Genetic Polymorphisms of the β2-Adrenergic Receptor Relate to Guanosine Protein-coupled Stimulator Receptor Dysfunction in Fibromyalgia Syndrome

Journal of Rheumatology

Volumn 38, Issue 6, 2011, Pages 1095-1103

  Xiao, Yangming ^a   He, Weijing ^b   Jon Russell, I ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

2 adrenergic receptor; Fibromyalgia syndrome; Guanosine protein coupled stimulator receptor; Single nucleotide polymorphisms

Indexed keywords

ARGININE; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; GLUTAMIC ACID; GLUTAMINE; GLYCINE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; ARTICLE; BETA2AR GENE; CODON; CONTROLLED STUDY; FEMALE; FIBROMYALGIA; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HETEROZYGOTE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SLEEP DISORDER; CASE CONTROL STUDY; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; CODON; CYCLIC AMP; FEMALE; FIBROMYALGIA; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, BETA-2;

EID: 79957873419     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.101104     Document Type: Article

References (50)

1. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum 1990;33:160-72.
2. Staud R. Pathogenesis of chronic muscle pain. Best Pract Res Clin Rheumatol 2007;21:581-9.
3. Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum 1995;38:19-28.
4. Mease P, Arnold LM, Bennett R, Boonen A, Buskila D, Carville S, et al. Fibromyalgia syndrome. J Rheumatol 2007;34:1415-25. (Pubitemid 46898129)
5. Wolfe F, Anderson J, Harkness D, Bennett RM, Caro X, Goldenberg DL, et al. A prospective, longitudinal, multicenter study of service utilization and costs in fibromyalgia. Arthritis Rheum 2007;40:1560-70.
6. Arnold LM. Biology and therapy of fibromyalgia. New therapies in fibromyalgia. Arthritis Res Ther 2006;8:212.
7. Clauw DJ. Fibromyalgia: more than just a musculoskeletal disease. Am Fam Physician 1995;52:843-51.
8. Russell IJ, Larson AA. Neurophysiopathogenesis of fibromyalgia syndrome: a unified hypothesis. Rheum Dis Clin North Am 2009;35:421-35.
9. Abeles AM, Pillinger MH, Solitar BM, Abeles M. Narrative review: the pathophysiology of fibromyalgia. Ann Intern Med 2007;146:726-34. (Pubitemid 351640000)
10. Wingenfeld K, Nutzinger D, Kauth J, Hellhammer DH, Lautenbacher S. Salivary cortisol release and hypothalamic pituitary adrenal axis feedback sensitivity in fibromyalgia is associated with depression but not with pain. J Pain 2010;11:1195-202.
11. Buskila D, Neumann L. Fibromyalgia syndrome (FM) and nonarticular tenderness in relatives of patients with FM. J Rheumatol 1977;24:941-4.
12. Arnold LM, Hudson JI, Hess EV, Ware AE, Fritz DA, Auchenbach MB, et al. Family study of fibromyalgia. Arthritis Rheum 2004;50:944-52. (Pubitemid 38326195)
13. Potvin S, Larouche A, Normand E, de Souza JB, Gaumond I, Grignon S, et al. DRD3 Ser9Gly polymorphism is related to thermal pain perception and modulation in chronic widespread pain patients and healthy controls. J Pain 2009;10:969-75.
14. Lee YH, Choi SJ, Ji JD, Song GG. Candidate gene studies of fibromyalgia: a systematic review and meta-analysis. Rheumatol Int 2010; Dec 1 (E-pub ahead of print).
15. Thompson MD, Siminovitch KA, Cole DE. G protein-coupled receptor pharmacogenetics. Methods Mol Biol 2008;448:139-85.
16. Yasuda K, Matsunaga T, Adachi T, Aoki N, Tsujimoto G, Tsuda K. Adrenergic receptor polymorphisms and autonomic nervous system function in human obesity. Trends Endocrinol Metab 2006;17:269-75. (Pubitemid 44287471)
17. Small KM, McCraw DW, Liggett SB. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu Rev Pharmacol Toxicol 2003;43:381-411. (Pubitemid 37372647)
18. Catapano LA, Manji HK. G protein-coupled receptors in major psychiatric disorders. Biochim Biophys Acta 2007;1768:976-93. (Pubitemid 46463941)
19. Mann JJ, Brown RP, Halper JP, Sweeney JA, Kocsis JH, Stokes PE, et al. Reduced sensitivity of lymphocyte beta-adrenergic receptor in patients with endogenous depression and psychomotor agitation. N Engl J Med 1985;313:715-20. (Pubitemid 15232424)
20. Maekawa K, Twe C, Lotaif A, Chiappelli F, Clark GT. Function of beta-adrenergic receptors on mononuclear cells in female patients with fibromyalgia. J Rheumatol 2003;30:364-8. (Pubitemid 36152606)
21. Reihsaus E, Innis M, MacIntyre N, Liggett SB. Mutations in the gene encoding for the beta2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 1993;8:334-9.
22. Chong LK, Chowdry J, Ghahramani P, Peachell PT. Influence of genetic polymorphisms in the beta2-adrenoreceptor on the desensitization in human lung mast cells. Pharmacogenetics 2000;10:153-62. (Pubitemid 30193077)
23. Tan S, Hall TP, Dewar J, Dow E, Lipworth B. Association between beta2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitization in moderately severe stable asthmatics. Lancet 1997;350:995-9. (Pubitemid 27421109)
24. Green SA, Cole G, Jacinto M, Innis M, Liggett SB. A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J Biol Chem 1993;268:23116-21.
25. Bleecker ER, Postma DS, Lawrance RM, Meyers DA, Ambrose HJ, Goldman M. Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies. Lancet 2007;370:2118-25.
26. Russell IJ, Fletcher EM, Michalek JE, McBroom PC, Hester GG. Treatment of primary fibrositis/fibromyalgia syndrome with ibuprofen and alprazolam. A double-blind, placebo-controlled study. Arthritis Rheum 1991;34:552-60.
27. Burckhardt CS, Clark SR, Bennett RM. The Fibromyalgia Impact Questionnaire: development and validation. J Rheumatol 1991;18:728-33.
28. Zung WW. The measurement of affects: depression and anxiety. Mod Probl Pharmacopsychiatry 1974;7:170-88.
29. Jenkins CD, Stanton BA, Niemcryk SJ, Rose RM. A scale for the estimation of sleep problems in clinical research. J Clin Epidem 1988;41:313-21.
30. Russell IJ. The reliability of algometry in the assessment of patients with fibromyalgia syndrome. J Musculoskelet Pain 1998;6:139-52.
31. Martinez FD, Graves PE, Baldini M, Solomon S, Erickson R. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997;100:3184-8.
32. Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve - an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000;52:595-638.
33. Hocking LJ, Smith BH, Jones GT, Reid DM, Strachan DP, Macfarlane GJ. Genetic variation in the beta2-adrenergic receptor but not catecholamine-O- methyltransferase predisposes to chronic pain: results from the 1958 British Birth Cohort Study. Pain 2010;149:143-51.
34. Diatchenko L, Anderson AD, Slade GD, Fillingim RB, Shabalina SA, Higgins TJ, et al. Three major haplotypes of the b2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet Part B 2006;141B:449-62.
35. Xiao YM, Upadhyaya B, Haynes WL, Michalek JE, Russell IJ. Heterotrimeric G-protein functionalities in lymphocytes from people with the fibromyalgia syndrome [abstract]. Arthritis Rheum 2006;54 Suppl:S610-1.
36. Vargas-Alarcón G, Fragoso JM, Cruz-Robles D, Vargas A, Martinez A, Lao-Villadóniga JI, et al. Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains. Arthritis Rheum 2009;60:2169-73.
37. Smith MT, Edwards RR, McCann UD, Haythornthwaite JA. The effects of sleep deprivation on pain inhibition and spontaneous pain in women. Sleep 2007;30:494-505.
38. Dishy V, Sofowora GG, Xie HG, Kim RB, Byrne DW, Stein CM, et al. The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med 2001;345:1030-5.
39. Miller GE, Chen E. Life stress and diminished expression of genes encoding glucocorticoid receptor and β2-adrenergic receptor in children with asthma. Proc Natl Acad Sci USA 2006;103:5496-501.
40. Xiao RP, Zhu W, Zheng M, Cao C, Zhang Y. Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart. Trends Pharmacol Sci 2006;27:330-7.
41. Xu BY, Arlehag L, Rantapää-Dahlquist SB, Lefvert AK. Beta2 adrenoceptor gene single nucleotide polymorphisms are associated with rheumatoid arthritis in northern Sweden. Ann Rheum Dis 2005;64:773-6.
42. Green SA, Turki J, Bejarano P, Hall IP, Liggett SB. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 1995;13:25-33.
43. Ohe M, Munakata M, Hizawa N, Itoh A, Doi I, Yamaguchi E, et al. Beta 2 adrenergic receptor gene restriction fragment length polymorphism and bronchial asthma. Thorax 1995;50:353-9.
44. Gratze G, Fortin J, Labugger R, Binder A, Kotanko P, Timmermann B, et al. Beta-2 adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult Caucasians. Hypertension 1999;33:1425-30.
45. Kaufmann I, Schelling G, Eisner C, Richter HP, Krauseneck T, Vogeser M, et al. Anandamide and neutrophil function in patients with fibromyalgia. Psychoneuroendocrinology 2008;33:676-85.
46. Yunus MB, Dailey JW, Aldag JC, Masi AT, Jobe PC. Plasma and urinary catecholamines in primary fibromyalgia: a controlled study. J Rheumatol 1992;19:95-7.
47. Arnold L, Mease P, Silverman S. Pregabalin: an alpha2-delta (alpha2-delta) ligand for the management of fibromyalgia. Am J Manag Care 2010;5 Suppl:S138-43.
48. Russell IJ, Mease P, Smith T, Kajdasz D, Wohlreich M, Detke MJ, et al. Efficacy and safety of duloxetine for the treatment of fibromyalgia in patients with or without major depressive disorder: results from a 6-month randomized, double-blind, placebo-controlled, fixed-dosed trial. Pain 2008;136:432-44.
49. Mease PJ, Clauw DJ, Gendreau RM, Rao SG, Kranzler J, Chen W, et al. The efficacy and safety of milnacipran for treatment of fibromyalgia: a randomized, double-blind, placebo-controlled trial. J Rheumatol 2009;36:1-12.
50. Large V, Hellström L, Reynisdottir S, Lonnqvist FEP, Lannfelt L, Arner P. Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function. J Clin Invest 1997;100:3005-13.