메뉴 건너뛰기




Volumn 121, Issue 2, 2011, Pages 343-356

ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: Roles of cadmium and ceramide transport

Author keywords

Cell death; Multidrug resistance; P glycoprotein; Sphingolipids; Transition metal

Indexed keywords

ANTIBODY; CADMIUM 109; CERAMIDE; MULTIDRUG RESISTANCE PROTEIN 1; RHODAMINE 123; UIC 2 ANTIBODY; UNCLASSIFIED DRUG; VALSPODAR;

EID: 79957862796     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr071     Document Type: Article
Times cited : (46)

References (47)
  • 1
    • 17144424240 scopus 로고    scopus 로고
    • Heterologously expressed bacterial and human multidrug resistance proteins confer cadmium resistance to Escherichia coli
    • Achard-Joris, M., van den Berg van Saparoea, H. B., Driessen, A. J., and Bourdineaud, J. P. (2005). Heterologously expressed bacterial and human multidrug resistance proteins confer cadmium resistance to Escherichia coli. Biochemistry 44, 5916-5922.
    • (2005) Biochemistry , vol.44 , pp. 5916-5922
    • Achard-Joris, M.1    van den Berg van Saparoea, H.B.2    Driessen, A.J.3    Bourdineaud, J.P.4
  • 2
    • 33847697804 scopus 로고    scopus 로고
    • A cadmium-transporting P1B-type ATPase in yeast Saccharomyces cerevisiae
    • Adle, D. J., Sinani, D., Kim, H., and Lee, J. (2007). A cadmium-transporting P1B-type ATPase in yeast Saccharomyces cerevisiae. J. Biol. Chem. 282, 47-955.
    • (2007) J. Biol. Chem. , vol.282 , pp. 947-955
    • Adle, D.J.1    Sinani, D.2    Kim, H.3    Lee, J.4
  • 4
    • 0033952264 scopus 로고    scopus 로고
    • N-butyldeoxygalactonojirimycin: a more selective inhibitor of glycosphingolipid biosynthesis than N-butsyldeoxynojirimycin, in vitro and in vivo
    • Andersson, U., Butters, T. D., Dwek, R. A., and Platt, F. M. (2000). N-butyldeoxygalactonojirimycin: a more selective inhibitor of glycosphingolipid biosynthesis than N-butsyldeoxynojirimycin, in vitro and in vivo. Biochem. Pharmacol. 59, 821-829.
    • (2000) Biochem. Pharmacol. , vol.59 , pp. 821-829
    • Andersson, U.1    Butters, T.D.2    Dwek, R.A.3    Platt, F.M.4
  • 5
    • 0029729308 scopus 로고    scopus 로고
    • Increase of P-glycoprotein-mediated drug resistance by hsp 90 beta
    • Bertram, J., Palfner, K., Hiddemann, W., and Kneba, M. (1996). Increase of P-glycoprotein-mediated drug resistance by hsp 90 beta. Anticancer Drugs 7, 38-845.
    • (1996) Anticancer Drugs , vol.7 , pp. 838-845
    • Bertram, J.1    Palfner, K.2    Hiddemann, W.3    Kneba, M.4
  • 6
    • 75149167512 scopus 로고    scopus 로고
    • Cadmium-induced DNA damage triggers G2/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells
    • Bork, U., Lee, W.-K., Kuchler, A., Dittmar, T., and Thévenod, F. (2010). Cadmium-induced DNA damage triggers G2/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells. Am. J. Physiol. Renal. Physiol. 298, F255-F265.
    • (2010) Am. J. Physiol. Renal. Physiol. , vol.298
    • Bork, U.1    Lee, W.-K.2    Kuchler, A.3    Dittmar, T.4    Thévenod, F.5
  • 7
    • 0036074018 scopus 로고    scopus 로고
    • Mammalian ABC transporters in health and disease
    • Borst, P., and Elferink, R. O. (2002). Mammalian ABC transporters in health and disease. Annu. Rev. Biochem. 71, 537-592.
    • (2002) Annu. Rev. Biochem. , vol.71 , pp. 537-592
    • Borst, P.1    Elferink, R.O.2
  • 8
    • 0029910521 scopus 로고    scopus 로고
    • Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans
    • Broeks, A., Gerrard, B., Allikmets, R., Dean, M., and Plasterk, R. H. (1996). Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO. J. 15, 6132-6143.
    • (1996) EMBO. J. , vol.15 , pp. 6132-6143
    • Broeks, A.1    Gerrard, B.2    Allikmets, R.3    Dean, M.4    Plasterk, R.H.5
  • 9
    • 77951957445 scopus 로고    scopus 로고
    • Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells
    • Chakraborty, P. K., Lee, W. K., Molitor, M., Wolff, N. A., and Thevenod, F. (2010). Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells. Mol. Cancer 9, 102.
    • (2010) Mol. Cancer , vol.9 , pp. 102
    • Chakraborty, P.K.1    Lee, W.K.2    Molitor, M.3    Wolff, N.A.4    Thevenod, F.5
  • 11
    • 70349270680 scopus 로고    scopus 로고
    • Conversion of MDCK cell line to suspension culture by transfecting with human siat7e gene and its application for influenza virus production
    • Chu, C., Lugovtsev, V., Golding, H., Betenbaugh, M., and Shiloach, J. (2009). Conversion of MDCK cell line to suspension culture by transfecting with human siat7e gene and its application for influenza virus production. Proc. Natl. Acad. Sci. U. S. A. 106, 14802-14807.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 14802-14807
    • Chu, C.1    Lugovtsev, V.2    Golding, H.3    Betenbaugh, M.4    Shiloach, J.5
  • 12
    • 22544457473 scopus 로고    scopus 로고
    • The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids
    • Eckford, P. D., and Sharom, F. J. (2005). The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple lycosphingolipids. Biochem. J. 389, 517-526.
    • (2005) Biochem. J. , vol.389 , pp. 517-526
    • Eckford, P.D.1    Sharom, F.J.2
  • 13
    • 0036941904 scopus 로고    scopus 로고
    • Effects of P-glycoprotein inhibitors on cadmium accumulation in cultured renal epithelial cells, LLCPK1, and OK
    • Endo, T., Kimura, O., and Sakata, M. (2002). Effects of P-glycoprotein inhibitors on cadmium accumulation in cultured renal epithelial cells, LLCPK1, and K. Toxicol. Appl. Pharmacol. 185, 166-171.
    • (2002) Toxicol. Appl. Pharmacol. , vol.185 , pp. 166-171
    • Endo, T.1    Kimura, O.2    Sakata, M.3
  • 14
    • 0242426661 scopus 로고    scopus 로고
    • Apoptosis by Cd2+ or CdMT in proximal tubule cells: different uptake routes and permissive role of endo/ lysosomal CdMT uptake
    • Erfurt, C., Roussa, E., and Thevenod, F. (2003). Apoptosis by Cd2+ or CdMT in proximal tubule cells: different uptake routes and permissive role of endo/ lysosomal CdMT uptake. Am. J. Physiol. Cell Physiol. 285, C1367-C1376.
    • (2003) Am. J. Physiol. Cell Physiol. , vol.285
    • Erfurt, C.1    Roussa, E.2    Thevenod, F.3
  • 15
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: role of ATP-dependent transporters
    • Gottesman, M. M., Fojo, T., and Bates, S. E. (2002). Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer 2, 48-58.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 16
    • 31844444140 scopus 로고    scopus 로고
    • The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research
    • Gottesman, M. M., and Ling, V. (2006). The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research. FEBS. Lett. 580, 98-1009.
    • (2006) FEBS. Lett. , vol.580 , pp. 998-1009
    • Gottesman, M.M.1    Ling, V.2
  • 17
    • 17044400063 scopus 로고    scopus 로고
    • Increased functional expression of P-glycoprotein in Caco-2 TC7 cells exposed long-term to cadmium
    • Huynh-Delerme, C., Huet, H., Noel, L., Frigieri, A., and Kolf-Clauw, M. (2005). Increased functional expression of P-glycoprotein in Caco-2 TC7 cells xposed long-term to cadmium. Toxicol. In Vitro 19, 439-447.
    • (2005) Toxicol. In Vitro , vol.19 , pp. 439-447
    • Huynh-Delerme, C.1    Huet, H.2    Noel, L.3    Frigieri, A.4    Kolf-Clauw, M.5
  • 18
    • 67649649748 scopus 로고    scopus 로고
    • Mechanisms of cadmium carcinogenesis
    • Joseph, P. (2009). Mechanisms of cadmium carcinogenesis. Toxicol. Appl. Pharmacol. 238, 272-279.
    • (2009) Toxicol. Appl. Pharmacol. , vol.238 , pp. 272-279
    • Joseph, P.1
  • 19
    • 17144465167 scopus 로고    scopus 로고
    • ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2
    • Keppler, D., Leier, I., Jedlitschky, G., and Konig, J. (1998). ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2. Chem. Biol. Interact. 111-112, 153-161.
    • (1998) Chem. Biol. Interact. , vol.111-112 , pp. 153-161
    • Keppler, D.1    Leier, I.2    Jedlitschky, G.3    Konig, J.4
  • 20
    • 12444257005 scopus 로고    scopus 로고
    • Effects of P-glycoprotein inhibitors on transepithelial transport of cadmium in cultured renal epithelial cells, transepithelial transport of cadmium in cultured renal epithelial cells, LLC-PK1 and LLC-GA5-COL-150
    • Kimura, O., Endo, T., Hotta, Y., and Sakata, M. (2005). Effects of P-glycoprotein inhibitors on transepithelial transport of cadmium in cultured renal epithelial cells, transepithelial transport of cadmium in cultured renal epithelial cells, LLC-PK1 and LLC-GA5-COL-150. Toxicology 208, 123-132.
    • (2005) Toxicology , vol.208 , pp. 123-132
    • Kimura, O.1    Endo, T.2    Hotta, Y.3    Sakata, M.4
  • 23
    • 33749385170 scopus 로고    scopus 로고
    • Caspase-dependent and -independent pathways for cadmium-induced apoptosis in cultured kidney proximal tubule cells
    • Lee, W. K., Abouhamed, M., and Thevenod, F. (2006). Caspase-dependent and -independent pathways for cadmium-induced apoptosis in cultured kidney proximal tubule cells. Am. J. Physiol. Renal Physiol. 291, F823-F832.
    • (2006) Am. J. Physiol. Renal Physiol. , vol.291
    • Lee, W.K.1    Abouhamed, M.2    Thevenod, F.3
  • 24
    • 34548775994 scopus 로고    scopus 로고
    • Cadmium-induced ceramide formation triggers calpain-dependent apoptosis in cultured kidney proximal tubule cells
    • Lee, W. K., Torchalski, B., and Thevenod, F. (2007). Cadmium-induced ceramide formation triggers calpain-dependent apoptosis in cultured kidney proximal tubule cells. Am. J. Physiol. Cell Physiol. 293, C839-C847.
    • (2007) Am. J. Physiol. Cell Physiol. , vol.293
    • Lee, W.K.1    Torchalski, B.2    Thevenod, F.3
  • 25
    • 78649698888 scopus 로고    scopus 로고
    • Static pressure accelerates ox-LDL-induced cholesterol accumulation via SREBP-1-mediated caveolin-1 downregulation in cultured vascular smooth muscle cells
    • Luo, D. X., Xia, C. L., Li, J. M., Xiong, Y., Yuan, H. Y., Tang, Z. W., Zeng, Y., and Liao, D. F. (2010). Static pressure accelerates ox-LDL-induced cholesterol accumulation via SREBP-1-mediated caveolin-1 downregulation in cultured vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 403, 52-8.
    • (2010) Biochem. Biophys. Res. Commun. , vol.403 , pp. 52-58
    • Luo, D.X.1    Xia, C.L.2    Li, J.M.3    Xiong, Y.4    Yuan, H.Y.5    Tang, Z.W.6    Zeng, Y.7    Liao, D.F.8
  • 26
    • 65249183817 scopus 로고    scopus 로고
    • Study of oxidized lipids as endogenous substrates of P-gp (ABCB1)
    • Masuda, M., Nakai, E., and Mizutani, T. (2008). Study of oxidized lipids as endogenous substrates of P-gp (ABCB1). Drug Metab. Lett. 2, 238-244.
    • (2008) Drug Metab. Lett. , vol.2 , pp. 238-244
    • Masuda, M.1    Nakai, E.2    Mizutani, T.3
  • 27
    • 0026711242 scopus 로고
    • Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody
    • Mechetner, E. B., and Roninson, I. B. (1992). Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc. Natl. cad. Sci. U. S. A. 89, 5824-5828.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 5824-5828
    • Mechetner, E.B.1    Roninson, I.B.2
  • 28
    • 77953687856 scopus 로고    scopus 로고
    • Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier
    • Miller, D. S. (2010). Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier. Trends Pharmacol. Sci. 31, 246-254.
    • (2010) Trends Pharmacol. Sci. , vol.31 , pp. 246-254
    • Miller, D.S.1
  • 29
    • 0029890656 scopus 로고    scopus 로고
    • Sensitive detection of metallothioneins-1, -2 and -3 in tissue homogenates by immunoblotting: a method for enhanced membrane transfer and retention
    • Mizzen, C. A., Cartel, N. J., Yu, W. H., Fraser, P. E., and McLachlan, D. R. (1996). Sensitive detection of metallothioneins-1, -2 and -3 in tissue homogenates by immunoblotting: a method for enhanced membrane transfer and retention. J. Biochem. Biophys. Methods 32, 77-83.
    • (1996) J. Biochem. Biophys. Methods , vol.32 , pp. 77-83
    • Mizzen, C.A.1    Cartel, N.J.2    Yu, W.H.3    Fraser, P.E.4    McLachlan, D.R.5
  • 30
    • 0026340512 scopus 로고
    • Cadmium causes increases of N-myc and multidrug-resistance gene mRNA in neuroblastoma cells
    • Murakami, T., Ohmori, H., Katoh, T., Abe, T., and Higashi, K. (1991). Cadmium causes increases of N-myc and multidrug-resistance gene mRNA in euroblastoma cells. J. UOEH. 13, 271-278.
    • (1991) J. UOEH. , vol.13 , pp. 271-278
    • Murakami, T.1    Ohmori, H.2    Katoh, T.3    Abe, T.4    Higashi, K.5
  • 32
    • 0025864903 scopus 로고
    • Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system
    • Neyfakh, A. A., Bidnenko, V. E., and Chen, L. B. (1991). Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system. Proc. Natl. Acad. Sci. U. S. A. 88, 4781-4785.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 4781-4785
    • Neyfakh, A.A.1    Bidnenko, V.E.2    Chen, L.B.3
  • 33
    • 0035399826 scopus 로고    scopus 로고
    • Glucosylceramide synthase inhibition enhances vincristine-induced cytotoxicity
    • Olshefski, R. S., and Ladisch, S. (2001). Glucosylceramide synthase inhibition enhances vincristine-induced cytotoxicity. Int. J. Cancer 93, 131-138.
    • (2001) Int. J. Cancer , vol.93 , pp. 131-138
    • Olshefski, R.S.1    Ladisch, S.2
  • 35
    • 0035849506 scopus 로고    scopus 로고
    • Phospholipid flippase activity of the reconstituted Pglycoprotein multidrug transporter
    • Romsicki, Y., and Sharom, F. J. (2001). Phospholipid flippase activity of the reconstituted Pglycoprotein multidrug transporter. Biochemistry 40, 6937-947.
    • (2001) Biochemistry , vol.40 , pp. 6937-6947
    • Romsicki, Y.1    Sharom, F.J.2
  • 36
    • 58149277751 scopus 로고    scopus 로고
    • Roles of bioactive sphingolipids in cancer biology and therapeutics
    • Saddoughi, S. A., Song, P., and Ogretmen, B. (2008). Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem. 49, 413-440.
    • (2008) Subcell Biochem , vol.49 , pp. 413-440
    • Saddoughi, S.A.1    Song, P.2    Ogretmen, B.3
  • 38
    • 0034602178 scopus 로고    scopus 로고
    • Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens
    • Tepper, A. D., Diks, S. H., van Blitterswijk, W. J., and Borst, J. (2000). Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens. J. Biol. Chem. 275, 34810-34817.
    • (2000) J. Biol. Chem. , vol.275 , pp. 34810-34817
    • Tepper, A.D.1    Diks, S.H.2    van Blitterswijk, W.J.3    Borst, J.4
  • 39
    • 0038271589 scopus 로고    scopus 로고
    • Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K(+)-ATPase through proteasomal and endo-/lysosomal proteolytic pathways
    • Thevenod, F., and Friedmann, J. M. (1999). Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K(+)-ATPase through proteasomal and endo-/lysosomal proteolytic pathways. FASEB. J. 13, 1751-1761.
    • (1999) FASEB. J. , vol.13 , pp. 1751-1761
    • Thevenod, F.1    Friedmann, J.M.2
  • 40
    • 0034695660 scopus 로고    scopus 로고
    • Upregulation of multidrug resistance P-glycoprotein via nuclear factor-kappa B activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis
    • Thevenod, F., Friedmann, J. M., Katsen, A. D., and Hauser, I. A. (2000). Upregulation of multidrug resistance P-glycoprotein via nuclear factor-kappa B activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis. J. Biol. Chem. 275, 1887-1896.
    • (2000) J. Biol. Chem. , vol.275 , pp. 1887-1896
    • Thevenod, F.1    Friedmann, J.M.2    Katsen, A.D.3    Hauser, I.A.4
  • 41
    • 34548329097 scopus 로고    scopus 로고
    • Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells
    • Thevenod, F., Wolff, N. A., Bork, U., Lee, W. K., and Abouhamed, M. (2007). Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells. Biometals 20, 807-820.
    • (2007) Biometals , vol.20 , pp. 807-820
    • Thevenod, F.1    Wolff, N.A.2    Bork, U.3    Lee, W.K.4    Abouhamed, M.5
  • 42
    • 0007544439 scopus 로고    scopus 로고
    • MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
    • van Helvoort, A., Smith, A. J., Sprong, H., Fritzsche, I., Schinkel, A. H., Borst, P., and van Meer, G. (1996). MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 87, 507-517.
    • (1996) Cell , vol.87 , pp. 507-517
    • van Helvoort, A.1    Smith, A.J.2    Sprong, H.3    Fritzsche, I.4    Schinkel, A.H.5    Borst, P.6    van Meer, G.7
  • 43
  • 44
    • 33646589316 scopus 로고    scopus 로고
    • Sphingolipid signaling and redox regulation
    • Won, J. S., and Singh, I. (2006). Sphingolipid signaling and redox regulation. Free Radic. Biol. Med. 40, 1875-1888.
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 1875-1888
    • Won, J.S.1    Singh, I.2
  • 45
    • 0029830096 scopus 로고    scopus 로고
    • Immortalization and characterization of proximal tubule cells derived from kidneys of spontaneously hypertensive and normotensive rats
    • Woost, P. G., Orosz, D. E., Jin, W., Frisa, P. S., Jacobberger, J. W., Douglas, J. G., and Hopfer, U. (1996). Immortalization and characterization of proximal tubule cells derived from kidneys of spontaneously hypertensive and normotensive rats. Kidney Int. 50, 125-134.
    • (1996) Kidney Int , vol.50 , pp. 125-134
    • Woost, P.G.1    Orosz, D.E.2    Jin, W.3    Frisa, P.S.4    Jacobberger, J.W.5    Douglas, J.G.6    Hopfer, U.7
  • 46
    • 0034282519 scopus 로고    scopus 로고
    • Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis
    • Yamada, T., Takaoka, A. S., Naishiro, Y., Hayashi, R., Maruyama, K., Maesawa, C., Ochiai, A., and Hirohashi, S. (2000). Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis. Cancer Res. 60, 4761-4766.
    • (2000) Cancer Res , vol.60 , pp. 4761-4766
    • Yamada, T.1    Takaoka, A.S.2    Naishiro, Y.3    Hayashi, R.4    Maruyama, K.5    Maesawa, C.6    Ochiai, A.7    Hirohashi, S.8
  • 47
    • 0034036739 scopus 로고    scopus 로고
    • Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin
    • Zhurinsky, J., Shtutman, M., and Ben-Zèev, A. (2000). Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and lakoglobin. Mol. Cell Biol. 20, 4238-4252.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 4238-4252
    • Zhurinsky, J.1    Shtutman, M.2    Ben-Zèev, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.