Cancer cells exploit the Eph-ephrin system to promote invasion and metastasis: Tales of unwitting partners

Science Signaling

Volumn 4, Issue 175, 2011, Pages

  Wang, Bingcheng ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN; EPHRIN A1; EPHRIN RECEPTOR A2; EPHRIN RECEPTOR A4; EPHRIN RECEPTOR B2; EPHRIN RECEPTOR B3; EPHRIN RECEPTOR B4; ERYTHROPOIETIN PRODUCING HEPATOMA; ERYTHROPOIETIN RECEPTOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; EPHRIN RECEPTOR;

CANCER CELL; CELL CONTACT; CELL MIGRATION; CONTACT INHIBITION; HUMAN; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW; SIGNAL TRANSDUCTION; STROMA CELL; TUMOR MICROENVIRONMENT; ARTICLE; BIOLOGICAL MODEL; CANCER INVASION; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSTATE TUMOR; TUMOR CELL LINE;

CELL LINE, TUMOR; CONTACT INHIBITION; EPHRINS; HUMANS; MALE; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROSTATIC NEOPLASMS; RECEPTORS, EPH FAMILY;

EID: 79957896942     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2002153     Document Type: Review

References (27)

1. J. W. Astin, J. Batson, S. Kadir, J. Charlet, R. A. Persad, D. Gillatt, J. D. Oxley, C. D. Nobes, Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells. Nat. Cell Biol. 12, 1194-1204 (2010).
2. M. Abercrombie, J. E. Heaysman, Observations on the social behaviour of cells in tissue culture. I. Speed of movement of chick heart fi broblasts in relation to their mutual contacts. Exp. Cell Res. 5, 111-131 (1953).
3. M. Abercrombie, J. E. Heaysman, Observations on the social behaviour of cells in tissue culture. II. Monolayering of fi broblasts. Exp. Cell Res. 6, 293-306 (1954).
4. R. Mayor, C. Carmona-Fontaine, Keeping in touch with contact inhibition of locomotion. Trends Cell Biol. 20, 319-328 (2010).
5. M. Abercrombie, J. E. Heaysman, Invasiveness of sarcoma cells. Nature 174, 697-698 (1954).
6. M. Abercrombie, Contact inhibition and malignancy. Nature 281, 259-262 (1979).
7. Eph Nomenclature Committee, Unifi ed nomenclature for Eph family receptors and their ligands, the ephrins. Cell 90, 403-404 (1997).
8. E. B. Pasquale, Eph receptor signalling casts a wide net on cell behaviour. Nat. Rev. Mol. Cell Biol. 6, 462-475 (2005).
9. E. B. Pasquale, Eph receptors and ephrins in cancer: Bidirectional signalling and beyond. Nat. Rev. Cancer 10, 165-180 (2010).
10. M. Nakamoto, A. D. Bergemann, Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis. Microsc. Res. Tech. 59, 58-67 (2002).
11. E. B. Pasquale, Eph-ephrin bidirectional signaling in physiology and disease. Cell 133, 38-52 (2008).
12. H. Miao, E. Burnett, M. Kinch, E. Simon, B. Wang, Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat. Cell Biol. 2, 62-69 (2000).
13. S. S. Foo, C. J. Turner, S. Adams, A. Compagni, D. Aubyn, N. Kogata, P. Lindblom, M. Shani, D. Zicha, R. H. Adams, Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell 124, 161-173 (2006).
14. N. K. Noren, G. Foos, C. A. Hauser, E. B. Pasquale, The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat. Cell Biol. 8, 815-825 (2006).
15. H. Dopeso, S. Mateo-Lozano, R. Mazzolini, P. Rodrigues, L. Lagares-Tena, J. Ceron, J. Romero, M. Esteves, S. Landolfi , J. Hernández-Losa, J. Castaño, A. J. Wilson, S. Ramon y Cajal, J. M. Mariadason, S. Schwartz Jr., D. Arango, The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis. Cancer Res. 69, 7430-7438 (2009).
16. V. Davalos, H. Dopeso, J. Castaño, A. J. Wilson, F. Vilardell, J. Romero-Gimenez, E. Espín, M. Armengol, G. Capella, J. M. Mariadason, L. A. Aaltonen, S. Schwartz Jr., D. Arango, EPHB4 and survival of colorectal cancer patients. Cancer Res. 66, 8943-8948 (2006).
17. H. Miao, K. Strebhardt, E. B. Pasquale, T. L. Shen, J. L. Guan, B. Wang, Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. J. Biol. Chem. 280, 923-932 (2005).
18. E. Batlle, J. T. Henderson, H. Beghtel, M. M. van den Born, E. Sancho, G. Huls, J. Meeldijk, J. Robertson, M. van de Wetering, T. Pawson, H. Clevers, Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 111, 251-263 (2002).
19. H. Miao, D.-Q. Li, A. Mukherjee, H. Guo, A. Petty, J. Cutter, J. P. Basilion, J. Sedor, J. Wu, D. Danielpour, A. E. Sloan, M. L. Cohen, B. Wang, EphA2 mediates ligand-dependent inhibition and ligandindependent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell 16, 9-20 (2009).
20. J. Wykosky, D. M. Gibo, C. Stanton, W. Debinski, EphA2 as a novel molecular marker and target in glioblastoma multiforme. Mol. Cancer Res. 3, 541-551 (2005).
21. B. C. Wang, PTPases: "Eph" ective arbitrators of attraction. Blood 112, 455-456 (2008).
22. S. H. Wimmer-Kleikamp, E. Nievergall, K. Gegenbauer, S. Adikari, M. Mansour, T. Yeadon, A. W. Boyd, N. R. Patani, M. Lackmann, Elevated protein tyrosine phosphatase activity provokes Eph/ ephrin-facilitated adhesion of pre-B leukemia cells. Blood 112, 721-732 (2008).
23. M. Hattori, M. Osterfi eld, J. G. Flanagan, Regulated cleavage of a contact-mediated axon repellent. Science 289, 1360-1365 (2000).
24. M. Macrae, R. M. Neve, P. Rodriguez-Viciana, C. Haqq, J. Yeh, C. Chen, J. W. Gray, F. McCormick, A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell 8, 111-118 (2005).
25. H. Guo, H. Miao, L. Gerber, J. Singh, M. F. Denning, A. C. Gilliam, B. Wang, Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin. Cancer Res. 66, 7050-7058 (2006).
26. S. Wang, J. Gao, Q. Lei, N. Rozengurt, C. Pritchard, J. Jiao, G. V. Thomas, G. Li, P. Roy-Burman, P. S. Nelson, X. Liu, H. Wu, Prostate-specifi c deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 4, 209-221 (2003).
27. Acknowledgments: I thank J. Schelling, L. Bruggeman, and members of my group for comments on this essay. Funding: Work from my laboratory is supported by grants from NIH (CA152371 and DK077876) and awards from Flight Attendant Medical Research Institute (FAMRI) and Prayers From Maria (PFMF) Foundation.