A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblasts

Annals of the Rheumatic Diseases

Volumn 70, Issue 7, 2011, Pages 1311-1319

  Geurts, Jeroen ^a,b   Vermeij, Eline A ^a   Pohlers, Dirk ^c   Arntz, Onno J ^a   Kinne, Raimund W ^c   Van Den Berg, Wim B ^a   Van De Loo, Fons A J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 1BETA; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE EXACERBATION; EDEMA; FIBROBLAST; GENE ACTIVITY; GENE CLUSTER; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MOLECULAR GENETICS; MOUSE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RHEUMATOID ARTHRITIS; SERUM AMYLOID A3 GENE; SYNOVIOCYTE; SYNOVITIS; SYNOVIUM; UPREGULATION;

ADULT; AGED; ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; CHOLESTEROL; CLUSTER ANALYSIS; DIAGNOSIS, DIFFERENTIAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEASIBILITY STUDIES; FIBROBLASTS; GENE EXPRESSION PROFILING; GENETIC VECTORS; HUMANS; LENTIVIRUS; MICE; MICE, INBRED C57BL; MIDDLE AGED; OSTEOARTHRITIS; PROMOTER REGIONS, GENETIC; SERUM AMYLOID A PROTEIN; SYNOVIAL MEMBRANE; TECHNETIUM; TRANSDUCTION, GENETIC;

EID: 79957655546     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2010.135665     Document Type: Article

References (49)

1. Armaka M, Apostolaki M, Jacques P, et al. Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med 2008;205:331-7.
2. Lee DM, Kiener HP, Agarwal SK, et al. Cadherin-11 in synovial lining formation and pathology in arthritis. Science 2007;315:1006-10.
3. Müller-Ladner U, Ospelt C, Gay S, et al. Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts. Arthritis Res Ther 2007;9:223.
4. Lefèvre S, Knedla A, Tennie C, et al. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 2009;15:1414-20.
5. Lens JW, van den Berg WB, van de Putte LB. Quantitation of arthritis by 99mTc-uptake measurements in the mouse knee-joint: correlation with histological joint inflammation scores. Agents Actions 1984;14:723-8.
6. Krenn V, Morawietz L, Burmester GR, et al. Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology 2006;49:358-64.
7. Timmer TC, Baltus B, Vondenhoff M, et al. Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis. Arthritis Rheum 2007;56:2492-502.
8. Galligan CL, Baig E, Bykerk V, et al. Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells:correlates with disease activity. Genes Immun 2007;8:480-91.
9. Huber R, Hummert C, Gausmann U, et al. Identification of intra-group, interindividual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane. Arthritis Res Ther 2008;10:R98.
10. Kasperkovitz PV, Timmer TC, Smeets TJ, et al. Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis. Arthritis Rheum 2005;52:430-41.
11. Lindberg J, af Klint E, Ulfgren AK, et al. Variability in synovial inflammation in rheumatoid arthritis investigated by microarray technology. Arthritis Res Ther 2006;8:R47.
12. van Baarsen LG, Wijbrandts CA, Timmer TC, et al. Synovial tissue heterogeneity in rheumatoid arthritis in relation to disease activity and biomarkers in peripheral blood. Arthritis Rheum 2010;62:1602-7.
13. van der Pouw Kraan TC, van Gaalen FA, Kasperkovitz PV, et al. Rheumatoid arthritis is a heterogeneous disease: evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues. Arthritis Rheum 2003;48:2132-45.
14. Aikawa Y, Morimoto K, Yamamoto T, et al. Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat Biotechnol 2008;26:817-23.
15. Han Z, Boyle DL, Manning AM, et al. AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity 1998;28:197-208.
16. Pope RM, Lovis R, Mungre S, et al. C/EBP beta in rheumatoid arthritis: correlation with inflammation, not disease specificity. Clin Immunol 1999;91:271-82.
17. Geurts J, Joosten LA, Takahashi N, et al. Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis. Mol Ther 2009;17:1877-87.
18. van den Broek MF, van den Berg WB, van de Putte LB, et al. Streptococcal cell wall-induced arthritis and flare-up reaction in mice induced by homologous or heterologous cell walls. Am J Pathol 1988;133:139-49.
19. Pohlers D, Beyer A, Koczan D, et al. Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther 2007;9:R59.
20. Zimmermann T, Kunisch E, Pfeiffer R, et al. Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture - primary culture cells markedly differ from fourth-passage cells. Arthritis Res 2001;3:72-6.
21. Barrett T, Troup DB, Wilhite SE, et al. NCBI GEO:mining tens of millions of expression profiles - database and tools update. Nucleic Acids Res 2007;35 ( Database issue ):D760-5.
22. Gouze E, Pawliuk R, Gouze JN, et al. Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation. Mol Ther 2003;7:460-6.
23. Mitta B, Rimann M, Fussenegger M. Detailed design and comparative analysis of protocols for optimized production of high-performance HIV-1-derived lentiviral particles. Metab Eng 2005;7:426-36.
24. Wunder A, Straub RH, Gay S, et al. Molecular imaging:novel tools in visualizing rheumatoid arthritis. Rheumatology (Oxford) 2005;44:1341-9.
25. del Rey MJ, Izquierdo E, Caja S, et al. Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1alpha/vascular endothelial growth factor-mediated pathway in immunodeficient mice. Arthritis Rheum 2009;60:2926-34.
26. Pierer M, Rethage J, Seibl R, et al. Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands. J Immunol 2004;172:1256-65.
27. Clavel G, Marchiol-Fournigault C, Renault G, et al. Ultrasound and Doppler microimaging in a model of rheumatoid arthritis in mice. Ann Rheum Dis 2008;67:1765-72.
28. Doria AS, Noseworthy M, Oakden W, et al. Dynamic contrast-enhanced MRI quantification of synovium microcirculation in experimental arthritis. AJR Am J Roentgenol 2006;186:1165-71.
29. Zhang N, Weber A, Li B, et al. An inducible nitric oxide synthase-luciferase reporter system for in vivo testing of anti-inflammatory compounds in transgenic mice. J Immunol 2003;170:6307-19.
30. Zhang N, Ahsan MH, Purchio AF, et al. Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition. J Immunol 2005;174:8125-34.
31. Zhang N, Fang Z, Contag PR, et al. Tracking angiogenesis induced by skin wounding and contact hypersensitivity using a Vegfr2-luciferase transgenic mouse. Blood 2004;103:617-26.
32. Wang X, Rosol M, Ge S, et al. Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging. Blood 2003;102:3478-82.
33. Zhang N, Ahsan MH, Zhu L, et al. NF-kappaB and not the MAPK signaling pathway regulates GADD45beta expression during acute inflammation. J Biol Chem 2005;280:21400-8.
34. Zhang N, Ahsan MH, Zhu L, et al. Regulation of IkappaBalpha expression involves both NF-kappaB and the MAP kinase signaling pathways. J Inflamm (Lond) 2005;2:10.
35. Gouze E, Gouze JN, Palmer GD, et al. Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases. Mol Ther 2007;15:1114-20.
36. Abdollahi-Roodsaz S, Joosten LA, Helsen MM, et al. Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production. Arthritis Rheum 2008;58:3753-64.
37. Joosten LA, Koenders MI, Smeets RL, et al. Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88. J Immunol 2003;171:6145-53.
38. Joosten LA, Helsen MM, van Den Berg WB. Blockade of endogenous interleukin 12 results in suppression of murine streptococcal cell wall arthritis by enhancement of interleukin 10 and interleukin 1Ra. Ann Rheum Dis 2000;59:196-205.
39. van den Berg WB, Joosten LA, Kollias G, et al. Role of tumour necrosis factor alpha in experimental arthritis:separate activity of interleukin 1beta in chronicity and cartilage destruction. Ann Rheum Dis 1999;58 (Suppl 1):I40-8.
40. Joosten LA, Abdollahi-Roodsaz S, Heuvelmans-Jacobs M, et al. T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways:crucial role of both interleukin-1beta and interleukin-17. Arthritis Rheum 2008;58:98-108.
41. Hiratsuka S, Watanabe A, Sakurai Y, et al. The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat Cell Biol 2008;10:1349-55.
42. Lagasse E, Weissman IL. Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Blood 1992;79:1907-15.
43. van Lent PL, Grevers L, Blom AB, et al. Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis. Ann Rheum Dis 2008;67:1750-8.
44. Huang JH, Liao WS. Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor. Mol Cell Biol 1994;14:4475-84.
45. Li XX, Huang JH, Rienhoff HY Jr, et al. Two adjacent C/EBP-binding sequences that participate in the cell-specific expression of the mouse serum amyloid A3 gene. Mol Cell Biol 1990;10:6624-31.
46. Nishioka K, Ohshima S, Umeshita-Sasai M, et al. Enhanced expression and DNA binding activity of two CCAAT/enhancer-binding protein isoforms, C/EBPbeta and C/EBPdelta, in rheumatoid synovium. Arthritis Rheum 2000;43:1591-6.
47. Benito MJ, Veale DJ, FitzGerald O, et al. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis 2005;64:1263-7.
48. Blom AB, van Lent PL, Libregts S, et al. Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis:involvement of matrix metalloproteinase 3. Arthritis Rheum 2007;56:147-57.
49. Bondeson J, Wainwright SD, Lauder S, et al. The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther 2006;8:R187.