:1063-1070.
    • (2002) Cereb Cortex , vol.12 , pp. 1063-1070
    • Volk, D.W.1    Pierri, J.N.2    Fritschy, J.M.3    Auh, S.4    Sampson, A.R.5    Lewis, D.A.6
  • 39
    • 0033985644 scopus 로고    scopus 로고
    • Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia
    • Glantz LA, Lewis DA. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry. 2000;57:65-73.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 65-73
    • Glantz, L.A.1    Lewis, D.A.2
  • 41
    • 36848999339 scopus 로고    scopus 로고
    • Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase
    • Behrens MM, Ali SS, Dao DN, Lucero J, Shekhtman G, Quick KL, Dugan LL. Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase. Science. 2007;318:1645-1647.
    • (2007) Science , vol.318 , pp. 1645-1647
    • Behrens, M.M.1    Ali, S.S.2    Dao, D.N.3    Lucero, J.4    Shekhtman, G.5    Quick, K.L.6    Dugan, L.L.7
  • 42
    • 55249115993 scopus 로고    scopus 로고
    • Prolonged exposure to NMDAR antagonist suppresses inhibitory synaptic transmission in prefrontal cortex
    • Zhang Y, Behrens MM, Lisman JE. Prolonged exposure to NMDAR antagonist suppresses inhibitory synaptic transmission in prefrontal cortex. J Neurophysiol. 2008;100:959-965.
    • (2008) J Neurophysiol , vol.100 , pp. 959-965
    • Zhang, Y.1    Behrens, M.M.2    Lisman, J.E.3
  • 43
    • 42749095376 scopus 로고    scopus 로고
    • Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    • Lisman JE, Coyle JT, Green RW, et al. Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci. 2008;31:234-242.
    • (2008) Trends Neurosci , vol.31 , pp. 234-242
    • Lisman, J.E.1    Coyle, J.T.2    Green, R.W.3
  • 45
    • 67649329655 scopus 로고    scopus 로고
    • Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior
    • Basu AC, Tsai GE, Ma CL, et al. Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Mol Psychiatry. 2009;14:719-727.
    • (2009) Mol Psychiatry , vol.14 , pp. 719-727
    • Basu, A.C.1    Tsai, G.E.2    Ma, C.L.3
  • 46
    • 78649726089 scopus 로고    scopus 로고
    • Altered cortical dendritic morphology in serine racemase knockout mice, a genetic model of NMDA receptor hypofunction
    • Abs. No. 443.16
    • Balu D, Basu AC, Coyle JT. Altered cortical dendritic morphology in serine racemase knockout mice, a genetic model of NMDA receptor hypofunction. Soc Neurosci. 2009. Abs. No. 443.16.
    • (2009) Soc Neurosci
    • Balu, D.1    Basu, A.C.2    Coyle, J.T.3
  • 47
    • 46249104490 scopus 로고    scopus 로고
    • Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database
    • Allen NC, Bagade S, McQueen MB, et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet. 2008;40:827-834.
    • (2008) Nat Genet , vol.40 , pp. 827-834
    • Allen, N.C.1    Bagade, S.2    McQueen, M.B.3
  • 48
    • 33745912772 scopus 로고    scopus 로고
    • Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    • Hahn CG, Wang HY, Cho DS, et al. Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med. 2006;12:824-828.
    • (2006) Nat Med , vol.12 , pp. 824-828
    • Hahn, C.G.1    Wang, H.Y.2    Cho, D.S.3
  • 50
    • 59149090292 scopus 로고    scopus 로고
    • Hyperactivity and hyperconnectivity of the default network in schizophrenia and in firstdegree relatives of persons with schizophrenia
    • Whitfield-Gabrieli S, Thermenos HW, Milanovic S, et al. Hyperactivity and hyperconnectivity of the default network in schizophrenia and in firstdegree relatives of persons with schizophrenia. Proc Natl Acad Sci U S A. 2009;106:1279-1284.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1279-1284
    • Whitfield-Gabrieli, S.1    Thermenos, H.W.2    Milanovic, S.3
  • 51
    • 78049295974 scopus 로고    scopus 로고
    • Dopamine system dysregulation by the ventral subiculum as the common pathophysiological basis for schizophrenia psychosis, psychostimulant abuse, and stress
    • (Epub ahead of print)
    • Grace AA. Dopamine system dysregulation by the ventral subiculum as the common pathophysiological basis for schizophrenia psychosis, psychostimulant abuse, and stress. Neurotox Res. 2010 (Epub ahead of print).
    • (2010) Neurotox Res
    • Grace, A.A.1
  • 52
    • 0027905017 scopus 로고
    • Modulation of neuronal migration by NMDA receptors
    • Komuro H, Rakic P. Modulation of neuronal migration by NMDA receptors. Science. 1993;260:95-97.
    • (1993) Science , vol.260 , pp. 95-97
    • Komuro, H.1    Rakic, P.2
  • 53
    • 0027394523 scopus 로고
    • Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development
    • Akbarian S, Bunney WE Jr, Potkin SG, Wigal SB, Hagman JO, Sandman CA, Jones EG. Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Arch Gen Psychiatry. 1993;50:169-177.
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 169-177
    • Akbarian, S.1    Bunney W.E., Jr.2    Potkin, S.G.3    Wigal, S.B.4    Hagman, J.O.5    Sandman, C.A.6    Jones, E.G.7
  • 54
    • 72049091251 scopus 로고    scopus 로고
    • Neuronal signaling pathways: genetic insights into the pathophysiology of major mental illness
    • Margolis RL, Ross CA. Neuronal signaling pathways: genetic insights into the pathophysiology of major mental illness. Neuropsychopharmacology. 2010;35:350-351.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 350-351
    • Margolis, R.L.1    Ross, C.A.2
  • 55
    • 62849120806 scopus 로고    scopus 로고
    • Network analysis of positional candidate genes of schizophrenia highlights myelin-related pathways
    • Rietkerk T, Boks MP, Sommer IE, de Jong S, Kahn RS, Ophoff RA. Network analysis of positional candidate genes of schizophrenia highlights myelin-related pathways. Mol Psychiatry. 2009;14:353-355.
    • (2009) Mol Psychiatry , vol.14 , pp. 353-355
    • Rietkerk, T.1    Boks, M.P.2    Sommer, I.E.3    de Jong, S.4    Kahn, R.S.5    Ophoff, R.A.6
  • 56
    • 32544449944 scopus 로고    scopus 로고
    • Splice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression
    • Bradley J, Carter SR, Rao VR, Wang J, Finkbeiner S. Splice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression. J Neurosci. 2006;26:1065-1076.
    • (2006) J Neurosci , vol.26 , pp. 1065-1076
    • Bradley, J.1    Carter, S.R.2    Rao, V.R.3    Wang, J.4    Finkbeiner, S.5
  • 57
    • 0034845802 scopus 로고    scopus 로고
    • NMDA receptor pharmacology: Perspectives from molecular biology
    • Lynch DR, Guttmann RP. NMDA receptor pharmacology: Perspectives from molecular biology. Curr. Drug Targets. 2001;2:215-231.
    • (2001) Curr. Drug Targets. , vol.2 , pp. 215-231
    • Lynch, D.R.1    Guttmann, R.P.2
  • 58
    • 0032415129 scopus 로고    scopus 로고
    • Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses
    • Berger AJ, Dieudonne S, Ascher P. Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses. J Neurophysiol. 1998;80:3336-3340.
    • (1998) J Neurophysiol , vol.80 , pp. 3336-3340
    • Berger, A.J.1    Dieudonne, S.2    Ascher, P.3
  • 59
    • 0023820777 scopus 로고
    • Cooperative modulation of [3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines
    • Ransom RW, Stec NL. Cooperative modulation of [3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines. J Neurochem 1988;51:830-836.
    • (1988) J Neurochem , vol.51 , pp. 830-836
    • Ransom, R.W.1    Stec, N.L.2
  • 60
    • 0023273862 scopus 로고
    • The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain
    • Foster AC, Wong EH. The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain. Br J Pharmacol. 1987;91:403-409.
    • (1987) Br J Pharmacol , vol.91 , pp. 403-409
    • Foster, A.C.1    Wong, E.H.2
  • 63
    • 2342637165 scopus 로고    scopus 로고
    • Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity
    • Liu L, Wong TP, Pozza MF, et al. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 2004;304:1021-1024.
    • (2004) Science , vol.304 , pp. 1021-1024
    • Liu, L.1    Wong, T.P.2    Pozza, M.F.3
  • 64
    • 33749074397 scopus 로고    scopus 로고
    • Glutamate and schizophrenia: beyond the dopamine hypothesis
    • Coyle JT. Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell Mol Neurobiol. 2006;26:365-384.
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 365-384
    • Coyle, J.T.1
  • 65
    • 0023091647 scopus 로고
    • Glycine potentiates the NMDA response in cultured mouse brain neurons
    • Johnson JW, Ascher P. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature. 1987;325:529-531.
    • (1987) Nature , vol.325 , pp. 529-531
    • Johnson, J.W.1    Ascher, P.2
  • 66
    • 0023754192 scopus 로고
    • Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes
    • Kleckner NW, Dingledine R. Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. Science. 1988;241:835-837.
    • (1988) Science , vol.241 , pp. 835-837
    • Kleckner, N.W.1    Dingledine, R.2
  • 67
    • 0024564769 scopus 로고
    • Glycine enhances NMDA-receptor mediated synaptic potentials in neocortical slices
    • Thomson AM, Walker VE, Flynn DM. Glycine enhances NMDA-receptor mediated synaptic potentials in neocortical slices. Nature. 1989;338:422-424.
    • (1989) Nature , vol.338 , pp. 422-424
    • Thomson, A.M.1    Walker, V.E.2    Flynn, D.M.3
  • 68
    • 0032441894 scopus 로고    scopus 로고
    • Modulation of N-methylD-aspartate receptor function by glycine transport
    • Bergeron R, Meyer TM, Coyle JT, Greene RW. Modulation of N-methylD-aspartate receptor function by glycine transport. Proc Natl Acad Sci U S A. 1998;95:15730-15734.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15730-15734
    • Bergeron, R.1    Meyer, T.M.2    Coyle, J.T.3    Greene, R.W.4
  • 69
    • 0037977113 scopus 로고    scopus 로고
    • Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the Nmethyl-D-aspartate receptor hypofunction hypothesis of schizophrenia
    • Hashimoto K, Fukushima T, Shimizu E, et al. Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the Nmethyl-D-aspartate receptor hypofunction hypothesis of schizophrenia. Arch Gen Psychiatry. 2003;60:572-576.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 572-576
    • Hashimoto, K.1    Fukushima, T.2    Shimizu, E.3
  • 72
    • 28244440276 scopus 로고    scopus 로고
    • Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia
    • Nilsson LK, Linderholm KR, Engberg G, et al. Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia. Schizophr Res. 2005;15;80:315-322.
    • (2005) Schizophr Res , vol.15 , Issue.80 , pp. 315-322
    • Nilsson, L.K.1    Linderholm, K.R.2    Engberg, G.3
  • 73
    • 0029020761 scopus 로고
    • Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration
    • Matsui T, Sekiguchi M, Hashimoto A, Tomita U, Nishikawa T, Wada, K. Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration. J Neurochem. 1995;65:454-458.
    • (1995) J Neurochem , vol.65 , pp. 454-458
    • Matsui, T.1    Sekiguchi, M.2    Hashimoto, A.3    Tomita, U.4    Nishikawa, T.5    Wada, K.6
  • 74
    • 0025141342 scopus 로고
    • D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes
    • 158-160
    • Watson GB, Bolanowski MA, Baganoff MP, Deppeler CL, Lanthorn TH. D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes. Brain Res. 1990;26;510:158-160.
    • (1990) Brain Res , vol.26 , pp. 510
    • Watson, G.B.1    Bolanowski, M.A.2    Baganoff, M.P.3    Deppeler, C.L.4    Lanthorn, T.H.5
  • 75
    • 77949447469 scopus 로고    scopus 로고
    • Strategies to enhance N-methyl-D-aspartate receptormediated neurotransmission in schizophrenia, a critical review and metaanalysis
    • Tsai GE, Lin PY. Strategies to enhance N-methyl-D-aspartate receptormediated neurotransmission in schizophrenia, a critical review and metaanalysis. Curr Pharm Des. 2010;16:522-537.
    • (2010) Curr Pharm Des , vol.16 , pp. 522-537
    • Tsai, G.E.1    Lin, P.Y.2
  • 76
    • 35748969317 scopus 로고    scopus 로고
    • The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments
    • Buchanan RW, Javitt DC, Marder SR, et al. The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments. Am J Psychiatry. 2007;164:1593-1602.
    • (2007) Am J Psychiatry , vol.164 , pp. 1593-1602
    • Buchanan, R.W.1    Javitt, D.C.2    Marder, S.R.3
  • 79
    • 0029116094 scopus 로고
    • Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia
    • Goff DC, Tsai G, Manoach DS, Coyle JT. Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia. Am J Psychiatry. 1995;152:1213-1215.
    • (1995) Am J Psychiatry , vol.152 , pp. 1213-1215
    • Goff, D.C.1    Tsai, G.2    Manoach, D.S.3    Coyle, J.T.4
  • 80
    • 0028246912 scopus 로고
    • Acute but not chronic activation of the NMDA-coupled glycine receptor with Dcycloserine facilitates learning and retention
    • Quartermain D, Mower J, Rafferty MF, Herting RL, Lanthorn TH. Acute but not chronic activation of the NMDA-coupled glycine receptor with Dcycloserine facilitates learning and retention. Eur J Pharmacol. 1994;257:712.
    • (1994) Eur J Pharmacol , vol.257 , pp. 712
    • Quartermain, D.1    Mower, J.2    Rafferty, M.F.3    Herting, R.L.4    Lanthorn, T.H.5
  • 81
    • 0030006443 scopus 로고    scopus 로고
    • The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning
    • Baker JD, Azorlosa JL. The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning. Behav Neurosci. 1996;110:618-620.
    • (1996) Behav Neurosci , vol.110 , pp. 618620
    • Baker, J.D.1    Azorlosa, J.L.2
  • 82
    • 0037088911 scopus 로고    scopus 로고
    • Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of Dcycloserine as assessed with fear-potentiated startle in rats
    • Walker DL, Ressler KJ, Lu KT, Davis M. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of Dcycloserine as assessed with fear-potentiated startle in rats. J Neurosci. 2002;22:2343-2351.
    • (2002) J Neurosci , vol.22 , pp. 2343-2351
    • Walker, D.L.1    Ressler, K.J.2    Lu, K.T.3    Davis, M.4
  • 83
    • 71349083402 scopus 로고    scopus 로고
    • D-cycloserine facilitates extinction of naloxone-induced conditioned place aversion in morphine-dependent rats
    • Myers KM, Carlezon WA Jr. D-cycloserine facilitates extinction of naloxone-induced conditioned place aversion in morphine-dependent rats. Biol Psychiatry. 2010;67:85-87.
    • (2010) Biol Psychiatry , vol.67 , pp. 85-87
    • Myers, K.M.1    Carlezon W.A., Jr.2
  • 84
    • 4644355629 scopus 로고    scopus 로고
    • Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear
    • Ressler KJ, Rothbaum BO, Tannenbaum L, et al. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry. 2004;61:1136-1144.
    • (2004) Arch Gen Psychiatry , vol.61 , pp. 1136-1144
    • Ressler, K.J.1    Rothbaum, B.O.2    Tannenbaum, L.3
  • 85
    • 44349151445 scopus 로고    scopus 로고
    • A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy
    • Norberg MM, Krystal JH, Tolin DF. A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. Biol Psychiatry. 2008;63:1118-1126.
    • (2008) Biol Psychiatry , vol.63 , pp. 1118-1126
    • Norberg, M.M.1    Krystal, J.H.2    Tolin, D.F.3
  • 86
    • 0015015914 scopus 로고
    • Uptake of radiolabeled essential amino acids by brain following arterial injection
    • Oldendorf WH. Uptake of radiolabeled essential amino acids by brain following arterial injection. Proc Soc Exp Biol Med. 1971;136:385-386.
    • (1971) Proc Soc Exp Biol Med , vol.136 , pp. 385-386
    • Oldendorf, W.H.1
  • 87
    • 3042757433 scopus 로고    scopus 로고
    • Effect of systemic administration of D-serine on the levels of Dand L-serine in several brain areas and periphery of rat
    • Hashimoto A, Chiba S. Effect of systemic administration of D-serine on the levels of Dand L-serine in several brain areas and periphery of rat. Eur J Pharmacol. 2004;495:153-158.
    • (2004) Eur J Pharmacol , vol.495 , pp. 153-158
    • Hashimoto, A.1    Chiba, S.2
  • 88
    • 0037401685 scopus 로고    scopus 로고
    • Differential effects of atypical and typical antipsychotic drugs on N-methyl-D-aspartateand electrically evoked responses in the pryramidal cells of the rat medial prefrontal cortex
    • Ninan I, Jardemark KE, Wang RY. Differential effects of atypical and typical antipsychotic drugs on N-methyl-D-aspartateand electrically evoked responses in the pryramidal cells of the rat medial prefrontal cortex. Synapse. 2003;48:66-79.
    • (2003) Synapse , vol.48 , pp. 66-79
    • Ninan, I.1    Jardemark, K.E.2    Wang, R.Y.3
  • 89
    • 15944428993 scopus 로고    scopus 로고
    • Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action
    • Javitt DC, Duncan L, Balla A, Sershen, H. Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action. Mol Psychiatry. 2005;10:275-287.
    • (2005) Mol Psychiatry , vol.10 , pp. 275-287
    • Javitt, D.C.1    Duncan, L.2    Balla, A.3    Sershen, H.4
  • 90
    • 0026714534 scopus 로고
    • Involvement of D-amino acid oxidase in elimination of Dserine in mouse brain
    • Nagata Y. Involvement of D-amino acid oxidase in elimination of Dserine in mouse brain. Experientia. 1992;48:753-755.
    • (1992) Experientia , vol.48 , pp. 753-755
    • Nagata, Y.1
  • 91
    • 0023445118 scopus 로고
    • Localization of D-amino acid oxidase in Bergmann glial cells and astrocytes of rat cerebellum
    • Horiike K, Tojo H, Arai R, Yamano T, Nozaki M, Maeda T. Localization of D-amino acid oxidase in Bergmann glial cells and astrocytes of rat cerebellum. Brain Res Bull. 1987;19:587-596.
    • (1987) Brain Res. Bull. , vol.19 , pp. 587-596
    • Horiike, K.1    Tojo, H.2    Arai, R.3    Yamano, T.4    Nozaki, M.5    Maeda, T.6
  • 92
    • 75549091955 scopus 로고    scopus 로고
    • The neurobiology of Damino acid oxidase and its involvement in schizophrenia
    • Verrall L, Burnet PW, Betts JF, Harrison PJ. The neurobiology of Damino acid oxidase and its involvement in schizophrenia. Mol Psychiatry. 2010;15:122-137.
    • (2010) Mol Psychiatry , vol.15 , pp. 122-137
    • Verrall, L.1    Burnet, P.W.2    Betts, J.F.3    Harrison, P.J.4
  • 93
    • 33745689721 scopus 로고    scopus 로고
    • G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis
    • Detera-Wadleigh SD, McMahon FJ. G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis. Biol Psychiatry. 2006;60:106-114.
    • (2006) Biol Psychiatry , vol.60 , pp. 106-114
    • Detera-Wadleigh, S.D.1    McMahon, F.J.2
  • 94
    • 36849031756 scopus 로고    scopus 로고
    • Allelic association of G72/ G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis
    • Shi J, Badner JA, Gershon ES, Liu C. Allelic association of G72/ G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis. Schizophr Res. 2008;98:89-97.
    • (2008) Schizophr Res , vol.98 , pp. 89-97
    • Shi, J.1    Badner, J.A.2    Gershon, E.S.3    Liu, C.4
  • 95
    • 33746813128 scopus 로고    scopus 로고
    • Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1)
    • Kapoor R, Lim KS, Cheng A, Garrick T, Kapoor V. Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1). Brain Res. 2006;1106:205-210.
    • (2006) Brain Res , vol.1106 , pp. 205-210
    • Kapoor, R.1    Lim, K.S.2    Cheng, A.3    Garrick, T.4    Kapoor, V.5
  • 98
    • 0037108758 scopus 로고    scopus 로고
    • Genetic and physiological data implicating the new human gene G72 and the gene for Damino acid oxidase in schizophrenia
    • Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H. et al. Genetic and physiological data implicating the new human gene G72 and the gene for Damino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A. 2002;99:13675-13680.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 13675-13680
    • Chumakov, I.1    Blumenfeld, M.2    Guerassimenko, O.3    Cavarec, L.4    Palicio, M.5    Abderrahim, H.6
  • 99
    • 38149040091 scopus 로고    scopus 로고
    • In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties
    • Adage T, Trillat AC, Quattropani A, et al. In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties. Eur Neuropsychopharmacol. 2008;18:200-214.
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 200-214
    • Adage, T.1    Trillat, A.C.2    Quattropani, A.3
  • 100
    • 67349116852 scopus 로고    scopus 로고
    • Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine
    • Hashimoto K, Fujita Y, Horio M, et al. Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine. Biol Psychiatry. 2009;65:1103-1106.
    • (2009) Biol Psychiatry , vol.65 , pp. 1103-1106
    • Hashimoto, K.1    Fujita, Y.2    Horio, M.3
  • 101
    • 62449161854 scopus 로고    scopus 로고
    • The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine
    • Smith SM, Uslaner JM, Yao L, et al. The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine. J Pharmacol Exp Ther. 2009;328:921-930.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 921-930
    • Smith, S.M.1    Uslaner, J.M.2    Yao, L.3
  • 102
    • 33645506167 scopus 로고    scopus 로고
    • Polymorphism in the 5'-promoter region of serine racemase gene in schizophrenia
    • Goltsov AY, Loseva JG, Andreeva TV, et al. Polymorphism in the 5'-promoter region of serine racemase gene in schizophrenia. Mol Psychiatry. 2006;11:325-326.
    • (2006) Mol Psychiatry , vol.11 , pp. 325-326
    • Goltsov, A.Y.1    Loseva, J.G.2    Andreeva, T.V.3
  • 103
    • 34247596490 scopus 로고    scopus 로고
    • A genetic variant of the serine racemase gene is associated with schizophrenia
    • Morita Y, Ujike H, Tanaka Y, Otani K, et al. A genetic variant of the serine racemase gene is associated with schizophrenia. Biol Psychiatry. 2007;61:1200-1203.
    • (2007) Biol Psychiatry , vol.61 , pp. 1200-1203
    • Morita, Y.1    Ujike, H.2    Tanaka, Y.3    Otani, K.4
  • 104
    • 68749087296 scopus 로고    scopus 로고
    • Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model
    • Labrie V, Fukumura R, Rastogi A, et al. Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet. 2009;18:3227-3243.
    • (2009) Hum Mol Genet , vol.18 , pp. 3227-3243
    • Labrie, V.1    Fukumura, R.2    Rastogi, A.3
  • 105
    • 0033539510 scopus 로고    scopus 로고
    • Serine racemase: A glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission
    • Wolosker H, Blackshaw S, Snyder SH. Serine racemase: A glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A. 1999;96:13409-13414.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 13409-13414
    • Wolosker, H.1    Blackshaw, S.2    Snyder, S.H.3
  • 106
    • 33744900653 scopus 로고    scopus 로고
    • Neuronderived D-serine release provides a novel means to activate N-methyl-Daspartate receptors
    • Kartvelishvily E, Shleper M, Balan L, Dumin E, Wolosker H. Neuronderived D-serine release provides a novel means to activate N-methyl-Daspartate receptors. J Biol Chem. 2006;281:14151-14162.
    • (2006) J Biol Chem , vol.281 , pp. 14151-14162
    • Kartvelishvily, E.1    Shleper, M.2    Balan, L.3    Dumin, E.4    Wolosker, H.5
  • 107
    • 53149109731 scopus 로고    scopus 로고
    • Serine racemase is predominantly localized in neurons in mouse brain
    • 641-654
    • Miya K, Inoue R, Takata Y, et al. Serine racemase is predominantly localized in neurons in mouse brain. J Comp Neurol. 2008;20;510:641-654.
    • (2008) J Comp Neurol , vol.20 , pp. 510
    • Miya, K.1    Inoue, R.2    Takata, Y.3
  • 109
    • 34047261852 scopus 로고    scopus 로고
    • Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS
    • Rutter AR, Fradley RL, Garrett EM, et al. Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS. Eur J Neurosci. 2007;25:1757-1766.
    • (2007) Eur J Neurosci , vol.25 , pp. 1757-1766
    • Rutter, A.R.1    Fradley, R.L.2    Garrett, E.M.3
  • 110
    • 1542640509 scopus 로고    scopus 로고
    • Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain
    • Helboe L, Egebjerg J, Møller M, Thomsen C. Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain. Eur J Neurosci. 2003;18:2227-2238.
    • (2003) Eur J Neurosci , vol.18 , pp. 2227-2238
    • Helboe, L.1    Egebjerg, J.2    Møller, M.3    Thomsen, C.4
  • 111
    • 12144289325 scopus 로고    scopus 로고
    • High affinity Dand L-serine transporter Asc-1: cloning and dendritic localization in the rat cerebral and cerebellar cortices
    • Matsuo H, Kanai Y, Tokunaga M, et al. High affinity Dand L-serine transporter Asc-1: cloning and dendritic localization in the rat cerebral and cerebellar cortices. Neurosci Lett. 2004;358:123-126.
    • (2004) Neurosci Lett , vol.358 , pp. 123-126
    • Matsuo, H.1    Kanai, Y.2    Tokunaga, M.3
  • 112
    • 56049092225 scopus 로고    scopus 로고
    • Allosteric modulation of NMDA receptor via elevation of brain glycine and D-serine: the therapeutic potentials for schizophrenia
    • Yang CR, Svensson KA. Allosteric modulation of NMDA receptor via elevation of brain glycine and D-serine: the therapeutic potentials for schizophrenia. Pharmacol Ther. 2008;120:317-332.
    • (2008) Pharmacol Ther , vol.120 , pp. 317-332
    • Yang, C.R.1    Svensson, K.A.2
  • 113
    • 23644450359 scopus 로고    scopus 로고
    • Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice
    • Xie X, Dumas T, Tang L, et al. Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice. Brain Res. 2005;1052:212-221.
    • (2005) Brain Res , vol.1052 , pp. 212-221
    • Xie, X.1    Dumas, T.2    Tang, L.3
  • 115
    • 0029014595 scopus 로고
    • Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS
    • Zafra F, Gomeza J, Olivares L, Aragón C, Giménez C. Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS. Eur J Neurosci. 1995;7:1342-1352.
    • (1995) Eur J Neurosci , vol.7 , pp. 1342-1352
    • Zafra, F.1    Gomeza, J.2    Olivares, L.3    Aragón, C.4    Giménez, C.5
  • 116
    • 0037320805 scopus 로고    scopus 로고
    • Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo
    • Chen L, Muhlhauser M, Yang CR. Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo. J Neurophysiol 2003;89:691-703.
    • (2003) J Neurophysiol , vol.89 , pp. 691-703
    • Chen, L.1    Muhlhauser, M.2    Yang, C.R.3
  • 117
    • 0041920952 scopus 로고    scopus 로고
    • The glycine transporter type 1 inhibitor N-[3-(4_-fluorophenyl)-3-(4_phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior
    • Kinney GG, Sur C, Burno M, et al. The glycine transporter type 1 inhibitor N-[3-(4_-fluorophenyl)-3-(4_phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior. J Neurosci. 2003;23:7586-7591.
    • (2003) J Neurosci , vol.23 , pp. 7586-7591
    • Kinney, G.G.1    Sur, C.2    Burno, M.3
  • 118
    • 33748675922 scopus 로고    scopus 로고
    • Progress in the preparation and testing of glycine transporter type-1 (GlyT1) inhibitors
    • Lindsley CW, Wolkenberg SE, Kinney GG. Progress in the preparation and testing of glycine transporter type-1 (GlyT1) inhibitors. Curr Top Med Chem. 2006;6:1883-1896.
    • (2006) Curr Top Med Chem , vol.6 , pp. 1883-1896
    • Lindsley, C.W.1    Wolkenberg, S.E.2    Kinney, G.G.3
  • 120
    • 34347241277 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs
    • Palucha A, Pilc A. Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs. Pharm Ther. 2007;115:116-147.
    • (2007) Pharm Ther , vol.115 , pp. 116-147
    • Palucha, A.1    Pilc, A.2
  • 121
    • 67651083577 scopus 로고    scopus 로고
    • The glutamate homeostasis hypothesis of addiction
    • Kalivas PW. The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci. 2009;10:561-572.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 561-572
    • Kalivas, P.W.1
  • 122
    • 58149119377 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia
    • Conn PJ, Lindsley CW, Jones CK. Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia. Trends Pharmacol Sci. 2009;30:25-31.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 25-31
    • Conn, P.J.1    Lindsley, C.W.2    Jones, C.K.3
  • 123
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn PJ, Pin J. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol. 1997;37: 205-237.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.2
  • 124
    • 0031036195 scopus 로고    scopus 로고
    • Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors
    • Scanziani M, Salin PA, Vogt KE, Malenka RC, Nicoll RA. Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors. Nature. 1997;385:630-634.
    • (1997) Nature , vol.385 , pp. 630-634
    • Scanziani, M.1    Salin, P.A.2    Vogt, K.E.3    Malenka, R.C.4    Nicoll, R.A.5
  • 125
    • 0033981186 scopus 로고    scopus 로고
    • Physiological antagonism between 5-hydroxytryptamine 2A and group II metabotropic glutamate receptors in prefrontal corotex
    • Marek GJ, Wright RA, Schoepp DD, Monn JA, Aghajanian GK. Physiological antagonism between 5-hydroxytryptamine 2A and group II metabotropic glutamate receptors in prefrontal corotex. J Pharmacol Exp Ther. 2000;292:76-87.
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 76-87
    • Marek, G.J.1    Wright, R.A.2    Schoepp, D.D.3    Monn, J.A.4    Aghajanian, G.K.5
  • 126
    • 0036118255 scopus 로고    scopus 로고
    • Presynaptic group II metabotropic glutamate receptors reduce stimulated and spontaneous transmitter release in human dentate gyrus
    • Dietrich D, Kral T, Clusmann H, Friedl M, Schramm J. Presynaptic group II metabotropic glutamate receptors reduce stimulated and spontaneous transmitter release in human dentate gyrus. Neuropharmacology. 2002;42:297-305.
    • (2002) Neuropharmacology , vol.42 , pp. 297-305
    • Dietrich, D.1    Kral, T.2    Clusmann, H.3    Friedl, M.4    Schramm, J.5
  • 127
    • 0032575715 scopus 로고    scopus 로고
    • Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats
    • Moghaddam B, Adams B. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science. 1998;281:1349-1352.
    • (1998) Science , vol.281 , pp. 1349-1352
    • Moghaddam, B.1    Adams, B.2
  • 128
    • 0030900732 scopus 로고    scopus 로고
    • Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex
    • Moghaddam B, Adams B, Verma A, Daly D. Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci. 1997;17: 2921-2927.
    • (1997) J Neurosci , vol.17 , pp. 2921-2927
    • Moghaddam, B.1    Adams, B.2    Verma, A.3    Daly, D.4
  • 129
  • 130
    • 33749645423 scopus 로고    scopus 로고
    • Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations
    • Lewis DA, Moghaddam B. Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations. Arch Neurol. 2006;63:1372-1376.
    • (2006) Arch Neurol , vol.63 , pp. 1372-1376
    • Lewis, D.A.1    Moghaddam, B.2
  • 131
    • 42749095376 scopus 로고    scopus 로고
    • Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    • Lisman JE, Coyle JT, Green RW, et al. Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci. 2008;31:234-242
    • (2008) Trends Neurosci , vol.31 , pp. 234-242
    • Lisman, J.E.1    Coyle, J.T.2    Green, R.W.3
  • 132
    • 0032834028 scopus 로고    scopus 로고
    • Pharmacological agents acting at subtypes of metabotropic glutamate receptors
    • Schoepp DD, Jane DE, Monn JA. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology. 1999;38:1431-1476.
    • (1999) Neuropharmacology , vol.38 , pp. 1431-1476
    • Schoepp, D.D.1    Jane, D.E.2    Monn, J.A.3
  • 133
    • 0032848507 scopus 로고    scopus 로고
    • The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats
    • Cartmell J, Monn JA, Schoepp DD. The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats. J Pharmacol Exp Ther. 1999;291:161-170.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 161-170
    • Cartmell, J.1    Monn, J.A.2    Schoepp, D.D.3
  • 134
    • 0033844601 scopus 로고    scopus 로고
    • Regulation of neurotransmitter release by metabotropic glutamate receptors
    • Cartmell J, Schoepp DD. Regulation of neurotransmitter release by metabotropic glutamate receptors. J Neurochem. 2000;75:889-907.
    • (2000) J Neurochem , vol.75 , pp. 889-907
    • Cartmell, J.1    Schoepp, D.D.2
  • 135
    • 27744597869 scopus 로고    scopus 로고
    • A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity
    • Galici R, Echemendia NG, Rodriguez AL, Conn PJ. A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity. J Pharmacol Exp Ther. 2005;315:1181-1187.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 1181-1187
    • Galici, R.1    Echemendia, N.G.2    Rodriguez, A.L.3    Conn, P.J.4
  • 136
    • 33745227414 scopus 로고    scopus 로고
    • Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychoticand anxiolytic-like effects in mice
    • Galici R, Jones CK, Hemstapat K, Nong Y, Echemendia NG, Williams LC, de Paulis T, Conn PJ. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychoticand anxiolytic-like effects in mice. J Pharmacol Exp Ther. 2006;318:173-185.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 173-185
    • Galici, R.1    Jones, C.K.2    Hemstapat, K.3    Nong, Y.4    Echemendia, N.G.5    Williams, L.C.6    de Paulis, T.7    Conn, P.J.8
  • 137
    • 27744446102 scopus 로고    scopus 로고
    • Pharmacological characterization of stress-induced hyperthermia in DBA/2 mice using metabotropic and ionotropic glutamate receptor ligands
    • Rorick-Kehn LM, Hart JC, McKinzie DL. Pharmacological characterization of stress-induced hyperthermia in DBA/2 mice using metabotropic and ionotropic glutamate receptor ligands. Psychopharmacology (Berl). 2005;183: 226-240.
    • (2005) Psychopharmacology (Berl) , vol.183 , pp. 226-240
    • Rorick-Kehn, L.M.1    Hart, J.C.2    McKinzie, D.L.3
  • 138
    • 17744369682 scopus 로고    scopus 로고
    • Phencyclidine-induced impairment in attention and response control depends on the background genotype of mice: reversal by the mGLU(2/3) receptor agonist LY379268
    • Greco B, Invernizzi RW, Carli M. Phencyclidine-induced impairment in attention and response control depends on the background genotype of mice: reversal by the mGLU(2/3) receptor agonist LY379268. Psychopharmacology (Berl). 2005;179:68-76.
    • (2005) Psychopharmacology (Berl) , vol.179 , pp. 68-76
    • Greco, B.1    Invernizzi, R.W.2    Carli, M.3
  • 139
    • 0032527894 scopus 로고    scopus 로고
    • Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine
    • Adams B, Moghaddam B. Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine. J Neurosci. 1998;15;18:5545-5554.
    • (1998) J Neurosci , vol.15 , Issue.18 , pp. 5545-5554
    • Adams, B.1    Moghaddam, B.2
  • 140
    • 34547198448 scopus 로고    scopus 로고
    • A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis
    • Benneyworth MA, Xiang Z, Smith RL, Garcia EE, Conn PJ, Sanders-Bush E. A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. Mol Pharmacol. 2007;72:477-484.
    • (2007) Mol Pharmacol , vol.72 , pp. 477-484
    • Benneyworth, M.A.1    Xiang, Z.2    Smith, R.L.3    Garcia, E.E.4    Conn, P.J.5    Sanders-Bush, E.6
  • 141
    • 34948858402 scopus 로고    scopus 로고
    • Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial
    • Patil ST, Zhang L, Martenyi F, et al. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial. Nat Med. 2007;13:1102-1107.
    • (2007) Nat Med , vol.13 , pp. 1102-1107
    • Patil, S.T.1    Zhang, L.2    Martenyi, F.3
  • 142
    • 20944439080 scopus 로고    scopus 로고
    • Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects
    • Krystal JH, Abi-Saab W, Perry E, et al. Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects. Psychopharmacology (Berl). 2005;179:303-309.
    • (2005) Psychopharmacology (Berl) , vol.179 , pp. 303-309
    • Krystal, J.H.1    Abi-Saab, W.2    Perry, E.3
  • 143
    • 15544385061 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate 2/3 receptors reverses the effects of NMDA receptor hypofunction on prefrontal cortex unit activity in awake rats
    • Homayoun H, Jackson ME, Moghaddam B. Activation of metabotropic glutamate 2/3 receptors reverses the effects of NMDA receptor hypofunction on prefrontal cortex unit activity in awake rats. J Neurophysiol. 2005;93:1989-2001.
    • (2005) J Neurophysiol , vol.93 , pp. 1989-2001
    • Homayoun, H.1    Jackson, M.E.2    Moghaddam, B.3
  • 144
    • 0030821474 scopus 로고    scopus 로고
    • Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus
    • Shigemoto R, Kinoshita A, Wada E, et al. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J Neurosci. 1997;17: 7503-7522.
    • (1997) J Neurosci , vol.17 , pp. 7503-7522
    • Shigemoto, R.1    Kinoshita, A.2    Wada, E.3
  • 145
    • 0035960059 scopus 로고    scopus 로고
    • Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to preand postsynaptic sites
    • Tamaru Y, Nomura S, Mizuno N, Shigemoto R Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to preand postsynaptic sites. Neuroscience. 2001;106:481-503.
    • (2001) Neuroscience , vol.106 , pp. 481-503
    • Tamaru, Y.1    Nomura, S.2    Mizuno, N.3    Shigemoto, R.4
  • 146
    • 34547686245 scopus 로고    scopus 로고
    • The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection
    • Corti C, Battaglia G, Molinaro G, et al. The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection. J Neurosci. 2007;27:8297-8308.
    • (2007) J Neurosci , vol.27 , pp. 8297-8308
    • Corti, C.1    Battaglia, G.2    Molinaro, G.3
  • 147
    • 0034717225 scopus 로고    scopus 로고
    • Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice
    • Spooren WP, Gasparini F, van der Putten H, Koller M, Nakanishi S, Kuhn R. Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice. Eur J Pharmacol. 2000;397:R1-R2.
    • (2000) Eur J Pharmacol , vol.397
    • Spooren, W.P.1    Gasparini, F.2    van der Putten, H.3    Koller, M.4    Nakanishi, S.5    Kuhn, R.6
  • 148
    • 58149119377 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia
    • Conn PJ, Lindsley CW, Jones CK. Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia. Trends Pharmacol Sci. 2009;30:25-31.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 25-31
    • Conn, P.J.1    Lindsley, C.W.2    Jones, C.K.3
  • 149
    • 58149193205 scopus 로고    scopus 로고
    • Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
    • Conn PJ, Christopoulos A, Lindsley CW. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders. Nat Rev Drug Discov. 2009;8:41-54.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 41-54
    • Conn, P.J.1    Christopoulos, A.2    Lindsley, C.W.3
  • 150
    • 0141569348 scopus 로고    scopus 로고
    • Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2
    • Schaffhauser H, Rowe BA, Morales S, et al. Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. Mol Pharmacol. 2003;64:798-810.
    • (2003) Mol Pharmacol , vol.64 , pp. 798-810
    • Schaffhauser, H.1    Rowe, B.A.2    Morales, S.3
  • 151
    • 0038155299 scopus 로고    scopus 로고
    • Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2trifluoroethylsulfonyl)pyrid-3-yl methylamine
    • Johnson MP, Baez M, Jagdmann GE, et al. Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2trifluoroethylsulfonyl)pyrid-3-yl methylamine. J Med Chem. 2003;46:3189-3192.
    • (2003) J Med Chem , vol.46 , pp. 3189-3192
    • Johnson, M.P.1    Baez, M.2    Jagdmann, G.E.3
  • 152
    • 20944447548 scopus 로고    scopus 로고
    • Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)
    • Johnson MP, Barda D, Britton TC, et al. Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology. 2005;179:271-283.
    • (2005) Psychopharmacology , vol.179 , pp. 271-283
    • Johnson, M.P.1    Barda, D.2    Britton, T.C.3
  • 154
    • 0036640537 scopus 로고    scopus 로고
    • Cerebral cystine uptake: a tale of two transporters
    • McBean GJ. Cerebral cystine uptake: a tale of two transporters. Trends Pharmacol Sci. 2002;23:299-302.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 299-302
    • McBean, G.J.1
  • 155
    • 21844443565 scopus 로고    scopus 로고
    • Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking
    • Moran MM, McFarland K, Melendez RI, Kalivas PW, Seamans JK. Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J Neurosci. 2005;25:6389-6393.
    • (2005) J Neurosci , vol.25 , pp. 6389-6393
    • Moran, M.M.1    McFarland, K.2    Melendez, R.I.3    Kalivas, P.W.4    Seamans, J.K.5
  • 156
    • 37849026004 scopus 로고    scopus 로고
    • N-acetylcysteine reduces extinction responding and induces enduring reductions in cueand heroin-induced drug-seeking
    • Zhou W, Kalivas PW. N-acetylcysteine reduces extinction responding and induces enduring reductions in cueand heroin-induced drug-seeking. Biol Psychiatry. 2008;63:338-340.
    • (2008) Biol Psychiatry , vol.63 , pp. 338-340
    • Zhou, W.1    Kalivas, P.W.2
  • 157
    • 33646565030 scopus 로고    scopus 로고
    • The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaineand food-seeking behavior in rats
    • Peters J, Kalivas PW. The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaineand food-seeking behavior in rats. Psychopharmacology (Berl). 2006;186:143-149.
    • (2006) Psychopharmacology (Berl) , vol.186 , pp. 143-149
    • Peters, J.1    Kalivas, P.W.2
  • 159
    • 48749112603 scopus 로고    scopus 로고
    • N-acetyl cysteine as a glutathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial
    • Berk M, Copolov D, Dean O, et al. N-acetyl cysteine as a glutathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial. Biol Psychiatry. 2008;64:361-368.
    • (2008) Biol Psychiatry , vol.64 , pp. 361-368
    • Berk, M.1    Copolov, D.2    Dean, O.3
  • 160
    • 0028339034 scopus 로고
    • NMDA receptor channels: subunit-specific potentiation by reducing agents
    • Köhr G, Eckardt S, Lüddens H, Monyer H, Seeburg PH. NMDA receptor channels: subunit-specific potentiation by reducing agents. Neuron. 1994;12:1031-1040.
    • (1994) Neuron , vol.12 , pp. 1031-1040
    • Köhr, G.1    Eckardt, S.2    Lüddens, H.3    Monyer, H.4    Seeburg, P.H.5
  • 161
    • 67650652986 scopus 로고    scopus 로고
    • Does schizophrenia arise from oxidative dysregulation of parvalbumin-interneurons in the developing cortex?
    • Behrens MM, Sejnowksi TJ. Does schizophrenia arise from oxidative dysregulation of parvalbumin-interneurons in the developing cortex? Neuropharmacology. 2009;57:193-200.
    • (2009) Neuropharmacology , vol.57 , pp. 193-200
    • Behrens, M.M.1    Sejnowksi, T.J.2
  • 162
    • 0033166537 scopus 로고    scopus 로고
    • Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
    • Tu JC, Xiao B, Naisbitt S, et al. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 1999;23:583-592.
    • (1999) Neuron , vol.23 , pp. 583-592
    • Tu, J.C.1    Xiao, B.2    Naisbitt, S.3
  • 163
    • 0030894148 scopus 로고    scopus 로고
    • (RS)-2chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus
    • Doherty AJ, Palmer MJ, Henley JM, Collingridge GL, Jane DE. (RS)-2chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology. 1997;36:265-267.
    • (1997) Neuropharmacology , vol.36 , pp. 265-267
    • Doherty, A.J.1    Palmer, M.J.2    Henley, J.M.3    Collingridge, G.L.4    Jane, D.E.5
  • 164
    • 0035959976 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons
    • Pisani A, Gubellini P, Bonsi P, et al. Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience. 2001;106:579-587.
    • (2001) Neuroscience , vol.106 , pp. 579-587
    • Pisani, A.1    Gubellini, P.2    Bonsi, P.3
  • 165
    • 0034332480 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus
    • Awad H, Hubert GW, Smith Y, Levey AI, Conn PJ. Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. J Neurosci. 2000;20:7871-7879.
    • (2000) J Neurosci , vol.20 , pp. 7871-7879
    • Awad, H.1    Hubert, G.W.2    Smith, Y.3    Levey, A.I.4    Conn, P.J.5
  • 166
    • 0036945935 scopus 로고    scopus 로고
    • The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity
    • Henry SA, Lehmann-Masten V, Gasparini F, Geyer MA, Markou A. The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity. Neuropharmacology. 2002;43:1199-1209.
    • (2002) Neuropharmacology , vol.43 , pp. 1199-1209
    • Henry, S.A.1    Lehmann-Masten, V.2    Gasparini, F.3    Geyer, M.A.4    Markou, A.5
  • 167
    • 0037665283 scopus 로고    scopus 로고
    • Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents
    • Kinney GG, Burno M, Campbell UC, et al. Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents. J Pharmacol Exp Ther. 2003;306:116-123.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 116-123
    • Kinney, G.G.1    Burno, M.2    Campbell, U.C.3
  • 168
    • 2942650911 scopus 로고    scopus 로고
    • Functional interaction Between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release
    • Homayoun H, Stefani MR, Adams BW, Tamagan GD, Moghaddam B. Functional interaction Between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release. Neuropsychopharmacology. 2004;29:1259-1269.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1259-1269
    • Homayoun, H.1    Stefani, M.R.2    Adams, B.W.3    Tamagan, G.D.4    Moghaddam, B.5
  • 170
    • 28644440123 scopus 로고    scopus 로고
    • Bursting of prefrontal cortex neurons in awake rats is regulated by metabotropic glutamate 5 (mGlu5) receptors: rate-dependent influence and interaction with NMDA receptors
    • Homayoun H, Moghaddam B. Bursting of prefrontal cortex neurons in awake rats is regulated by metabotropic glutamate 5 (mGlu5) receptors: rate-dependent influence and interaction with NMDA receptors. Cereb Cortex. 2006;16:93-105.
    • (2006) Cereb Cortex , vol.16 , pp. 93-105
    • Homayoun, H.1    Moghaddam, B.2
  • 171
    • 57349174038 scopus 로고    scopus 로고
    • ADX47273 [S-(4-fluorophenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-pipe ridin-1-yl}methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities
    • Liu F, Grauer S, Kelley C, Navarra R, et al. ADX47273 [S-(4-fluorophenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-pipe ridin-1-yl}methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther. 2008;327:827-839.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 827-839
    • Liu, F.1    Grauer, S.2    Kelley, C.3    Navarra, R.4
  • 172
    • 70350182198 scopus 로고    scopus 로고
    • Comparison of the mGlu receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activity
    • Schlumberger C, Pietraszek M, Gravius A, et al. Comparison of the mGlu receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activity. Eur J Pharmacol. 2009;623:73-83.
    • (2009) Eur J Pharmacol , vol.623 , pp. 73-83
    • Schlumberger, C.1    Pietraszek, M.2    Gravius, A.3
  • 173
    • 43349105701 scopus 로고    scopus 로고
    • Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia
    • Hashimoto T, Bazmi HH, Mirnics K, Wu Q, Sampson AR, Lewis DA. Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. Am J Psychiatry. 2008;165:479-489.
    • (2008) Am J Psychiatry , vol.165 , pp. 479-489
    • Hashimoto, T.1    Bazmi, H.H.2    Mirnics, K.3    Wu, Q.4    Sampson, A.R.5    Lewis, D.A.6
  • 174
    • 58149385775 scopus 로고    scopus 로고
    • Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia
    • Behrens MM, Ali SS, Dugan LL. Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia. J Neurosci. 2008;28:13957-13966.
    • (2008) J Neurosci , vol.28 , pp. 13957-13966
    • Behrens, M.M.1    Ali, S.S.2    Dugan, L.L.3
  • 175
    • 0242475319 scopus 로고    scopus 로고
    • Interneuron diversity series: inhibitory interneurons and network oscillations in vitro
    • Whittington MA, Traub RD. Interneuron diversity series: inhibitory interneurons and network oscillations in vitro. Trends Neurosci. 2003;26:676-682.
    • (2003) Trends Neurosci , vol.26 , pp. 676-682
    • Whittington, M.A.1    Traub, R.D.2
  • 176
    • 70450182120 scopus 로고    scopus 로고
    • Role of GABAA receptors in cognition
    • Mohler H. Role of GABAA receptors in cognition. Biochem Soc Trans. 2009;37:1328-1333.
    • (2009) Biochem Soc Trans , vol.37 , pp. 1328-1333
    • Mohler, H.1
  • 177
    • 67651113930 scopus 로고    scopus 로고
    • Selective alterations in postsynaptic markers of chandelier cell inputs to cortical pyramidal neurons in subjects with schizophrenia
    • Cruz DA, Weaver CL, Lovallo EM, Melchitzky DS, Lewis DA. Selective alterations in postsynaptic markers of chandelier cell inputs to cortical pyramidal neurons in subjects with schizophrenia. Neuropsychopharmacology. 2009;34:2112-2124.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 2112-2124
    • Cruz, D.A.1    Weaver, C.L.2    Lovallo, E.M.3    Melchitzky, D.S.4    Lewis, D.A.5
  • 178
    • 28044453713 scopus 로고    scopus 로고
    • A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction
    • Yee BK, Keist R, von Boehmer L, et al. A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction. Proc Natl Acad Sci U S A. 2005;102:17154-17159.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17154-17159
    • Yee, B.K.1    Keist, R.2    von Boehmer, L.3
  • 179
    • 30844456191 scopus 로고    scopus 로고
    • GABA-based therapeutic approaches: GABAA receptor subtype functions
    • Rudolph U, Mohler H. GABA-based therapeutic approaches: GABAA receptor subtype functions. Curr Opin Pharmacol. 2006;6:18-23.
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 18-23
    • Rudolph, U.1    Mohler, H.2
  • 180
    • 57349167353 scopus 로고    scopus 로고
    • Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia
    • Lewis DA, Cho RY, Carter CS, et al. Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia. Am J Psychiatry. 2008;165:1585-1593.
    • (2008) Am J Psychiatry , vol.165 , pp. 1585-1593
    • Lewis, D.A.1    Cho, R.Y.2    Carter, C.S.3
  • 181
    • 1842562921 scopus 로고    scopus 로고
    • 10. Identification of GABAA receptor subunit variants in midbrain dopaminergic neurons
    • Okada H, Matsushita N, Kobayashi K, Kobayashi K. 10. Identification of GABAA receptor subunit variants in midbrain dopaminergic neurons. J Neurochem. 2004;89:7-14.
    • (2004) J Neurochem , vol.89 , pp. 7-14
    • Okada, H.1    Matsushita, N.2    Kobayashi, K.3    Kobayashi, K.4
  • 182
    • 38349193123 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors as CNS drug targets
    • Langmead CJ, Watson J, Reavill C. Muscarinic acetylcholine receptors as CNS drug targets. Pharmacol Ther. 2008;117:232-243.
    • (2008) Pharmacol Ther , vol.117 , pp. 232-243
    • Langmead, C.J.1    Watson, J.2    Reavill, C.3
  • 183
    • 0031774720 scopus 로고    scopus 로고
    • International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors
    • Caulfield MP, Birdsall NJ. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev. 1998;50:279-290.
    • (1998) Pharmacol Rev , vol.50 , pp. 279-290
    • Caulfield, M.P.1    Birdsall, N.J.2
  • 184
    • 27144524511 scopus 로고    scopus 로고
    • Effect of rivastigmine in the treatment of behavioral disturbances associated with dementia: review of neuropsychiatric impairment in Alzheimer's disease
    • Grossberg GT. Effect of rivastigmine in the treatment of behavioral disturbances associated with dementia: review of neuropsychiatric impairment in Alzheimer's disease. Curr Med Res Opin. 2005;21:1631-1639.
    • (2005) Curr Med Res Opin , vol.21 , pp. 1631-1639
    • Grossberg, G.T.1
  • 185
    • 38549149803 scopus 로고    scopus 로고
    • A systematic review of the effectiveness of rivastigmine for the treatment of behavioral disturbances in dementia and other neurological disorders
    • Figiel G, Sadowsky C. A systematic review of the effectiveness of rivastigmine for the treatment of behavioral disturbances in dementia and other neurological disorders. Curr Med Res Opin. 2008;24:157-166.
    • (2008) Curr Med Res Opin , vol.24 , pp. 157-166
    • Figiel, G.1    Sadowsky, C.2
  • 186
    • 48949095543 scopus 로고    scopus 로고
    • Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia
    • Shekhar A, Potter WZ, Lightfoot J, et al. Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. Am J Psychiatry. 2008;165:1033-1039.
    • (2008) Am J Psychiatry , vol.165 , pp. 1033-1039
    • Shekhar, A.1    Potter, W.Z.2    Lightfoot, J.3
  • 187
    • 0037691865 scopus 로고    scopus 로고
    • Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity
    • Bymaster FP, Carter PA, Yamada M, et al. Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. Eur J Neurosci. 2003;17:1403-1410.
    • (2003) Eur J Neurosci , vol.17 , pp. 1403-1410
    • Bymaster, F.P.1    Carter, P.A.2    Yamada, M.3
  • 188
    • 34548362105 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
    • Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov. 2007;6:721-733.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 721-733
    • Wess, J.1    Eglen, R.M.2    Gautam, D.3
  • 189
    • 0034975130 scopus 로고    scopus 로고
    • Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: a study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment
    • Crook JM, Tomaskovic-Crook E, Copolov DL, Dean B. Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: a study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment. Am J Psychiatry. 2001;158:918-925.
    • (2001) Am J Psychiatry , vol.158 , pp. 918-925
    • Crook, J.M.1    Tomaskovic-Crook, E.2    Copolov, D.L.3    Dean, B.4
  • 190
    • 0036932174 scopus 로고    scopus 로고
    • Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia
    • Dean B, McLeod M, Keriakous D, McKenzie J, Scarr E. Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol Psychiatry. 2002;7:1083-1091.
    • (2002) Mol Psychiatry , vol.7 , pp. 1083-1091
    • Dean, B.1    McLeod, M.2    Keriakous, D.3    McKenzie, J.4    Scarr, E.5
  • 191
    • 0037220723 scopus 로고    scopus 로고
    • Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice
    • Anagnostaras SG, Murphy GG, Hamilton SE, et al. Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nat Neurosci. 2003;6:51-58.
    • (2003) Nat Neurosci , vol.6 , pp. 51-58
    • Anagnostaras, S.G.1    Murphy, G.G.2    Hamilton, S.E.3
  • 192
    • 0035910050 scopus 로고    scopus 로고
    • Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice
    • Gerber DJ, Sotnikova TD, Gainetdinov RR, Huang SY, Caron MG, Tonegawa S. Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice. Proc Natl Acad Sci U S A. 2001;98:15312-15317.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 15312-15317
    • Gerber, D.J.1    Sotnikova, T.D.2    Gainetdinov, R.R.3    Huang, S.Y.4    Caron, M.G.5    Tonegawa, S.6
  • 193
    • 9444239189 scopus 로고    scopus 로고
    • M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies
    • Tzavara ET, Bymaster FP, Davis RJ, et al. M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies. FASEB J. 2004;18:1410-1412.
    • (2004) FASEB J , vol.18 , pp. 1410-1412
    • Tzavara, E.T.1    Bymaster, F.P.2    Davis, R.J.3
  • 194
    • 0042575347 scopus 로고    scopus 로고
    • Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice
    • Tzavara ET, Bymaster FP, Felder CC, et al. Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Mol Psychiatry. 2003;8:673-679.
    • (2003) Mol Psychiatry , vol.8 , pp. 673-679
    • Tzavara, E.T.1    Bymaster, F.P.2    Felder, C.C.3
  • 195
    • 30644461032 scopus 로고    scopus 로고
    • Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus
    • Shinoe T, Matsui M, Taketo MM, Manabe T. Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus. J Neurosci. 2005;25:11194-11200.
    • (2005) J Neurosci , vol.25 , pp. 11194-11200
    • Shinoe, T.1    Matsui, M.2    Taketo, M.M.3    Manabe, T.4
  • 196
    • 0032530817 scopus 로고    scopus 로고
    • Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-Daspartate (NMDA) receptor currents in hippocampal pyramidal cells
    • Marino MJ, Rouse ST, Levey AI, Potter LT, Conn PJ. Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-Daspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proc Natl Acad Sci U S A. 1998;95:11465-11470.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11465-11470
    • Marino, M.J.1    Rouse, S.T.2    Levey, A.I.3    Potter, L.T.4    Conn, P.J.5
  • 197
    • 61349093537 scopus 로고    scopus 로고
    • Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders
    • Conn PJ, Jones CK, Lindsley CW. Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends Pharmacol Sci. 2009;30:148-155.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 148-155
    • Conn, P.J.1    Jones, C.K.2    Lindsley, C.W.3
  • 198
    • 37249054670 scopus 로고    scopus 로고
    • An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission
    • Shirey JK, Xiang Z, Orton D, et al. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol. 2008;4:42-50.
    • (2008) Nat Chem Biol , vol.4 , pp. 42-50
    • Shirey, J.K.1    Xiang, Z.2    Orton, D.3
  • 199
    • 55249118679 scopus 로고    scopus 로고
    • Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats
    • Jones CK, Brady AE, Davis AA, et al. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J Neurosci. 2008;28:10422-10433.
    • (2008) J Neurosci , vol.28 , pp. 1042210433
    • Jones, C.K.1    Brady, A.E.2    Davis, A.A.3
  • 200
    • 70449640543 scopus 로고    scopus 로고
    • A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning
    • Shirey JK, Brady AE, Jones PJ, et al. A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. J Neurosci. 2009;29:14271-14278.
    • (2009) J Neurosci , vol.29 , pp. 14271-14278
    • Shirey, J.K.1    Brady, A.E.2    Jones, P.J.3
  • 201
    • 49449108109 scopus 로고    scopus 로고
    • Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia
    • Chan WY, McKinzie DL, Bose S, et al. Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia. Proc Natl Acad Sci U S A. 2008;105:10978-10983.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10978-10983
    • Chan, W.Y.1    McKinzie, D.L.2    Bose, S.3
  • 202
    • 57349113845 scopus 로고    scopus 로고
    • Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamineinduced hyperlocomotor activity in rats
    • Brady AE, Jones CK, Bridges TM, et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamineinduced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008;327:941-953.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 941-953
    • Brady, A.E.1    Jones, C.K.2    Bridges, T.M.3
  • 204
    • 0032746548 scopus 로고    scopus 로고
    • Smoking habits, current symptoms, and premorbid characteristics of schizophrenic patients in Nithsdale
    • Kelly C, McCreadie RG. Smoking habits, current symptoms, and premorbid characteristics of schizophrenic patients in Nithsdale, Scotland. Am J Psychiatry. 1999;156:1751-1757.
    • (1999) Scotland. Am J Psychiatry. , vol.156 , pp. 1751-1757
    • Kelly, C.1    McCreadie, R.G.2
  • 205
    • 11844263996 scopus 로고    scopus 로고
    • Tobacco use in schizophrenia: a study of cotinine concentrations in the saliva of patients and controls
    • Strand JE, Nyback H. Tobacco use in schizophrenia: a study of cotinine concentrations in the saliva of patients and controls. Eur Psychiatry. 2005;20:50-54.
    • (2005) Eur Psychiatry , vol.20 , pp. 50-54
    • Strand, J.E.1    Nyback, H.2
  • 207
    • 0031751031 scopus 로고    scopus 로고
    • Schizophrenia, sensory gating, and nicotinic receptors
    • Adler LE, Olincy A, Waldo M, et al. Schizophrenia, sensory gating, and nicotinic receptors. Schizophr Bull. 1998;24:189-202.
    • (1998) Schizophr Bull , vol.24 , pp. 189-202
    • Adler, L.E.1    Olincy, A.2    Waldo, M.3
  • 210
    • 33847029091 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system
    • Dani JA, Bertrand D. Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annu Rev Pharmacol Toxicol. 2007;47:699-729.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 699-729
    • Dani, J.A.1    Bertrand, D.2
  • 211
    • 0022376548 scopus 로고
    • Cholinergic innervation of the rat hippocampus as revealed by choline acetyltransferase immunocytochemistry: a combined light and electron microscopic study
    • Frotscher M, Leranth C. Cholinergic innervation of the rat hippocampus as revealed by choline acetyltransferase immunocytochemistry: a combined light and electron microscopic study. J Comp Neurol. 1985;239:237-246.
    • (1985) J Comp Neurol , vol.239 , pp. 237246
    • Frotscher, M.1    Leranth, C.2
  • 212
    • 0029805769 scopus 로고    scopus 로고
    • Hippocampal synaptic transmission enhanced by low concentrations of nicotine
    • Gray R, Rajan AS, Radcliffe KA, Yakehiro M, Dani JA. Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature. 1996;383:713-716.
    • (1996) Nature , vol.383 , pp. 713-716
    • Gray, R.1    Rajan, A.S.2    Radcliffe, K.A.3    Yakehiro, M.4    Dani, J.A.5
  • 213
    • 0034991547 scopus 로고    scopus 로고
    • Parvalbumin-containing interneurons of the human cerebral cortex express nicotinic acetylcholine receptor proteins
    • Krenz I, Kalkan D, Wevers A, et al. Parvalbumin-containing interneurons of the human cerebral cortex express nicotinic acetylcholine receptor proteins. J Chem Neuroanat. 2001;21:239-246.
    • (2001) J Chem Neuroanat , vol.21 , pp. 239-246
    • Krenz, I.1    Kalkan, D.2    Wevers, A.3
  • 214
    • 0032531893 scopus 로고    scopus 로고
    • Synaptic potentials mediated via alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal interneurons
    • Frazier CJ, Buhler AV, Weiner JL, Dunwiddie TV. Synaptic potentials mediated via alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal interneurons. J Neurosci. 1998;18:8228-8235.
    • (1998) J Neurosci , vol.18 , pp. 82288235
    • Frazier, C.J.1    Buhler, A.V.2    Weiner, J.L.3    Dunwiddie, T.V.4
  • 215
    • 0035282788 scopus 로고    scopus 로고
    • Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei
    • Klink R, de Kerchove d'Exaerde A, Zoli M, Changeux JP. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci. 2001;21:1452-1463.
    • (2001) J Neurosci , vol.21 , pp. 1452-1463
    • Klink, R.1    de Kerchove d'Exaerde, A.2    Zoli, M.3    Changeux, J.P.4
  • 216
    • 0037075602 scopus 로고    scopus 로고
    • Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas
    • Mansvelder HD, Keath JR, McGehee DS. Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron. 2002;33:905-919.
    • (2002) Neuron , vol.33 , pp. 905-919
    • Mansvelder, H.D.1    Keath, J.R.2    McGehee, D.S.3
  • 217
    • 0034672822 scopus 로고    scopus 로고
    • Putative role of presynaptic alpha7* nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area
    • Schilstrom B, Fagerquist MV, Zhang X, et al. Putative role of presynaptic alpha7* nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area. Synapse. 2000;38:375-383.
    • (2000) Synapse , vol.38 , pp. 375-383
    • Schilstrom, B.1    Fagerquist, M.V.2    Zhang, X.3
  • 218
    • 0032168029 scopus 로고    scopus 로고
    • Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7)
    • Gault J, Robinson M, Berger R, et al. Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). Genomics. 1998;52:173-185.
    • (1998) Genomics , vol.52 , pp. 173-185
    • Gault, J.1    Robinson, M.2    Berger, R.3
  • 219
    • 0032872325 scopus 로고    scopus 로고
    • Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: alpha-bungarotoxin and nicotine binding in the thalamus
    • Court J, Spurden D, Lloyd S, et al. Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: alpha-bungarotoxin and nicotine binding in the thalamus. J Neurochem. 1999;73:1590-1597.
    • (1999) J Neurochem , vol.73 , pp. 1590-1597
    • Court, J.1    Spurden, D.2    Lloyd, S.3
  • 220
    • 0029085870 scopus 로고
    • Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia
    • Freedman R, Hall M, Adler LE, Leonard S. Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Biol Psychiatry. 1995;38:22-33.
    • (1995) Biol Psychiatry , vol.38 , pp. 22-33
    • Freedman, R.1    Hall, M.2    Adler, L.E.3    Leonard, S.4
  • 221
    • 0034945151 scopus 로고    scopus 로고
    • Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia
    • Marutle A, Zhang X, Court J, et al. Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia. J Chem Neuroanat. 2001;22:115-126.
    • (2001) J Chem Neuroanat , vol.22 , pp. 115-126
    • Marutle, A.1    Zhang, X.2    Court, J.3
  • 222
    • 0344861848 scopus 로고    scopus 로고
    • Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia
    • Martin-Ruiz CM, Haroutunian VH, Long P, et al. Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia. Biol Psychiatry. 2003;54:1222-1233.
    • (2003) Biol Psychiatry , vol.54 , pp. 1222-1233
    • Martin-Ruiz, C.M.1    Haroutunian, V.H.2    Long, P.3
  • 223
    • 1842799731 scopus 로고    scopus 로고
    • The alpha7 nicotinic acetylcholine receptor in schizophrenia: decreased mRNA levels in peripheral blood lymphocytes
    • Perl O, Ilani T, Strous RD, Lapidus R, Fuchs S. The alpha7 nicotinic acetylcholine receptor in schizophrenia: decreased mRNA levels in peripheral blood lymphocytes. FASEB J. 2003;17:1948-1950.
    • (2003) FASEB J , vol.17 , pp. 1948-1950
    • Perl, O.1    Ilani, T.2    Strous, R.D.3    Lapidus, R.4    Fuchs, S.5
  • 224
    • 33751334112 scopus 로고    scopus 로고
    • Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice
    • Young JW, Crawford N, Kelly JS, et al. Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice. Eur Neuropsychopharmacol. 2007;17:145-155.
    • (2007) Eur Neuropsychopharmacol , vol.17 , pp. 145-155
    • Young, J.W.1    Crawford, N.2    Kelly, J.S.3
  • 225
    • 0037154981 scopus 로고    scopus 로고
    • Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory
    • Levin ED, Bradley A, Addy N, Sigurani N. Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory. Neuroscience. 2002;109:757-765.
    • (2002) Neuroscience , vol.109 , pp. 757-765
    • Levin, E.D.1    Bradley, A.2    Addy, N.3    Sigurani, N.4
  • 226
    • 0033237390 scopus 로고    scopus 로고
    • AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats
    • Levin ED, Bettegowda C, Blosser J, Gordon J. AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. Behav Pharmacol. 1999;10:675-680.
    • (1999) Behav Pharmacol , vol.10 , pp. 675-680
    • Levin, E.D.1    Bettegowda, C.2    Blosser, J.3    Gordon, J.4
  • 227
    • 20444483610 scopus 로고    scopus 로고
    • Tropisetron improves deficits in auditory P50 suppression in schizophrenia
    • Koike K, Hashimoto K, Takai N, et al. Tropisetron improves deficits in auditory P50 suppression in schizophrenia. Schizophr Res. 2005;76:6772.
    • (2005) Schizophr Res , vol.76 , pp. 6772
    • Koike, K.1    Hashimoto, K.2    Takai, N.3
  • 228
    • 65649092520 scopus 로고    scopus 로고
    • Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders
    • Roncarati R, Scali C, Comery TA, et al. Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J Pharmacol Exp Ther. 2009;329:459-468.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 459-468
    • Roncarati, R.1    Scali, C.2    Comery, T.A.3
  • 229
    • 0002100551 scopus 로고    scopus 로고
    • 3[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner
    • Meyer EM, Tay ET, Papke RL, Meyers C, Huang GL, de Fiebre CM. 3[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner. Brain Res. 1997;768:49-56.
    • (1997) Brain Res , vol.768 , pp. 49-56
    • Meyer, E.M.1    Tay, E.T.2    Papke, R.L.3    Meyers, C.4    Huang, G.L.5    de Fiebre, C.M.6
  • 230
    • 0031003185 scopus 로고    scopus 로고
    • Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo
    • Briggs CA, Anderson DJ, Brioni JD, et al. Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol Biochem Behav. 1997;57:231-241.
    • (1997) Pharmacol Biochem Behav , vol.57 , pp. 231-241
    • Briggs, C.A.1    Anderson, D.J.2    Brioni, J.D.3
  • 231
    • 0042594579 scopus 로고    scopus 로고
    • Mecamylamine reversal by nicotine and by a partial alpha7 nicotinic acetylcholine receptor agonist (GTS-21) in rabbits tested with delay eyeblink classical conditioning. Behav
    • Woodruff-Pak DS. Mecamylamine reversal by nicotine and by a partial alpha7 nicotinic acetylcholine receptor agonist (GTS-21) in rabbits tested with delay eyeblink classical conditioning. Behav Brain Res. 2003;143:159-167.
    • (2003) Brain Res , vol.143 , pp. 159167
    • Woodruff-Pak, D.S.1
  • 232
    • 0031596817 scopus 로고    scopus 로고
    • Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice
    • Stevens KE, Kem WR, Mahnir VM, Freedman R. Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology (Berl). 1998;136:320-327.
    • (1998) Psychopharmacology (Berl) , vol.136 , pp. 320-327
    • Stevens, K.E.1    Kem, W.R.2    Mahnir, V.M.3    Freedman, R.4
  • 233
    • 0038690569 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers
    • Kitagawa H, Takenouchi T, Azuma R, et al. Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers. Neuropsychopharmacology. 2003;28:542-551.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 542-551
    • Kitagawa, H.1    Takenouchi, T.2    Azuma, R.3
  • 234
    • 33847351996 scopus 로고    scopus 로고
    • Schizophrenia and the alpha7 nicotinic acetylcholine receptor
    • Martin LF, Freedman R. Schizophrenia and the alpha7 nicotinic acetylcholine receptor. Int Rev Neurobiol. 2007;78:225-246.
    • (2007) Int Rev Neurobiol , vol.78 , pp. 225-246
    • Martin, L.F.1    Freedman, R.2
  • 235
    • 33744911665 scopus 로고    scopus 로고
    • et al Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia
    • Olincy A, Harris JG, Johnson LL, et al Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Arch Gen Psychiatry. 2006;63:630-638.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 630-638
    • Olincy, A.1    Harris, J.G.2    Johnson, L.L.3
  • 236
    • 48949099564 scopus 로고    scopus 로고
    • Initial phase 2 trial of a nicotinic agonist in schizophrenia
    • Freedman R, Olincy A, Buchanan RW, et al. Initial phase 2 trial of a nicotinic agonist in schizophrenia. Am J Psychiatry. 2008;165:1040-1047.
    • (2008) Am J Psychiatry , vol.165 , pp. 1040-1047
    • Freedman, R.1    Olincy, A.2    Buchanan, R.W.3
  • 237
    • 76749132562 scopus 로고    scopus 로고
    • Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophrenia
    • Tregellas JR, Olincy A, Johnson L, et al. Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophrenia. Neuropsychopharmacology. 2010;35:938-942.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 938-942
    • Tregellas, J.R.1    Olincy, A.2    Johnson, L.3
  • 239
    • 33845698922 scopus 로고    scopus 로고
    • SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: binding and functional profile
    • Biton B, Bergis OE, Galli F, et al. SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: binding and functional profile. Neuropsychopharmacology. 2007;32:1-16.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 1-16
    • Biton, B.1    Bergis, O.E.2    Galli, F.3
  • 240
    • 33845719612 scopus 로고    scopus 로고
    • SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia
    • Pichat P, Bergis OE, Terranova JP, et al. SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology. 2007;32:17-34.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 17-34
    • Pichat, P.1    Bergis, O.E.2    Terranova, J.P.3
  • 241
    • 67349167960 scopus 로고    scopus 로고
    • Pro-cognitive and antipsychotic efficacy of the alpha7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia
    • Barak S, Arad M, De Levie A, Black MD, Griebel G, Weiner I. Pro-cognitive and antipsychotic efficacy of the alpha7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia. Neuropsychopharmacology. 2009;34:1753-1763.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 1753-1763
    • Barak, S.1    Arad, M.2    De Levie, A.3    Black, M.D.4    Griebel, G.5    Weiner, I.6
  • 242
    • 34548677767 scopus 로고    scopus 로고
    • Allosteric modulation of nicotinic acetylcholine receptors
    • Bertrand D, Gopalakrishnan M. Allosteric modulation of nicotinic acetylcholine receptors. Biochem Pharmacol. 2007;74:1155-1163.
    • (2007) Biochem Pharmacol , vol.74 , pp. 1155-1163
    • Bertrand, D.1    Gopalakrishnan, M.2
  • 243
    • 20944441082 scopus 로고    scopus 로고
    • A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization
    • Hurst RS, Hajos M, Raggenbass M, et al. A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J Neurosci. 2005;25:4396-4405.
    • (2005) J Neurosci , vol.25 , pp. 4396-4405
    • Hurst, R.S.1    Hajos, M.2    Raggenbass, M.3
  • 244
    • 33747597579 scopus 로고    scopus 로고
    • Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators
    • Broad LM, Zwart R, Pearson KH, et al. Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J Pharmacol Exp Ther. 2006;318:1108-1117.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1108-1117
    • Broad, L.M.1    Zwart, R.2    Pearson, K.H.3
  • 245
    • 55749111553 scopus 로고    scopus 로고
    • Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site
    • Young GT, Zwart R, Walker AS, Sher E, Millar NS. Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc Natl Acad Sci U S A. 2008;105:14686-14691.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14686-14691
    • Young, G.T.1    Zwart, R.2    Walker, A.S.3    Sher, E.4    Millar, N.S.5
  • 246
    • 76849087246 scopus 로고    scopus 로고
    • Studies on the hippocampal formation: From basic development to clinical applications: Studies on schizophrenia
    • Freedman R, Goldowitz D. Studies on the hippocampal formation: From basic development to clinical applications: Studies on schizophrenia. Prog Neurobiol. 2010:90:263-275.
    • (2010) Prog Neurobiol , vol.90 , pp. 263-275
    • Freedman, R.1    Goldowitz, D.2
  • 247
    • 58149359426 scopus 로고    scopus 로고
    • Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA
    • Liu J, Pearlson G, Windemuth A, Ruano G, Perrone-Bizzozero NI, Calhoun V. Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA. Hum Brain Mapp. 2009;30:241-255.
    • (2009) Hum Brain Mapp , vol.30 , pp. 241-255
    • Liu, J.1    Pearlson, G.2    Windemuth, A.3    Ruano, G.4    Perrone-Bizzozero, N.I.5    Calhoun, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.