Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion

Endocrine-Related Cancer

Volumn 15, Issue 3, 2008, Pages 787-799

  Latini, Flavia R M ^a   Hemerly, Jefferson P ^a   Oler, Gisele ^a   Riggins, Gregory J ^b   Cerutti, Janete M ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABI3 BINDING PROTEIN; BETA GALACTOSIDASE; BINDING PROTEIN; HETEROCHROMATIN PROTEIN 1; KI 67 ANTIGEN; PROTEIN P21; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL AGING; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; HETEROCHROMATIN; HUMAN; HUMAN CELL; HURTHLE CELL ADENOMA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; THYROID CANCER; THYROID PAPILLARY CARCINOMA; THYROID PARAFOLLICULAR CELL; THYROID TUMOR; TUMOR GROWTH;

ADENOCARCINOMA, FOLLICULAR; ANIMALS; CARRIER PROTEINS; CELL AGING; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; THYROID NEOPLASMS; TRANSFECTION; TUMOR STEM CELL ASSAY; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 53849083069     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/ERC-08-0079     Document Type: Article

References (42)

1. Braig M & Schmitt CA 2006 Oncogene-induced senescence: putting the brakes on tumor development. Cancer Research 66 2881-2884.
2. Brown JP, Wei W & Sedivy JM 1997 Bypass of senescence after disruption of p21CIP1/WAFI gene in normal diploid human fibroblasts. Science 277 831-834.
3. Campisi J 2001 Cellular senescence as a tumor-suppressor mechanism. Trends in Cell Biology 11 S27-S31.
4. Cerutti J, Trapasso F, Battaglia C, Zhang L, Martelli ML, Visconti R, Berlingieri MT, Fagin JA, Santoro M & Fusco A 1996 Block of c-myc expression by antisense oligonucleotides inhibits proliferation of human thyroid carcinoma cell lines. Clinical Cancer Research 2 119-126.
5. Cerutti JM, Delcelo R, Amadei MJ, Nakabashi C, Maciel RM, Peterson B, Shoemaker J & Riggins GJ 2004 A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression. Journal of Clinical Investigation 113 1234-1242.
6. Cerutti JM, Latini FR, Nakabashi C, Delcelo R, Andrade VP, Amadei MJ, Maciel RM, Hojaij FC, Hollis D, Shoemaker J et al. 2006 Diagnosis of suspicious thyroid nodules using four protein biomarkers. Clinical Cancer Research 12 3311-3318.
7. Cerutti JM, Oler G, Michaluart P Jr, Delcelo R, Beaty RM, Shoemaker J & Riggins GJ 2007 Molecular profiling of matched samples identifies biomarkers of papillary thyroid carcinoma lymph node metastasis. Cancer Research 67 7885-7892.
8. Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W et al. 2005 Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436 725-730.
9. Collado M & Serrano M 2006 The power and the promise of oncogene-induced senescence markers. Nature Reviews. Cancer 6 472-476.
10. Collado M, Medema RH, Garcia-Cao I, Dubuisson ML, Barradas M, Glassford J, Rivas C, Burgering BM, Serrano M & Lam EW 2000 Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. Journal of Biological Chemistry 275 21960-21968.
11. Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, Benguria A, Zaballos A, Flores JM, Barbacid M et al. 2005 Tumour biology: senescence in premalignant turnouts. Nature 436 642.
12. Dimri GP, Hara E & Campisi J 1994 Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. Journal of Biological Chemistry 269 16180-16186.
13. Dimri GP, Itahana K, Acosta M & Campisi J 2000 Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Molecular and Cellular Biology 20 273-285.
14. Fagin JA, Matsuo K, Karmakar A, Chen DL, Tang SH & Koeffler HP 1993 High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. Journal of Clinical Investigation 91 179-184.
15. Guimaraes GS, Latini FR, Camacho CP, Maciel RM, Dias-Neto E & Cerutti JM 2006 Identification of candidates for tumor-specific alternative splicing in the thyroid. Genes, Chromosomes and Cancer 45 540-553.
16. Hirao N, Sato S, Gotoh T, Maruoka M, Suzuki J, Matsuda S, Shishido T & Tani K 2006 NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. FEBS Letters 580 6464-6470.
17. Ichigotani Y, Fujii K, Hamaguchi M & Matsuda S 2002a In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review). International Journal of Molecular Medicine 9 591-595.
18. Ichigotani Y, Yokozaki S, Fukuda Y, Hamaguchi M & Matsuda S 2002b Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells. Cancer Research 62 2215-2219.
19. Iervolino A, Iuliano R, Trapasso F, Viglietto G, Melillo RM, Carlomagno F, Santoro M & Fusco A 2006 The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins. Cancer Research 66 6280-6287.
20. Itahana K, Dimri G & Campisi J 2001 Regulation of cellular senescence by p53. European Journal of Biochemistry 268 2784-2791.
21. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE & Fagin JA 2003 High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Research 63 1454-1457.
22. Kyoung Kim H, Kyoung Kim Y, Song IH, Baek SH, Lee SR, Hye Kim J & Kim JR 2005 Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 60 4-9.
23. Linskens MH, Feng J, Andrews WH, Enlow BE, Saati SM, Tonkin LA, Funk WD & Villeponteau B 1995 Cataloging altered gene expression in young and senescent cells using enhanced differential display. Nucleic Acids Research 23 3244-3251.
24. Lowe SW, Cepero E & Evan G 2004 Intrinsic tumour suppression. Nature 432 307-315.
25. Mason DX, Jackson TJ & Lin AW 2004 Molecular signature of oncogenic ras-induced senescence. Oncogene 23 9238-9246.
26. Matsuda S, Iriyama C, Yokozaki S, Ichigotani Y, Shirafuji N, Yamaki K, Hayakawa T & Hamaguchi M 2001 Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3. Journal of Human Genetics 46 483-486.
27. Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, Majoor DM, Shay JW, Mooi WJ & Peeper DS 2005 BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436 720-724.
28. Mitsuuchi Y, Johnson SW, Selvakumaran M, Williams SJ, Hamilton TC & Testa JR 2000 The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel. Cancer Research 60 5390-5394.
29. Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H & Komuro I 2004 Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO Journal 23 212-220.
30. Nagayama Y, Yokoi H, Takeda K, Hasegawa M, Nishihara E, Namba H, Yamashita S & Niwa M 2000 Adenovirus-mediated tumor suppressor p53 gene therapy for anaplastic thyroid carcinoma in vitro and in vivo. Journal of Clinical Endocrinology and Metabolism 85 4081-4086.
31. Narita M, Nunez S, Heard E, Lin AW, Hearn SA, Spector DL, Hannon GJ & Lowe SW 2003 Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113 703-716.
32. Onda M, Nagai H, Yoshida A, Miyamoto S, Asaka S, Akaishi J, Takatsu K, Nagahama M, Ito K, Shimizu K et al. 2004 Up-regulation of transcriptional factor E2F1 in papillary and anaplastic thyroid cancers. Journal of Human Genetics 49 312-318.
33. Ouyang B, Knauf JA, Ain K, Nacev B & Fagin JA 2002 Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1. Clinical Endocrinology 56 341-350.
34. Park C, Lee I & Kang WK 2006 E2F-1 is a critical modulator of cellular senescence in human cancer. International Journal of Molecular Medicine 17 715-720.
35. Serrano M & Blasco MA 2001 Putting the stress on senescence. Current Opinion in Cell Biology 13 748-753.
36. Severino J, Allen RG, Balin S, Balin A & Cristofalo VJ 2000 Is beta-galactosidase staining a marker of senescence in vitro and in vivo? Experimental Cell Research 257 162-171.
37. Terauchi K, Shimada J, Uekawa N, Yaoi T, Maruyama M & Fushiki S 2006 Cancer-associated loss of TARSH gene expression in human primary lung cancer. Journal of Cancer Research and Clinical Oncology 132 28-34.
38. Uekawa N, Terauchi K, Nishikimi A, Shimada J & Maruyama M 2005 Expression of TARSH gene in MEFs senescence and its potential implication in human lung cancer. Biochemical and Biophysical Research Communications 329 1031-1038.
39. Vajkoczy P, Knyazev P, Kunkel A, Capelle HH, Behrndt S, von Tengg-Kobligk H, Kiessling F, Eichelsbacher U, Essig M, Read TA et al. 2006 Dominant-negative inhibition of the Ax1 receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival. PNAS 103 5799-5804.
40. Vuaroqueaux V, Urban P, Labuhn M, Delorenzi M, Wirapati P, Benz CC, Flury R, Dieterich H, Spyratos F, Eppenberger U et al. 2007 Low E2F1 transcript levels are a strong determinant of favorable breast cancer outcome. Breast Cancer Research 9 R33.
41. Xin MG, Zhang J, Block ER & Patel JM 2003 Senescence-enhanced oxidative stress is associated with deficiency of mitochondrial cytochrome c oxidase in vascular endothelial cells. Mechanisms of Ageing and Development 124 911-919.
42. Zhu J, Woods D, McMahon M & Bishop JM 1998 Senescence of human fibroblasts induced by oncogenic Raf. Genes and Development 12 2997-3007.