Synthesis of renieramycins: Construction of the core ring system of cribrostatin 4 through modified Pictet-Spengler cyclization of 3,6-bisarylpiperazine-2,5-dione with diethoxyethyl benzoate

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 6, 2011, Pages 787-792

  Yokoya, Masashi ^a   Ito, Hiroshi ^a   Saito, Naoki ^a  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cribrostatin 4; Marine natural product; Pictet Spengler cyclization; Preparation; Tetrahydroisoquinoline

Indexed keywords

3,6 BISARYLPIPERAZINE 2,5 DIONE DERIVATIVE; ALKALOID DERIVATIVE; CRIBOSTATIN 4; DIETHOXYETHYL BENZOATE; NITROGEN; RENIERAMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; HYDROGENATION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BENZOATES; CYCLIZATION; HYDROGENATION; ISOQUINOLINES; MOLECULAR CONFORMATION; PIPERAZINES; TETRAHYDROISOQUINOLINES;

EID: 79957837553     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.787     Document Type: Article

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