Alleviating allergic airway diseases by means of short-term administration of IL-2 and dexamethasone

Journal of Allergy and Clinical Immunology

Volumn 127, Issue 6, 2011, Pages

  Ma, Jiexian ^a   Yang, Apeng ^a   Qin, Wenming ^c   Shi, Yi ^c   Zhao, Botao ^b   Jin, Youxin ^b,c   Xie, Yanhui ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY   (China)

^c INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

CD25; FoxO3a; Regulatory T cells

Indexed keywords

DEXAMETHASONE; PROTEIN KINASE; PROTEIN KINASE B; RECOMBINANT INTERLEUKIN 2; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR FOXP3A; UNCLASSIFIED DRUG;

ALLERGIC AIRWAY DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL PROTECTION; COMBINATION CHEMOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT ALLERGY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; UPREGULATION;

EID: 79957830804     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.01.032     Document Type: Article

References (21)

1. Sears MR. Epidemiology of childhood asthma. Lancet 1997;350:1015-20. (Pubitemid 27421119)
2. Wills-Karp M, Santeliz J, Karp CL. The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev Immunol 2001;1:69-75. (Pubitemid 33741977)
3. Wilson MS, Taylor MD, Balic A. Suppression of allergic airway inflammation by helminth-induced regulatory T cells. J Exp Med 2005;202:1199-212. (Pubitemid 41586951)
4. Wilson MS, Pesce JT, Ramalingam TR, Thompson RW, Cheever A, Wynn TA. Suppression of murine allergic airway disease by IL-2: anti-IL-2 monoclonal antibody-induced regulatory T cells. J Immunol 2008;181:6942-54.
5. Kearley J, Barker JE, Robinson DS, Lloyd CM. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J Exp Med 2005;202:1539-47. (Pubitemid 41746600)
6. Hadeiba H, Locksley RM. Lung CD25+ CD4+ regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol 2003;170:5502-10. (Pubitemid 36617838)
7. Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF, et al. In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2002;195:603.
8. Jeffery LE, Burke F, Mura M, Zheng Y, Qureshi OS, Hewison M, et al. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol 2009;183:5458-67.
9. Chen X, Oppenheim JJ, Winkler-Pickett RT, Ortaldo JR, Howard OMZ. Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3+CD4+CD25+ T regulatory cells in vivo and enhances their capacity to suppress EAE. Eur J Immunol 2006;36:2139-49. (Pubitemid 44251759)
10. Polte T. CD137-mediated immunotherapy for allergic asthma. J Clin Invest 2006;116:1025-36.
11. Chuang Y-H, Suen J-L, Chiang B-L. Fas-ligand-expressing adenovirus-transfected dendritic cells decrease allergen-specific T cells and airway inflammation in a murine model of asthma. J Mol Med 2006;84:595-603. (Pubitemid 43992851)
12. Ma J, Xie Y, Shi Y, Qin W. Glucocorticoid-induced apoptosis requires FoxO3a activity. Biochem Biophys Res Commun 2008;377:894-8.
13. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-6. (Pubitemid 36432314)
14. Yanhui Xie. Min Wu. Glucocorticoid amplifies IL-2-induced expansion of CD4+CD25+FOXP3+ regulatory T cells in vivo selectively and suppresses graft versus host disease after allogeneic lymphocyte transplantation. Acta Biochim Biophys Sin 2009;41:781-91.
15. + T cell homeostasis. J Immunol 2008;181:1806-13.
16. Brunet A, Park J, Tran H. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 2001;21:952-6.
17. Cottrez F, Hurst SD, Coffman RL, Groux HS. T regulatory cells 1 inhibit a Th2-specific response in vivo. J Immunol 2000;165:4848-53.
18. Tamang DL, Redelman D, Alves BN. Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens: multiclonal responses that are extremely lytic if triggered and short-lived after cytokine withdrawal. Cytokine 2006;36:148-59. (Pubitemid 46275463)
19. Yamagiwa S, Gray JD, Hashimoto S. A role for TGF-β in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol 2001;166:7282-9. (Pubitemid 32525603)
20. Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA. IL-2 receptor β-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol 2007;178:280-90. (Pubitemid 46033611)
21. Murray PJ. The JAK-STAT signaling pathway: input and output integration. J Immunol 2007;178:2623-9. (Pubitemid 46333135)