AME position statement on adrenal incidentaloma

European Journal of Endocrinology

Volumn 164, Issue 6, 2011, Pages 851-870

  Terzolo, M ^a   Stigliano, A ^b   Chiodini, I ^c   Loli, P ^d   Furlani, L ^e   Arnaldi, G ^f   Reimondo, G ^a   Pia, A ^a   Toscano, V ^b   Zini, M ^g   Borretta, G ^h   Papini, E ⁱ   Garofalo, P ^j   Allolio, B ^k   Dupas, B ^l   Mantero, F ^m   Tabarin, A ⁿ  

^a UNIVERSITY OF TURIN   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^d OSPEDALE NIGUARDA CA GRANDA   (Italy)

^e SACRO CUORE DON CALABRIA HOSPITAL   (Italy)

^f Azienda Ospedaliera Umberto I   (Italy)

^g Endocrinology Unit   (Italy)

^h Division of Endocrinology   (Italy)

ⁱ Regina Apostolurum Hospital   (Italy)

^j VILLA SOFIA CERVELLO HOSPITAL   (Italy)

^k UNIVERSITY OF WÜRZBURG   (Germany)

^l NANTES UNIVERSITY HOSPITAL   (France)

^m UNIVERSITY OF PADOVA   (Italy)

ⁿ BORDEAUX UNIVERSITY HOSPITAL   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 11; CATECHOLAMINE; DEXAMETHASONE; FLUORODEOXYGLUCOSE F 18; HYDROCORTISONE; IODINE 123; METOMIDATE; STEROID;

ADRENAL INCIDENTALOMA; ADRENALECTOMY; ASPIRATION BIOPSY; ATTENUATION; CANCER SURGERY; CLINICAL PRACTICE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONSENSUS; CONTRAST ENHANCEMENT; CUSHING SYNDROME; DEXAMETHASONE SUPPRESSION TEST; DRUG MEGADOSE; ENDOCRINOLOGY; EVIDENCE BASED PRACTICE; HUMAN; HYPERCORTISOLISM; HYPERTENSION; HYPOKALEMIA; LOW DRUG DOSE; MEDICAL SOCIETY; METASTASIS; METHODOLOGY; PHEOCHROMOCYTOMA; POSITRON EMISSION TOMOGRAPHY; PRACTICE GUIDELINE; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL; REVIEW; SCREENING; AGE DISTRIBUTION; CANCER INCIDENCE; CANCER RISK; CLINICAL EVALUATION; CONSENSUS DEVELOPMENT; CUSHING DISEASE; DIAGNOSTIC ACCURACY; ECHOGRAPHY; ENDOCRINE FUNCTION TEST; ETHNICITY; HORMONE BLOOD LEVEL; MALIGNANT TRANSFORMATION; MORBIDITY; MORTALITY; NUCLEAR MAGNETIC RESONANCE IMAGING; SCINTIGRAPHY; SENSITIVITY AND SPECIFICITY;

ADRENAL CORTEX HORMONES; ADRENAL GLAND NEOPLASMS; ADRENALECTOMY; CONSENSUS; DISEASE PROGRESSION; HUMANS; INCIDENTAL FINDINGS; ITALY; RISK; TOMOGRAPHY, X-RAY COMPUTED;

EID: 79957739287     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-10-1147     Document Type: Review

References (164)

1. Aron DC. The adrenal incidentaloma: disease of modern technology and public health problem. Reviews in Endocrine and Metabolic Disorders 2001 2 335-342. (doi:10.1023/A:1011580819132)
2. Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, Guyatt GH, Harbour RT, Haugh MC, Henry D, Hill S, Jaeschke R, Leng G, Liberati A, Magrini N, Mason J, Middleton P, Mrukowicz J, O'Connell D, Oxman AD, Phillips B, Schünemann HJ, Edejer TT, Varonen H, Vist GE, Williams JW Jr, Zaza S & GRADE Working Group. Grading quality of evidence and strength of recommendations. BMJ 2004 328 1490-1497. (doi:10.1136/bmj.328.7454.1490)
3. Swiglo BA, Murad MH, Schünemann HJ, Kunz R, Vigersky RA, Guyatt GH & Montori VM. A case for clarity, consistency, and helpfulness: state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system. Journal of Clinical Endocrinology and Metabolism 2008 93 666-673. (doi:10.1210/jc.2007- 1907)
4. Mansmann G, Lau J, Balk E, Rothberg M, Miyachi Y & Bornstein SR. The clinically inapparent adrenal mass: update in diagnosis and management. Endocrine Reviews 2004 25 309-340. (doi:10.1210/er.2002-0031)
5. Grumbach MM, Biller BMK, Braunstein GD, Campbell KK, Carney JA, Godley PA, Harris EL, Lee JKT, Oertel YC, Posner MC, Schlechte JA & Wieand HS. Management of the clinically inapparent adrenal mass ('Incidentaloma'). Annals of Internal Medicine 2003 138 424-429. (Pubitemid 36262654)
6. Kloos RT, Gross MD, Francis IR, Korobkin M & Shapiro B. Incidentally discovered adrenal masses. Endocrine Reviews 1995 16 460-484.
7. Benitah N, Yeh BM, Qayyum A, Williams G, Breiman RS & Coakley FV. Minor morphologic abnormalities of adrenal glands at CT: prognostic importance in patients with lung cancer. Radiology 2005 235 517-522. (doi:10.1148/radiol. 2352031708)
8. Mantero F, Terzolo M, Arnaldi G, Osella G, Masini AM, Ali A, Giovagnetti M, Opocher G & Angeli A. A survey on adrenal incidentaloma in Italy. Study group on adrenal tumors of the Italian Society of Endocrinology. Journal of Clinical Endocrinology and Metabolism 2000 85 637-644. (doi:10.1210/jc.85.2.637)
9. Barzon L, Sonino N, Fallo F, Palù G & Boscaro M. Prevalence and natural history of adrenal incidentalomas. European Journal of Endocrinology 2003 149 273-285. (doi:10.1530/eje.0.1490273)
10. Bovio S, Cataldi A, Reimondo G, Sperone P, Novello S, Berruti A, Borasio P, Fava C, Dogliotti L, Scagliotti GV, Angeli A & Terzolo M. Prevalence of adrenal incidentaloma in a contemporary computerized tomography series. Journal of Endocrinological Investigation 2006 29 298-302. (Pubitemid 43905318)
11. Mayer SK, Oligny LL, Deal C, Yezbeck S, Gagnè N & Blanchard H. Childhood adrenocortical tumours: case series and reevaluation of prognosis - a 24-year experience. Journal of Pediatric Surgery 1997 32 911-915. (doi:10.1016/S0022-3468(97)90649-7)
12. Terzolo M, Osella G, Ali A, Borretta G, Cesario F, Paccotti P & Angeli A. Subclinical Cushing's syndrome in adrenal incidentaloma. Clinical Endocrinology 1998 48 89-97. (doi:10.1046/j.1365-2265.1998.00357.x)
13. Terzolo M, Bovio S, Pia A, Reimondo G & Angeli A. Management of adrenal incidentaloma. Best Practice and Research. Clinical Endocrinology and Metabolism 2009 23 233-243. (doi:10.1016/j.beem.2009.04.001)
14. Bernini G, Moretti A, Argenio G & Salvetti A. Primary aldosteronism in normokalemic patients with adrenal incidentalomas. European Journal of Endocrinology 2002 146 523-529. (doi:10.1530/eje.0.1460523)
15. Cawood TJ, Hunt PJ, O'Shea D, Cole D & Soule S. Recommended evaluation of adrenal incidentalomas is costly, has high false-positive rates and confers a risk of fatal cancer that is similar to the risk of the adrenal lesion becoming malignant; time for a rethink? European Journal of Endocrinology 2009 161 513-527. (doi:10.1530/EJE-09-0234)
16. Young WF. The incidentally discovered adrenal mass. New England Journal of Medicine 2007 356 601-610. (doi:10.1056/NEJMcp065470)
17. Lam KY & Lo CY. Metastatic tumours of the adrenal glands: a 30-year experience in a teaching hospital. Clinical Endocrinology 2002 56 95-101. (doi:10.1046/j.0300-0664.2001.01435.x)
18. Francis IR, Smid A, Gross MD, Shapiro B, Naylor B & Glazer GM. Adrenal masses in oncologic patients: functional and morphologic evaluation. Radiology 1988 166 353-356. (Pubitemid 18030738)
19. Lenert JT, Barnett CC Jr, Kudelk AP, Sellin RV, Gagel RF, Prieto VG, Skibber JM, Ross MI, Pisters PW, Curley SA, Evans DB & Lee JE. Evaluation and surgical resection of adrenal masses in patients with a history of extra-adrenal malignancy. Surgery 2001 130 1060-1067. (doi:10.1067/msy.2001. 118369)
20. Frilling A, Tecklenborg K, Weber F, Kuhl H, Muller S, Stamatis G & Broelsch C. Importance of adrenal incidentaloma in patient with a history of malignancy. Surgery 2004 136 1289-1296. (doi:10.1016/j.surg.2004.06.060)
21. Lee JE, Evans DB, Hickey RC, Sherman SI, Gagel RF, Abbruzzese MC & Abbruzzese JL. Unknown primary cancer presenting as an adrenal mass: frequency and implications for diagnostic evaluation of adrenal incidentalomas. Surgery 1998 124 1115-1122. (doi:10.1067/msy.1998.92009)
22. Michalkiewcz E, Sandrini B, Figueiredo B, Miranda ECM, Caran E, Oliveira-Filho AG, Marques R, Pianovski MAD, Lacerda L, Cristofani LM, Jenkins J, Rodriguez-Galindo C & Ribeiro RC. Clinical and outcome characteristics of children with adrenocortical tumors: a report from the international pediatric adrenocortical tumor registry. Journal of Clinical Oncology 2004 22 838-845. (doi:10.1200/JCO.2004.08.085)
23. Mazzuco TL, Bourdeau I & Lacroix A. Adrenal incidentalomas and subclinical Cushing's syndrome: diagnosis and treatment. Current Opinion in Endocrinology, Diabetes, and Obesity 2009 16 203-210. (doi:10.1097/MED. 0b013e32832b7043)
24. Hamrahian AH, Ioachimescu AG, Remer EM, Motta-Ramirez G, Bogabathina H, Levin HS, Reddy S, Gill IS, Siperstein A & Bravo EL. Clinical utility of noncontrast computed tomography attenuation value (Hounsfield units) to differentiate adrenal adenomas/hyperplasias from nonadenomas: Cleveland Clinic experience. Journal of Clinical Endocrinology and Metabolism 2005 90 871-877. (doi:10.1210/jc.2004-1627)
25. Yeh HC. Sonography of the adrenal glands: normal glands and small masses. American Journal of Roentgenology 1980 135 1167-1177.
26. Suzuki K, Fujita K, Ushiyama T, Mugiya S, Kageyama S & Ishikawa A. Efficacy of an ultrasonic surgical system for laparoscopic adrenalectomy. Journal of Urology 1995 154 484-486. (doi:10.1016/S0022-5347(01)67079-4)
27. Abrams HL, Siegelman SS, Adams DF, Sanders R, Finberg HJ, Hessel SJ & McNeil BJ. Computed tomography versus ultrasound of the adrenal gland: a prospective study. Radiology 1982 143 121-128. (Pubitemid 12142186)
28. Suzuki Y, Sasagawa I, Suzuki H, Izumi T, Kaneko H & Nakada T. The role of ultrasonography in the detection of adrenal masses: comparison with computed tomography and magnetic resonance imaging. International Urology and Nephrology 2001 32 303-306. (doi:10.1023/A:1017583211460)
29. Fontana D, Porpiglia F, Destefanis P, Fiori C, Al? A, Terzolo M, Osella G & Angeli A. What is the role of ultrasonography in the follow up of adrenal incidentalomas? Urology 1999 54 612-616. (doi:10.1016/S0090-4295(99)00226-5)
30. Blake MA, Kalra MK, Sweeney AT, Lucey BC, Maher MM, Sahani DV, Halpern EF, Mueller PR, Hahn PF & Boland GW. Distinguishing benign from malignant adrenal masses: multidetector row CT protocol with 10-minute delay. Radiology 2006 238 578-585. (doi:10.1148/radiol.2382041514)
31. Lee MJ, Hahn PF, Papanicolaou N, Egglin TK, Saini S, Mueller PR & Simeone JF. Benign and malignant adrenal masses: CT distinction with attenuation coefficients, size, and observer analysis. Radiology 1991 179 415-418.
32. Korobkin M, Brodeur FJ, Francis IR, Quint LE, Dunnick NR & Londy F. CT time-attenuation washout curves of adrenal adenomas and nonadenomas. American Journal of Roentgenology 1998 170 747-752. (Pubitemid 28106677)
33. Pena CS, Boland GW, Hahn PF, Lee MJ & Mueller PR. Characterization of indeterminate (lipid-poor) adrenal masses: use of washout characteristics at contrast enhanced CT. Radiology 2000 217 798-802.
34. Caoili EM, Korobkin M, Francis IR, Cohan RH, Platt JF, Dunnick NR & Raghupathi KI. Adrenal masses: characterization with combined unenhanced and delayed enhanced CT. Radiology 2002 222 629-633. (doi:10.1148/radiol.2223010766)
35. Szolar DH & Kammerhuber FH. Adrenal adenomas and nonadenomas: assessment of washout at delayed contrast-enhanced CT. Radiology 1998 207 369-375. (Pubitemid 28259051)
36. Johnson PT, Horton KM & Fishman EK. Adrenal mass imaging with multidetector CT: pathologic conditions, pearls, and pitfalls. Radiographics 2009 29 1333-1351. (doi:10.1148/rg.295095027)
37. Korobkin M, Lombardi TJ, Aisen AM, Francis IR, Quint LE, Dunnick NR, Londy F, Shapiro B, Gross MD & Thompson NW. Characterization of adrenal masses with chemical shift and gadolinium-enhanced MR imaging. Radiology 1995 197 411-418.
38. Outwater EK, Siegelman ES, Radecki PD, Piccoli CW & Mitchell DG. Distinction between benign and malignant adrenal masses: value of T1-weighted chemical-shift MR imaging. American Journal of Roentgenology 1995 165 579-583.
39. Bilbey JH, McLoughlin RF, Kurkjian PS, Wilkins GE, Chan NH, Schmidt N & Singer J. MR imaging of adrenal masses: value of chemical-shift imaging for distinguishing adenomas from other tumors. American Journal of Roentgenology 1995 164 637-642.
40. McNicholas MM, Lee MJ, Mayo-SmithWW, Hahn PF, Boland GW & Mueller PR. An imaging algorithm for the differential diagnosis of adrenal adenomas and metastases. American Journal of Roentgenology 1995 165 1453-1459.
41. Heinz-Peer G, Hönigschnabl S, Schneider B, Niederle B, Kaserer K & Lechner G. Characterization of adrenal masses using MR imaging with histopathologic correlation. American Journal of Roentgenology 1999 173 15-22. (Pubitemid 29291081)
42. Israel GM, Korobkin M, Wang C, Hecht EN & Krinsky GA. Comparison of unenhanced CT and chemical shift MRI in evaluating lipid-rich adrenal adenomas. American Journal of Roentgenology 2004 183 215-219. (Pubitemid 38789040)
43. Haider MA, Ghai S, Jhaveri K & Lockwood G. Chemical shift MR imaging of hyperattenuating (> 10 HU) adrenal masses: does it still have a role? Radiology 2004 231 711-716. (doi:10.1148/radiol.2313030676)
44. Korobkin M. CT characterization of adrenal masses: the time has come. Radiology 2000 217 629-632.
45. Dunnick NR & Korobkin M. Imaging of adrenal incidentalmomas: current status. American Journal of Roentgenology 2002 179 559-568. (Pubitemid 34919559)
46. Park BK, Kim CK, Kim B & Lee JH. Comparison of delayed enhanced CT and chemical shift MR for evaluating hyper-attenuating incidental adrenal masses. Radiology 2007 243 760-765. (doi:10.1148/radiol.2433051978)
47. Boland GW, Blake MA, Hahn PF & Mayo-Smith WW. Incidental adrenal lesions: principles, techniques, and algorithms for imaging characterization. Radiology 2008 249 756-775. (doi:10.1148/radiol.2493070976)
48. Rubello D, Bui C, Casara D, Gross MD, Fig LM & Shapiro B. Functional scintigraphy of the adrenal gland. European Journal of Endocrinology 2002 147 13-28. (doi:10.1530/eje.0.1470013)
49. Carey JE, Thrall JH, Freitas JE & Beierwaltes WH. Absorbed dose to the human adrenals from lodomethylnorcholesterol (I-131) 'NP-59': concise communication. Journal of Nuclear Medicine 1979 20 60-62.
50. Gross MD, Shapiro B, Francis IR, Glazer GM, Bree RL, Arcomano MA, Schteingart DE, Mc Leod MK, Sanfield JA & Thompson NW. Scintigrafic evaluation of clinically silent adrenal masses. Journal of Nuclear Medicine 1994 35 1145-1152.
51. Gross MD, Shapiro B, Bouffard AJ, Glazer GM, Francis IR, Wilton GP, Khafagi F & Sonda LP. Distinguishing benign from malignant euadrenal masses. Annals of Internal Medicine 1998 109 613-618.
52. Falke TH & Sandler MP. Classification of silent adrenal masses: time to get practical. Journal of Nuclear Medicine 1994 35 1152-1154.
53. Barzon L, Scaroni C, Sonino N, Fallo F, Gregianin M, Macrì C & Boscaro M. Incidentally discovered adrenal tumors: endocrine and scintigraphic correlates. Journal of Clinical Endocrinology and Metabolism 1988 83 55-62. (doi:10.1210/jc.83.1.55)
54. Boland GW, Goldberg MA, Lee MJ, Mayo-Smith WW, Dixon J, McNicholas MM & Mueller PR. Indeterminate adrenal mass in patients with cancer: evaluation at PET with 2-[F-18]-fluoro-2-deoxy-D-glucose. Radiology 1995 194 131-134. (Pubitemid 24380938)
55. 18F-fluorodeoxyglucose positron emission tomography. American Journal of Roentgenology 1997 168 1357-1360.
56. Maurea S, Mainolfi C, Bazzicalupo L, Panico MR, Imparato C, Alfano B, Ziviello M & Salvatore M. Imaging of adrenal tumors using FDG-PET: comparison of benign and malignant lesions. American Journal of Roentgenology 1999 173 25-29. (Pubitemid 29291083)
57. Yun M, Kim W, Alnafisi N, Lacorte L, Jang S & Alavi A. 18F-FDG PET in characterizing adrenal lesions detected on CT or MRI. Journal of Nuclear Medicine 2001 42 1795-1799. (Pubitemid 34016347)
58. 18F- fluorodeoxyglucose positron emission tomography as a diagnostic tool for malignancy of adrenocortical tumours? Preliminary results in 13 consecutive patients European Journal of Endocrinology 2004 150 789-792. (doi:10.1530/eje.0.1500789)
59. 18F- Fluorodeoxyglucose positron emission tomography for the diagnosis of adrenocortical tumors: a prospective study in 77 operated patients. Journal of Clinical Endocrinology and Metabolism 2009 94 1713-1722. (doi:10.1210/jc.2008- 2302)
60. Nunes MN, Rault A, Teynie J, Valli N, Guyot M, Gaye D, Belleannee G & Tabarin A. 18F-FDG PET for the identification of adrenocortical carcinomas among indeterminate adrenal tumors at computed tomography scanning. World Journal of Surgery 2010 34 1506-1510. (doi:10.1007/s00268-010-0576-3)
61. 18F-FDG PET/CT add diagnostic accuracy in incidentally identified nonsecreting adrenal tumours? European Journal of Nuclear Medicine and Molecular Imaging 2008 35 2018-2025. (doi:10.1007/s00259-008-0849-3)
62. Metser U, Miller E, Lerman H, Lievshitz G, Avital S & Even-Sapir E. 18F-FDG PET/CT in the evaluation of adrenal masses. Journal of Nuclear Medicine 2006 47 32-37. (Pubitemid 46768509)
63. Caoili EM, Korobkin M, Brown RK, Mackie G & Shulkin BL. Differentiating adrenal adenomas from nonadenomas using (18)F-FDG PET/CT: quantitative and qualitative evaluation. Academic Radiology 2007 14 468-475. (doi:10.1016/j.acra.2007.01.009)
64. Blake MA, Slattery JM, Kalra MK, Halpern EF, Fischman AJ, Mueller PR & Boland GW. Adrenal lesions: characterization with fused PET/CT image in patients with proved or suspected malignancy - initial experience. Radiology 2006 238 970-977. (doi:10.1148/radiol.2383042164)
65. Minn H, Salonen A, Friberg J, Roivainen A, Viljanen T, Långsjö J, Salmi J, Välimäki M, Någren K & Nuutila P. Imaging of adrenal incidentalomas with PET using (11)C-metomidate and (18)FFDG. Journal of Nuclear Medicine 2004 45 972-979. (Pubitemid 47611684)
66. Hennings J, Lindhe O, Bergström M, Långström B, Sundin A & Hellman P. [11C]Metomidate positron emission tomography of adrenocortical tumors in correlation with histopathological findings. Journal of Clinical Endocrinology and Metabolism 2006 91 1410-1414. (doi:10.1210/jc.2005-2273)
67. Hahner S, Stuermer A, Kreissl M, Reiners C, Fassnacht M, Haenscheid H, Beuschlein F, Zink M, Lang K, Allolio B & Schirbel A. [123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes. Journal of Clinical Endocrinology and Metabolism 2008 93 2358-2365. (doi:10.1210/jc.2008-0050)
68. Bernardino ME, Walther MM, Phillips VM, Graham SD Jr, Sewell CW, Gedgaudas-McClees K, Baumgartner BR, Torres WE & Erwin BC. CT-guided adrenal biopsy: accuracy, safety, and indications. American Journal of Roentgenology 1985 144 67-69. (Pubitemid 15153877)
69. Welch TJ, Sheedy PF, Stephens DH, Johnson CM & Swensen SJ. Percutaneous adrenal biopsy: review of a 10-year experience. Radiology 1994 193 341-344. (Pubitemid 24338311)
70. Harisinghani MG, Maher MM, Hahn PF, Gervais DA, Jhaveri K, Varghese J & Mueller PR. Predictive value of benign percutaneous adrenal biopsies in oncology patients. Clinical Radiology 2002 57 898-901. (doi:10.1053/crad.2002. 1054)
71. Quayle FJ, Spitler JA, Pierce RA, Lairmore TC, Moley JF & Brunt LM. Needle biopsy of incidentally discovered adrenal masses is rarely informative and potentially hazardous. Surgery 2007 142 497-502. (doi:10.1016/j.surg.2007. 07.013)
72. Paulsen SD, Nghiem HV, Korobkin M, Caoili EM & Higgins EJ. Changing role of imaging-guided percutaneous biopsy of adrenal masses: evaluation of 50 adrenal biopsies. American Journal of Roentgenology 2004 182 1033-1037. (Pubitemid 38391670)
73. Berland LL, Silverman SG, Gore RM, Mayo-Smith WW, Megibow AJ, Yee J, Brink JA, Mark E, Baker ME, Michael P, Federle MP, Foley WD, Francis IR, Herts BR, Israel GM, Glenn Krinsky G, Platt JF, Shuman WP & Taylor AJ. Managing incidental findings on abdominal CT: white paper of the ACR incidental findings committee. Journal of the American College of Radiology 2010 7 754-773. (doi:10.1016/j.jacr.2010.06.013)
74. Casola G, Nicolet V, vanSonnenberg E, Withers C, Bretagnolle M, Saba RM & Bret PM. Unsuspected pheochromocytoma: risk of blood-pressure alterations during percutaneous adrenal biopsy. Radiology 1986 159 733-735.
75. Lenders JW, Pacak K, Walther MM, Linehan WM, Mannelli M, Friberg P, Keiser HR, Goldstein DS & Eisenhofer G. Biochemical diagnosis of pheochromocytoma: which is the best test? Journal of the American Medical Association 2002 287 1427-1434. (doi:10.1001/jama.287.11.1427)
76. Boyle JG, Davidson DF, Perry CG & Connell JM. Comparison of diagnostic accuracy of urinary free metanephrines, vanillyl mandel acid and cathecolamines and plasma catecolamines for diagnosis of phaeochromocytoma. Journal of Clinical Endocrinology and Metabolism 2007 92 4602-4608. (doi:10.1210/jc.2005-2668)
77. Eisenhofer G, Goldstein DS, Walther MM, Friberg P, Lenders JW, Keiser HR & Pacak K. Biochemical diagnosis of pheochromocytoma: how to distinguish true- from false-positive test results. Journal of Clinical Endocrinology and Metabolism 2003 88 2656-2666. (doi:10.1210/jc.2002-030005)
78. Lenders JW, Eisenhofer G, Mannelli M & Pacak K. Phaeochromocytoma. Lancet 2005 366 665-675. (doi:10.1016/S0140-6736(05)67139-5)
79. Pacak K, Eisenhofer G, Ahlman H, Bornstein SR, Gimenez-Roqueplo AP, Grossman AB, Kimura N, Mannelli M, McNicol AM & Tischler AS. Phaeochromocytoma: recommendations for clinical practice from the First International Symposium. Nature Clinical Practice. Endocrinology and Metabolism 2006 3 92-102. (doi:10.1038/ncpendmet0396)
80. Funder JW, Carey RM, Fardella C, Gomez-Sanchez CE, Mantero F, Stowasser M, Young WF & Montori VM. Case detection, diagnosis, and treatment of patients with primary aldosteronism: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism 2008 93 3266-3281. (doi:10.1210/jc.2008-0104)
81. Zeiger MA, Thompson GB, Duh QY, Hamrahian AH, Angelos P, Elaraj D, Fishman E & Kharlip J. The American Association of Clinical Endocrinologists and American Association of Endocrine Surgeons medical guidelines for the management of adrenal incidentalomas. Endocrine Practice 2009 15 1-20.
82. Médeau V, Moreau F, Trinquart L, Clemessy M, Wémeau JL, Vantyghem MC, Plouin PF & Reznik Y. Clinical and biochemical characteristics of normotensive patients with primary aldosteronism: a comparison with hypertensive cases. Clinical Endocrinology 2008 69 20-28. (doi:10.1111/j.1365- 2265.2008.03213.x)
83. Young WF. Primary aldosteronism: renaissance of a syndrome. Clinical Endocrinology 2007 66 607-618. (doi:10.1111/j.1365-2265.2007.02775.x)
84. Montori VM & Young WF Jr. Use of plasma aldosteron concentration-to-plasma renin activity ratio as a screening test for primary hyperaldosteronism. A systematic review of the literature. Endocrinology and Metabolism Clinics of North America 2002 31 619-632. (doi:10.1016/S0889-8529(02) 00013-0)
85. Mulatero P, Stowaser M, Loh KC, Fardella CE, Gordon RD, Mosso L, Gomez-Sanchez CE, Veglio F & Young WF Jr. Increased diagnosis of primary hyperaldosteronism in centers from five continents. Journal of Clinical Endocrinology and Metabolism 2004 89 1045-1950. (doi:10.1210/jc.2003-031337)
86. Stowasser M & Gordon RD. The aldosterone-renin ratio for screening for primary hyperaldosteronism. Endocrinologist 2004 14 267-276. (doi:10.1097/01.ten.0000139006.29471.9e)
87. Tiu SC, Choi CH, Shek CC, Ng YW, Cyhan FK, Ng CM & Kong AP. The use of aldosterone-renin ratio as a diagnostic test for primary hyperaldosteronism and its test characteristic under different conditions of blood sampling. Journal of Clinical Endocrinology and Metabolism 2005 90 72-78. (doi:10.1210/jc.2004-1149)
88. Perschel FH, Schemer R, Seiler L, Reincke M, Deinum J, Maser- Gluth C, Mechelhoff D, Tauber R & Diederich S. Rapid screening test for primary hyperaldosteronism: ratio of plasma aldosterone to renin concentration determined by fully automated chemiluminescence immunoassays. Clinical Chemistry 2004 50 1650-1655. (doi:10.1373/clinchem.2004.033159)
89. Ferrari P, Shaw SG, Nicod J, Saner E & Nussberger J. Active renin versus plasma renin activity to define aldosterone-to-renin ratio for primary aldosteronism. Journal of Hypertension 2004 22 377-381. (doi:10.1097/00004872- 200402000-00023)
90. Nieman LK, Biller BMK, Findling JW, Newell-Price J, Savage M, Stewart PM& Montori VM. The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology and Metabolism 2008 93 1526-1540. (doi:10.1210/jc.2008-0125)
91. Arnaldi G, Angeli A, Atkinson AB, Bertagna X, Cavagnini F, Chrousos GP, Fava GA, Findling JW, Gaillard RC, Grossman AB, Kola B, Lacroix A, Mancini T, Mantero F, Newell-Price J, Nieman LK, Sonino N, Vance ML, Giustina A & Boscaro M. Diagnosis and complication's of Cushing's syndrome: a consensus statement. Journal of Clinical Endocrinology and Metabolism 2003 88 5593-5602. (doi:10.1210/jc.2003-030871)
92. Raff H & Findling JW. A physiologic approach to diagnosis of the Cushing syndrome. Annals of Internal Medicine 2003 138 980-991. (Pubitemid 38129119)
93. Wood PJ, Barth JH, Freedman DB, Perry L & Sheridan B. Evidence for the low dose dexamethasone suppression test to screen for Cushing's syndrome-recommendations for a protocol for biochemistry laboratories. Annals of Clinical Biochemistry 1997 34 222-229. (Pubitemid 27236924)
94. Newell Price J, Bertagna X, Grossman AB & Nieman LK. Cushing's syndrome. Lancet 2006 367 1605-1617. (doi:10.1016/S0140-6736(06)68699-6)
95. Pecori Giraldi F, Ambrogio AG, De Martin M, Fatti LM, Scacchi M & Cavagnini F. Specificity of first-line tests for the diagnosis of Cushing's syndrome: assessment in a large series. Journal of Clinical Endocrinology and Metabolism 2007 92 4123-4129. (doi:10.1210/jc.2007-0596)
96. Elamin MB, Murad MH, Mullan R, Erickson D, Harris K, Nadeem S, Ennis R, Erwin PJ & Montori VM. Accuracy of diagnostic tests for Cushing's syndrome: a systematic review and metaanalyses. Journal of Clinical Endocrinology and Metabolism 2008 93 1553-1562. (doi:10.1210/jc.2008-0139)
97. Terzolo M, Bovio S, Reimondo G, Pia A, Osella G, Borretta G & Angeli A. Subclinical Cushing's syndrome in adrenal incidentalomas. Endocrinology and Metabolism Clinics of North America 2005 34 423-439. (doi:10.1016/j.ecl.2005.01. 008)
98. Fagour C, Bardet S, Rohmer V, Arimone Y, Lecomte P, Valli N & Tabarin A. Usefulness of adrenal scintigraphy in the follow-up of adrenocortical incidentalomas: a prospective multicenter study. European Journal of Endocrinology 2009 160 257-264. (doi:10.1530/EJE-08-0299)
99. Lacroix A, Ndiaye N, Tremblay J & Hamet P. Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome. Endocrine Reviews 2001 22 75-110. (doi:10.1210/er.22.1.75)
100. Herrera MF, Grant CS, van Heerden JA, Sheedy PF & Ilstrup DM. Incidentally discovered adrenal tumors: an institutional perspective. Surgery 1991 110 1014-1021.
101. Reincke M, Nieke J, Krestin GP, Saeger W, Allolio B & Winkelmann W. Preclinical Cushing's syndrome in adrenal "incidentalomas": comparison with adrenal Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism 1992 75 826-832. (doi:10.1210/jc.75.3.826)
102. Caplan RH, Strutt PJ & Wickus GG. Subclinical hormone secretion by incidentally discovered adrenal masses. Archives of Surgery 1994 129 291-296. (Pubitemid 24103322)
103. Osella G, Terzolo M, Borretta G, Magro G, Alí A, Piovesan A, Paccotti P & Angeli A. Endocrine evaluation of incidentally discovered adrenal masses (incidentalomas). Journal of Clinical Endocrinology and Metabolism 1994 79 1532-1539. (doi:10.1210/jc.79.6.1532)
104. Flecchia D, Mazza E, Carlini M, Blatto A, Olivieri F, Serra G, Camanni F & Messina M. Reduced serum levels of dehydroepiandrosterone sulphate in adrenal incidentalomas: a marker of adrenocortical tumour. Clinical Endocrinology 1995 42 129-134. (doi:10.1111/j.1365-2265.1995.tb01852.x)
105. Ambrosi B, Peverelli S, Passini E, Re T, Ferrario R, Colombo P, Sartorio A & Faglia G. Abnormalities of endocrine function in patients with clinically 'silent' adrenal masses. European Journal of Endocrinology 1995 132 422-428. (doi:10.1530/eje.0.1320422)
106. 131I-6 beta-iodomethylnorcholesterol scintigraphy: an assessment of its role in the investigation of adrenocortical incidentalomas. Clinical Endocrinology 1996 44 587-596. (doi:10.1046/j.1365- 2265.1996.720541.x)
107. Linos DA, Stylopoulos N & Raptis SA. Adrenaloma: a call for more aggressive management. World Journal of Surgery 1996 20 788-792. (doi:10.1007/s002689900120)
108. Bondanelli M, Campo M, Trasforini G, Ambrosio MR, Zatelli MC, Franceschetti P, Valentini A, Pansini R & degli Uberti EC. Evaluation of hormonal function in a series of incidentally discovered adrenal masses. Metabolism 1997 46 107-113. (doi:10.1016/S0026-0495(97)90176-1)
109. Kasperlik-Zeluska AA, Rosłonowska E, Słowinska-Srzednicka J, Migdalska B, Jeske W, Makowska A & Snochowska H. Incidentally discovered adrenal mass (incidentaloma): investigation and management of 208 patients. Clinical Endocrinology 1997 46 29-37. (doi:10.1046/j.1365-2265.1997.d01-1751.x)
110. Tsagarakis S, Roboti C, Kokkoris P, Vasiliou V, Alevizaki C & Thalassinos N. Elevated post-dexamethasone suppression cortisol concentrations correlate with hormonal alterations of the hypothalamo-pituitary adrenal axis in patients with adrenal incidentalomas. Clinical Endocrinology 1998 49 165-171. (doi:10.1046/j.1365-2265.1998.00509.x)
111. Rossi R, Tauchmanova L, Luciano A, Di Martino M, Battista C, Del Viscovo L, Nuzzo V & Lombardi G. Subclinical Cushing's syndrome in patients with adrenal incidentaloma: clinical and biochemical features. Journal of Clinical Endocrinology and Metabolism 2000 85 1440-1448. (doi:10.1210/jc.85.4.1440)
112. Favia G, Lumachi F, Basso S & D'Amico DF. Management of incidentally discovered adrenal masses and risk of malignancy. Surgery 2000 128 918-924. (doi:10.1067/msy.2000.109965)
113. Tanabe A, Naruse M, Nishikawa T, Yoshimoto T, Shimizu T, Seki T, Takagi S, Imaki T & Takano K. Autonomy of cortisol secretion in clinically silent adrenal incidentaloma. Hormone and Metabolic Research 2001 33 444-450. (doi:10.1055/s-2001-16234)
114. Midorikawa S, Sanada H, Hashimoto S, Suzuki T, Watanabe T & Sasano H. Analysis of cortisol secretion in hormonally inactive adrenocortical incidentalomas: study of in vitro steroid secretion and immunohistochemical localization of steroidogenic enzymes. Endocrine Journal 2001 48 167-174. (doi:10.1507/endocrj.48.167)
115. Grossrubatscher E, Vignati F, Possa M & Loli P. The natural history of incidentally discovered adrenocortical adenomas: a retrospective evaluation. Journal of Endocrinological Investigation 2001 24 846-855. (Pubitemid 34036714)
116. Valli N, Catargi B, Ronci N, Vergnot V, Leccia F, Ferriere JM, Chene G, Grenier N, Laurent F & Tabarin A. Biochemical screening for subclinical cortisol-secreting adenomas amongst adrenal incidentalomas. European Journal of Endocrinology 2001 144 401-408. (doi:10.1530/eje.0.1440401)
117. Barzon L, Fallo F, Sonino N & Boscaro M. Development of overt Cushing's syndrome in patients with adrenal incidentaloma. European Journal of Endocrinology 2002 146 61-66. (doi:10.1530/eje.0.1460061)
118. Bülow B, Ahrén B & Swedish Research Council Study Group of Endocrine Abdominal Tumours. Adrenal incidentaloma - experience of a standardized diagnostic programme in the Swedish prospective study. Journal of Internal Medicine 2002 252 239-246. (doi:10.1046/j.1365-2796.2002.01028.x)
119. Libè R, Dall'Asta C, Barbetta L, Baccarelli A, Beck-Peccoz P & Ambrosi B. Long-term follow-up study of patients with adrenal incidentalomas. European Journal of Endocrinology 2002 147 489-494. (doi:10.1530/eje.0.1470489)
120. Tauchmanovà L, Rossi R, Biondi B, Pulcrano M, Nuzzo V, Palmieri EA, Fazio S & Lombardi G. Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular risk. Journal of Clinical Endocrinology and Metabolism 2002 87 4872-4878. (doi:10.1210/jc.2001-011766)
121. Emral R, Uysal AR, Asik M, Gullu S, Corapcioglu D, Tonyukuk V & Erdogan G. Prevalence of subclinical Cushing's syndrome in 70 patients with adrenal incidentaloma: clinical, biochemical and surgical outcomes. Endocrine Journal 2003 50 399-408. (doi:10.1507/endocrj.50.399)
122. Hadjidakis D, Tsagarakis S, Roboti C, Sfakianakis M, Iconomidou V, Raptis SA & Thalassinos N. Does subclinical hypercortisolism adversely affect the bone mineral density of patients with adrenal incidentalomas? Clinical Endocrinology 2003 58 72-77. (doi:10.1046/j.1365-2265.2003.01676.x)
123. Katabami T, Obi R, Shirai N, Naito S & Saito N. Discrepancies in results of low- and high-dose dexamethasone suppression tests for diagnosing preclinical Cushing's syndrome. Endocrine Journal 2005 52 463-469. (doi:10.1507/endocrj.52.463)
124. Terzolo M, Bovio S, Pia A, Conton PA, Reimondo G, Dall'Asta C, Bemporad D, Angeli A, Opocher G, Mannelli M, Ambrosi B & Mantero F. Midnight serum
125. Tabarin A, Bardet S, Bertherat J, Dupas B, Chabre O, Hamoir E, Laurent F, Tenenbaum F, Cazalda M, Lefebvre H, Valli N & Rohmer V. Exploration and management of adrenal incidentalomas. French Society of Endocrinology Consensus. Annales d'Endocrinologie 2008 69 487-500. (doi:10.1016/j.ando.2008.09.003)
126. Reimondo G, Allasino B, Bovio S, Saba L, Ardito A, Angeli A & Terzolo M. Pros and cons of dexamethasone suppression test for screening of subclinical Cushing's syndrome in patients with adrenal incidentalomas. Journal of Endocrinological Investigation 2011 34 e1-e5.
127. Doi M, Sekizawa N, Tani Y, Tsuchiya K, Kouyama R, Tateno T, Izumiyama H, Yoshimoto T & Hirata Y. Late-night salivary cortisol as a screening test for the diagnosis of Cushing's syndrome in Japan. Endocrine Journal 2008 55 121-126. (doi:10.1507/endocrj.K07E-023)
128. Masserini B, Morelli V, Bergamaschi S, Ermetici F, Eller-Vainicher C, Barbieri AM, Maffini MA, Scillitani A, Ambrosi B, Beck-Peccoz P & Chiodini I. The limited role of midnight salivary cortisol levels in the diagnosis of subclinical hypercortisolism in patients with adrenal incidentaloma. European Journal of Endocrinology 2009 160 87-92. (doi:10.1530/EJE-08-0485)
129. Nunes ML, Vattaut S, Corcuff JB, Rault A, Loiseau H, Gatta B, Valli N, Letenneur L & Tabarin A. Late-night salivary cortisol for diagnosis of overt and subclinical Cushing's syndrome in hospitalized and ambulatory patients. Journal of Clinical Endocrinology and Metabolism 2009 94 456-462. (doi:10.1210/jc.2008-1542)
130. Bencsik Z, Szabolcs I, Kovacs Z, Ferencz A, Voros A, Kaszas I, Bor K, Gonczi J, Goth M, Kovacs L, Dohan O & Szilagyi G. Low dehydroepiandrosterone sulfate (DHEA-S) level is not a good predictor of hormonal activity in nonselected patients with incidentally detected adrenal tumors. Journal of Clinical Endocrinology and Metabolism 1996 81 1726-1729. (doi:10.1210/jc. 81.5.1726)
131. Terzolo M, Osella G, Al?' A, Borretta G, Magro GP, Termine A, Paccotti P & Angeli A. Different patterns of steroid secretion in patients with adrenal incidentaloma. Journal of Clinical Endocrinology and Metabolism 1996 81 740-744. (doi:10.1210/jc.81.2.740)
132. Eller-Vainicher C, Morelli V, Salcuni AS, Torlontano M, Coletti F, Iorio L, Cuttitta A, Ambrosio A, Vicentini L, Carnevale V, Beck-Peccoz P, Arosio M, Ambrosi B, Scillitani A & Chiodini I. Postsurgical hypocortisolism after removal of an adrenal incidentaloma: is it predictable by an accurate endocrinological work-up before surgery? European Journal of Endocrinology 2010 162 91-99. (doi:10.1530/EJE-09-0775)
133. Allolio B & Fassnacht M. Clinical review: adrenocortical carcinoma: clinical update. Journal of Clinical Endocrinology and Metabolism 2006 91 2027-2037. (doi:10.1210/jc.2005-2639)
134. Amar L, Peyrard S, Rossignol P, Zinzindohoue F, Gimenez-Roqueplo AP & Plouin PF. Changes in urinary total metanephrine excretion in recurrent and malignant pheochromocytomas and secreting paragangliomas. Annals of the New York Academy of Sciences 2006 1073 383-391. (doi:10.1196/annals.1353.042)
135. Eisenhofer G, Siegert G, Kotzerke J, Bornstein SR & Pack K. Current progress and future challenges in the biochemical diagnosis and treatment of pheochromocytoma and paragangliomas. Hormone and Metabolic Research 2008 40 329-337. (doi:10.1055/s-2008-1073156)
136. Bulow B, Jansson S, Juhlin C, Steen L, Thoren M,Wahrenberg H, Valdemarsson S & Ahren B. Adrenal incidentaloma - follow-up results from a Swedish prospective study. European Journal of Endocrinology 2006 154 419-423. (doi:10.1530/eje.1.02110)
137. Bernini GP, Moretti A, Oriandini C, Bardini M, Taurino C & Salvetti A. Long-term morphological and hormonal follow-up in a single unit on 115 patients with adrenal incidentalomas. British Journal of Cancer 2005 92 1104-1109. (doi:10.1038/sj.bjc.6602459)
138. Tsvetov G, Shimon I & Benbassat C. Adrenal incidentaloma: clinical characteristics and comparison between patients with and without extraadrenal malignancy. Journal of Endocrinological Investigation 2007 30 647-652. (Pubitemid 350104093)
139. Barzon L, Scaroni C, Sonino N, Fallo F, Paoletta A & Boscaro M. Risk factors and long-term follow-up of adrenal incidentalomas. Journal of Clinical Endocrinology and Metabolism 1999 84 520-526. (doi:10.1210/jc.84.2.520)
140. Angeli A & Terzolo M. Adrenal incidentaloma - a modern disease with old complications. Journal of Clinical Endocrinology and Metabolism 2002 87 4869-4871. (doi:10.1210/jc.2002-021436)
141. Riencke M. Subclinical Cushing's syndrome. Endocrinology and Metabolism Clinics of North America 2000 29 43-56. (doi:10.1016/S0889-8529(05)70115-8)
142. Young WF. Management approaches to adrenal incidentalomas. Aview from Rochester, Minnesota. Endocrinology and Metabolism Clinics of North America 2000 29 159-185. (doi:10.1016/S0889-8529(05)70122-5)
143. Giordano R, Marinazzo E, Berardelli R, Picu A, Maccario M, Ghigo E & Arvat E. Long-term morphological, hormonal, and clinical follow-up in a single unit on 118 patients with adrenal incidentalomas. European Journal of Endocrinology 2010 162 779-785. (doi:10.1530/EJE-09-0957)
144. Terzolo M, Pia A, Alì A, Osella G, Reimondo G, Bovio S, Daffara F, Procopio M, Paccotti P, Borretta G & Angeli A. Adrenal incidentaloma: a new cause of the metabolic syndrome? Journal of Clinical Endocrinology and Metabolism 2002 87 998-1003. (doi:10.1210/jc.87.3.998)
145. Chiodini I, Torlontano M, Carnevale V, Guglielmi G, Cammisa M, Trischitta V & Scillitani A. Bone loss rate in adrenal incidentalomas: a longitudinal study. Journal of Clinical Endocrinology and Metabolism 2001 86 5337-5341. (doi:10.1210/jc.86.11.5337)
146. Chiodini I, Guglielmi G, Battista C, Carnevale V, Torlontano M, Cammisa M, Trischitta V & Scillitani A. Spinal volumetric bone mineral density and vertebral fractures in female patients with adrenal incidentalomas: the effects of subclinical hypercortisolism and gonadal status. Journal of Clinical Endocrinology and Metabolism 2004 89 2237-2241. (doi:10.1210/jc.2003-031413)
147. Chiodini I, Viti R, Coletti F, Guglielmi G, Battista C, Ermetici F, Morelli V, Salcuni A, Carnevale V, Urbano F, Muscarella S, Ambrosi B, Arosio M, Beck-Peccoz P & Scillitani A. Eugonadal male patients with adrenal incidentalomas and subclinical hypercortisolism have increased rate of vertebral fractures. Clinical Endocrinology 2009 70 208-213. (doi:10.1111/j.1365-2265. 2008.03310.x)
148. Chiodini I, Morelli V, Masserini B, Salcuni AS, Eller-Vainicher C, Viti R, Coletti F, Guglielmi G, Battista C, Carnevale V, Iorio L, Beck-Peccoz P, Arosio M, Ambrosi B & Scillitani A. Bone mineral density, prevalence of vertebral fractures, and bone quality in patients with adrenal incidentalomas with and without subclinical hypercortisolism: an Italian multicenter study. Journal of Clinical Endocrinology and Metabolism 2009 94 3207-3214. (doi:10.1210/jc.2009-0468)
149. Reincke M, Fassnacht M, Väth S, Mora P & Allolio B. Adrenal incidentalomas: a manifestation of the metabolic syndrome? Endocrine Research 1996 22 757-761.
150. Alexander CM, Landsman PB, Teutsch SM & Haffner SM. NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older, Third National Health and Nutrition Examination Survey (NHANES III); National Cholesterol Education Program (NCEP). Diabetes 2003 52 1210-1214. (doi:10.2337/diabetes.52.5.1210)
151. Malik S,Wong ND, Franklin SS, Kamath TV, L'Italien GJ, Pio JR & Williams GR. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 2004 110 1245-1250. (doi:10.1161/01.CIR.0000140677.20606.0E)
152. Sirén J, Tervahartiala P, Sivula A & Haapiainen R. Natural course of adrenal incidentalomas: seven-year follow-up study. World Journal of Surgery 2000 24 579-582. (doi:10.1007/s002689910095)
153. Midorikawa S, Sanada H, Hashimoto S, Suzuki T & Watanabe T. The improvement of insulin resistance in patients with adrenal incidentaloma by surgical resection. Clinical Endocrinology 2001 54 797-804. (doi:10.1046/j.1365- 2265.2001.01274.x)
154. Mitchell IC, Auchus RJ, Juneja K, Chang AY, Holt SA, Snyder WH III & Nwariaku FE. "Subclinical Cushing's syndrome" is not subclinical: improvement after adrenalectomy in 9 patients. Surgery 2007 142 900-905. (doi:10.1016/j.surg.2007.10.001)
155. Erbil Y, Ademoǧlu E, Ozbey N, Barbaros U, Yanik BT, Salmaslioǧlu A, Bozbora A & Ozarmaǧan S. Evaluation of the cardiovascular risk in patients with subclinical Cushing syndrome before and after surgery. World Journal of Surgery 2006 30 1665-1671. (doi:10.1007/s00268- 005-0681-x)
156. Tsuiki M, Tanabe A, Takagi S, Naruse M & Takano K. Cardiovascular risks and their long-term clinical outcome in patients with subclinical Cushing's syndrome. Endocrine Journal 2008 55 737-745. (doi:10.1507/endocrj. K07E-177)
157. Toniato A, Merante-Boschin I, Opocher G, Pelizzo MR, Schiavi F & Ballotta E. Surgical versus conservative management for subclinical Cushing syndrome in adrenal incidentalomas: a prospective randomized study. Annals of Surgery 2009 249 388-391. (doi:10.1097/SLA.0b013e31819a47d2)
158. Sereg M, Szappanos A, Toke J, Karlinger K, Feldman K, Kaszper E, Varga I, Gláz E, Rácz K & Tóth M. Atherosclerotic risk factors and complications in patients with non-functioning adrenal adenomas treated with or without adrenalectomy: a long-term follow-up study. European Journal of Endocrinology 2009 160 647-655. (doi:10.1530/EJE-08-0707)
159. Chiodini I, Morelli V, Salcuni AS, Eller-Vainicher C, Torlontano M, Coletti F, Iorio L, Cuttitta A, Ambrosio A, Vicentini L, Pellegrini F, Copetti M, Beck-Peccoz P, Arosio M, Ambrosi B, Trischitta V & Scillitani A. Beneficial metabolic effects of prompt surgical treatment in patients with an adrenal incidentaloma causing biochemical hypercortisolism. Journal of Clinical Endocrinology and Metabolism 2010 95 2736-2745. (doi:10.1210/jc.2009-2387)
160. Lal G & Duh QY. Laparoscopic adrenalectomy - indications and technique. Surgical Oncology 2003 12 105-123. (doi:10.1016/S0960-7404(03)00036- 7)
161. Murphy MM, Witkowski ER, Ng SC, McDade TP, Hill JS, Larkin AC, Whalen GF, Litwin DE & Tseng JF. Trends in adrenalectomy: a recent national review. Surgical Endoscopy 2010 24 2518-2526. (doi:10.1007/s00464-010-0996-z)
162. Tessier DJ, Iglesias R, Chapman WC, Kercher K, Matthews BD, Gorden DL & Brunt LM. Previously unreported high-grade complications of adrenalectomy. Surgical Endoscopy 2009 23 97-102. (doi:10.1007/s00464-008-9947-3)
163. Nieman LJ. Approach to the patient with an adrenal incidentaloma. Journal of Clinical Endocrinology and Metabolism 2010 95 4106-4113. (doi:10.1210/jc.2010-0457)
164. Terzolo M, Reimondo G & Angeli A. Definition of an optimal strategy to evaluate and follow-up adrenal incidentalomas: time for further research. European Journal of Endocrinology 2009 161 529-532. (doi:10.1530/EJE-09-0473)