Enhanced expression and DNA binding activity of two CCAAT/enhancer- binding protein isoforms, C/EBPβ and C/EBPδ, in rheumatoid synovium

Arthritis and Rheumatism

Volumn 43, Issue 7, 2000, Pages 1591-1596

  Nishioka, Katsuhiro ^a   Ohshima, Shiro ^a   Umeshita Sasai, Mitsuko ^a   Yamaguchi, Norihiko ^a   Mima, Toru ^a   Nomura, Shintaro ^a   Murata, Norikazu ^b   Shimizu, Masatoshi ^b   Miyake, Tadao ^c   Yoshizaki, Kazuyuki ^a   Suemura, Masaki ^a   Kishimoto, Tadamitsu ^d   Saeki, Yukihiko ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b MINAMI OSAKA GENERAL HOSPITAL   (Japan)

^c OSAKA GENERAL MEDICAL CENTER   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CCAAT ENHANCER BINDING PROTEIN; CD14 ANTIGEN; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; ISOPROTEIN; MESSENGER RNA; TRANSCRIPTION FACTOR AP 1;

ADULT; AGED; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVITIS; SYNOVIUM;

AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID; CCAAT-ENHANCER-BINDING PROTEINS; DNA; DNA-BINDING PROTEINS; ELBOW JOINT; ELECTROPHORESIS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; KNEE JOINT; MIDDLE AGED; NUCLEAR PROTEINS; OSTEOARTHRITIS; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNOVIAL MEMBRANE;

EID: 0033948984     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200007)43:7<1591::AID-ANR24>3.0.CO;2-9     Document Type: Article

References (12)

1. Poli V. The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J Biol Chem 1998;273:29279-82.
2. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
3. Schreiber E, Matthias P, Muller MM, Schaffner W. Rapid detection of actamer binding proteins with 'mini-extracts,' prepared from a small number of cells. Nucleic Acids Res 1989;17:6419.
4. Asahara H, Asanuma M, Ogawa N, Nishibayashi S, Inoue H. High DNA-binding activity of transcription factor NF-κB in synovial membranes of patients with rheumatoid arthritis. Biochem Mol Biol Int 1995;37:827-32.
5. Marok R, Winyard PG, Coumbe A, Kus ML, Gaffney K, Blades S, et al. Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue. Arthritis Rheum 1996;39:583-91.
6. Pope MP, Lovis R, Mungre S, Perlman H, Koch AE, Haines GK. C/EBPβ in rheumatoid arthritis: correlation with inflammation, not disease specificity. Clin Immunol 1999;91:271-82.
7. Kinoshita S, Akira S, Kishomoto T. A member of the C/EBP family. NF-IL6β, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad Sci U S A 1992;89: 1473-6.
8. Natsuka S, Akira S, Nishio Y, Hashimoto S, Sugita T, Isshiki H, et al. Macrophage differentiation-specific expression of NF-IL6, a transcription factor for IL-6. Blood 1992;79:460-6.
9. Handel ML, McMorrow LB, Gravallese EM. Nuclear factor-κB in rheumatoid synovium: localization of p50 and p65. Arthritis Rheum 1995;38:1762-70.
10. Kinne RW, Boehm S, Iftner T, Aigner T, Vornehm G, Weseloh G, et al. Synovial fibroblast-like cells strongly express Jun-B and c-Fos proto-oncogenes in rheumatoid and osteoarthritis. Scand J Rheumatol Suppl 1995;101:121-5.
11. Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsushima K, Kishimoto T, et al. Transcription factors NF-IL6 and NF-kappaB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A 1993;90:10193-7.
12. Doyle GAR, Perce RA, Parks WC. Transcriptional induction of collagenase-1 in differentiated monocyte-like (U937) cells is regulated by AP-1 and an upstream C/EBP-β site. J Biol Chem 1997;272:11840-9.