A new highly efficient substrate-trapping mutant of Protein Tyrosine Phosphatase 1B (PTP1B) reveals full autoactivation of the insulin receptor precursor

Journal of Biological Chemistry

Volumn 286, Issue 22, 2011, Pages 19373-19380

  Boubekeur, Samira ^a,b   Boute, Nicolas ^a,b   Pagesy, Patrick ^a,b   Zilberfarb, Vladimir ^a,b   Christeff, Névéna ^a,b   Issad, Tarik ^a,b  

^a INSTITUT COCHIN   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOACTIVATION; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CELL SURFACES; CYTOSOLIC; ENDOPLASMIC RETICULUM; INSULIN RECEPTORS; PLASMA MEMBRANES; PROTEIN-TYROSINE PHOSPHATASE 1B;

AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CELL MEMBRANES; ENERGY TRANSFER; EXPERIMENTS; INSULIN; PHOSPHATASES; PHOSPHORYLATION; PROTEINS;

SUBSTRATES;

ALANINE; ASPARTIC ACID; INSULIN RECEPTOR; IODINE 125; MUTANT PROTEIN; PHENYLALANINE; PROTEIN PRECURSOR; PROTEIN TYROSINE PHOSPHATASE 1B; TYROSINE;

ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CELL MEMBRANE TRANSPORT; CELL SURFACE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INSULIN BINDING; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS;

AMINO ACID SUBSTITUTION; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; INSULIN; MUTATION, MISSENSE; PROTEIN PRECURSORS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RECEPTOR, INSULIN;

EID: 79957627535     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.222984     Document Type: Article

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