A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: Development of a synthetically accessible protein kinase C activator with bryostatin-like activity

Journal of the American Chemical Society

Volumn 131, Issue 22, 2009, Pages 7573-7579

  Nakagawa, Yu ^a   Yanagita, Ryo C ^a   Hamada, Naoko ^a   Murakami, Akira ^a   Takahashi, Hideyuki ^b   Saito, Naoaki ^b   Nagai, Hiroshi ^c   Irie, Kazuhiro ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KOBE UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF MARINE SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALZHEIMER'S DISEASE; ANTI-TUMOR; ANTICANCER ACTIVITIES; ANTINEOPLASTIC AGENTS; BRYOSTATIN 1; CLINICAL TRIAL; EPSTEIN-BARR VIRUS; FURTHER DEVELOPMENT; HUMAN CANCER CELLS; HUMAN IMMUNODEFICIENCY VIRUS; INHIBITORY EFFECT; NATURAL SOURCES; NATURALLY OCCURRING; NUCLEAR MEMBRANES; PHENYLACETATE; PHORBOL ESTERS; PROTEIN KINASE C; THERAPEUTIC AGENTS; THERAPEUTIC STRATEGY; THERAPEUTIC TARGETS; THERAPEUTIC USE;

CELL CULTURE; CELL MEMBRANES; CHEMICAL ACTIVATION; ESTERS;

TUMORS;

APLYSIATOXIN; BRYOSTATIN; EPSTEIN BARR VIRUS ANTIGEN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C EPSILON; TUMOR PROMOTER; ANTINEOPLASTIC AGENT; BRYOSTATIN 1; LYNGBYATOXIN; PROTEIN KINASE C DELTA;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL NUCLEUS MEMBRANE; CHO CELL; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; NONHUMAN; TUMOR PROMOTION; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; KINETICS; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BRYOSTATINS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HUMANS; KINETICS; LYNGBYA TOXINS; PROTEIN KINASE C-DELTA;

EID: 67650558672     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja808447r     Document Type: Article

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