The cutaneous microfibrillar apparatus contains latent transforming growth factor-β binding protein-1 (LTBP-1) and is a repository for latent TGF-β1

Journal of Investigative Dermatology

Volumn 111, Issue 4, 1998, Pages 559-564

  Raghunath, M ^a   Unsold, C ^a   Kubitscheck, U ^a   Bruckner Tuderman, L ^a   Peters, R ^a   Meuli, M ^a  

^a INST OF REPRO MED OF THE UNIV   (Germany)

Author keywords

Fibrillin; Keratinocyte autografts burns; Microfibrils

Indexed keywords

BINDING PROTEIN; ELASTIN; FIBRILLIN; MICROCRYSTALLINE COLLAGEN; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; CHILD; EXTRACELLULAR MATRIX; FIBER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; KERATINOCYTE; MARFAN SYNDROME; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; SCAR FORMATION; WOUND HEALING;

EID: 0031691462     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1998.00339.x     Document Type: Article

References (31)

1. M.H. Barcellos-hoff R. Derynck ML-S. Tsang J.A. Weatherbee Transforming growth factor-β activation in irradiated murine mammary gland J Clin Invest 93 1994 892 899
2. W.A. Border E. Ruoslahti Transforming growth factor-β in diseases: the dark side of tissue repair J Clin Invest 90 1992 1 7
3. S.L. Dallas K. Miyazono T.M. Skerry G.R. Mundy L.F. Bonewald Dual role for the latent transforming growth factor β-binding protein in storage of latent TGF-β in the extracellular matrix and as a structural matrix protein J Cell Biol 131 1995 539 549
4. M.A. Gibson G. Hatzinikolas E.C. Davis E. Baker G.R. Sutherland R.P. Mecham Bovine latent transforming growth factor beta 1-binding protein 2: molecular cloning identification of tissue isoforms and immunolocalization to elastin-associated microfibrils Mol Cell Biol 15 1995 6932 6942
5. R. Giltay G. Kostka R. Timpl Sequence and expression of a novel member (LTBP-4) of the family of latent transforming growth factor-beta binding proteins FEBS Lett 411 1997 164 168
6. D.J. Grainger P.R. Kemp A.C. Liu R.M. Lawn J.C. Metcalfe Activation of transforming growth factor β is inhibited in transgenic apolipoprotein (a) mice Nature 370 1994 460 462
7. T. Kanzaki A. Olofsson A. Morén TGFβ1 binding protein: a component of the large latent complex of TGFβ1 with multiple repeat sequences Cell 61 1990 1051 1061
8. C.M. Kielty M. Raghunath L. Siracusa M.J. Sheratt C.A. Shuttleworth R. Peters S. Jimenez The tight skin mouse: demonstration of mutant fibrillin-1 production and microfibrillar abnormalities J Cell Biol 140 1998 1 8
9. M. Laiho J. Keski-oja Transforming growth factors-β as regulators of cellular growth and phenotype Crit Rev Oncog 3 1992 1 12
10. B.K. Maddox L.Y. Sakai D.R. Keene R.W. Glanville Connective tissue microfibrils Isolation and characterization of three large pepsin-resistant domains of fibrillin J Biol Chem 264 1989 21381 21385
11. P. Martin Wound healing – aiming for perfect skin regeneration Science 276 1997 75 81
12. J. Massagué The transforming growth factor-β family Annu Rev Cell Biol 6 1990 597 641
13. K. Miyazono J.H. Ichi C-H. Heldin Transforming growth factors-β: latent forms binding proteins and receptors Growth Factors 8 1993 11 22
14. K. Miyazono A. Olofsson P. Colosetti C-H. Heldin A role of the latent TGF-β1-binding protein in the assembly and secretion of TGF-β1 Embo J 10 1991 1091 1101
15. T. Mizoi H. Ohtani K. Miyazono M. Miyazawa S. Matsuno H. Nagura Immunoelectron microcroscopic localisation of transforming growth factor beta 1 and latent transforming growth factor beta 1 binding protein in human gastrointestinal carcinomas: qualitative difference between cancer cells and stromal cells Cancer Res 53 1993 183 190
16. A. Morén A. Olofsson G. Stenman Identification and characterization of LTBP-2 a novel latent transforming growth factor β-binding protein J Biol Chem 269 1994 32469 32478
17. Y. Nakajima K. Miyazono M. Katao M. Takase T. Ymagishi H. Nakamura Extracellular fibrillar structure of latent TGF-β-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart J Cell Biol 136 1997 193 204
18. I. Nunes P-E. Gelizes C.N. Metz D.B. Rifkin Latent transforming growth factor -β binding domains involved in activation and transglutaminase-dependendent cross-linking of latent transforming growth factor-β J Cell Biol 136 1997 1151 1163
19. A. Oloffsson H. Ichi Jo A. Morén P. ten Dijke K. Miyazono C-H. Heldin Efficient association of an amino-terminally extended form of human latent transforming growth factor-β-binding protein with the extracellular matrix J Biol Chem 270 1995 31294 31297
20. M. Raghunath Th Bächi M. Meuli S. Altermatt R. Gobet L. Bruckner-tuderman B. Steinmann Fibrillin and elastin expression in skin regenerating from cultured keratinocyte autografts: morphogenesis of microfibrils begins at the dermo-epidermal junction and precedes elastic fiber formation J Invest Dermatol 106 1996 1090 1095
21. M. Raghunath M. Meuli Cultured epithelial autografts: diving from surgery into matrix biology Ped Surg Int 12 1997 478 483
22. F. Ramirez Fibrillin mutations in Marfan syndrome and related phenotypes Curr Opin Genet Dev 6 1996 309 315
23. D.B. Rifkin S. Kojima M. Abe J.G. Harpe TGF-β structure function and formation Thromb Haemostas 70 1993 177 179
24. J. Saharinen J. Taipale J. Keski-oja Association of the small latent transforming growth factor-β with an eight cysteine repeat of its binding protein LTBP-1 Embo J 15 1996 245 253
25. H. Sakamoto T. Broekelmann D.A. Cheresh F. Ramirez J. Rosenbloom R.P. Mecham Cell-type specific recognition of RGD- and non-RGD containing cell binding domains in fibrillin-1 J Biol Chem 271 1996 4916 4922
26. M.B. Sporn A.B. Roberts TGF-β Problems Prospects Cell Regul 1 1990 875 882
27. J. Taipale J. Keski-oja Growth factors in the extracellular matrix Faseb J 11 1997 51 59
28. J. Taipale K. Koli J. Keski-oja Release of transforming growth factor-β1-binding protein from the pericellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin J Biol Chem 267 1992 25378 25384
29. J. Taipale K. Miyazono C-H. Heldin J. Keski-oja Latent transforming growth facor β1-associates to fibroblast extracellular matrix via latent TGF-β binding protein J Cell Biol 124 1994 171 181
30. J. Taipale J. Saharinen K. Hedman J. Keski-oja Latent transforming growth factor and its binding protein (LTBP-1) are components of extracellular matrix microfibrils J Histochem Cytochem 44 1996 875 889
31. W. Yin E. Smiley J. Germiller R.P. Mecham J.B. Florer R. Wenstrup J. Bonadio Isolation of a novel latent transforming growth factor-β binding protein gene (LTBP-3 J Biol Chem 270 1995 10147 10160