Synthesis of the tetrahydroisoquinoline alkaloid (±)-renieramycin G and a (zb)-lemonomycinone analogue from a common intermediate

Journal of the American Chemical Society

Volumn 127, Issue 36, 2005, Pages 12476-12477

  Magnus, Philip ^a   Matthews, Kenneth S ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; LEMONOMYCINONE; RENIERAMYCIN G; SAFRAMYCIN; TETRAHYDROISOQUINOLINE DERIVATIVE; TRABECTEDIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG SYNTHESIS; STEREOCHEMISTRY; X RAY ANALYSIS;

ALKALOIDS; MOLECULAR CONFORMATION; STEREOISOMERISM; TETRAHYDROISOQUINOLINES;

EID: 24744436189     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0535817     Document Type: Article

References (26)

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21. 2O, 85% yield, X-ray) gave a 1:1 mixture of cis:trans isomers, crystallizing as a 4:1 mixture.
22. 2, 1 h, 85% yield. X-ray).
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25. An authentic sample of renieramycin G was not available for comparison, but spectral data were consistent with published data (ref 2).
26. We are grateful to Prof. R. M. Williams for sending us a preprint of their manuscript describing the synthesis of (-)-renieramycin G.