Short synthesis of piperizinohydroisoquinoline ring by selective Pictet-Spengler cyclization and evaluation of antitumor activity

Tetrahedron

Volumn 63, Issue 36, 2007, Pages 8781-8787

  Chang, Yu An ^a   Sun, Tsung Hsien ^b   Chiang, Michael Y ^b   Lu, Pei Jung ^c   Huang, Yi Ting ^c   Liang, Li Ching ^c   Ong, Chi Wi ^b  

^a CHUNG CHOU INSTITUTE OF TECHNOLOGY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4,10,13 TETRAMETHOXY 9,16 DIMETHYL 5,6,9,15 TETRAHYDRO 6,15 IMINOISOQUINO[3,2B] 3 BENZAZOCINE 7 ONE; 2 BENZYLOXYCARBONYL 7,10 DIMETHOXY 3 (2,5 DIMETHOXYBENZYL) 6 METHYL 2,3,11,11A TETRAHYDRO 6H PYRAZINO[1,2B]ISOQUINOLINE 1,4 DIONE; 3,6 BIS[(2,5 DIMETHOXY PHENYL)METHYL]PIPERIZINE 2,5 DIONE; 7 HYDROXY 1,4,10,13 TETRAMETHOXY 9,16 DIMETHYL 5,6,9,15 TETRAHYDRO 6,15 IMINOISOQUINO[3,2B] 3 BENZAZOCINE; 7,10 DIMETHOHY 3 (2,5 DIMETHOXYBENZYL) 6 METHYL 2,3,11,11A TETRAHYDRO 6H PYRAZINO[1,2B]ISOQUINOLINE 1,4 DIONE; ALDEHYDE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZYL 1,4,10,13 TETRAMETHOXY 9 METHYL 7 OXO 5,6,9,15 TETRAHYDRO 6,15 IMINOISOQUINO[3,2B] 3 BENZAZOCINE 16 CARBOXYLIC ACID; CRIBROSTATIN; ET 729; ISOQUINOLINE DERIVATIVE; RENIERAMYCIN C; RENIERAMYCIN F; SAFRAMYCIN; SAFRAMYCIN A; SAFRAMYCIN B; SAFRAMYCIN S; TRABECTEDIN; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DEHYDROGENATION; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; MOUTH CANCER; PICTET SPENGLER REACTION; PRIORITY JOURNAL; SYNTHESIS; UTERINE CERVIX CANCER;

EID: 34547109880     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2007.06.030     Document Type: Article

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