Design and synthesis of protein kinase Cα activators based on 'out of pocket' interactions

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 12, 2011, Pages 3587-3590

  Hirai, Go ^a   Ohkubo, Megumi ^a   Tamura, Yuki ^a,b   Sodeoka, Mikiko ^a,b  

^a RIKEN   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Binding model; Enzymatic activity; Isobenzofuranone derivatives; myo Inositol; Protein kinase C

Indexed keywords

PHORBOL ESTER; PHTHALIDE DERIVATIVE; PROTEIN KINASE C ALPHA;

ARTICLE; BINDING AFFINITY; DRUG BINDING SITE; DRUG DESIGN; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; DRUG DESIGN; ENZYME ACTIVATION; ENZYME ACTIVATORS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PHORBOL ESTERS; PROTEIN BINDING; PROTEIN KINASE C-ALPHA;

EID: 79957797258     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.108     Document Type: Article

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