-
1
-
-
0030477686
-
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
-
Alcorta D.A., Xiong Y., Phelps D., Hannon G., Beach D., Barrett J.C. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:13742-13747.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 13742-13747
-
-
Alcorta, D.A.1
Xiong, Y.2
Phelps, D.3
Hannon, G.4
Beach, D.5
Barrett, J.C.6
-
2
-
-
0029111404
-
Increased activity of p53 in senescing fibroblasts
-
Atadja P., Wong H., Garkavtsev I., Veillette C., Riabowol K. Increased activity of p53 in senescing fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:8348-8352.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 8348-8352
-
-
Atadja, P.1
Wong, H.2
Garkavtsev, I.3
Veillette, C.4
Riabowol, K.5
-
3
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
-
Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005, 120:513-522.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
4
-
-
34548186667
-
Cellular senescence: when bad things happen to good cells
-
Campisi J., d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 2007, 8:729-740.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 729-740
-
-
Campisi, J.1
d'Adda di Fagagna, F.2
-
5
-
-
44649095065
-
Unexpected pieces to the senescence puzzle
-
Cichowski K., Hahn W.C. Unexpected pieces to the senescence puzzle. Cell 2008, 133:958-961.
-
(2008)
Cell
, vol.133
, pp. 958-961
-
-
Cichowski, K.1
Hahn, W.C.2
-
6
-
-
12144285600
-
Proteases, extracellular matrix, and cancer: a workshop of the path B study section
-
DeClerck Y.A., Mercurio A.M., Stack M.S., Chapman H.A., Zutter M.M., Muschel R.J., Raz A., Matrisian L.M., Sloane B.F., Noel A., Hendrix M.J., Coussens L., Padarathsingh M. Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am. J. Pathol. 2004, 164:1131-1139.
-
(2004)
Am. J. Pathol.
, vol.164
, pp. 1131-1139
-
-
DeClerck, Y.A.1
Mercurio, A.M.2
Stack, M.S.3
Chapman, H.A.4
Zutter, M.M.5
Muschel, R.J.6
Raz, A.7
Matrisian, L.M.8
Sloane, B.F.9
Noel, A.10
Hendrix, M.J.11
Coussens, L.12
Padarathsingh, M.13
-
7
-
-
34347209876
-
Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9
-
Denault J.B., Eckelman B.P., Shin H., Pop C., Salvesen G.S. Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem. J. 2007, 405:11-19.
-
(2007)
Biochem. J.
, vol.405
, pp. 11-19
-
-
Denault, J.B.1
Eckelman, B.P.2
Shin, H.3
Pop, C.4
Salvesen, G.S.5
-
8
-
-
45549088468
-
Expression, purification, and characterization of caspases
-
(Chapter 21, Unit 21)
-
Denault J.B., Salvesen G.S. Expression, purification, and characterization of caspases. Curr. Protoc. Protein Sci. 2003, 13. (Chapter 21, Unit 21).
-
(2003)
Curr. Protoc. Protein Sci.
, pp. 13
-
-
Denault, J.B.1
Salvesen, G.S.2
-
9
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:9363-9367.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.E.7
Linskens, M.8
Rubelj, I.9
Pereira-Smith, O.10
-
10
-
-
0035158471
-
Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism
-
Galbiati F., Volonte D., Liu J., Capozza F., Frank P.G., Zhu L., Pestell R.G., Lisanti M.P. Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism. Mol. Biol. Cell 2001, 12:2229-2244.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 2229-2244
-
-
Galbiati, F.1
Volonte, D.2
Liu, J.3
Capozza, F.4
Frank, P.G.5
Zhu, L.6
Pestell, R.G.7
Lisanti, M.P.8
-
11
-
-
0022004518
-
Molecular cloning of a bovine cathepsin
-
Gay N.J., Walker J.E. Molecular cloning of a bovine cathepsin. Biochem. J. 1985, 225:707-712.
-
(1985)
Biochem. J.
, vol.225
, pp. 707-712
-
-
Gay, N.J.1
Walker, J.E.2
-
12
-
-
1842789989
-
Mechanisms of cellular senescence in human and mouse cells
-
Itahana K., Campisi J., Dimri G.P. Mechanisms of cellular senescence in human and mouse cells. Biogerontology 2004, 5:1-10.
-
(2004)
Biogerontology
, vol.5
, pp. 1-10
-
-
Itahana, K.1
Campisi, J.2
Dimri, G.P.3
-
13
-
-
0033525019
-
Transforming growth factor beta triggers two independent-senescence programs in cancer cells
-
Katakura Y., Nakata E., Miura T., Shirahata S. Transforming growth factor beta triggers two independent-senescence programs in cancer cells. Biochem. Biophys. Res. Commun. 1999, 255:110-115.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.255
, pp. 110-115
-
-
Katakura, Y.1
Nakata, E.2
Miura, T.3
Shirahata, S.4
-
15
-
-
21044440422
-
Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues
-
Kos J., Sekirnik A., Premzl A., Zavasnik Bergant V., Langerholc T., Turk B., Werle B., Golouh R., Repnik U., Jeras M., Turk V. Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues. Exp. Cell Res. 2005, 306:103-113.
-
(2005)
Exp. Cell Res.
, vol.306
, pp. 103-113
-
-
Kos, J.1
Sekirnik, A.2
Premzl, A.3
Zavasnik Bergant, V.4
Langerholc, T.5
Turk, B.6
Werle, B.7
Golouh, R.8
Repnik, U.9
Jeras, M.10
Turk, V.11
-
16
-
-
23944468031
-
Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer
-
Krueger S., Kalinski T., Hundertmark T., Wex T., Kuster D., Peitz U., Ebert M., Nägler D.K., Kellner U., Malfertheiner P., Naumann M., Rocken C., Roessner A. Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer. J. Pathol. 2005, 207:32-42.
-
(2005)
J. Pathol.
, vol.207
, pp. 32-42
-
-
Krueger, S.1
Kalinski, T.2
Hundertmark, T.3
Wex, T.4
Kuster, D.5
Peitz, U.6
Ebert, M.7
Nägler, D.K.8
Kellner, U.9
Malfertheiner, P.10
Naumann, M.11
Rocken, C.12
Roessner, A.13
-
17
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680.
-
(1970)
Nature
, vol.227
, pp. 680
-
-
Laemmli, U.K.1
-
18
-
-
53849083069
-
Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion
-
Latini F.R., Hemerly J.P., Oler G., Riggins G.J., Cerutti J.M. Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion. Endocr. Relat. Cancer 2008, 15:787-799.
-
(2008)
Endocr. Relat. Cancer
, vol.15
, pp. 787-799
-
-
Latini, F.R.1
Hemerly, J.P.2
Oler, G.3
Riggins, G.J.4
Cerutti, J.M.5
-
19
-
-
33845986378
-
RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties
-
Lechner A.M., Assfalg-Machleidt I., Zahler S., Stoeckelhuber M., Machleidt W., Jochum M., Nägler D.K. RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties. J. Biol. Chem. 2006, 281:39588-39597.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 39588-39597
-
-
Lechner, A.M.1
Assfalg-Machleidt, I.2
Zahler, S.3
Stoeckelhuber, M.4
Machleidt, W.5
Jochum, M.6
Nägler, D.K.7
-
21
-
-
0043063959
-
Synergistic decline in expressions of p73 and p21 with invasion in esophageal cancers
-
Masuda N., Kato H., Nakajima T., Sano T., Kashiwabara K., Oyama T., Kuwano H. Synergistic decline in expressions of p73 and p21 with invasion in esophageal cancers. Cancer Sci. 2003, 94:612-617.
-
(2003)
Cancer Sci.
, vol.94
, pp. 612-617
-
-
Masuda, N.1
Kato, H.2
Nakajima, T.3
Sano, T.4
Kashiwabara, K.5
Oyama, T.6
Kuwano, H.7
-
22
-
-
33749017931
-
Cysteine cathepsins: multifunctional enzymes in cancer
-
Mohamed M.M., Sloane B.F. Cysteine cathepsins: multifunctional enzymes in cancer. Nat. Rev. Cancer 2006, 6:764-775.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 764-775
-
-
Mohamed, M.M.1
Sloane, B.F.2
-
23
-
-
17744380207
-
Cathepsin X binds to cell surface heparan sulfate proteoglycans
-
Nascimento F.D., Rizzi C.C., Nantes I.L., Stefe I., Turk B., Carmona A.K., Nader H.B., Juliano L., Tersariol I.L. Cathepsin X binds to cell surface heparan sulfate proteoglycans. Arch. Biochem. Biophys. 2005, 436:323-332.
-
(2005)
Arch. Biochem. Biophys.
, vol.436
, pp. 323-332
-
-
Nascimento, F.D.1
Rizzi, C.C.2
Nantes, I.L.3
Stefe, I.4
Turk, B.5
Carmona, A.K.6
Nader, H.B.7
Juliano, L.8
Tersariol, I.L.9
-
24
-
-
56849118516
-
Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
-
Nogueira V., Park Y., Chen C.C., Xu P.Z., Chen M.L., Tonic I., Unterman T., Hay N. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 2008, 14:458-470.
-
(2008)
Cancer Cell
, vol.14
, pp. 458-470
-
-
Nogueira, V.1
Park, Y.2
Chen, C.C.3
Xu, P.Z.4
Chen, M.L.5
Tonic, I.6
Unterman, T.7
Hay, N.8
-
25
-
-
2942563740
-
Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia
-
Nägler D.K., Krüger S., Kellner A., Ziomek E., Ménard R., Buhtz P., Krams M., Roessner A., Kellner U. Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia. Prostate 2004, 60:109-119.
-
(2004)
Prostate
, vol.60
, pp. 109-119
-
-
Nägler, D.K.1
Krüger, S.2
Kellner, A.3
Ziomek, E.4
Ménard, R.5
Buhtz, P.6
Krams, M.7
Roessner, A.8
Kellner, U.9
-
26
-
-
30844444331
-
An enzyme-linked immunosorbent assay for human cathepsin X, a potential new inflammatory marker
-
Nägler D.K., Lechner A.M., Oettl A., Kozaczynska K., Scheuber H.P., Gippner-Steppert C., Bogner V., Biberthaler P., Jochum M. An enzyme-linked immunosorbent assay for human cathepsin X, a potential new inflammatory marker. J. Immunol. Methods 2006, 308:241-250.
-
(2006)
J. Immunol. Methods
, vol.308
, pp. 241-250
-
-
Nägler, D.K.1
Lechner, A.M.2
Oettl, A.3
Kozaczynska, K.4
Scheuber, H.P.5
Gippner-Steppert, C.6
Bogner, V.7
Biberthaler, P.8
Jochum, M.9
-
27
-
-
0040234054
-
Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions
-
Nägler D.K., Ménard R. Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions. FEBS Lett. 1998, 434:135-139.
-
(1998)
FEBS Lett.
, vol.434
, pp. 135-139
-
-
Nägler, D.K.1
Ménard, R.2
-
28
-
-
0040366645
-
Human cathepsin X: a cysteine protease with unique carboxypeptidase activity
-
Nägler D.K., Zhang R., Tam W., Sulea T., Purisima E.O., Ménard R. Human cathepsin X: a cysteine protease with unique carboxypeptidase activity. Biochemistry 1999, 38:12648-12654.
-
(1999)
Biochemistry
, vol.38
, pp. 12648-12654
-
-
Nägler, D.K.1
Zhang, R.2
Tam, W.3
Sulea, T.4
Purisima, E.O.5
Ménard, R.6
-
29
-
-
0034617210
-
Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells
-
Park W.Y., Park J.S., Cho K.A., Kim D.I., Ko Y.G., Seo J.S., Park S.C. Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells. J. Biol. Chem. 2000, 275:20847-20852.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 20847-20852
-
-
Park, W.Y.1
Park, J.S.2
Cho, K.A.3
Kim, D.I.4
Ko, Y.G.5
Seo, J.S.6
Park, S.C.7
-
30
-
-
12244286059
-
Loss of p16 expression is associated with histological features of melanoma invasion
-
Pavey S.J., Cummings M.C., Whiteman D.C., Castellano M., Walsh M.D., Gabrielli B.G., Green A., Hayward N.K. Loss of p16 expression is associated with histological features of melanoma invasion. Melanoma Res. 2002, 12:539-547.
-
(2002)
Melanoma Res.
, vol.12
, pp. 539-547
-
-
Pavey, S.J.1
Cummings, M.C.2
Whiteman, D.C.3
Castellano, M.4
Walsh, M.D.5
Gabrielli, B.G.6
Green, A.7
Hayward, N.K.8
-
31
-
-
54049117149
-
On the role of major vault protein in the resistance of senescent human diploid fibroblasts to apoptosis
-
Ryu S.J., An H.J., Oh Y.S., Choi H.R., Ha M.K., Park S.C. On the role of major vault protein in the resistance of senescent human diploid fibroblasts to apoptosis. Cell Death Differ. 2008, 15:1673-1680.
-
(2008)
Cell Death Differ.
, vol.15
, pp. 1673-1680
-
-
Ryu, S.J.1
An, H.J.2
Oh, Y.S.3
Choi, H.R.4
Ha, M.K.5
Park, S.C.6
-
32
-
-
34247371847
-
Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts
-
Ryu S.J., Oh Y.S., Park S.C. Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts. Cell Death Differ. 2007, 14:1020-1028.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 1020-1028
-
-
Ryu, S.J.1
Oh, Y.S.2
Park, S.C.3
-
33
-
-
0345687901
-
PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression
-
Seminario M.C., Precht P., Wersto R.P., Gorospe M., Wange R.L. PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression. Oncogene 2003, 22:8195-8204.
-
(2003)
Oncogene
, vol.22
, pp. 8195-8204
-
-
Seminario, M.C.1
Precht, P.2
Wersto, R.P.3
Gorospe, M.4
Wange, R.L.5
-
34
-
-
77249161680
-
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice
-
Sevenich L., Schurigt U., Sachse K., Gajda M., Werner F., Muller S., Vasiljeva O., Schwinde A., Klemm N., Deussing J., Peters C., Reinheckel T. Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:2497-2502.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 2497-2502
-
-
Sevenich, L.1
Schurigt, U.2
Sachse, K.3
Gajda, M.4
Werner, F.5
Muller, S.6
Vasiljeva, O.7
Schwinde, A.8
Klemm, N.9
Deussing, J.10
Peters, C.11
Reinheckel, T.12
-
35
-
-
2342570379
-
Hallmarks of senescence in carcinogenesis and cancer therapy
-
Shay J.W., Roninson I.B. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004, 23:2919-2933.
-
(2004)
Oncogene
, vol.23
, pp. 2919-2933
-
-
Shay, J.W.1
Roninson, I.B.2
-
36
-
-
3242752701
-
The role of replicative senescence in cancer and human ageing: utility (or otherwise) of murine models
-
Smith S.K., Kipling D. The role of replicative senescence in cancer and human ageing: utility (or otherwise) of murine models. Cytogenet. Genome Res. 2004, 105:455-463.
-
(2004)
Cytogenet. Genome Res.
, vol.105
, pp. 455-463
-
-
Smith, S.K.1
Kipling, D.2
-
37
-
-
34548133214
-
Single exposure of human fibroblasts (WI-38) to a sub-cytotoxic dose of UVB induces premature senescence
-
Straface E., Vona R., Ascione B., Matarrese P., Strudthoff T., Franconi F., Malorni W. Single exposure of human fibroblasts (WI-38) to a sub-cytotoxic dose of UVB induces premature senescence. FEBS Lett. 2007, 581:4342-4348.
-
(2007)
FEBS Lett.
, vol.581
, pp. 4342-4348
-
-
Straface, E.1
Vona, R.2
Ascione, B.3
Matarrese, P.4
Strudthoff, T.5
Franconi, F.6
Malorni, W.7
-
38
-
-
33744917827
-
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer
-
Vasiljeva O., Papazoglou A., Kruger A., Brodoefel H., Korovin M., Deussing J., Augustin N., Nielsen B.S., Almholt K., Bogyo M., Peters C., Reinheckel T. Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res. 2006, 66:5242-5250.
-
(2006)
Cancer Res.
, vol.66
, pp. 5242-5250
-
-
Vasiljeva, O.1
Papazoglou, A.2
Kruger, A.3
Brodoefel, H.4
Korovin, M.5
Deussing, J.6
Augustin, N.7
Nielsen, B.S.8
Almholt, K.9
Bogyo, M.10
Peters, C.11
Reinheckel, T.12
-
39
-
-
0036323674
-
Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts
-
Volonte D., Zhang K., Lisanti M.P., Galbiati F. Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts. Mol. Biol. Cell 2002, 13:2502-2517.
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 2502-2517
-
-
Volonte, D.1
Zhang, K.2
Lisanti, M.P.3
Galbiati, F.4
-
40
-
-
40949141784
-
A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis
-
Weinmann L., Wischhusen J., Demma M.J., Naumann U., Roth P., Dasmahapatra B., Weller M. A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ. 2008, 15:718-729.
-
(2008)
Cell Death Differ.
, vol.15
, pp. 718-729
-
-
Weinmann, L.1
Wischhusen, J.2
Demma, M.J.3
Naumann, U.4
Roth, P.5
Dasmahapatra, B.6
Weller, M.7
-
41
-
-
0031775398
-
Recombinant, replication-defective adenovirus gene transfer vectors induce cell cycle dysregulation and inappropriate expression of cyclin proteins
-
Wersto R.P., Rosenthal E.R., Seth P.K., Eissa N.T., Donahue R.E. Recombinant, replication-defective adenovirus gene transfer vectors induce cell cycle dysregulation and inappropriate expression of cyclin proteins. J. Virol. 1998, 72:9491-9502.
-
(1998)
J. Virol.
, vol.72
, pp. 9491-9502
-
-
Wersto, R.P.1
Rosenthal, E.R.2
Seth, P.K.3
Eissa, N.T.4
Donahue, R.E.5
|