Coreceptor and cytokine concentrations may not explain differences in disease progression observed in HIV-1 clade A and D infected ugandans

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Wright, Edward ^a,b   Mugaba, Susan ^a   Grant, Paul ^c   Parkes Ratanshi, Rosalind ^a   van der Paal, Lieve ^a   Grosskurth, Heiner ^a,d   Kaleebu, Pontiano ^a,d  

^a UGANDA VIRUS RESEARCH INSTITUTE   (Uganda)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL DENSITY; CLADISTICS; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE COURSE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; MALE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TH1 CELL; TH2 CELL; UGANDA; BLOOD; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; MIDDLE AGED; PHYSIOLOGY; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CHEMOKINE CCL4; DISEASE PROGRESSION; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-2; MALE; MIDDLE AGED; RECEPTORS, CCR5; RECEPTORS, CXCR4; UGANDA;

EID: 79957875565     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019902     Document Type: Article

References (44)

1. Plantier JC, Leoz M, Dickerson JE, De Oliveira F, Cordonnier F, et al. (2009) A new human immunodeficiency virus derived from gorillas. Nat Med 15: 871-872.
2. Bernstein A, (2008) An HIV/AIDS vaccine: where do we go from here? Trends Microbiol 16: 553-554.
3. Willey S, Aasa-Chapman MM, (2008) Humoral immunity to HIV-1: neutralisation and antibody effector functions. Trends Microbiol 16: 596-604.
4. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, et al. (1995) Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270: 1811-1815.
5. Feng Y, Broder CC, Kennedy PE, Berger EA, (1996) HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272: 872-877.
6. Moore JP, Kitchen SG, Pugach P, Zack JA, (2004) The CCR5 and CXCR4 coreceptors-central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses 20: 111-126.
7. Clapham PR, McKnight A, (2001) HIV-1 receptors and cell tropism. Br Med Bull 58: 43-59.
8. Schuitemaker H, Kootstra NA, de Goede RE, de Wolf F, Miedema F, et al. (1991) Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture. J Virol 65: 356-363.
9. Ostrowski MA, Chun TW, Justement SJ, Motola I, Spinelli MA, et al. (1999) Both memory and CD45RA+/CD62L+ naive CD4(+) T cells are infected in human immunodeficiency virus type 1-infected individuals. J Virol 73: 6430-6435.
10. Huang W, Eshleman SH, Toma J, Stawiski E, Whitcomb JM, et al. (2009) Vertical transmission of X4-tropic and dual-tropic HIV-1 in five Ugandan mother-infant pairs. Aids 23: 1903-1908.
11. Serwanga J, Shafer LA, Pimego E, Auma B, Watera C, et al. (2009) Host HLA B*allele-associated multi-clade Gag T-cell recognition correlates with slow HIV-1 disease progression in antiretroviral therapy-naive Ugandans. PLoS One 4: e4188.
12. Connor RI, Sheridan KE, Ceradini D, Choe S, Landau NR, (1997) Change in coreceptor use coreceptor use correlates with disease progression in HIV-1-infected individuals. J Exp Med 185: 621-628.
13. Koot M, Keet IP, Vos AH, de Goede RE, Roos MT, et al. (1993) Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern Med 118: 681-688.
14. Richman DD, Bozzette SA, (1994) The impact of the syncytium-inducing phenotype of human immunodeficiency virus on disease progression. J Infect Dis 169: 968-974.
15. van Rensburg EJ, Smith TL, Zeier M, Robson B, Sampson C, et al. (2002) Change in co-receptor usage of current South African HIV-1 subtype C primary isolates. AIDS 16: 2479-2480.
16. White EJ, McColgan B, Kassaye S, Zijenah L, Katzenstein D, (2010) Unusual five amino acid insert within subtype C HIV-1 envelope contributes to dual-tropism (X4R5). Aids 24: 1063-1064.
17. Casper C, Naver L, Clevestig P, Belfrage E, Leitner T, et al. (2002) Coreceptor change appears after immune deficiency is established in children infected with different HIV-1 subtypes. AIDS Res Hum Retroviruses 18: 343-352.
18. Esbjornsson J, Mansson F, Martinez-Arias W, Vincic E, Biague AJ, et al. (2010) Frequent CXCR4 tropism of HIV-1 subtype A and CRF02_AG during late-stage disease-indication of an evolving epidemic in West Africa. Retrovirology 7: 23.
19. Simmons G, Wilkinson D, Reeves JD, Dittmar MT, Beddows S, et al. (1996) Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry. J Virol 70: 8355-8360.
20. Aasa-Chapman MM, Seymour CR, Williams I, McKnight A, (2006) Novel envelope determinants for CCR3 use by human immunodeficiency virus. J Virol 80: 10884-10889.
21. Neil SJ, Aasa-Chapman MM, Clapham PR, Nibbs RJ, McKnight A, et al. (2005) The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. J Virol 79: 9618-9624.
22. Baeten JM, Chohan B, Lavreys L, Chohan V, McClelland RS, et al. (2007) HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads. J Infect Dis 195: 1177-1180.
23. Kaleebu P, French N, Mahe C, Yirrell D, Watera C, et al. (2002) Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda. J Infect Dis 185: 1244-1250.
24. Kiwanuka N, Laeyendecker O, Robb M, Kigozi G, Arroyo M, et al. (2008) Effect of Human Immunodeficiency Virus Type 1 (HIV-1) Subtype on Disease Progression in Persons from Rakai, Uganda, with Incident HIV-1 Infection. J Infect Dis.
25. Kaleebu P, Nankya IL, Yirrell DL, Shafer LA, Kyosiimire-Lugemwa J, et al. (2007) Relation between chemokine receptor use, disease stage, and HIV-1 subtypes A and D: Results from a rural Ugandan cohort. J Acquir Immune Defic Syndr 45: 28-33.
26. Croitoru-Lamoury J, Guillemin GJ, Boussin FD, Mognetti B, Gigout LI, et al. (2003) Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation. Glia 41: 354-370.
27. Kwa D, van Rij RP, Boeser-Nunnink B, Vingerhoed J, Schuitemaker H, (2003) Association between an interleukin-4 promoter polymorphism and the acquisition of CXCR4 using HIV-1 variants. AIDS 17: 981-985.
28. Lin YL, Mettling C, Portales P, Rouzier R, Clot J, et al. (2008) The chemokine CCL5 regulates the in vivo cell surface expression of its receptor, CCR5. Aids 22: 430-432.
29. Sloan RD, Donahue DA, Kuhl BD, Bar-Magen T, Wainberg MA, (2010) Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes. Retrovirology 7: 44.
30. Gonzalez E, Kulkarni H, Bolivar H, Mangano A, Sanchez R, et al. (2005) The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science 307: 1434-1440.
31. Morgan D, Malamba SS, Maude GH, Okongo MJ, Wagner HU, et al. (1997) An HIV-1 natural history cohort and survival times in rural Uganda. AIDS 11: 633-640.
32. Wakeham K, Parkes-Ratanshi R, Watson V, Ggayi AB, Khoo S, et al. (2010) Co-administration of fluconazole increases nevirapine concentrations in HIV-infected Ugandans. J Antimicrob Chemother 65: 316-319.
33. Buckton AJ, Bissett SL, Myers RE, Beddows S, Edwards S, et al. (2008) Development and optimization of an internally controlled dried blood spot assay for surveillance of human immunodeficiency virus type-1 drug resistance. J Antimicrob Chemother 62: 1191-1198.
34. Delwart EL, Herring B, Rodrigo AG, Mullins JI, (1995) Genetic subtyping of human immunodeficiency virus using a heteroduplex mobility assay. PCR Methods Appl 4: S202-216.
35. Kaleebu P, Whitworth J, Hamilton L, Rutebemberwa A, Lyagoba F, et al. (2000) Molecular epidemiology of HIV type 1 in a rural community in southwest Uganda. AIDS Res Hum Retroviruses 16: 393-401.
36. Morgan D, Kaleebu P, Whitworth J, Yirrell D, Rutebemberwa A, et al. (2001) The stability between two HIV-1 RNA measurements one year apart and the relationship with HIV subtype in rural Uganda. Int J STD AIDS 12: 116-121.
37. Karita E, Ketter N, Price MA, Kayitenkore K, Kaleebu P, et al. (2009) CLSI-derived hematology and biochemistry reference intervals for healthy adults in eastern and southern Africa. PLoS One 4: e4401.
38. Poveda E, Briz V, de Mendoza C, Benito JM, Corral A, et al. (2007) Prevalence of X4 tropic HIV-1 variants in patients with differences in disease stage and exposure to antiretroviral therapy. J Med Virol 79: 1040-1046.
39. Oishi K, Hayano M, Yoshimine H, Tugume SB, Kebba A, et al. (2000) Expression of chemokine receptors on CD4+ T cells in peripheral blood from HIV-infected individuals in Uganda. J Interferon Cytokine Res 20: 597-602.
40. van Rij RP, Hazenberg MD, van Benthem BH, Otto SA, Prins M, et al. (2003) Early viral load and CD4+ T cell count, but not percentage of CCR5+ or CXCR4+ CD4+ T cells, are associated with R5-to-X4 HIV type 1 virus evolution. AIDS Res Hum Retroviruses 19: 389-398.
41. Choi B, Gatti PJ, Fermin CD, Vigh S, Haislip AM, et al. (2008) Down-regulation of cell surface CXCR4 by HIV-1. Virol J 5: 6.
42. Lelievre JD, Petit F, Perrin L, Mammano F, Arnoult D, et al. (2004) The density of coreceptors at the surface of CD4+ T cells contributes to the extent of human immunodeficiency virus type 1 viral replication-mediated T cell death. AIDS Res Hum Retroviruses 20: 1230-1243.
43. Alfano M, Poli G, (2005) Role of cytokines and chemokines in the regulation of innate immunity and HIV infection. Mol Immunol 42: 161-182.
44. Rizzardini G, Piconi S, Ruzzante S, Fusi ML, Lukwiya M, et al. (1996) Immunological activation markers in the serum of African and European HIV-seropositive and seronegative individuals. AIDS 10: 1535-1542.