Elevated post-dexamethasone suppression cortisol concentrations correlate with hormonal alterations of the hypothalamo-pituitary adrenal axis in patients with adrenal incidentalomas

Clinical Endocrinology

Volumn 49, Issue 2, 1998, Pages 165-171

  Tsagarakis, S ^a   Roboti, C ^a   Kokkoris, P ^a   Vasiliou, V ^a   Alevizaki, C ^a   Thalassinos, N ^a  

^a EVANGELISMOS HOSPITAL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; CORTICOTROPIN; DEXAMETHASONE; GLUCOCORTICOID; HYDROCORTISONE; LIPID; METADRENALIN; PRASTERONE SULFATE; RENIN; VANILMANDELIC ACID;

ADRENAL CORTEX ADENOMA; ADULT; AGED; ARTICLE; DEXAMETHASONE SUPPRESSION TEST; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE URINE LEVEL; HYPERCORTISOLISM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADENOMA; ADRENAL CORTEX FUNCTION TESTS; ADRENAL CORTEX NEOPLASMS; ADRENOCORTICOTROPIC HORMONE; ADULT; AGED; DEHYDROEPIANDROSTERONE SULFATE; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LIPIDS; MALE; MIDDLE AGED; PITUITARY-ADRENAL SYSTEM;

EID: 0031854749     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1998.00509.x     Document Type: Article

References (23)

1. Abecassis, M., McLoughlin, M.J., Langer, B. & Kudlow, J.E. (1985) Serendepitous adrenal masses: prevalence, significance, and management. American Journal of Surgery 149, 783-788.
2. Ambrosi, B., Peverelli, S., Passini, E., Re, T., Ferrario, R., Colombo, P., Sartorio, A. & Faglia, G. (1995) Abnormalities of endocrine function in patients with clinically "silent" adrenal masses. European Journal of Endocrinology, 132, 422-428.
3. 131I-6βiodomethylnorcholesterol scintigraphy: an assessment of oils role in the investigation of adrenocortical incidentalomas. Clinical Endocrinology, 44, 587-596.
4. Bencsik, Z., Szabolcs, I., Kovacs, Z., Ferencz, A., Voros, A., Kaszas, I., Bor, K., Gonczi, J., Goth, M., Kovacs, L., Dohan, O. & Szilagyi, G. (1996) Low dehydroepiandrosterone sulfate (DHEA-S) level is not a good predictor of hormonal activity in nonselected patients with incidentally detected adrenal tumours. Journal of Clinical Endocrinology and Metabolism, 81, 1726-1729.
5. Baulieu, E.-E. (1996) Dehydroepiandrosterone (DHEA): A fountain of youth? Journal of Clinical Endocrinology and Metabolism, 81, 3147-3151.
6. Chidiac, R.M. & Aron, D.V. (1997) Incidentalomas: a disease of modern technology. Endocrinology and Metabolism Clinics of North America, 26, 233-253.
7. Flecchia, D., Mazza, E., Carlini, ?., Blatto, A., Olivieri, F., Serra, G., Camanni, F. & Messina, M. (1995) Reduced serum levels of dehydroepiandrosterone sulphate in adrenal incidentalomas: a marker of adrenocortical tumour. Clinical Endocrinology, 42, 129-134.
8. Griffing, G.T. (1994) Editorial: A-I-D-S: The new endocrine epidemic. Journal of Clinical Endocrinology and Metabolism, 79, 1530-1531.
9. Gross, M.D. & Shapiro, B. (1993) Clinically silent adrenal masses. Journal of Clinical Endocrinology and Metabolism, 77, 885-888.
10. Huiras, C., Pehling, G.B. & Caplan, R.H. (1989) Adrenal insufficiency after operative removal of apparently nonfunctioning adrenal adenomas. JAMA, 261, 894-898.
11. Kasperlik-Zaluska, A.A., Rostonowska, E., Slowinska-Srzednicka, J., Migdalska, B., Jeske, W., Makowska, A. & Snochowska, H. (1997) Incidentally discovered adrenal mass (incidentalomas): investigation and management of 208 patients. Clinical Endocrinology, 46, 29-37.
12. Kloos, R.T., Gross, M.D., Francis, I.R., Korohkin, M. & Shapiro, B. (1995) Incidentally discovered adrenal masses. Endocrine Reviews, 16, 460-484.
13. Lavoie, H. & Lacroix, A. (1995) Partially autonomous cortisol secretion by incidentally discovered adrenal adenomas. Trends in Endocrinology and Metabolism, 6, 191-197.
14. Newell-Price, J., Trainer, P., Perry, L., Wass, J., Grossman, A. & Besser, M. (1995) A single sleeping midnight cortisol has a 100% sensitivity for the diagnosis of Cushing's syndrome. Clinical Endocrinology, 43, 545-550.
15. Osella, G., Terzolo, M., Borretta, G., Magro, G., Ali, A., Piovesan, A., Paccotti, P. & Angeli, A. (1994) Endocrine evaluation of incidentally discovered adrenal masses (incidentalomas). Journal of Clinical Endocrinology and Metabolism, 79, 1532-1539.
16. Reaven, G.H. (1988) Role of insulin resistance in human disease. Diabetes, 37, 1595-1607.
17. Reincke, M., Nieke, J., Krestin, G.P., Saeger, W., Allolio, B. & Winkelman, W. (1992) Preclinical Cushing's syndrome in adrenal "incidentalomas": comparison with adrenal Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism, 75, 826-832.
18. Reincke, M., Faßnacht, M., Vath, S., Mora, P. & Allolio, B. (1996) Adrenal incidentalomas: A manifestation of the metabolic syndrome? Endocrine Research, 22, 757-761.
19. Terzolo, M., Osella, G., Ali, A., Borretta, G., Magro, G.P., Termine, A., Paccotti, P. & Angeli, A. (1996) Different patterns of steroid secretion in patients with adrenal incidentaloma. Journal of Clinical Endocrinology and Metabolism, 81, 740-744.
20. Trainer, P.J. & Grossman, A. (1991) The diagnosis and differential diagnosis of Cushing's syndrome. Clinical Endocrinology, 34, 317-3311.
21. Tsagarakis, S., Kokkoris, P., Roboti, C., Malagari, C., Kaskarelis, J., Vlassopoulou, V., Alevizaki, C. & Thalassinos, N. (1998) The low-dose dexamethasone suppression test in patients with adrenal incidentalomas: comparisons with clinically euadrenal subjects and patients with Cushing's syndrome. Clinical Endocrinology, 48, 627-633.
22. Virkalla, A., Valimaki, M., Pelkonen, R., Huikuri, K., Kahri, A., Kivisaari, L., Korhonen, T., Salmi, J. & Seppala, P. (1989) Endocrine abnormalities in patients with adrenal tumours incidentally discovered on computed tomography. Acta Endocrinologica, 121, 67-72.
23. Weber, A., Clark, A.J.L., Perry, L.A., Honour, J.W. & Savage, M.O. (1997) Diminished adrenal androgen secretion in familial glucocorticoid deficiency implicates a significant role for ACTH in the induction of adrenarche. Clinical Endocrinology, 46, 431-137.