A brief focus on hepatoprotective leads from herbal origin

International Journal of Pharmacology

Volumn 7, Issue 2, 2011, Pages 212-216

  Ansari, J A ^a   Ali, S ^b   Ansari, M A ^c  

^a MESCO College of Pharmacy   (India)

^b ANNAMALAI UNIVERSITY   (India)

^c Varanasi College of Pharmacy   (India)

Author keywords

Liver toxicity; Part of plant; Plant extract

Indexed keywords

ALISMA ORIENTALE EXTRACT; ANDROGRAPHIS LINEATA EXTRACT; ARONIA MELANOCARPA EXTRACT; BIDENS PILOSA EXTRACT; CAREYA ARBOREA EXTRACT; CASSIA OCCIDENTALIS EXTRACT; CIRSIUM SETIDENS EXTRACT; CUSCUTA CHINENSIS EXTRACT; CYPERUS SCARIOSUS EXTRACT; FUMARIA INDICA EXTRACT; GANODERMA LUCIDUM EXTRACT; GLYCERRHIZA GLABRA EXTRACT; GREEN TEA EXTRACT; HEDYOTIS CORYMBOSA EXTRACT; HIBISCUS SABDARIFFA EXTRACT; HYPERICUM JAPONICUM EXTRACT; LACTUCA INDICA EXTRACT; LEUCOPHYLLUM FRUTESCENS EXTRACT; MYRISTICA FRAGRANS EXTRACT; PHYLLANTHUS POLYPHYLLUS EXTRACT; PHYLLANTHUS RHEEDII EXTRACT; PICORRHIZA KURROA EXTRACT; PIPER CHABA EXTRACT; PLANT EXTRACT; PUERARIA LOBATA EXTRACT; RUMES PATIENTIA EXTRACT; SILYMARIN; SOLANUM NIGRUM EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZANTHOXYLUM PIPERITUM EXTRACT;

ACUTE LIVER FAILURE; ANDROGRAPHIS LINEATA; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CAREYA ARBOREA; CASSIA OCCIDENTALIS; CHRONIC LIVER DISEASE; CIRSIUM SETIDENS; FLOWER; FRUIT; FUMARIA INDICA; HERBAL MEDICINE; HUMAN; HYPERICUM JAPONICUM; IMMUNOMODULATION; LACTUCA INDICA; LIVER DISEASE; LIVER DYSFUNCTION; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; NONHUMAN; PATENT; PHYLLANTHUS POLYPHYLLUS; PICORRHIZA KURROA; PIPER CHABA; PLANT LEAF; PLANT SEED; RHIZOME; SYMPTOMATOLOGY; TRADITIONAL MEDICINE; WOOD; ZANTHOXYLUM PIPERITUM;

EID: 79957790736     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2011.212.216     Document Type: Article

References (58)

1. Aftab, A., K.K. Pillai and K. Abdul, 2007. Hepatoprotective effect of jigrine. J. Ethnopharmacol., 79: 35-35.
2. Amin, A. and A. A. Hamza, 2005. Hepatoprotective effects of hibiscus, rosmarinus and salvia on azathioprine-induced toxicity in rats. Life Sci., 77: 266-278.
3. Ansari, J.A., A.M. Khan and M.B. Anwar, 2009. Liver toxicity caused by synthetic drugs. J. Chem. Pharm. Sci., 2: 265-269.
4. Ansari, J.A., 2010. Therapeutic approaches in management of drug-induced hepatotoxicity. J. Biol. Sci., 10: 386-395.
5. Ansari, J.A. and N.N. Inamdar, 2010. The promise of traditional medicines. Int. J. Pharmacol., 6: 808-812.
6. Balderas-Renteria, I., M.R. Camacho-Corona, P. Carranza-Rosales, H.G. Lozano-Garza, D. Castillo-Nava, F.J. Alvarez-Mendoza and E.M. Tamez-Cantu, 2007. Hepatoprotective effect of Leucophyttum frutescens on Wistar albino rats intoxicated with carbon tetrachloride. Ann. Hepatol., 6: 251-254.
7. Chattopadhyay, R.R., 2003. Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: Part II. J. Ethnopharmacol., 89: 217-219.
8. Chattopadhyay, R.R. and M. Bandyopadhyay, 2005. Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract against paracetamol-induced hepatic damage in rats: Part III. Indian J. Pharmacol, 37: 184-185.
9. Dhiman, R.K. and Y.K. Chawla, 2005. Herbal Medicines for liver diseases. Digestive Dis. Sci., 10: 1807-1812.
10. Germano, M.P., V. D'Angelo, R. Sanogo, S. Catania, R. Alma, R. De Pasquale and G. Bisignano, 2005. Hepatoprotective and Antibacterial effects of Trichilia emetica Vahl. (Meliaceae). J. Ethnopharmacol., 96: 227-232.
11. Gilani, A.U. and K.H. Janbaz, 1995. Studies on protective effect of Cyperus scariosus extract on acetaminophen and CC14 induced hepatotoxicity. General Pharmacol., 26: 627-631.
12. Han, G.P., Z.Y. Wang and S.L. Peng, 1997. Binggan capsule combined with interferon for treatment of 30 cases of hepatitis C. Henan Zhongyi, 12: 43-44.
13. Handa, S.S., A. Sharma and K.K. Chakraborti, 1986. Natural products and plants as liver protecting drugs. Fitoterapia, 57: 307-351.
14. Hur, J.M., J.W. Choi and J.C. Park, 2007. Effects of methanol extract oiAlisma orientale rhizome and its major component, alisol B 23-acetate, on hepatic drug metabolizing enzymes in rats treated with bromobenzene. Arch. Pharm. Res., 30: 1543-1549.
15. Huseini, F., S.M. Alavian, R. Heshmat, M.R. Heydari and K. Abolmaali, 2005. The efficacy of Liv-52 on liver cirrhotic patients: A randomized, double-blind, placebo-controlled first approach. Phytomedicine, 12: 619-624.
16. Hwang, Y.P., C.Y. Choi, Y.C. Chung, S.S. Jeon and H.G. Jeong, 2007. Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. Arch. Pharm. Res., 30: 1309-1317.
17. Jafn, M.A., M.J. Subham, K. Javed and S. Singh, 1999. Hepatoprotective activity of leaves of Cassia occidentalis against paracetamol and ethyl alcohol intoxication in rats. J. Ethnopharmacol., 66: 355-361.
18. Jiang, Y.H., 1999. Treatment of 20 cases of hepatitis C using a self-prescribed yizhu oral liquid. Nanjing Zhongyiyao Daxue Xuebao, 15: 256-256.
19. Kaviarasan, S. and C.V. Anuradha, 2007. Fenugreek (Trigonella foenum graecum) seed polyphenols protect liver alcohol toxicity: A role on hepatic detoxification system and apoptosis. Pharmazi, 62: 299-304.
20. Kim, K.H., Y.H. Kim and K.R. Lee, 2007. Isolation of quimc acid derivatives and flavonoids from the aerial parts of Lactuca indica L. and their hepatoprotective activity in vitro. Bioorg. Med. Chem. Lett, 17: 6739-6743.
21. Lee, H.S., K.Y. Keum and S.K. Ku, 2007. Effects of Picrorrhiza rhizoma water extracts on the subacute liver damages induced by carbon tetrachloride. J. Med. Food, 10: 110-117.
22. Lee, S.H., S.I. Heo, L. Li, M.J. Lee and M.H. Wang, 2008a. Antioxidant and hepatoprotective activities of Cirsium setidens NAKAI against CC1 (4)-induced liver damage. Am. J. Chin. Med., 36: 107-114.
23. Lee, ST., H.J. Kim and Y.C. Boo, 2008b. Effect of green tea and (-)-epigallocatechin gallate on ethanol-induced toxicity in HepG2 cells. Phytother. Res., 22: 669-674.
24. Lee, S.J. andK.T. Lim, 2008. Glycoprotein of Zanthoxylum piperitum DC has a hepatoprotective effect via anti-oxidative character in vivo and in vitro. Toxicol. In Vitro, 22: 376-385.
25. Lin, H.M., H.C. Tseng, C.J. Wang, J.J. Lm, C.W. Lo and F.P. Chou, 2008. Hepatoprotective effects of Solanum nigrum Linn extract against CC14-iduced oxidative damage in rats. Chem. Biol. Interact, 171: 283-293.
26. Lone, I.A., G. Kaur, M. Athar and M.S. Alam, 2007. Protective effect of Rumex patentia (English Spinach) roots on ferric nitrilotriacetate (Fe-NTA) induced hepatic oxidative stress and tumor promotion response. Food Chem. Toxiol., 45: 1821-1829.
27. Luper, N.D.S., 1998. A review of plants used in the treatment of liver disease: Part 1. J. Alter. Med. Rev., 3: 410-421.
28. Matsuda, H., K. Ninomiya, T. Morikawa, D. Yasuda, I. Yamaguchi and M. Yoshikawa, 2008. Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alpha-induced cell death in mouse hepatocytes. Bioorg. Med. Chem. Lett., 18: 2038-2042.
29. Nan, J.X., X.J. Jin, L.H. Lian, X.F. Cai, Y.Z. Jiang, H.R. Jin and J.J. Lee, 2008. A diterpenoid acanthoic acid from Acanthopanax koreanum protects against D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice. Biol. Pharm. Bull., 31: 738-742.
30. Padhy, B.M., A. Srivastava and V.L. Kumar, 2007. Calotropis procera latex affords protection against carbon tetrachloride induced hepatotoxicity in rats. J. Ethnopharmacol., 113: 498-502.
31. Pei, Z.G., Y.L. Liu and S.M. Zhao, 1996. Therapeutic observation on Binggan decoction combined with interferon in treating 46 cases of hepatitis C. Shiyong Zhongxiyi Jiehe Linchuang, 9: 444-444.
32. Pramyothin, P., H. Chirdchupunsare, A. Rungsipipat and C. Chaichantipyuth, 2005. Hepatoprotective activity of Thunbergia laurifolia Linn extract in rats treated with ethanol: In vitro and In vivo studies. J. Ethnopharmacol., 102: 408-411.
33. Pramyothin, P., P. Samosorn, S. Poungshompoo and C. Chaichantipyuth, 2006. The protective effects of Phyllanthus emblica Linn, extract on ethanol induced rat hepatic injury. J. Ethnopharmacol., 107: 361-364.
34. Preetha, S.P., M. Kanniappan, E. Selvakumar, M. Nagaraj and P. Varalakshmi, 2006. Lupeol ameliorates aflatoxin B-l-induced peroxidative hepatic damage in rats. Comp. Biochem. Physiol. C Toxicol. Pharmacol., 143: 333-339.
35. Rahman, S. and S. Sultana, 2007. Protective effects of Picorrhiza kurroa extract against 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats. J. Environ. Pathol. Toxicol. Oncol., 26: 195-205.
36. Rajesh, M.G. and M.S. Latha, 2004. Preliminary evaluation of the antihepatotoxic activity of Kamilari, a polyherbal formulation. J. Ethnopharmacol., 91: 99-104.
37. Rajkapoor, B., Y. Venugopal, J. Anbu and N. Harikrishnan, 2008. Protective effect of Phyllanthus polyphyllus on acetaminophen induced hepatotoxicity in rats. Pak. J. Pharm. Sci., 21: 57-62.
38. Rathi, A., A.K. Srivastava, A. Shirwaikar, A.K.S. Rawat and S. Mehrotra, 2007. Hepatoprotective potential of Fumaria indica Pugsley whole plant extracts, fractions and an isolated alkaloid protopine. Phytomedicine, 15: 470-477.
39. Sangameswaran, B., T.C. Reddy and B. Jayakar, 2008. Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats. Phytother. Res., 22: 124-126.
40. Senthilkumar, N., S. Badami, S.H. Dongre and S. Bhojraj, 2008. Antioxidant and hepatoprotective activity of the methanol extract of Careya arborea bark in Ehrlich ascites carcinoma-bearing mice. J. Nat. Med., 62: 336-339.
41. Shi, Y., J. Sun, H. He, H. Guo and S. Zhang, 2008. Hepatoprotective effects of Ganoderma lucidum peptides against D-galactosamine-induced liver injury in mice. J. Ethnopharmacol., 117: 415-419.
42. Shyur, L.F., C.C. Huang, CP. Lo, C.Y. Chiu, Y.P. Chen, S.Y. Wang and S.T. Chang, 2008. Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators. Phytochem., 69: 1348-1358.
43. Sini, S., P.G. Lathab, J.M. Sasikumara, S. Rajashekaranb, S. Shyamal and V.J. Shine, 2006. Hepatoprotective studies on Hedyotis corymbosa (L.) Lam. J. Ethnopharmacol, 106: 245-249.
44. Sohn, J.H., K.L. Han, J.H. Kim, Y. Rukayadi and J.K. Hwang, 2008. Protective effects of macelignan on cisplatin-induced hepatotoxicity is associated with JNK activation. Biol. Pharm. Bull, 31: 273-277.
45. Song, Y.W. and Y.Z. Song, 1994. Observation of Chinese herbal treatment based on spleen and kidney on asymptomatic carriers of hepatitis B virus. Zhejiang Zhongyi Zazhi, 12: 487-488.
46. Shekel, F. and D. Schuppan, 2007. Herbal medicine in the treatment of liver diseases. Dig. Liver Dis., 39: 293-304.
47. Suresh, K.S.V., C. Sujatha, J. Syamala, B. Nagasudha and S.H. Mishra, 2006. Protective effect of root extract of Operculina turpethum L. against paracetamol-induced hepatotoxicity in rats. Indian J. Pharm. Sci., 68: 32-35.
48. Suresh, V. and V.V. Asha, 2008. Preventive effect of ethanol extract of Phyllanthus rheedii Wight, on D-galactosamine induced hepatic damage in Wistar rats. J. Ethnopharmacol, 116: 447-453.
49. Thyagarajan, S.P., S. Jayaram, V. Gopalakrishnan, R. Hari, P. Jeyakumar and M.S. Sripathi, 2002. Herbal medicines for liver diseases in India. J. Gastroenterol. Hepatol, 17: S370-S376.
50. Trease, G.E. and W.C. Evans, 2002. Pharmacognosy. 15th Edn., WB Saunders, London, ISBN: 8131200876, pp: 406.
51. Valcheva-Kuzmanova, S., K. Marazova, I. Krasnaliev, B. Galunska, P. Borisova and A. Belcheva, 2005. Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in rats. Exp. Toxicol. Pathol, 56: 385-392.
52. Wang, N, P. Li, Y. Wang, W. Peng and Z. Wuetal., 2008. Hepatoprotective effect of Hypericum japonicum extract and its fractions. J. Ethnopharmacol, 116:1-6.
53. Yamashiki, M., A. Nishimura, H. Suzuki, S. Sakaguchi and Y. Kosaka, 1997. Effects of the Japanese herbal medicine Sho-saiko-to (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C. Hepatology, 25: 1390-1397.
54. Yang, M., K. Chen and J.C. Shih, 2000. Yang-Gan-Wan protect mice against experimental liver damage. Am. J. Chin. Med., 28: 155-162.
55. Yen, F.L., T.H. Wu, L.T. Lin, T.M. Cham and C.C. Lin, 2008. Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats. Food Chem. Toxicol, 46: 1771-1777.
56. Yoo, Y.M., J.H. Nam, M.Y. Kim, J. Choi and H.J. Park, 2008. Pectolinarin and pectolinarigenin of Cirsium setidens prevent the hepatic injury in rats caused by D-galactosamine via an antioxidant mechanism. Biol. Pharm. Bull, 31: 760-764.
57. Yu, W., 1995. Yi Er Gan decoction for treatment of 40 cases of hepatitis C. Xin Zhongyi, 27: 46-47.
58. Yuan, L.P., F.H. Chen, L. Ling, P.F. Dou, H. Bo, M.M. Zhong and L.J. Xia, 2008. Protective effects of total flavonoids oiBidens pilosa L. (TFB) on animal liver injury and liver fibrosis. J. Ethnopharmacol, 116: 539-546.