Applying macromolecular crowding to enhance extracellular matrix deposition and its remodeling in vitro for tissue engineering and cell-based therapies

Advanced Drug Delivery Reviews

Volumn 63, Issue 4, 2011, Pages 277-290

  Chen, Clarice ^a,c   Loe, Felicia ^a,c   Blocki, Anna ^a,c   Peng, Yanxian ^a   Raghunath, Michael ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Collagen assembly; Differentiated cells; Excluded volume effect; Matrix maturation; Microenvironment; Stem cells

Indexed keywords

CELL-BASED THERAPY; CULTURE MEDIA; CULTURE MEDIUM; DIFFERENTIATED CELLS; EX-VIVO; EXCLUDED VOLUME EFFECTS; EXTRACELLULAR MATRICES; EXTRACELLULAR MATRIX DEPOSITION; IN-VITRO; MACROMOLECULAR CROWDING; MATRIX; MICROENVIRONMENTS; MULTICELLULAR ORGANISMS; PROGENITOR CELL; THREE DIMENSIONAL SCAFFOLD;

CARBOHYDRATES; CELL CULTURE; ENZYME ACTIVITY; MACROMOLECULES; STEM CELLS; TISSUE;

SCAFFOLDS (BIOLOGY);

BIOMATERIAL; COLLAGEN; MATRIX METALLOPROTEINASE; PROCOLLAGEN; TISSUE INHIBITOR OF METALLOPROTEINASE;

CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CELL THERAPY; CHEMICAL ANALYSIS; COLLAGEN METABOLISM; CULTURE MEDIUM; EMBRYONIC STEM CELL; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; HYDRODYNAMICS; IN VITRO STUDY; MACROMOLECULAR CROWDING; MICROENVIRONMENT; MOLECULAR DYNAMICS; MOLECULAR SIZE; PRIORITY JOURNAL; REVIEW; THERMODYNAMICS; TISSUE ENGINEERING;

ANIMALS; CARBOHYDRATES; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; EXTRACELLULAR MATRIX; HUMANS; MACROMOLECULAR SUBSTANCES; STEM CELLS; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TISSUE THERAPY;

EID: 79957675684     PISSN: 0169409X     EISSN: 0169409X     Source Type: Journal    
DOI: 10.1016/j.addr.2011.03.003     Document Type: Review

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